Herein,we report an efficient photochemical method for the synthesis of poly-substituted pyrazoles through a multicomponent reaction of acceptor-only diazoalkanes,alkynes,and solvents(cyclic ethers or nitriles).The ke...Herein,we report an efficient photochemical method for the synthesis of poly-substituted pyrazoles through a multicomponent reaction of acceptor-only diazoalkanes,alkynes,and solvents(cyclic ethers or nitriles).The key to this success was driven by the photolysis of acceptor-only diazoalkanes to form free carbene species and the fast in situ[3+2]-cycloaddition formation of nucleophilic N–H pyrazole derivatives.This work also serves as an entry to allow future reaction design on the combination of carbene reactivity of diazoalkanes with their other reaction modes.展开更多
基金the National Natural Science Foundation of China(Nos.21971001 and 21702001)the Natural Science Foundation of Anhui Province(No.1808085MB47),for financial support。
文摘Herein,we report an efficient photochemical method for the synthesis of poly-substituted pyrazoles through a multicomponent reaction of acceptor-only diazoalkanes,alkynes,and solvents(cyclic ethers or nitriles).The key to this success was driven by the photolysis of acceptor-only diazoalkanes to form free carbene species and the fast in situ[3+2]-cycloaddition formation of nucleophilic N–H pyrazole derivatives.This work also serves as an entry to allow future reaction design on the combination of carbene reactivity of diazoalkanes with their other reaction modes.
