Diethyl (1-cyanoethyl) phosphorate 1 was reacted with n-butyl-lithium in tetrahydrofuran (THF) at - 78 °C and the resulting carbanion 2 reacted with perfluoroalkanoic add anhydride to afford perfluoroacylated pho...Diethyl (1-cyanoethyl) phosphorate 1 was reacted with n-butyl-lithium in tetrahydrofuran (THF) at - 78 °C and the resulting carbanion 2 reacted with perfluoroalkanoic add anhydride to afford perfluoroacylated phosphorate 3. Without isolation 3 was attacked by Grignard reagents giving perfluoroalkylated α, β-unsaturated nitriles in 46%-88% yields with high Z-stereoselectivity (Z: E = 89–62:11–38).展开更多
文摘Diethyl (1-cyanoethyl) phosphorate 1 was reacted with n-butyl-lithium in tetrahydrofuran (THF) at - 78 °C and the resulting carbanion 2 reacted with perfluoroalkanoic add anhydride to afford perfluoroacylated phosphorate 3. Without isolation 3 was attacked by Grignard reagents giving perfluoroalkylated α, β-unsaturated nitriles in 46%-88% yields with high Z-stereoselectivity (Z: E = 89–62:11–38).
