Exploring the scientific rationality of“Different dosage forms of the same prescription”base on Q-markers of pulvis and pill of Chuanxiong Chatiao Prescription

Objective:To predict and analyze the potential Q-markers of Chuanxiong Chatiao Prescription,and the pharmacokinetic properties of pulvis and pills in vivo were studied,which provided a basis for the rational evaluation of the phenomenon of“Different Dosage Forms of the Same Prescription”.Methods and Material:Q-markers analysis of Chuanxiong Chatiao Prescription based on the“Five Principles”(traceability and transmissibility,specificity,effectiveness,prescription compatibility and testability).The content determination method of Q-markers in Chuanxiong Chatiao Prescription was established by UPLC,and the content difference of Q-markers in the two dosage forms ware determined and compared.The Q-markers in rabbit plasma was determined by LC-MS/MS method,and the pharmacokinetic parameters of Q-markers in pulvis and pills were analyzed.Results:A total of 16 potential Q-markers from the“Five Principles”were used,nine components of tetramethylprazine,ferulic acid,glycyrrhizin,glycyrrhizic acid,luteolin,cimicifugoside,senkyunolideⅠ,isoimperatorin,nodakenin were identified as Q-markers of Chuanxiong Chatiao Presciption.The content of tetramethylprazine and other components in the pulvis form was found to be significantly higher than that in the pills,while the content of senkyunolideⅠwas lower than that in the pills,which may be related to the preparation process of the dosage form and the physicochemical properties of the components.Compared with pulvis,the Tmax and t_(1/2)of ferulic acid and other components in pills were significantly prolonged.To a certain extent,it can explain the classical theory of traditional Chinese medicine“Components in pulvis release quickly and take effect in fast-acting manner,while in pills release slowly and take effect in slow-acting”.Meanwhile,the Cmax and AUC0-t of tetramethylprazine and other components in pills were higher than those in pulvis,which showed unexpected pharmacokinetic characteristics,indicating the complexity of compounding and the importance of dosage form design.Conclusions:A method for the determination of Q-markers content was established by UPLC,which provide reference for the quality control of Chuanxiong Chatiao Prescription.In vivo studies have found the pharmacokinetic parameters indicate the absorption and distribution characteristics of pulvis and pills.However,it is also found that the release behavior of different components not only affected by the dosage form but also closely related to their own physical and chemical properties.

Dynamic caustics test of blast load impact on neighboring different cross-section roadways

Using digital laser dynamic caustics experimental system and conducting simulation experiment researched the influence rule of blasting excavation of a new roadway on neighboring existed different cross-section roadways. The experimental results show that the influence of blast load on adjacent roadway has a good relationship with the cross-section of roadway. The expansion distance of precrack existed in circular, arch-wall, rectangular roadway is respectively 1.76, 1.61 and 0 cm under blast load.At the same time, the direct-blast side of rectangular roadway has more obvious damage compared with circular and arch-wall roadway. It explains that plane reflects more stress wave than arc, so that it exerts more tensile failure in the direct-blast side, which leads to less stress wave diffracting to the precrack in the back-blast side. When the precrack extends, higher value dynamic stress intensity factor in circular roadway works longer than that of arch-wall roadway. Indirectly, it explains that plane's weakening function on stress wave is significantly stronger than arc. Stress wave brings about self-evident influence on the upper and bottom endpoints of the rectangular roadway, and it respectively extends 1.03, 2.06 cm along the line link direction of the center of the blasthole and the upper and bottom endpoints on the right wall.

CFD-Based Method of Determining Form Factor k for Different Ship Types and Different Drafts

The value of form factor k at different drafts is important in predicting full-scale total resistance and speed for different types of ships. In the ITTC community, most organizations predict form factor k using a low-speed model test. However, this method is problematic for ships with bulbous bows and transom. In this article, a Computational Fluid Dynamics(CFD)-based method is introduced to obtain k for different type of ships at different drafts, and a comparison is made between the CFD method and the model test. The results show that the CFD method produces reasonable k values. A grid generating method and turbulence model are briefly discussed in the context of obtaining a consistent k using CFD.

Converting circular tubes into square cross-sectional parts using incremental forming process

Incremental forming process is recently developed to form tubular parts.The fabrication cost and accuracy could be optimized if the effects of process parameters and the optimum values are specified.The aim of this research is using incremental forming of copper tubes to convert a circular tube into a square cross-sectional part.An experimental setup,consisting of a spherical forming punch and a fixture for clamping the tube is designed.The forming punch movement is controlled by a CNC machine.Full factorial design of experiments is carried out in order to determine the effects of process parameters including linear velocity,radial feed,and axial feed of the tool on the thinning ratio and the maximum outer diameter of the square cross-sectional parts.Results show that the radial feed has the major influence on the thinning ratio,while the axial feed plays the major role for the final profile.Increase of radial feed results in higher thinning ratio,and decrease of axial feed results in better shape conformity.Linear velocity does not have a significant effect on thinning ratio.Regression models are also given for predicting the determined responses.

The development of real time data driving multi-axis linkage and synergic movement control system of 3D variable cross-section roll forming machine

The three dimensional variable cross-section roll forming is a kind of new metal forming technol- ogy which combines large forming force, multi-axis linkage movement and space synergic movement, and the sequential synergic movement of the ganged roller group is used to complete the metal sheet forming according to the shape of the complicated and variable forming part data. The control system should meet the demands of quick response to the test requirements of the product part. A new kind of real time data driving multi-axis linkage and synergic movement control strategy of 3D roll forming is put forward in the paper. In the new control strategy, the forming data are automatically generated according to the shape of the parts, and the multi-axis linkage movement together with cooperative motion among the six stands of the 3D roll forming machine is driven by the real-time information, and the control nodes are also driven by the forming data. The new control strategy is applied to a 48 axis 3D roll forming machine developed by our research center, and the control servo period is less than 10ms. A forming experiment of variable cross section part is carried out, and the forming preci- sion is better than ＋ 0.5mm by the control strategy. The result of the experiment proves that the control strategy has significant potentiality for the development of 3D roll forming production line with large scale, multi-axis ganged and svner^ic movement

An Empirical Study on the Impact of Different Structural Systems on Carbon Emissions of Prefabricated Buildings Based on SimaPro

In the context of global emission reduction, the low-carbon sustainable development of the construction industry has become an important research content. With the vigorous development of new industrial technologies, the application of prefabrication technology to buildings had become a mainstream. However, the research on the role of prefabricated technology in reducing building carbon emissions was not yet comprehensive, and the research on the relationship between prefabricated structure types and carbon emissions in the construction stage was not yet thorough. Guided by life cycle assessment (LCA), this paper used the scenario analysis method to set different working conditions for five different structural systems, and used SimaPro software to evaluate the carbon emissions of prefabricated buildings in order to clarify the carbon emissions of prefabricated buildings under different structural systems, and explore their impact mechanisms in depth. Finally, take the existing buildings in China as an empirical study, the results showed that: 1) The carbon emissions produced by the four common prefabricated structural systems were almost the same. Different structures had different requirements for the combination of components. The carbon emissions of individual buildings would be superimposed according to the carbon emission characteristics of various individual components to form the final total carbon emissions. 2) When the building structure system requires more combinations of components, the greater the amount of transportation invested in the transportation process, the more carbon emissions would be caused. In the calculation of all individual building construction stages, the carbon emissions generated by tower cranes almost exceed the sum of the carbon emissions of all mobile machinery. 3) Prefabricated shear wall structures and prefabricated frame-shear wall structures require a large amount of hoisting of prefabricated shear walls, so the carbon emissions of their mechanical equipment were also the highest.

Second premolar agenesis is associated with mandibular form： a geometric morphometric analysis of mandibular cross-sections

The aim of this study was to compare mandibular form （i.e., size and shape） between patients with agenesis of the lower second premolar （P2） and a control group with no agenesis. Three hypotheses were tested： （H1） agenesis causes a change in mandibular morphology because of inadequate alveolar ridge development in the area of the missing tooth （mandibular plasticity）; （H2） agenesis is caused by spatial limitations within the mandible （dental plasticity）; and （H3） common genetic/ epigenetic factors cause agenesis and affect mandibular form （pleiotropy）. A geometric morphometric analysis was applied to cross-sectional images of computed tomography （CT） scans of three matched groups （n= 50 each）： （1） regularly erupted P2; （2） agenesis of P2 and the primary second molar in situ; and （3） agenesis of P2 and the primary second molar missing for 〉3 months. Cross-sections of the three areas of interest （first premolar, P2, first molar） were digitized with 23 landmarks and superimposed by a generalized Procrustes analysis. On average, the mandibular cross-sections were narrower and shorter in patients with P2 agenesis compared with that in the control group. Both agenesis groups featured a pronounced submandibular fossa. These differences extended at least one tooth beyond the agenesis-affected region. Taken together with the large interindividual variation that resulted in massively overlapping group distributions, these findings support genetic and/or epigenetic pleiotropy （H3） as the most likely origin of the observed covariation between mandibular form and odontogenesis. Clinically, reduced dimensions and greater variability of mandibular form, as well as a pronounced submandibular fossa, should be expected during the treatment planning of patients with P2 agenesis.

A UNIFORMLY CONVERGENT SECOND ORDER DIFFERENCE SCHEME FOR A SINGULARLY PERTURBED SELF-ADJOINT ORDINARY DIFFERENTIAL EQUATION IN CONSERVATION FORM

In this paper, based on the idea of El-Mistikawy and Werle[1] we construct a difference scheme for a singularly perturbed self-adjoint ordinary differential equation in conservation form. We prove that it is a uniformly convergent second order scheme.

Microscopic Calculations of Core-Polarization Effect on Inelastic Electron Scattering Form Factors for Different Parity States in （14^）

Inelastic electron scattering form factors has been calculated for different parity for the two （C3） transitions of 14^N for （5.83MeV） （f^π, T = 20） level and, （5.106MeV） （f^π, T = 30） level in the frame work of shell model. The model space wave functions are generated by using the Cohen-Kurath （CK） interaction, where 4He is assumed as a core and ten nucleons are distributed over the lp-shell which forms the model space. Core-polarization effects （CP） （the effects from outside lp-shell model space） are included through the first order perturbation theory. The core-polarization effects increase the form factor to be up near the experimental data which are not sufficient to give a good comparison with the calculating data.

A HIGH ACCURACY DIFFERENCE SCHEME FOR THE SINGULAR PERTURBATION PROBLEM OF THE SECOND-ORDER LINEAR ORDINARY DIFFERENTIAL EQUATION IN CONSERVATION FORM

In this paper, combining the idea of difference method and finite element method, we construct a difference scheme for a self-adjoint problem in conservation form. Its solution uniformly converges to that of the original differential equation problem with order h3.

Viscous warm pressure bulging process of AZ31B magnesium alloy with different ellipticity dies

Based on the bulging principle of different ellipticity dies, the methyl vinyl silicone rubber with excellent thermal stability and heat transfer performance was chosen as the viscous medium. The finite element analysis and experiments of viscous warm pressure bulging （VWPB） of AZ31B magnesium alloy were conducted to analyze the influence of different ellipticity dies on the formability of AZ31B magnesium alloy. At the same time, based on the grid strain rule, the forming limit diagram （FLD） of VWPB of AZ31B magnesium alloy was obtained through measuring the strain of bulging specimens. The results showed that at the temperature range of viscous medium thermal stability, the viscous medium can fit the geometry variation of sheet and generate non-uniform pressure field, and as the die ellipticity increases, the difference value of non-uniform pressure reduces. Meanwhile, according to the FLD, the relationship between part complexity and ultimate deformation was investigated.

A Comparison of Address Forms in American English and Chinese

As one of the most frequently used language forms in people's daily communication,the address form carries many different social semantic meanings. This paper aims to compare western and eastern cultures through a tentative study of address forms in American English and Chinese. By finding their similarities and differences it will explore the deep structures of each culture.

Effects of Inorganic Sodium Salt in Soil on Concentration of Zinc Ion in Different Patterns

[Objective] The aim was to study on effects of inorganic sodium salt in soil on concentration of zinc ion in different patterns. [Method] Tessier sequential extraction was used to study on effects of inorganic sodium salts （in different species and different concentrations） on concentration of zinc ion in different patterns. [Result] Different inorganic sodium salts had different effects on zinc form. Content of ex- changeable Zn would reduce if Na2CO3 or Na2SO4 was added and the content would increase if NaCI was added. Content of carbonate zinc, which was significantly influ- enced by Na2SO4, would increase if NaCI or Na2SO4 was added, and would decrease if Na2CO3 was added. For Zn bound to Fe-Mn oxides and organic matters, and residual Zn, the contents would decrease if NaCI or Na2SO4 was added and the decrease showed much more significantly if high concentration sodium salts were added. In addition, content of Zn bound to Fe-Mn oxides decreased if Na2CO3 was added. If low concentration Na2CO3 was added, Zn bound to organic matters and residual would increase in content but would lower if high concentration one was added. [Conclusion] The research provided references for measurement of heavy metal ion content in soil in different places.

Analysis of the mass of behind-armor debris generated by RHA subjected to normal penetration of variable cross-section EFP

Analyzing the mass of behind-armor debris (BAD) generated by Rolled Homogeneous Armor (RHA) subjected to normal penetration of variable cross-section Explosively Formed Projectile (EFP) is the purpose of this paper. So theoretical analysis, numerical simulation and experimental data are combined to analyze the influence of variable cross-section characteristic on the time history of crater radius. Moreover the relationships between time history of crater radius (as well as mass of BAD) and the thickness of RHA (from 30mm to 70 mm) and the impact velocity of EFP (1650 m/s to 1860 m/s) are also investigated. The results indicate that: 1) being compared to the variable cross-section characteristic is ignored, the theoretical time history of crater radius is in better agreement with the simulation results when the variable cross-section characteristic is considered;2) being compared to the other three conditions of plug, the theoretical mass of BAD is in the best agreement with the simulation results when the shape of plug is frustum of a cone and the angle between generatrix and bottom is 45- and the axial length of mushroom is considered.

Effect of strain rate difference between inside and outside groove in M-K model on prediction of forming limit curve of Ti6Al4V at elevated temperatures

The influence of initial groove angle on strain rate inside and outside groove of Ti6Al4V alloy was investigated.Based on the evolution of strain rate inside and outside groove,the effect of strain rate difference on the evolution of normal stress and effective stress inside and outside groove was also analyzed.The results show that when linear loading path changes from uniaxial tension to equi-biaxial tension,the initial groove angle plays a weaker role in the evolution of strain rate in the M-K model.Due to the constraint of force equilibrium between inside and outside groove,the strain rate difference makes the normal stress inside groove firstly decrease and then increase during calculation,which makes the prediction algorithm of forming limit convergent at elevated temperature.The decrease of normal stress inside groove is mainly caused by high temperature softening effect and the rotation of groove,while the increase of normal stress inside groove is mainly due to strain rate hardening effect.

Forms and functions of inorganic carbon in the Jiaozhou Bay sediments

Inorganic carbon forms and their influencing factors, mutual transformation and contribution to carbon cycling in the Jiaozhou Bay sediments were discussed. The results show that inorganic carbon in sediments could be divided into five forms： NaCl form, NH3-H20 form, NaOH form, NH20H-HCl form and HCI form. Thereinto, NH2OH.HCl form and HCl form account for more than 70% of total inorganic carbon. There was close relationship among every form of inorganic carbon and their correlativity was clearly different with different sedimentary environment except the similar strong positive correlation among NH-OH-HCl form, HCl form and total inorganic carbon in all regions of the Jiaozhou Bay. All forms of inorganic carbon were influenced by organic carbon, pH, Eh, Es, nitrogen and phosphorus in sediments, but their influence had different characteristics in different regions. Every form of inorganic carbon transformed into each other continuously during early diagenesis of sediments and the common phenomenon was that NaCl form, NH3-H2O form, NaOH form and NH2OH-HCl form might transform into steady HCl form. NaCl form, NH3-H2O form, NaOH form and NH2OH-HCl form could participate in carbon recycle and they are potential carbon source; HCl form may be buried for a long time in sediments, and it may be one of the final resting places of atmospheric C02. Inorganic carbon which entered into sediments was about 4.98× 1010 g in the Jiaozhou Bay every year, in which about 1.47×1010 g of inorganic carbon might be buried for a long time and about 3.51 × 1010 g of inorganic carbon might return into seawater and take part in carbon recycling.

Comparison of the arch forms and dimensions in various malocclusions of the Turkish population

Objectives: The aim of this study is to determine the distribution of morphological differences in the cli- nical mandibular arch forms seen in Angle Class I, II and III malocclusions in Turkish population and to examine the effect of gender on arch dimension pa- rameters. Material and methods: This study has been conducted on pretreatment mandibular study models of 600 individuals (362 girls, 238 boys) aged between 14 and 19. On the photocopies derived from these models, 4 linear and 2 proportional measurements have been made. The samples have been evaluated as square, ovoid and tapered (OrthoForm-3M Unitek) arch form templates. Results: The most frequent arch form encountered among all the groups was the ta- pered one (62.5%) followed by the ovoid (27.3%) and the square one (10.2%). Gender difference influences on morphological structure was apparent. Generally, compared with girls, arch width and depth were found to be more in boys. Conclusion: The most fre- quent arch form seen in Angle malocclusion groups was the tapered one, followed by the less frequent ovoid and square ones.

卤水表面附近盐岩结晶特征研究

【目的】为了弥补现代盐湖沉积考察中丢失的信息,获取盐岩动态结晶过程,指导古盐湖沉积研究。【方法】借助室内石盐蒸发实验,观察卤水蒸发过程中氯化钠结晶特征,分析石盐结晶与沉积环境之间的关系,为盐湖沉积模式建立提供参考。【结果与结论】石盐沉积位置受结晶习性影响,晶体可以在卤水界面之上沉积,其形成的动力除了蒸发泵作用外,还受空气湿度和石盐潮解共同控制;人字晶一般形成于漏斗晶基础之上,在发育空间受限时,绕不同漏斗晶核生长的纹层斜交后形成人字晶纹,两种晶型可以同时沉积于水面之上;盐湖干涸之前,可能经历岩层封锁水面的现象,并可能对临层的碎屑沉积物产生影响。

秸秆配施不同形态氮肥对设施土壤养分转化的影响

以取自设施栽培园区土壤为试材,在日光温室条件下,施用不同秸秆(不施秸秆R0、油菜秸秆R1、稻草秸秆R2)和等氮量不同形态氮肥(不施氮肥N0、普通尿素N1、硝酸钾N2、控释尿素N3)进行双因素随机区组试验,测定施入不同物料对土壤养分参数的影响并分析各参数间的相关性,以期为西北设施栽培下有机+无机肥料配施对土壤改良与配肥技术提供参考依据。结果表明:1)施用秸秆后,土壤脲酶活性显著提高,油菜秸秆和稻草秸秆较不施秸秆有机质分别提高10.6%和22.4%,矿物结合态有机碳提高5.7%和8.8%;速效钾提高25.9%和26.7%;2)施入油菜秸秆速效磷提高23.6%,硝态氮降低32.2%;施入稻草秸秆全氮、铵态氮分别提高14.8%和23.8%;3)施入等量不同形态氮肥后,N1、N2处理显著抑制土壤脲酶活性,N1、N3铵态氮含量分别是N0的41.5倍和13.9倍,各处理土壤硝态氮含量均显著提高,N1处理较N0速效磷增加47.4%;4)土壤有机质和矿物结合态有机碳、全氮及脲酶活性间呈显著正相关,土壤中硝态氮含量与EC值、速效钾含量呈显著正相关。综上,考虑设施栽培下土壤盐渍化、封闭环境易发生氨中毒及园艺作物的营养特性,建议油菜秸秆配施普通尿素进行设施土壤培肥与改良。

苏轼“诗书一体”观:内涵、机理与成因

苏轼将诗书画引向深度结合,“诗不能尽,溢而为书,变而为画,皆诗之余”是苏轼“诗书一体”观的核心表达,其内涵是以“德”为灵魂,以诗意为统领的综合艺术论。破体为文、体兼众妙、形式相连、书卷气息构成了苏轼不同文体、书体之间以及文学与书法两种不同艺术形式之间的内在机理,“书卷气”是苏轼书法人文化、文学化的典型表现。苏轼的“吾所谓文,必与道俱”“慧之生定,速于定之生慧”以及“笔墨之迹,托于有形,有形则有弊”等文艺思想和哲学观念,乃是形成其“诗书一体”观以及文学与书法在求道之途上存在统一性、多样性、层次性和差异性的主要缘由。