Clinical study of anesthetization by dezocine combined with propofol for indolent colonoscopy

AIM: To assess the use of dezocine combined with propofol for the anesthetization of patients undergoing indolent colonoscopy.METHODS: A cross-sectional survey of patients undergoing indolent colonoscopy in the Xinjiang people's Hospital was conducted from April 1 to April 30, 2015. The survey collected patient general information and anesthesia data, including overall medical experience and pain management. Thirty minutes after colonoscopy surgery, samples of venous blood were collected and the biochemical indicators of gastrointestinal function were analyzed. RESULTS: There were 98 female and 62 male respondents. Indolent colonoscopy was found to be more suitable for mid to older-aged patients. The necessary conditions for the diagnosis of digestive diseases were required in 65 of the 73 inpatients. Adverse reactions to the intraoperative process included two cases of body movement and two cases of respiratory depression. Gastrin and vasoactive intestinal peptide levels were slightly increased. However, somatostatin and endothelin levels were slightly decreased. CONCLUSION: This study revealed that dezocine combined with propofol can be successfully used for the anesthetization of indolent colonoscopy patients without pain and should be widely used.

Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial

BACKGROUND Gastroscopy and colonoscopy are important and common endoscopic methods for the diagnosis and treatment of gastrointestinal and colorectal diseases.However,endoscopy is usually associated with adverse reactions such as nervousness,nausea,vomiting,choking cough,and pain.Severe discomfort,such as vomiting,coughing,or body movement,may lead to aggravation of a preexisting condition or even interruption of examination or treatment,especially in some critically ill patients with physiological dysfunction(e.g.,cardiovascular or respiratory disease).The optimal methods for inducing analgesia and sedation in endoscopy are areas of ongoing debate;nevertheless,determining an appropriate regimen of sedation and analgesia is important.AIM To evaluate the effects of propofol combined with dezocine,sufentanil,or fentanyl in painless gastroscopy and colonoscopy.METHODS Four hundred patients were randomly assigned to one of four groups for anesthesia:intravenous dezocine,sufentanil,fentanyl,or saline.Propofol was administered intravenously for induction and maintenance of anesthesia.RESULTS The dosage of propofol in the dezocine group was significantly lower than those in other groups(P<0.01).Bispectral index and Steward score(0-6 points,an unresponsive,immobile patient whose airway requires maintenance to a fully recovered patient)after eye opening in the dezocine group were significantly higher than those in other groups(P<0.01).Awakening time and postoperative pain score(0-10 points,no pain to unbearable pain)in the dezocine group were significantly lower than those in other groups(P<0.01).Mean arterial pressure and pulse oxygen saturation in the dezocine group were significantly more stable at various time points(before dosing,disappearance of eyelash reflex,and wakeup)than those in other groups(P<0.01).The rates of hypopnea,jaw thrust,body movements,and usage of vasoactive drugs in the dezocine group were significantly lower than those in other groups(P<0.01).Additionally,the rates of reflex coughing,nausea,and vomiting were not statistically different between the four groups(P>0.05).CONCLUSION The combination of propofol and dezocine can decrease propofol dosage,reduce the risk for the development of inhibitory effects on the respiratory and cardiovascular systems,increase analgesic effect,decrease body movement,shorten awakening time,and improve awakening quality.

Study on the Clinical Effect of Dezocine and Remifentanil Combined with Propofol in Anesthesia for Painless Abortion

Objective:To investigate the anesthetic effect of dezocine and remifentanil combined with propofol in painless artificial abortion.Methods:90 cases in total of painlessinduced abortion 1n our hospital from May 2017to May 2020 were retrospectively analyzed,29cases of propofol anesthesia(group A),29cases of dezocine combined with propofol anesthesia(group B),and 32 cases of remifentanil combined with propofol anesthesia(group C)were compared the anesthesia situation.Resuits:Compared with the cases in group A,the incidence of pain,body movement and sPo,90oat the injection site were lower in group B and group C,the use of propofol was reduced,and the VAS scores were lower when the patients begin to awake,and the efficiency was higher than that in group A(P<0.05);there was no statistic difference in the changes of SBP,DBP and HR index data in the operation time,postoperative awake time,and preoperative,intraoperative and postoperative time points of the three groups(P<0.05).Conclusion:Dezocine and remifentamil combined with propofol for painless artificial abortion anesthesia has more significant effect than propofol anesthesia alone,which can relieve patients'pain and reduce the chance of respiratory depression.

Effects of dezocine on postoperative stress response and immune function in patients with breast cancer

Objective: To investigate the effects of dezocine on postoperative stress response and immune function in patients with breast cancer. Methods: According to random data table method, a total of 80 patients who were scheduled for breast cancer radical surgery from September 2016 to May 2017 were divided into observation group and the control group, 40 cases in each group. The observation group gave intravenous injection of dezocine as an advanced analgesia 15 min before anesthesia induction, the control group given the same amount of sodium chloride injection. The levels of serum inflammatory factors and immune function were measured and compared between the two groups before and after operation. Results: The levels of angiotensin Ⅱ, renin, cortisol, aldosterone, CD3+, CD4+, CD8+and CD4+/CD8+ in the two groups before treatment were not statistically significant. The levels of angiotensin Ⅱ, renin, cortisol, aldosterone in the two groups were increased at first and then decreased, which were significantly higher than those in the same group before operation at 1 d and 3 d;and the levels of angiotensin Ⅱ, renin, cortisol, aldosterone in the observation group were significantly lower than those in the control group after 1 d and 3 d, the difference was statistically significant. The levels of serum CD3+, CD4+ and CD4+/CD8+ in the two groups were decreased at first and then increased, which were significantly lower than those in the same group before operation at 1 d and 3 d;and the observation group levels were significantly higher than those in the control group after 1 d and 3 d, the above indicators were compared with the difference was statistically significant. The levels of serum CD8+ in the two groups were increased at first and decreased subquently, which were significantly higher than those in the same group before operation at 1 d and 3 d and the observation group levels were significantly lower than those in the control group after 1 d and 3 d, the above indicators were compared with the difference was statistically significant. The above indicators have restore to preoperative levels after 5 d. Conclusion: Dezocine can reduce the stress response in patients with perioperative breast cancer, improve the immune function of patients, which has important clinical value, so it is worth promoting.

Effects of dexmedetomidine combined with dezocine on tumor factors, immune function levels and related serum factors in patients with laparoscopic surgery for ovarian cancer

Objective:To study the effects of dexmedetomidine combined with dezocine on tumor factors, immune function levels and related serum factors in patients with laparoscopic surgery for ovarian cancer.Methods: To select 120 cases of laparoscopic ovarian cancer treated and planned to undergo laparoscopic radical operation in our hospital were randomly and equally divided into control group and treatment group. The patients in control group were treated with dezocine, the treatment group were treated with dexmedetomidine combined with dezocine. To detect and compare the serum HE4, YKL-40, TSGF, NSE, S100β protein, MDA, SOD and peripheral blood CD3+, CD4+, CD8+ and calculate CD4+/CD8+ before and after operation. Results: Before the surgery, there was no significant difference in serum HE4, YKL-40, TSGF, NSE, S100β protein, MDA and SOD between the two groups(P>0.05). After surgery, there were significant differences between the two groups in serum HE4, YKL-40, TSGF, NSE, S100β protein, MDA and SOD levels and the same group before surgery (P<0.05), the improvement of each index in the treatment group was better than those in the control group, and the differences were significantly (P<0.05). Before the surgery, the differences between the two groups in peripheral blood CD3+, CD4+, CD8+ and CD4+/CD8+ had no significant difference (P>0.05), After surgery, the differences between the two groups and the same group before operation in peripheral blood CD3+, CD4+, CD8+ levels and CD4+/CD8+ were significantly (P<0.05), the improvement of each index in the treatment group was better than that in the control group, the differences were significantly (P<0.05).Conclusion:Dexmedetomidine combined with dezocine can reduce the serum HE4, YKL-40, TSGF, NSE, S100β protein levels in patients with ovarian cancer after laparoscopic operation, reduce the oxidative stress reaction, has smaller effect on cellular immune function.

The Applications of Dexmedetomidine Given Composite Dezocine Spinal Anesthesia in Patients Undergoing Total Hip Replacement Surgery

Objective:Objective:To evaluate the applications of dexmedetomidine given composite dezocine spinal anesthesia in patients undergoing total hip replacement surgery.Methods:120 cases ASAⅠ~Ⅱgrade elective surgery THA patients were divided into group A(n=40),group B(n=40),C group(n=40)from June 2015 to June 2016.Group A were routined with endotracheal intubation operation;Group B were gap into the line L2-3 spinal anesthesia,anesthesia after a fixed pumping 0.2 mg dezocine a mixture of 3 ml;Group C were threatmented with dextrose infusion 3μg Mi Ding mixture 3.5 ml.The levels of mean arterial pressure(MAP),heart rate(HR),oxygen saturation(SPO2),endtidal carbon dioxide(PETCO2)and other hemodynamic parameters and plasma epinephrine(E),norepinephrine(NE),malondialdehyde(MDA)of three groups before and after 10 min of anesthesia 5min(T0),of anesthesia(T1),at the start of surgery(T2),1 Xiaoshi(T3)after completion of anesthesia,the end of the surgery(T4).The anesthetic complications occur of three groups were compared.Results:The levels of MAP,HR,SPO2,PETCO2,E,NE,MDA in T1~T4 time were increased than T0 stage(P<0.05).The levels of MAP,HR,SPO2,PETCO2,E,NE,MDA in T1~T4 time of Groups A were increased than Groups B,Group C(P<0.05).The levels of MAP,HR,SPO2,PETCO2,E,NE,MDA in T1~T4 time of Groups A and Groups B were compared.The cognitive disorders,nausea,vomiting,restlessness,chills,a high incidence of respiratory depression of Group A were higher than Group B,Group C(P<0.05),will high incidence of respiratory depression of Group B were higher than Groups C(P<0.05).Conclusion:dexmedetomidine given composite dezocine spinal anesthesia can effectively stabilize hemodynamics THA patients and reduce patient stress and blood vessels,its low incidence of postoperative complications,worthy of promotion application.

Effect of dezocine pretreatment on emergence agitation and relatedinternal environment changes in children with general anesthesia surgery

Objective:To study the effect of dezocine pretreatment on the emergence agitation and related internal environment changes in children with general anesthesia surgery.Methods: A total of 200 children who underwent general anesthesia surgery in the Central Hospital of Xiaogan between January 2015 and December 2017 were enrolled in the study and divided into two groups by random number table method, dezocine group received routine general anesthesia and intravenous injection of dezocine 30 min before the end of surgery, and control group received routine general anesthesia and intravenous injection of saline 30 min before the end of surgery. The CHEPOS score of emergence agitation was performed during anesthesia recovery;the levels of inflammatory stress mediators in serum as well as the expression of stress signal molecules and inflammatory signal molecules in peripheral blood were measured before anesthesia induction and during anesthesia recovery.Results: The CHEPOS score of emergence agitation of dezocine group was lower than that of control group;compared with those of same group before anesthesia induction, serum ACTH, Cor, INS, ICAM1 and TNF-α levels as well as peripheral blood CHOP, GRP78, JNK, c-jun, CD14 and SR expression intensity of both groups of patients were significantly higher whereas IRS-1, IRS-2 and PKB expression intensity were significantly lower during anesthesia recovery, and serum ACTH, Cor, INS, ICAM1 and TNF-α levels as well as peripheral blood CHOP, GRP78, JNK, c-jun, CD14 and SR expression intensity of dezocine group during anesthesia recovery were significantly lower than those of control group whereas IRS-1, IRS-2 and PKB expression intensity were significantly higher than those of control group.Conclusions: Dezocine pretreatment has improving effect on the emergence agitation and related internal environment changes in children with general anesthesia surgery.

Effect of dezocine combined with sufentanil patient-controlled intravenous analgesia on general pain and inflammatory mediators after laparoscopic hepatectomy

Objective:To study the effect of dezocine combined with sufentanil patient-controlled intravenous analgesia on general pain and inflammatory mediators after laparoscopic hepatectomy.Methods: A total of 68 patients with primary liver cancer who received laparoscopic surgical treatment in our hospital between July 2014 and December 2016 were collected, the therapies were reviewed, and then patients were divided into the control group (n=35) who received sufentanil PCIA and the observation group (n=33) who received dezocine combined with sufentanil PCIA. Differences in serum levels of pain mediators, acute phase proteins and interleukins were compared between the two groups of patients before and after operation.Results: Before operation, the differences in serum levels of pain mediators, acute phase proteins and interleukins were not statistically significant between the two groups of patients. 6h after operation, serum pain mediators SP, NPY, DA and NE levels in observation group were lower than those in control group;acute phase proteins CRP, HP, CER and AAG levels were lower than those in control group;interleukins IL-1β, IL-6 and IL-8 levels were lower than those in control group.Conclusion: Dezocine combined with sufentanil PCIA after laparoscopic hepatectomy is effective in reducing the early postoperative pain mediator levels and relieving systemic inflammatory response.

Effects of dezocine on cardiovascular response, stress response and cellular immune function before anesthesia induction in radical mastectomy for breast cancer

Objective: To investigate the effects of dezocine on cardiovascular response, stress response and cellular immune function before anesthesia induction in radical mastectomy for breast cancer. Methods: From January 2014 to January 2018, 220 patients with breast cancer undergoing modified radical mastectomy were randomly divided into observation group (110 cases) and control group (110 cases). The observation group was given dezocine before induction of anesthesia, while the control group was given the same amount of Sodium Chloride Injection. Heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation (SpO2), aldosterone (ALD), renin (REN), cortisol (Cor), angiotensin Ⅱ (Ang-Ⅱ) and the level of T cell subsets at 5 time points before anesthesia (T1), 2 h after operation (T2), 10 hours (T3), 24 h (T4) and 48 h (T5) after operation were compared between the two groups. Results:There was no significant difference in HR and MAP between the two groups before anesthesia (30 min). HR and MAP of the two groups were higher at 2 h after operation and 10 h after operation than before, and the HR and MAP of the control group were higher than those of the observation group. There was no significant difference in ALD, REN, Cor and Ang-Ⅱ between the two groups at 30 min before anesthesia and 48 h after operation. ALD, REN, Cor and Ang-Ⅱ in the two groups at 2 h after operation and 10 h, 24 h after operation were higher than those at the 30 min before anesthesia, and ALD, REN, Cor and Ang-Ⅱ in the control group were higher than those in the observation group. There was no significant difference in CD3+, CD4+, CD4+/ CD8+ between the two groups at 30 min before anesthesia and 48 h after operation. CD3+, CD4+, CD4+/CD8+ in the two groups at 2 h after operation and 10 h, 24 h after operation were lower than those at the 30 min before anesthesia, and CD3+, CD4+, CD4+/CD8+ in the control group were lower than those in the observation group. Conclusion: Dezocine before anesthesia induction in radical mastectomy can effectively reduce cardiovascular response and stress response, and play a protective role in cellular immune function.

地佐辛用于局部麻醉鼻中隔矫正术超前镇痛效果的初步分析

目前,国内和发展中国家许多医院鼻内镜手术仍在局部麻醉下进行,如何减轻患者术中疼痛、增加舒适度和安全性是值得我们研究的课题。地佐辛为人工合成的混合型阿片受体激动-拮抗剂,具有镇痛效应强、安全性高、药物依赖发生率较低及副作用小等特点[1]。本研究将地佐辛用于局麻内镜鼻中隔矫正术患者,观察其超前镇痛的有效性和安全性,为进一步临床研究提供依据。

地佐辛经鼻给药对鼻内镜手术围拔管期血流动力学及眼内压的影响

鼻内镜手术因其具有创伤小、病灶清除彻底、快速康复等优点广泛应用于临床[1]。但鼻内镜手术对麻醉要求高,特别是围拔管期,如果处理不当可导致血流动力学波动、术区出血、眼内压（intraocular pressure,IOP）升高等严重后果,因此平稳的度过围拔管期对于鼻内镜手术患者至关重要。本研究旨在探讨地佐辛经鼻给药对鼻内镜手术苏醒期躁动及IOP的影响。