PHASE SEPARATION OF RETINAL SCHIFF BASE IN TWO-COMPONENT LB FILM WITH DIFFERENT LIPIDS

Phase sepertion of 9-cis-retinal schiff base in two-component LB film with different lipids has been observed under Brewster Angle Microscope

Tunable Optical Filters Based on Different Configurations with Cholesteric Liquid Crystals

Optical filters with different configurations based on cholesteric liquid crystals （CLCs） are designed. The central wavelength from CLCs can be tuned by the electric field or temperature. For the electric field tuning, the ITO is designed with circular patterns, which can make the tunable range 18 nm. For the temperature tuning, two-layer- CLC configurations are used. The experimental results indicate that a deepened or broadened bandgap from the CLC can be achieved by different handedness or concentrations of chiral dopants. The spectrum study is carried out.

Outcome assessment of stroke convalescence using multiple scales based on different dimensions

BACKGROUND: Convalescence is an important stage of stroke treatment. A lot of patients have somatic and mental disorders at various degrees. The primary standard can only reflect partial conditions of somatic disorder; in addition, multiple dimensions of patients at the phase of stroke convalescence are further observed by using a lot of standards, such as signs and symptoms of traditional Chinese medicine, daily activity and psychological status. OBJECTIVE: To analyze the outcome assessments of the cases of stroke convalescence measured with different criteria consisting of various dimensions by a cross-sectional investigation of the condition of stroke convalescent patients. DESIGN: Scale evaluation. SETTING: Departments of Clinical Epidemiology Exploratory Development and Neurology, the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine; National Center for Training of Design, Measurement and Evaluation in Clinical Research,Guangzhou University of Traditional Chinese Medicine. PARTICIPANTS: A total of 194 stroke convalescent patients treated in the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from July 26, 2000 to February 28, 2001 were taken as subjects of the study. There were 126 males and 68 females aged from 40 to 89 years, and the illness course ranged from 14 to 181 days. All patients met diagnosis-treatment criteria of stroke (the second version)[DTCS(V2.0)] and various kinds of diagnostic points of cerebrovascular diseases; moreover, all patients provided confirmed consents. METHODS: They were assessed by assessment methods including the following assessment instruments: DTCS(V2.0), self-designed scale of traditional Chinese medicine (TCM) symptoms (28 symptoms and physical signs were scored as 0, 1, 2 marks from none to severity), modified Edinburgh-Scandinavia stroke scale (a total of 45 marks, 0 to 15 marks as mild defect, 16 to 30 as moderate defect, 31 to 45 as severe defect), modified Barthel activities of daily life (ADL) index (a total of 100 marks, less than 60 marks as unable self-care), vitality and mental health (subscales derived from Health Survey Questionnaire, SF-36). The collected data from scales and inter-scale correlation were processed by the statistic methods mainly including descriptive analysis, Spearmen correlation analysis, factor analysis, etc. MAIN OUTCOME MEASURES: ① Average scores of scales and criteria; ② correlation between modified Edinburgh-Scandinavia stroke scale and other scales. RESULTS: All of the patients completed the assessment, and analyzed in the final analysis. ① The average scores of the scales and criteria: The average scores of DTCS(V2.0), self-designed scale of TCM symptoms, modified Edinburgh-Scandinavia stroke scale, modified Barthel ADL index, vitality and mental health scales were 6.51±6.29, 13.73±6.97, 7.56±7.35, 63.58±23.68, 52.79±23.32 and 62.83±22.75 respectively. ② Correlation between modified Edinburgh-Scandinavia stroke scale and other scales: The Spearman correlation coefficients (R ’) of modified Edinburgh-Scandinavia stroke scale with diagnosis-treatment criteria of stroke, scales of TCM symptoms, modified Barthel ADL index, vitality scale and mental health scale were 20.885, 0.302, -0.824, -0.294 and -0.258 respectively. CONCLUSION: The modified Edinburgh-Scandinavia stroke scale and DTCS(V2.0) shared the same assessment dimension, so they can be mutually alternated in some clinical practices. Discrepancy in measurements of health status was gained due to the diverse dimensions applied in outcome assessments. It is necessary to build up a multi-dimensional assessment criteria system, such as signs and symptoms, daily activities and psychological status, for assessing the stroke convalescent cases in a more comprehensive scope and reflecting the efficacy of TCM treatment scientifically.

A Dynamic Model of Heavy Ion ~7Li Irradiation Mutagenesis Based on Maize Inbred Line Nutrition Difference

To reveal the saddle-type dose effect relationship, we propose a radiation mutagenesis model based on maize nutrition difference resulting from heavy ion ~7Li radiation. Through irradiation mutagenesis, apparent trait selection, amino acids and fatty acids content determination, and modeling, dynamic evolution from microscopic damage and repair initiation to the final macroscopic biological effects are considered simultaneously. The results show that the steady state nature is independent of evolution time and only relates to different radiation doses.Heavy ion ~7Li radiation could effectively cause maize phenotypic variation and could improve nutritional quality.This model not only gives a good fit to the experimental results on most types of amino acids and fatty acids, but also offers an adequate explanation of the experimental phenomenon underlying the saddle-type bimodal dose effect. By combining experimental results with theoretical analyses, we suggest that the synergy of the stimulus effect and momentum transfer is the main cause of the saddle-type dose effect bimodal curve. This provides an effective strategy for conducting maize germplasm innovation.

马大正老师治疗经行头痛经验介绍

[目的]探讨马大正老师治疗各型经行头痛的经验。[方法]通过分析马大正老师对经行头痛病因病机的认识、总结马老的临证思路和典型案例,来阐述马大正老师治疗妇科经行头痛的临床经验。[结果]经过马大正老师的中医辨证方法拟方,分别以外感风邪、肝火上逆、血虚生风、痰浊内阻、肝胃不和、气滞血瘀等治疗各型经行头痛,临床取得良好的效果。[结论]引起经行头痛的病因很多,但马老根据患者的特点辨证论治选方用药精准能取得很好的疗效,对临床治疗经行头痛有很好的指导作用。

混合微分求积法在功能梯度材料平板柱形弯曲问题中的应用

利用混合微分求积法,对任意荷载作用下不同材料梯度分布的功能梯度材料平板柱形弯曲问题进行了分析。针对广义微分求积法求解集中荷载问题精度不高的缺点,本文利用小波微分求积法进行了改进。由于小波对突变信号具有良好的自适应描述能力,因此在平板宽度方向上,利用小波微分求积法可以有效地处理集中荷载;而在材料梯度变化的板厚方向上,则利用广义微分求积法计算量小且精度高的特点进行离散计算。计算表明,混合微分求积法不仅保留了广义微分求积法高效的特点,而且能有效地求解任意荷载作用的问题。通过算例,分析了在机械荷载作用下,材料不同梯度形式、平板上下表面材料性质差异对功能梯度平板结构响应的影响。

老年痴呆症辨治浅识

老年痴呆症是指老年期慢性进行性智能全面衰退性疾病。中医辨证论治,病程较短者,多以实证为主,重在祛痰化瘀,可改善症状,疗效较好;久病,病程长者,常以虚证为主,重在补虚,疗效相对较差。不论是实证或虚证,只要坚持治疗,即可出现逆转佳象,达到一定程度智能恢复的目标。

马大正教授治疗闭经新法探析

[目的]探讨马大正教授治疗闭经的独特临床经验。[方法]分析马大正教授对闭经病因病机的认识、治疗闭经独特的辨证论治和精准的选方用药以及典型案例,阐述马大正教授治疗闭经的独特临床经验。[结果]马大正教授治疗闭经方法不同寻常,针对冲任不足、瘀血阻滞、冲气上逆、寒凝瘀滞、湿阻胞脉、痰瘀凝滞、血热煎熬导致的闭经,分别采用补益冲任、磨积导滞、降气导冲、温经散寒、渗利湿浊、软坚散结、清热化瘀等方法,临床取得良好的效果。[结论]马大正教授治疗闭经方法独特,为临床治疗闭经提供了新的思路和方法,值得临床应用推广。

分型辨治震颤麻痹浅述

震颤麻痹又称帕金森病,是一种发生于中老年人常见的锥体外系疾病。临床主要症状为静止性震颤、僵直、运动徐缓及姿势反射丧失等,并有面具脸,头部前倾,躯干俯屈,行走时上肢无摆动及慌张步态等特殊姿态。中医辨证论治可以延缓其病程进展,减轻症状,减少相关西药用量,可提高患者的生活质量。

糖尿病患者的中医辨证护理体会

目的:探讨中医辨证施护对糖尿病患者的临床疗效。方法:将60例糖尿病患者随机分为观察组和对照组,每组各30例,对照组给予西医常规护理,观察组根据不同证候分型采用中医辨证施护,连续护理3个月后比较两组患者的治疗效果。结果:护理治疗3个月后中医观察组对疾病知识掌握者占92.5%,没有出现护理并发症,病房综合满意率为100%。西医对照组对疾病知识掌握者占71.0%,有5例出现护理并发症,病房综合满意率为70.5%。结论:中医辨证护理方法能有效地提高糖尿病患者的临床治疗效果,改善病人的生活质量,值得临床推广。

Sex differences in SARS-CoV-2 infections,anti-viral immunity and vaccine responses

The COVID-19 pandemic has revealed sex-based differences in anti-viral responses,with a higher rate of SARS-CoV-2 infections as well as a higher rate of morbidity and mortality in men than in women.Males and females also show disparate immune responses to COVID-19 infection,which may be important contributors to lower rates of infection,disease severity and deaths in women than in men.Here,the authors review sex differences in SARS-CoV-2 infections,anti-viral immunity and vaccine responses,putting forth the importance of sex,the underappreciated variables in vaccine response and disease infectivity.

BLOCK BASED NEWTON-LIKE BLENDING INTERPOLATION

Newton＇s polynomial interpolation may be the favourite linear interpolation in the sense that it is built up by means of the divided differences which can be calculated recursively and produce useful intermediate results. However Newton interpolation is in fact point based interpolation since a new interpolating polynomial with one more degree is obtained by adding a new support point into the current set of support points once at a time. In this paper we extend the point based interpolation to the block based interpolation. Inspired by the idea of the modern architectural design, we first divide the original set of support points into some subsets （blocks）, then construct each block by using whatever interpolation means, linear or rational and finally assemble these blocks by Newton＇s method to shape the whole interpolation scheme. Clearly our method offers many flexible interpolation schemes for choices which include the classical Newton＇s polynomial interpolation as its special case. A bivariate analogy is also discussed and numerical examples are given to show the effectiveness of our method.

Midinfrared optical frequency comb based on difference frequency generation using high repetition rate Er-doped fiber laser with single wall carbon nanotube film

We demonstrated stable midinfrared(MIR) optical frequency comb at the 3.0 μm region with difference frequency generation pumped by a high power, Er-doped, ultrashort pulse fiber laser system. A soliton mode-locked161 MHz high repetition rate fiber laser using a single wall carbon nanotube was fabricated. The output pulse was amplified in an Er-doped single mode fiber amplifier, and a 1.1–2.2 μm wideband supercontinuum(SC) with an average power of 205 m W was generated in highly nonlinear fiber. The spectrogram of the generated SC was examined both experimentally and numerically. The generated SC was focused into a nonlinear crystal, and stable generation of MIR comb around the 3 μm wavelength region was realized.

Recent progress on terahertz generation based on difference frequency generation:from power scaling to compact and portable sources

The progress achieved on power scaling and compact and portable THz sources is reviewed.By reversely stacking the GaP plates,the photon conversion efficiency is improved from 25% to 40% which corresponds to the maximum value.When the number of the plates is increased from four to five,the output power decreases because of back conversion.The THz generation is also investigated by mixing the two frequencies generated by a single Nd：YLF solid-state laser.The average output power reaches 1 μW.The introduction of two Nd：YLF crystals significantly improves the output power to 4.5 μW.This configuration facilitates the generation of different output frequencies.

Amplification assisted difference frequency generation for efficient mid-infrared conversion based on monolithic tandem lithium niobate superlattice

We report the investigation on the performance of an amplification assisted difference frequency generation(AA-DFG) system driven by pulsed pump and continuous-wave primary signal lasers. A monolithic tandem lithium niobate superlattice was employed as the nonlinear crystal with a uniform grating section for the DFG process, followed by a chirp section for the optical parametric amplification process. The impacts of pump pulse shape, primary signal power, input beam diameter, and crystal structure on the pump-to-idler conversion efficiency of the AA-DFG system were comprehensively studied by numerically solving the coupled wave equations. It is concluded that square pump pulse and high primary signal power are beneficial to high pump-to-idler conversion efficiency. In addition, tighter input beam focus and smaller DFG length proportion could redeem the reduction in conversion efficiency resulting from wider acceptance bandwidths for the input lasers. We believe that such systems combining the merits of high stability inherited from cavity-free configuration and high efficiency attributed from the cascaded nonlinear conversion should be of great interest to a wide community,especially when the pulse shaping technique is incorporated.

中西医结合治疗阵发性睡眠性血红蛋白尿36例临床观察

为提高阵发性睡眠性血红蛋白尿的临床疗效,采用中西医结合的方法治疗该病患者36例,中医辨证分为肝肾阴虚、淤血湿热内停型和脾肾阳虚、淤血寒湿内停型,治疗以大菟丝子饮为基础方加减;溶血急性期治以茵陈五苓散合二至丸加减,各型同时服免疫丸。西药治以强地松、维生素E、康力龙等。临床以血红蛋白尿、周围血象、骨髓增生改善情况为观察指标。结果:近期明显进步者22例,近期进步者7例,无效4例,死亡3例,总有效率为80.56 ％。同时检测了36例患者治疗前后周围血象的变化,白细胞总数、血小板、网织红细胞治疗后均有改善的趋势,血红蛋白较治疗前明显上升,经统计学处理,治疗前后有非常显著的差异(t=8.51P<0.01)。

王彦晖治疗天疱疮的临床经验探析

天疱疮为一组累及皮肤黏膜的自身免疫性表皮内水疱的大疱性皮肤病。文章总结了王彦晖教授治疗天疱疮的临床经验。王教授基于中西医理论来认识天疱疮的病因病机,以象、症结合的状态辨治为主,注重症状和舌、脉象的及时反馈以调整天疱疮的用药。并附临证典型病案1则以展示王教授治疗天疱疮的思路。