Preparation of polyethylene oxide with 4-amino-N-(2-pyrimidinyl) benzene sulfonamide and diethylenetriaminepentaacetic acid end groups and its enrichment in tumour tissues

Using polyethylene oxide (PEO) with 4 amino N (2 pyrimidinyl) benzene sulfonamide (APBS) and hydroxyl end groups (PEO a h ) as parent compounds, PEO with diethylenetriaminepentaacetic acid (DTPA) and APBS end groups (PEO a d ) was prepared by functionization of PEO a h . After complexation of PEO a d with isotopes of 153 Sm and 99 Tc, and injecting the polymer drug into the Kunming white mouse transplanted with Sarcoma 180, it was confirmed by γ counter that the PEO a d could be concentrated selectively in the tumour tissues, the ratio of concentration of the polymer drug in tumour tissue to that in ordinary organs such as liver, heart, spleen, muscle, blood and bone marrow is about 2.3:1 or even 10:1.

Comments on “Efficient adsorption of Mn(Ⅱ) by layered double hydroxides intercalated with diethylenetriaminepentaacetic acid and the mechanistic study.J.Environ.Sci.85,56-65”

In the paper entitled"Efficient adsorption of Mn(Ⅱ)by layered double hydroxides intercalated with di ethylenetriaminepentaacetic acid and the mechanistic study"in Journal of Environmental Sciences,volume 85,page 56-65,there were problems with mathematical notation and dimensional errors in the calculation for Giibbs free energy.In Section 2.5:Adsorption isotherms and thermodynamics studies,authors calculated the Gibbs free energy change(△G°)

Efficient adsorption of Mn(Ⅱ) by layered double hydroxides intercalated with diethylenetriaminepentaacetic acid and the mechanistic study

In this study,greatly enhanced Mn(Ⅱ) adsorption was achieved by as-synthesized diethylenetriaminepentaacetate acid intercalated Mg/Al layered double hydroxides (LDHs-DTPA).The adsorption capacity of LDHs-DTPA was 83.5 mg/g,which is much higher than that of LDHs-EDTA (44.4 mg/g),LDHs-Oxalate (21.6 mg/g) and LDHs (28.8 mg/g).The adsorption data of aqueous Mn(Ⅱ) using LDHs-DTPA could be well described by the pseudosecond order kinetics and Langrnuir isotherm model.Thermodynamics study results also showed that the adsorption process of Mn(Ⅱ) by LDHs-DTPA was exothermic as indicated by the negative △H value.Furthermore,based on the structural,morphological and thermostable features,as well as FT-IR and XPS characterizations of LDHs-DTPA and the pristine LDHs,the adsorption mechanism of Mn(Ⅱ) was proposed.The carboxyl groups of DTPA were proposed to be the main binding sites for Mn(Ⅱ),and the hydroxyl groups of LDHs also played a minor role in the adsorption process.Among the three common regeneration reagents,0.1 mol/L Na2CO3 was the best for reusing LDHs-DTPA in Mn(Ⅱ) adsorption.Besides,the Mn(Ⅱ) adsorption performance could be hindered in the presence of typical inorganic ions,especially cations.Further specific modifications of LDHs-DTPA are suggested to get more selective adsorption of Mn(ll) in practical applications.

Gadoxetic acid-enhanced magnetic resonance imaging can predict the pathologic stage of solitary hepatocellular carcinoma

BACKGROUND Although important for determining long-term outcome, pathologic stage of hepatocellular carcinoma (HCC) is difficult to predict before surgery. Current state-of-the-art magnetic resonance imaging (MRI) using gadoxetic acid provides many imaging features that could potentially be used to classify single HCC as pT1 or pT2. AIM To determine which gadoxetic acid-enhanced MRI (EOB-MRI) findings predict pathologic stage T2 in patients with solitary HCC (cT1). METHODS Pre-operative EOB-MRI findings were reviewed in a retrospective cohort of patients with solitary HCC. The following imaging features were examined: Hyperintensity in unenhanced T2-weighted images, hypointensity in unenhanced T1-weighted images, arterial enhancement, corona enhancement, washout appearance, capsular appearance, hypointensity in the tumor tissue during the hepatobiliary (HB) phase, peritumoral hypointensity in the HB phase, hypointense rim in the HB phase, intratumoral fat, hyperintensity on diffusionweighted imaging, hypointensity on apparent diffusion coefficient map, mosaic appearance, nodule-in-nodule appearance, and the margin (smooth or irregular). Surgical pathology was used as the reference method for tumor staging. Univariate and multivariate analyses were performed to identify predictors of microvascular invasion or satellite nodules. RESULTS There were 39 (34.2%;39 of 114) and 75 (65.8%;75 of 114) pathological stage T2 and T1 HCCs, respectively. Large tumor size (≥ 2.3 cm) and two MRI findings, i.e., corona enhancement [odds ratio = 2.67;95% confidence interval: 1.101-6.480] and peritumoral hypointensity in HB phase images (odds ratio = 2.203;95% confidence interval: 0.961-5.049) were associated with high risk of pT2 HCC. The positive likelihood ratio was 6.25 (95% confidence interval: 1.788-21.845), and sensitivity of EOB-MRI for detecting pT2 HCC was 86.2% when two or three of these MRI features were present. Small tumor size and hypointense rim in the HB phase were regarded as benign features. Small HCCs with hypointense rim but not associated with aggressive features were mostly pT1 lesions (specificity, 100%). CONCLUSION Imaging features on EOB-MRI could potentially be used to predict the pathologic stage of solitary HCC (cT1) as pT1 or pT2.

Focal liver lesions detection and characterization: The advantages of gadoxetic acid-enhanced liver MRI

Since its clinical introduction, several studies in literature have investigated gadolinium ethoxybenzhyl diethylenetriaminepentaacetic acid or gadoxetic acid(Gd-EOB-DTPA) properties. Following contrast injection, it provides dynamic vascular phases(arterial, portal and equilibrium phases) and hepatobiliary phase, the latter due to its uptake by functional hepatocytes. The main advantages of Gd-EOB-DTPA of focal liver lesion detection and characterization are discussed in this paper. Namely, we focus on the possibility of distinguishing focal nodular hyperplasia(FNH) from hepatic adenoma(HA), the identification of early hepatocellular carcinoma(HCC) and the pre-operative assessment of metastasis in liver parenchyma. Regarding the differentiation between FNH and HA, adenoma typically appears hypointense in hepatobiliary phase, whereas FNH is isointense or hyperintense to the surrounding hepatic parenchyma. As for the identification of early HCCs, many papers recently published in literature have emphasized the contribution of hepatobiliary phase in the characterization of nodules without a typical hallmark of HCC. Atypical nodules(no hypervascularizaton observed on arterial phase and/or no hypovascular appearance on portal phase) with low signal intensity in the hepatobiliary phase, have a high probability of malignancy. Finally, regarding the evaluation of focal hepatic metastases, magnetic resonance pre-operative assessment using gadoxetic acid allows for more accurate diagnosis.

The Preparation of Perovskite Nano Powder by Sol-gel from DTPA and the Mechanism of Thermal Decomposition

Dy0.8Sr0.2FeO3 nano powder, a synthetic oxide, is made by sol-gel method from metal nitrate and diethylenetriaminepentaacetic acid (DTPA), and the processing parameters are optimized. The process of the preparation, thermal decomposition and the property of the powder are studied by TG-DTA, IR, TEM, and XRD. The diameter of the average grain is about 70 nm. This new technique can be used in the preparation and the studying of na'no materials in the complex oxide system.

Syntheses and Structure of Nine-Coordinate Gd~Ⅲ Complexes,Na[Gd~Ⅲ(edta)(H_2O)_3]·5H_2O and Na_4[Gd~Ⅲ(dtpa)(H_2O)]_2·14H_2O

The crystal and molecular structures of the Na[Gd Ⅲ(edta)(H_2O)_3]·5H_2O (edta=ethylenediaminetetraacetic acid) and Na_4[Gd Ⅲ(dtpa)(H_2O)]_2·14H_2O (dtpa=diethylenetriaminepentaacetic acid) complexes were determined by single-crystal X-ray structure analyses. The crystal of the Na[Gd Ⅲ(edta)(H_2O)_3]·5H_2O belongs to orthorhombic crystal system and Fdd2 space group. The crystal data are as follows: a =1.9424(7)nm,b =3.5496(12)nm,c =1.2125(4)nm,V =8.360(5)nm 3,Z =16,M =612.63,D _c=1.947 g·cm (-3),μ =3.274 mm (-1) and F (000)=4880. The final R and wR values are 0.0295 and 0.0677 for 3102 [ I>2.0σ(I) ] unique reflections,and 0.0328 and 0.0695 for all 8269 reflections,respectively. The [Gd Ⅲ(edta)(H_2O)_3]-complex anion has a nine-coordinate pseudo-monocapped square antiprismatic structure in which the nine coordinate atoms,two N and seven O are from one edta ligand and three coordinate water molecules. The crystal of the Na_4[Gd Ⅲ(dtpa)(H_2O)]_2·14H_2O belongs to monoclinic crystal system and P2(1)/n space group. The crystal data are as follows: a =1.4894(6)nm,b =1.7987(7)nm, c =1.9600(7)nm,β =99.496(7),V =5.179(3)nm3,Z=4,M =1471.44,D _c=1.841 g·cm (-3),μ =2.676 mm (-1) and F (000)=2872. The final R and wR are 0.0435 and 0.0979 for 8929 [ I>2.0σ(I) ] unique reflections,and 0.0820 and 0.1167 for all 20717 reflections,respectively. The total complex moleculue is composed of two close parts in structure. The [Gd Ⅲ(dtpa)(H_2O)] (2-) complex anion in the every part has a nine-coordinate structure with distorted monocapped square antiprismatic prism,in which the dtpa coordinates with central Gd Ⅲ ion acting as a octadentate ligand with three N atoms and five O atoms,and one water as the ninth ligand directly coordinates with central Gd Ⅲ ion.

Synthesis and Crystal Structure of a Heteronuclear Complex［MnSc（DTPA）（H_2O）_2］·2H_2O

The title complex, [MnSc (DTPA) (H2O)2]·2H2O (DTPA is diethylenetriaminepentaacetic acid). has been synthesized in aqueous solution. Its crystal structure has been determined by four-circle X-ray diffractometer. The crystal is monoclinic with space group P21/n. The cell parameters are as follows:α=0.7886 (3) nm, b=1.5094 (5) nm. c=1. 8162(6) nm; β=100. 32(2)°, V= 2. 121 (2) nm3 , Z= 4 , Dc =1. 75 g/cm3. In the crystal,Sc3+ ion is coordinated by five oxygen atoms and three nitrogen atoms of DTPA with coordination number eight. taking a trigondodecahedron arrangement. Mn2+ ion is coordinated by four oxygen atoms from different DTPA and two oxygen atoms from H2O molecules with coordination number six, forming an octahedron. Each Sc(DTPA) is further connected with Mn2+ ions through four carboxyl groups of DPTA serving as bridges to form a three dimensional network.

Synthesis and Structural Determination of Nine-coordinate K2［YⅢ(dtpa)(H2O)］.7H2O

The synthesis and structure of the title complex K_2[Y Ⅲ(dtpa)(H_2O)]·7H_2O (dtpa=diethylenetriaminepentaacetate) were studied. The crystal and molecular structures of the complex were determined by single-crystal X-ray structure analysis. The crystal of the complex K_2[Y Ⅲ(dtpa)(H_2O)]·7H_2O belongs to triclinic crystal system and P(-1) space group.The crystal data are as follows:a=0.9671(2)nm,b=1.1327(2)nm,c=1.3389(3)nm,β=86.76(3)°,γ=68.72(3)°,V=1.3324(5)nm3,Z=2,M=699.53,D_C=1.744 g·cm -3,μ=2.586 mm -1 and F(000)=720. The final R and R_W are 0.0467 and 0.1195 for 4524(I>2σ(I)) unique reflections, respectively. The complex anion [Y Ⅲ(dtpa)(H_2O)] 2- has a pseudo-monocapped square antiprismatic nine-coordinate structure in which eight coordinate atoms, three N and five O are from a dtpa ligand and one water molecule coordinates to Y Ⅲ ion directly as the ninth ligand.

Synthesis and relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) complexes with dihydropyridine derivative of diethvlenetriaminepentaacetic acid

A novel ligand of DTPA-dihydropyridine derivative was synthesized by reaction of DTPA-dianhydride with 4-aniline-1,4-dihydropyridine. Its complexes of gadolinium, manganese and iron were prepared. Their spin-lattice relaxivities (T1) were investigated. The results show that the NMR T1 relaxivitives (R1) for complexes of Fe(Ⅲ), Mn(Ⅱ) are less than that of Gd(Ⅲ) complex,which has a high relaxivity (R1) on the surrounding water protons, indicating that the Gd(Ⅲ) complex possesses the precondition to be contrast agents for magnetic resonance imaging.

Dopamine-containing gadolinium complex as magnetic resonance imaging contrast agent

Gadolinium diethylenetriamine-pentaacetic bisdopamide （Gd-DTPA-2DA） was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid （DTPA） and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and pro- duced highly contrasted visualization of the brain.