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Low-carbon Agriculture Development Models in Southern Jiangsu Province
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作者 万玉山 李娜 +2 位作者 丁庆忠 张平 王明新 《Agricultural Science & Technology》 CAS 2012年第4期867-871,共5页
[Objective] To investigate the appropriate low-carbon agriculture model in Southern Jiangsu Province. [Method] Through the analysis of regional features in Southern Jiangsu and several matured low-carbon agriculture d... [Objective] To investigate the appropriate low-carbon agriculture model in Southern Jiangsu Province. [Method] Through the analysis of regional features in Southern Jiangsu and several matured low-carbon agriculture development models at present, the low-carbon agriculture development modes suitable for Southern Jiangsu were investigated, and corresponding supporting measures for the development of the models were put forward. [Result] Low-carbon agriculture is the environment- friendly agriculture which achieves low emissions, low pollution, high efficiency and high-yield through efficient recycling of energy and resources and continuous im- provements on ecological environment. With a variety of development models, the specific development model for practical use should be determined according to the local conditions, and supported by corresponding supporting measures, to achieve the rapid development of low-carbon agriculture. [Conclusion] This study laid the foundation for the development of low-carbon agriculture model in Southern Jiangsu. 展开更多
关键词 Southern Jiangsu Province Low-carbon agriculture Low-carbon technol- ogy Development model
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Comparison of the Development Model of DTP Pharmacy between China and the United States and Its Enlightenment
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作者 Li Yanli Huang Zhe 《Asian Journal of Social Pharmacy》 2024年第2期168-177,共10页
Objective To systematically analyze the development status of DTP pharmacy in the United States and China,and to find out the problems in China’s DTP pharmacy and put forward some countermeasures and suggestions.Meth... Objective To systematically analyze the development status of DTP pharmacy in the United States and China,and to find out the problems in China’s DTP pharmacy and put forward some countermeasures and suggestions.Methods Relevant literature was searched and reviewed to study the history,market scale and development trend of DTP pharmacy in the United States and China.Then,the problems in China’s DTP pharmacy were found out.Results and Conclusion DTP pharmacy model in the U.S.has taken shape and is maturing.The high degree of industry concentration is an important feature of the U.S.pharmacy.In contrast,China’s DTP pharmacy started late,and the industry pattern has not yet been finalized.There are still some problems in the DTP pharmacy certification and quality management.It is recommended to promote the rapid development of DTP pharmacies in China by encouraging the outflow of prescription drugs,establishing a third-party pharmacy accreditation organization and strengthening the team of licensed pharmacists and other personnel. 展开更多
关键词 DTP pharmacy specialty pharmacy development model policy implication
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Appraisal of typical rural development models during rapid urbanization in the eastern coastal region of China 被引量:10
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作者 刘彦随 张富刚 张潆文 《Journal of Geographical Sciences》 SCIE CSCD 2009年第5期557-567,共11页
The sustainability of regional rural development depends on the integrated status and the coordination between rural resources-environment conditions and rural socioeco- nomic development. In this paper a diagnostic i... The sustainability of regional rural development depends on the integrated status and the coordination between rural resources-environment conditions and rural socioeco- nomic development. In this paper a diagnostic indicator system is proposed to appraise four representative rural development models such as Mentougou model, Taicang model, Yueqing model and Qionghai model in the eastern coastal region of China from the integrated perspective of population, resources, environment, and development. In conclusion, the formation and evolution of these diverse rural deveJopment models are the direct response to the very different characteristics in the environment, market demand, and regional culture. These models are common in that their sustainability depends on the scientific guidance of the regional development functional positioning, strong intra-regional interactions, and self-adaptability to the external conditions. 展开更多
关键词 rural development model URBANIZATION coordinated development degree the eastern coastal China
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Rural Tourism Development in China:Principles,Models and the Future 被引量:9
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作者 WANG Ling-en CHENG Sheng-kui +3 位作者 ZHONG Lin-sheng MU Song-lin DHRUBA Bijaya GC REN Guo-zhu 《Journal of Mountain Science》 SCIE CSCD 2013年第1期116-129,共14页
Rural tourism in China,has undergone a rapid development in the last three decades.It is an emerging and effective catalyst that promotes industrial restructuring,agricultural development and the upgrading of rural ar... Rural tourism in China,has undergone a rapid development in the last three decades.It is an emerging and effective catalyst that promotes industrial restructuring,agricultural development and the upgrading of rural areas.However,there remains little understanding about the core issues of rural tourism in China:the exact connotation,the principles,the development models and the future directions.This review paper identifies the key issues based on literature analysis,national statistics and press reports to form a general picture of the past,the current and the future prospects of China's rural tourism.The paper firstly addresses the definition,content and principles of rural tourism,and then provides an overview and brief evaluation of the progress and the current development models in China.Finally,based on the analysis of the experiences and problems,the authors sum up with five pathways of the future development of China's rural tourism from the perspective of rural tourism resources,product,market and promotion. 展开更多
关键词 Rural tourism Definitions Principles Development models China
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Application of Pore Evolution and Fracture Development Coupled Models in the Prediction of Reservoir "Sweet Spots" in Tight Sandstones 被引量:3
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作者 ZHANG Linyan ZHUO Xizhun +3 位作者 MA Licheng CHEN Xiaoshuai SONG Licai ZHOU Xingui 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2015年第3期1051-1052,共2页
The Chang-63 reservoir in the Huaqing area has widely developed tight sandstone "thick sand layers, but not reservoirs characterized by rich in oil", and it is thus necessary to further study its oil and gas enrichm... The Chang-63 reservoir in the Huaqing area has widely developed tight sandstone "thick sand layers, but not reservoirs characterized by rich in oil", and it is thus necessary to further study its oil and gas enrichment law. This study builds porosity and fracture development and evolution models in different deposition environments, through core observation, casting thin section, SEM, porosity and permeability analysis, burial history analysis, and "four-property-relationships" analysis. 展开更多
关键词 Sweet Spots in Tight Sandstones Application of Pore Evolution and Fracture Development Coupled models in the Prediction of Reservoir
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某三级甲等专科医院互联网医院发展的实践与思考 被引量:2
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作者 谢诗蓉 叶卿云 叶正强 《中国卫生资源》 CSCD 北大核心 2023年第3期293-297,共5页
介绍复旦大学附属眼耳鼻喉科医院互联网医院建设历程和运营管理模式。该院互联网医院通过手机即可在线预约、挂号、支付,查看电子病历、检查检验结果、电子发票和药品配送情况等,实现就诊服务全流程移动化,大幅提升患者在线就诊体验。运... 介绍复旦大学附属眼耳鼻喉科医院互联网医院建设历程和运营管理模式。该院互联网医院通过手机即可在线预约、挂号、支付,查看电子病历、检查检验结果、电子发票和药品配送情况等,实现就诊服务全流程移动化,大幅提升患者在线就诊体验。运营3年来,该院互联网医疗数据始终领先于上海各类医院,单科接诊量、周互联网服务量、年互联网服务量、周互联网处方量均保持全市第一。并从患者、医生和医院层面提出未来公立医院互联网医院持续稳定发展的建议和思考。 展开更多
关键词 专科医院specialized hospital 互联网医院Internet hospital 发展模式development model 实践practice
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Business Models,Operation Models and Service Development of IPTV
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作者 Yu Yifang (Network Division of ZTE Corporation,Nanjing 210012,China) 《ZTE Communications》 2006年第3期32-34,共3页
IPTV,as a newborn service,is restricted on market operation by multiple factors. Therefore,exploration is required in respect of its business,operations and service provision models. First,an IPTV industry value chain... IPTV,as a newborn service,is restricted on market operation by multiple factors. Therefore,exploration is required in respect of its business,operations and service provision models. First,an IPTV industry value chain can be formed by integrating the advantages of the existing business models of telecommunication,broadcasting and TV,and Internet industries,which helps realize win-win cooperation of all the parties on the chain. Second,plans for technology implementation and network deployment should be made after comprehensive consideration according to various development stages of the IPTV. Third,a reasonable profit allocation model may promote the growth of IPTV services. Last,market competitiveness will be improved by services bundling. Generally,IPTV will become a breakthrough point for the strategic transformation of telecom operators and meet their innovation demands. Therefore,IPTV is expected to be a promising technology helping telecom operators find more growth space in the information communication market. 展开更多
关键词 Business models Operation models and Service Development of IPTV 中兴 通讯技术
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An overview of efficient development practices at low permeability sandstone reservoirs in China 被引量:1
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作者 Bingyu Ji Jichao Fang 《Energy Geoscience》 2023年第3期149-157,共9页
Low permeability sandstone reservoirs in China typically have more complicated geological conditions, pore structures, and flow characteristics as compared to medium-to-high-permeability sandstone reservoirs. Traditio... Low permeability sandstone reservoirs in China typically have more complicated geological conditions, pore structures, and flow characteristics as compared to medium-to-high-permeability sandstone reservoirs. Traditional geological and seepage theories, and engineering methods are not applicable to the development of these low permeability reservoirs, and wells drilled into them often produce oil and gas at very low rates. Recent breakthroughs in reservoir exploitation technology have greatly improved the productivity of low permeability reservoirs, making them the primary target for oil exploration and extraction in China. The development theories and practices applied to low permeability reservoirs in China are reviewed in this study— based on relevant geological and engineering practices, including drilling, fracturing, recovery, and surface engineering. A unique series of technological advances that aid the development of low permeability reservoirs in China are summarized here. This study may serve as a meaningful guide in achieving scale efficiency for the development of low permeability reservoirs. 展开更多
关键词 Well pattern FRACTURING Development model Reservoir description Low permeability reservoir
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Geographical features and development models of estuarine cities
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作者 CHEN Mingxing XIAN Yue +2 位作者 HUANG Yaohuan SUN Zhigang WU Chengbin 《Journal of Geographical Sciences》 SCIE CSCD 2024年第1期25-40,共16页
Cities are the key areas for human beings to achieve sustainable development goals in the future.Estuarine cities are a special type of coastal city in urgent need of a clear definition.This paper proposed that estuar... Cities are the key areas for human beings to achieve sustainable development goals in the future.Estuarine cities are a special type of coastal city in urgent need of a clear definition.This paper proposed that estuarine cities are cities developed on the coast where rivers and oceans meet and defined four connotations,including the intersection of rivers and marine water systems,the coordinated development of land and oceans,the location advantages of connecting rivers and seas,and the important fragility of the ecological environment.We used Hydro SHEDS,OSM,GPW,and urban socioeconomic statistics and selected 50 estuarine cities with large rivers as representatives to summarize the main geographical basis and socioeconomic characteristics.Cities are primarily found in low-altitude,flat regions with average annual temperatures that mainly vary from 10℃to 25℃,relatively abundant precipitation,and extensive biological resources.There are substantial variations in the socioeconomic features of estuarine cities.We proposed eight development patterns,including open and inclusive city spirit,high-quality livable cities,high-quality development driven by innovation,integration of internal and external communication with ports and cities,construction of an international financial center,ecological environment protection and restoration,active promotion of cultural tourism,and positive international exchanges. 展开更多
关键词 estuarine cities great rivers development models SUSTAINABILITY physical geography socioeconomy
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Is the Long-term Economic Decline of the Philippines Unstoppable? Trends, Reasons, Outlook
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作者 Peter Richter 《Journal of Sustainable Business and Economics》 2023年第4期1-19,共19页
The Philippines was in the 1960s a model of development in Asia and second to Japan,but occupies presently only the 11th position under South-East and East Asian countries in terms of GDP-per capita.The article explor... The Philippines was in the 1960s a model of development in Asia and second to Japan,but occupies presently only the 11th position under South-East and East Asian countries in terms of GDP-per capita.The article explores why this important Asian country with a long colonial past and enormous economic potential still ranks under lower-income countries and has in the last decades let pass by many other Asian countries.In answering this question,the approach of external triggers for accelerated development is being applied.In stark contrast to the success stories of the strongly outward-looking Asian countries like the four Tigers,later of Thailand and Vietnam the Philippines never developed a vision of an open economy connecting pro-actively to the world markets.Trade is hampered by a non-competitive and highly protected national economy.The existing FDI is more oriented to the profitable local markets.Foreign debts were never effectively used and international tourism was never well promoted.Linking these failures to the existing power structures in the country,it seems very much that the backward forces like the big landowners,the local producers and industrialists never wanted and continue not to want to open up the economy to international competition and governments are complacent with these groups.Various indicators demonstrate the long-term decline of the Philippines:Among them the slow growth of the GDP and the continuously high poverty rates.As the alliance of big business and policy holds firm no change in the failing nationalistic economic model can be detected leaving the bleak outlook that the economic decline will continue. 展开更多
关键词 External triggers of accelerated development strategies Promotion of exports Protection of local industries Foreign direct investments Foreign indebting International tourism Concentration of the national economy Failures of the development model
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Analysis on the Protection of Settlement Shape in Sichuan 被引量:1
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作者 李红 周波 《Journal of Landscape Research》 2010年第2期67-70,共4页
This article elaborated the characteristics of settlement shape in detail with examples. Aiming at the negative effects on settlement shape by construction, we put forward some measures, such as respect for ecological... This article elaborated the characteristics of settlement shape in detail with examples. Aiming at the negative effects on settlement shape by construction, we put forward some measures, such as respect for ecological environment, selection mode of space development, protection of historical features, and excavation of culture connotation, so as to realize the protection of settlement shape. 展开更多
关键词 Settlement shape Spatial shape Space development model
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A Sand Control and Development Model in Sandy Land Based on Mixed Experiments of Arsenic Sandstone and Sand: A Case Study in Mu Us Sandy Land in China 被引量:13
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作者 WANG Ni XIE Jiancang HAN Jichang 《Chinese Geographical Science》 SCIE CSCD 2013年第6期700-707,共8页
Serious desertification caused by human activity and climate change,in addition to water loss and soil erosion related to arsenic sandstone in the Mu Us Sandy Land,lead to severe scarcity of soil and water resources,w... Serious desertification caused by human activity and climate change,in addition to water loss and soil erosion related to arsenic sandstone in the Mu Us Sandy Land,lead to severe scarcity of soil and water resources,which causes worse local agricultural conditions accordingly.Many physical properties of arsenic sandstone is complementary with that of sand,arsenic sandstone is therefore supposed to be blended to enhance water productivity and arability of sandy land.Container experiments are carried out to study the enhancement of water holding capacity of the mixture,the blending ratio of arsenic sandstone and sand,and the proper size of the arsenic sandstone particles,respectively.The results of the experiments show that particle size of 4 cm with a ratio of 1∶2 between arsenic sandstone and sand are the proper parameters on blending.Both water content and fertility increase after blending.Water use efficiency in the mixture is 2.7 times higher than that in sand by the water release curves from experiments.Therefore,a new sand control and development model,including arsenic sandstone blending with sand,efficient water irrigation management and reasonable farming system,is put forward to control and develop sandy land so that water-saving agriculture could be developed.Demonstration of potato planting about 153.1 ha in area in the Mu Us Sandy Land in China indicates that water consumption is 3018 m3/ha in the whole growth period.It means that about 61%of irrigation water can be saved compared with water use in coarse sand without treatment.Recycle economic mode and positive feedback of sand resource-crop planting-soil resource are constructed,which changes sand into arable soil and make it possible to develop water-saving agriculture on it.The proposed model will be helpful for soil-water resources utilization and management in the Mu Us Sandy Land. 展开更多
关键词 soil-water resource arsenic sandstone sand control and development model water-saving effect Mu Us Sandy Land
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The Performance of Atmospheric Component Model R42L9 of GOALS/LASG 被引量:31
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作者 吴统文 刘平 +3 位作者 王在志 刘屹岷 宇如聪 吴国雄 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2003年第5期726-742,共17页
This paper examines the performance of an atmospheric general circulation model (AGCM) developed at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of ... This paper examines the performance of an atmospheric general circulation model (AGCM) developed at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics (LASG/IAP). It is a spectral model truncated at R42(2.8125°long×1.66°lat) resolution and with nine vertical levels, and referred to as R42L9/LASG hereafter. It is also the new version of atmospheric component model R15L9 of the global ocean-atmosphere-land system (GOALS/LASG). A 40-year simulation in which the model is forced with the climatological monthly mean sea surface temperature is compared with the 40-year (1958-97) U.S. National Center for Environmental Prediction (NGEP) global reanalysis and the 22-year (1979-2000) Xie-Arkin monthly precipitation climatology. The mean DJF and JJA geographical distributions of precipitation, sea level pressure, 500-hPa geopotential height, 850-hPa and 200-hPa zonal wind, and other fields averaged for the last 30-year integration of the R42L9 model are analyzed. Results show that the model reproduces well the observed basic patterns, particularly precipitation over the East Asian region. Comparing the new model with R15L9/LASG, the old version with coarse resolution (nearly 7.5°long×4.5°lat), shows an obvious improvement in the simulation of regional climate, especially precipitation. The weaknesses in simulation and future improvements of the model are also discussed. 展开更多
关键词 Global ocean-atmosphere-land system (GOALS) model development general atmospheric model (R42L9) model performance
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The Identification and Modeling of the Volcanic Weathering Crust in the Yingcheng Formation of the Xujiaweizi Fault Depression, Songliao Basin 被引量:5
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作者 LIU Cai CHI Huanzhao +1 位作者 SHAN Xuanlong HAO Guoli 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第4期1339-1351,共13页
Through the analysis of core descriptions, well-logs, seismic data, geochemical data and structural settings of the volcanic rock of the Yingcheng Formation in the Xujiaweizi fault depression, Songliao Basin, and the ... Through the analysis of core descriptions, well-logs, seismic data, geochemical data and structural settings of the volcanic rock of the Yingcheng Formation in the Xujiaweizi fault depression, Songliao Basin, and the geological section of the Yingcheng Formation in the southeast uplift area, this work determined the existence of volcanic weathering crust exists in the study area. The identification marks on the volcanic weathering crust can be recognized on the scale of core, logging, seismic, geochemistry, etc. In the study area, the structure of this crust is divided into clay layer, leached zone, fracture zone and host rocks, which are 5-118 m thick (averaging 27.5 m). The lithology of the weathering crust includes basalt, andesite, rhyolite and volcanic breccia, and the lithofacies are igneous effusive and extrusive facies. The volcanic weathering crusts are clustered together in the Dashen zone and the middle of the Xuzhong zone, whereas in the Shengshen zone and other parts of the Xuzhong zone, they have a relatively scattered distribution. It is a major volcanic reservoir bed, which covers an area of 2104.16 km2. According to the geotectonic setting of the Songliao Basin, the formation process of the weathering crust is complete. Combining the macroscopic and microscopic features of the weathering crust of the Yingcheng Formation in Xujiaweizi with the logging and three-dimensional seismic sections, we established a developmental model of the paleo uplift and a developmental model of the slope belt that coexists with the sag on the Xujiaweizi volcanic weathering crust. In addition, the relationship between the volcanic weathering crust and the formation and distribution of the oil/gas reservoir is discussed. 展开更多
关键词 Xujiaweizi fault depression Yingcheng Formation identification marks volcanic weathering crust developmental model
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Development and Validation of a Model for Predicting Diabetic Nephropathy in Chinese People 被引量:8
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作者 MIAO Dan Dan PAN En Chun +3 位作者 ZHANG Qin SUN Zhong Ming QIN Yu WU Ming 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第2期106-112,共7页
Objective To develop a risk model for predicting later development of diabetic nephropathy (DN) in Chinese people with type 2 diabetes mellitus (T2DM) and evaluate its performance with independent validation. Meth... Objective To develop a risk model for predicting later development of diabetic nephropathy (DN) in Chinese people with type 2 diabetes mellitus (T2DM) and evaluate its performance with independent validation. Methods We used data collected from the project 'Comprehensive Research on the Prevention and Control of Diabetes', which was a community-based study conducted by the Jiangsu Center for Disease Control and Prevention in 2013. A total of 11,771 eligible participants were included in our study. The endpoint was a clear diagnosis of DN. Data was divided into two components: a training set for model development and a test set for validation. The Cox proportional hazard regression was used for survival analysis in men and women. The model's performance was evaluated by discrimination and calibration. Results The incidence (cases per 10,000 person-years) of DN was 9.95 (95% CI; 8.66-11.43) in women and 11.28 (95% CI; 9.77-13.03) in men. Factors including diagnosis age, location, body mass index, high-density-lipoprotein cholesterol, creatinine, hypertension, dyslipidemia, retinopathy, diet control, and physical activity were significant in the final model. The model showed high discrimination and good calibration. Conclusion The risk model for predicting DN in people with T2DM can be used in clinical practice for improving the quality of risk management and intervention. 展开更多
关键词 Type 2 diabetes mellitus Diabetic nephropathy Risk factors Model development andvalidation
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Development of Mathematical Model on Preparation of Functionally Graded Material by Co-sedimentation 被引量:6
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作者 Zhongmin YANG, Lianmeng ZHANG and Qiang SHEN Institute of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2001年第2期275-277,共3页
From the process of sedimentation the mathematical relationships among deposition Volume and powder properties as well as sedimentation parameters were deduced. Based on the formula a mathematical model was set up and... From the process of sedimentation the mathematical relationships among deposition Volume and powder properties as well as sedimentation parameters were deduced. Based on the formula a mathematical model was set up and simulated through the computer. At last the validity of mathematical model was supported by the representative experiment on Ti-Mo system FGM prepared by co-sedimentation. 展开更多
关键词 CO MO Development of Mathematical Model on Preparation of Functionally Graded Material by Co-sedimentation
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Deepwater oil and gas field development in South China Sea 被引量:4
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作者 Zhang Dagang Wybro Pieter Kang Yongtian 《Engineering Sciences》 EI 2013年第4期2-9,共8页
This paper focuses on potential development models of future oil and gas exploration in South China Sea. A detailed study of current development models worldwide is performed through some examples of industry installe... This paper focuses on potential development models of future oil and gas exploration in South China Sea. A detailed study of current development models worldwide is performed through some examples of industry installed/ongoing projects and major technical issues encountered during these practice. Key technologies are discussed for the success of field development. Some of the technologies and field development experience can be used for South China Sea project. Several models are studied in field development for different scenarios,including marginal field,large oil field and gas field. With the massive investment activities,continued improved technologies,and rapidly growing pool of professionals,the offshore industry in China will soon encounter a golden period. 展开更多
关键词 field development deepwater exploration development model deepwater technology combinedsystem
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Evaluation of coordinated development of regional resources and economy around Shandong Peninsula urban agglomerations 被引量:3
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作者 LI Na WANG Kui-feng 《Journal of Groundwater Science and Engineering》 2016年第3期220-228,共9页
Promoting coordinated development of resources and environment is an important aspect of building a harmonious society and ecologically sustainable civilization. Here we provide scientific basis to promote the develop... Promoting coordinated development of resources and environment is an important aspect of building a harmonious society and ecologically sustainable civilization. Here we provide scientific basis to promote the development of ecologically sensitive civilization, via a mathematical statistics method that calculates the degree of coordinated development. This model is of great practical and social significance, providing strength to research around coordinated development of resources and economy. Based on evaluation of characteristics of the present resource environment and economic development of Shandong Peninsula city group, a coordinated measure of resource environment and economic development was calculated. Overall, the highest coordination measurement was found for Weihai, followed by Yantai, Qingdao, Ji'nan, Weifang, Rizhao, Zibo and Dongying. According to evaluation results of coordination measures for each city, we put forward suggestions for sustainable development of Shandong Peninsula region. 展开更多
关键词 Shandong Peninsula Urban Agglomerations Resources Economic development Coordinated development model Sustainable development
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Human umbilical cord-derived mesenchymal stem cells promote repair of neonatal brain injury caused by hypoxia/ischemia in rats 被引量:3
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作者 Yang Jiao Yue-Tong Sun +9 位作者 Nai-Fei Chen Li-Na Zhou Xin Guan Jia-Yi Wang Wen-Juan Wei Chao Han Xiao-Lei Jiang Ya-Chen Wang Wei Zou Jing Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第11期2518-2525,共8页
Administration of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)is believed to be an effective method for treating neurodevelopmental disorde rs.In this study,we investigated the possibility of hUC-MSCs... Administration of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)is believed to be an effective method for treating neurodevelopmental disorde rs.In this study,we investigated the possibility of hUC-MSCs treatment of neonatal hypoxic/ischemic brain injury associated with maternal immune activation and the underlying mechanism.We established neonatal rat models of hypoxic/ischemic brain injury by exposing pregnant rats to lipopolysaccharide on day 16 or 17 of pregnancy.Rat offspring were intranasally administe red hUC-MSCs on postnatal day 14.We found that polypyrimidine tract-binding protein-1(PTBP-1)participated in the regulation of lipopolysaccharide-induced maternal immune activation,which led to neonatal hypoxic/ischemic brain injury.Intranasal delive ry of hUC-MSCs inhibited PTBP-1 expression,alleviated neonatal brain injury-related inflammation,and regulated the number and function of glial fibrillary acidic protein-positive astrocytes,there by promoting plastic regeneration of neurons and im p roving brain function.These findings suggest that hUC-MSCs can effectively promote the repair of neonatal hypoxic/ischemic brain injury related to maternal immune activation through inhibition of PTBP-1 expression and astrocyte activation. 展开更多
关键词 developmental brain disease model disease-associated astrocytes intranasal administration LIPOPOLYSACCHARIDE maternal immune activation neonatal brain injury neuroplasticity repair polypyrimidine tract-binding protein-1 stem cell therapy umbilical cord-derived mesenchymal stem cells
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Characteristics and development model of karst reservoirs in the fourth member of Sinian Dengying Formation in central Sichuan Basin,SW China 被引量:1
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作者 YAN Haijun HE Dongbo +11 位作者 JIA Ailin LI Zhiping GUO Jianlin PENG Xian MENG Fankun LI Xinyu ZHU Zhanmei DENG Hui XIA Qinyu ZHENG Guoqiang YANG Shan SHI Xiaomin 《Petroleum Exploration and Development》 CSCD 2022年第4期810-823,共14页
The reservoir space,types and distribution characteristics of karst carbonate gas reservoirs in the fourth member of Sinian Dengying Formation(Deng 4 Member)in central Sichuan Basin are analyzed based on the drilling,... The reservoir space,types and distribution characteristics of karst carbonate gas reservoirs in the fourth member of Sinian Dengying Formation(Deng 4 Member)in central Sichuan Basin are analyzed based on the drilling,logging and seismic data.A development model of karst reservoirs is constructed to support the high-efficiency development of gas pools.The research shows that the reservoirs in Deng 4 Member have mainly small-scale karst vugs and fractures as storage space,and can be divided into three types,fracture-vug,pore-vug and pore types.The development patterns of the karst reservoirs are determined.On the plane,the karst layers increase from 65 m to 170 m in thickness from the karst platform to the karst slope,and the high-quality reservoirs increase from 25.0 m to 42.2 m in thickness;vertically,the reservoirs at the top of Deng 4 Member appear in multiple layers,and show along-bedding and along fracture dissolution characteristics.The reservoirs at the bottom are characterized by the dissolution parallel to the water level during the karstification period,and have 3-5 large-scale fracture-cave systems.Based on the reservoir development characteristics and the genetic mechanism,three types of reservoir development models of karst reservoir are established,i.e.,bed-dissolved body,fracture-dissolved body and paleohorizon-dissolved body.The construction of karst reservoir development models and seismic response characteristics of the three types of reservoirs can provide parameter for well placement and trajectory design,and substantially improve productivity and development indices of individual wells and gas reservoirs.The designed production capacity of the gas reservoir has enhanced from the initial 3.6 billion to 6 billion cubic meters,making the profit of the reservoir development increase noticeably. 展开更多
关键词 gas reservoir characteristics karst reservoir karst cave bed-dissolved body fracture-dissolved body paleohorizon-dissolved body development model Sinian Dengying Formation central Sichuan Basin
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