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头孢克肟固体分散体的制备及溶出度测定 被引量:1
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作者 严少康 刘永红 +2 位作者 黎璐平 肖芳 刘永琼 《武汉工程大学学报》 CAS 2011年第11期27-30,共4页
采用固体分散体技术提高头孢克肟在水中的溶解度,以提高生物利用度.以A为载体,采用溶剂-熔融法制备头孢克肟固体分散体.用正交设计方法优选制剂工艺,确定出最优处方为:头孢克肟载体A乙醇=l48(g/g/g).选用红外光谱法对头孢克肟... 采用固体分散体技术提高头孢克肟在水中的溶解度,以提高生物利用度.以A为载体,采用溶剂-熔融法制备头孢克肟固体分散体.用正交设计方法优选制剂工艺,确定出最优处方为:头孢克肟载体A乙醇=l48(g/g/g).选用红外光谱法对头孢克肟固体分散体进行物相鉴定,并测定其溶出度.结果表明:头孢克肟-载体A(14)固体分散体在水中(20℃)的溶出度为95.2%,明显高于原料药(24.8%)及物理混合物(28.6%);红外光谱法检测出头孢克肟固体分散体在1 780cm-1附近处的羰基吸收峰的强度大幅度降低.说明采用溶剂-熔融法形成了头孢克肟固体分散体.头孢克肟形成稳定的固体分散体后,溶出度显著提高. 展开更多
关键词 头孢克肟 固体分散体 制备 溶出度 红外光谱
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左炔诺孕酮显色标记及在透明硅胶体模中弥散规律的实验研究 被引量:2
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作者 孟胤妤 蒋成素 +2 位作者 尤孟媛 李会兴 肖雁冰 《遵义医学院学报》 2019年第4期416-421,共6页
目的用化学方法显色标记左炔诺孕酮(levonorgestrel,LNG),以色彩强弱变化显示LNG在透明硅胶体模壁中的变化,并研究其弥散规律,以期为左炔诺孕酮宫内缓释系统治疗子宫腺肌病存在“病灶阈值”现象的学术观点提供实验依据。方法将LNG与氨... 目的用化学方法显色标记左炔诺孕酮(levonorgestrel,LNG),以色彩强弱变化显示LNG在透明硅胶体模壁中的变化,并研究其弥散规律,以期为左炔诺孕酮宫内缓释系统治疗子宫腺肌病存在“病灶阈值”现象的学术观点提供实验依据。方法将LNG与氨基磺酸、异烟肼混合制成含化学物质标记的LNG(marked LNG,M-LNG),并将相同浓度的M-LNG与LNG使用紫外分光光度计进行紫外光谱分析和性质鉴定。以硅胶制作出透明硅胶体模,将M-LNG溶于甘油后放置于透明硅胶体模腔中,再将透明硅胶体模放入37℃恒温水浴箱中30、60、90 d后观察透明硅胶体模的颜色变化,再以透明硅胶体模腔为中心间距1 cm向外逐层取切片,将切片放入无水乙醇溶液中24 h后使用紫外分光光度计测出M-LNG的吸光度,利用已建立的标准曲线计算出M-LNG的浓度。结果M-LNG与LNG在波长345 nm处波峰未发生明显偏移,表示M-LNG性质未发生明显改变。加入M-LNG的透明硅胶体模在37℃恒温水浴箱中放置30、60、90 d后呈黄色,且颜色以透明硅胶体模腔最深,向外黄色逐渐变淡。在不同弥散距离中,透明硅胶体模中M-LNG的浓度随弥散距离的增加而下降(P<0.01),其规律符合线性回归关系,放置30、60、90 d其线性回归方程分别为:Y=-0.0247x+0.1136,r=0.9937;Y=-0.0243x+0.1135,r=0.9918;Y=-0.0243x+0.1125,r=0.9846。在一定弥散距离内,透明硅胶体模中M-LNG的浓度随放置时间延长下降缓慢,各观测时间点M-LNG浓度差异无统计学意义(P>0.05)。结论①LNG可被氨基磺酸和异烟肼标记显黄色,这种化学标记并未明显改变LNG性质及在透明硅胶体模中的弥散规律。②M-LNG在透明硅胶体模中弥散规律符合线性回归,并同时存在距离依赖的“浓度梯度”和时间依赖的“浓度稳定”现象,从实验上证明了左炔诺孕酮宫内缓释系统治疗子宫腺肌病存在“病灶阈值”现象的学术观点。 展开更多
关键词 子宫腺肌病 透明硅胶体模 左炔诺孕酮 弥散规律
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复方热痱粉预防和治疗婴儿尿布皮炎100例
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作者 樊少晶 王春 《中华医学写作杂志》 2003年第5期447-447,共1页
关键词 复方热痱粉 预防 治疗 婴儿尿布皮炎(compound prickly-heat POWDER prevention therapy INFANT DIAPER dermatitis)
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An Innovative Antiseptic, Antiperspirant and Deodourant Diaper for the Older and Frail Older People Suffering from Urinary Incontinence
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作者 Elaine Wat Alex W. L. Lin +5 位作者 Cyrus Mak Ivan Lam Clara Bik-San Lau Frency Sau-Fun Ng Patrick Chi-Leung Hui Ping-Chung Leung 《Advances in Aging Research》 2017年第2期29-37,共9页
Background: Urinary Incontinence is a common symptom among the older and frail older people. Apart from affecting the quality of life and skin complications, the demand on assistance could be too high for any sufferer... Background: Urinary Incontinence is a common symptom among the older and frail older people. Apart from affecting the quality of life and skin complications, the demand on assistance could be too high for any sufferer. While conservative means of treatment do not work, special incontinence apparel could be a good compromise. Objective: To create an absorbent, antiseptic, antiperspirant and deodourant diaper for the older and dependent people suffering from urinary incontinence. Material and Methods: Antiperspirant and antiseptic medicinal materials have been reported in Traditional Chinese Medicine and two herbs were screened out to provide the required effects. A combination of Fraxini Cortex, Calamine and Zinc oxide made in powder forms was impregnated into a pocket of the diaper. Laboratory tests were performed to confirm the antiseptic, antiperspirant and deodourant effects of the materials. A self-control clinical trial on the diaper was organized in an elderly home. Results: Antibacterial effects against Staphylococcus, E. coli and Candida were proven. Antiperspirant effects were confirmed using acetylcholinesterase inhibitor testings. Volunteers using the Sudoscan machine further demonstrated the weak antiperspirant effects of the herbs. A pilot study on 31 dependent diaper users gave positive feedbacks of more comfort, less leakage, odour and better skin conditions. The overall satisfaction reached 79%. Conclusion: A special diaper with antiseptic, antiperspirant and deodourant effects could be created with inexpensive herbal powder impregnated and could be recommended to the older and frail older people with urinary incontinence. 展开更多
关键词 Urinary INCONTINENCE OLDER And FRAIL OLDER TOILET Assistance Rehabilitation Adult DIAPER
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Recovery of Soil Transmitted Helminthes (STH) Ova from Diaper of Female Child
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作者 Muhammad Mazhar Ayaz Yadong Zheng 《Journal of Zoological Research》 2020年第4期31-32,共2页
Soil Transmitted Helminthes(STH)is always a problem in developing and under developed countries.Children are mostly prone to STH in tropical and non-tropical countries including Pakistan.We have observed ova of Ascari... Soil Transmitted Helminthes(STH)is always a problem in developing and under developed countries.Children are mostly prone to STH in tropical and non-tropical countries including Pakistan.We have observed ova of Ascaris and some non-descriptive objects in the parasitological examination of the fecal material of infant collected from diaper. 展开更多
关键词 STH INFANTS OVA DIAPER
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The effect of protective genital care protocol on preventing diaper dermatit development in 0 - 18 month old children using antibiotics
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作者 Gulbeyaz Baran Saniye Cimen 《Open Journal of Nursing》 2013年第1期153-161,共9页
Diaper dermatit is among the widely seen inflamatory skin diseases in neonatals and small 0 - 18 month old children. Control of causative agents as well as providing good genital care may prevent or reduce the risk of... Diaper dermatit is among the widely seen inflamatory skin diseases in neonatals and small 0 - 18 month old children. Control of causative agents as well as providing good genital care may prevent or reduce the risk of the disease. The aim of this study is find out the effect of protective genital care on reducing the diaper dermatit development in 0 - 18 months old inpatient 0 - 18 month old children who are using antibiotic. The study was conducted as prospective half-experimetal using control-experimental groups. Our samples comprise of 0 - 18 month old children admitted at Dokuz Eylul University Practical and Research Hospital, pediatric clinic between January and May 2009, 41 0 - 18 month old children as a control group were not under protective genital care, and 42 0 - 18 month old children as an experimental group were under the protecion and using vaseline. The mothers of the experimental group 0 - 18 month old children were given education. All 0 - 18 month old children were followed-up 3 - 7 days and the collected data were evaluated in computer using Pearson’s chisquare, Fisher’s exact chi-square and Yatest-corrected chi-square tests. The diaper dermatit develop- ment ratio was 34.1% in the control group and 7.1% in the experimental group 展开更多
关键词 Diaper Dermatit Vaseline 0 - 18 Month Old Children Antibiotic Protective Genital Care
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