AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted betwee...AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression analysis.RESULTS: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced cancer.CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study.展开更多
目的了解瘦素及瘦素受体与乳腺癌浸润、转移关系。方法测量对比良性乳腺疾病与乳腺癌患者体重指数(body mass index,BMI)的差别;按腋窝淋巴结转移数由低到高分5组,S-P方法检测不同分组中乳腺癌组织中瘦素及其受体的表达,ELASE方法检测...目的了解瘦素及瘦素受体与乳腺癌浸润、转移关系。方法测量对比良性乳腺疾病与乳腺癌患者体重指数(body mass index,BMI)的差别;按腋窝淋巴结转移数由低到高分5组,S-P方法检测不同分组中乳腺癌组织中瘦素及其受体的表达,ELASE方法检测乳腺癌患者血清中瘦素的表达。结果良性乳腺疾病患者BMI为24.36±3.74,乳腺癌患者BMI为25.77±4.12,二者比较P=0.028。瘦素在乳腺癌组织中的表达为:A组163.87±16.33,B组147.24±8.03,C组133.54±18.82,D组105.73±10.39,E组81.52±8.72;乳腺癌组织中瘦素受体的表达为:A组147.93±12.31,B组125.03±16.15,C组113.85±17.59,D组107.25±12.85,E组80.47±7.38;乳腺癌血清中瘦素的表达为:A组16.378±0.471,B组21.393±1.551,C组28.978±2.570,D组35.706±2.942,E组39.186±7.377。结论肥胖是乳腺癌发病的高危因素。瘦素及其受体在乳腺癌组织中的表达随淋巴结转移数增多而依次升高,提示瘦素及其受体促进乳腺癌的转移、复发。展开更多
甲状腺癌是最常见的内分泌系统恶性肿瘤,约占全身恶性肿瘤的1%[1],而甲状腺乳头状癌(papillary thyroid cancer,PTC)是甲状腺癌最常见的病理学类型[2]。Paes等[3]发现,患者较高的体质量指数(body mass index,BMI)与肿瘤侵袭性弱及复发...甲状腺癌是最常见的内分泌系统恶性肿瘤,约占全身恶性肿瘤的1%[1],而甲状腺乳头状癌(papillary thyroid cancer,PTC)是甲状腺癌最常见的病理学类型[2]。Paes等[3]发现,患者较高的体质量指数(body mass index,BMI)与肿瘤侵袭性弱及复发风险降低有关,但相反地Trésallet等[4]认为BMI是PTC术后局部复发的独立危险因素。展开更多
文摘AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression analysis.RESULTS: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced cancer.CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study.
文摘目的了解瘦素及瘦素受体与乳腺癌浸润、转移关系。方法测量对比良性乳腺疾病与乳腺癌患者体重指数(body mass index,BMI)的差别;按腋窝淋巴结转移数由低到高分5组,S-P方法检测不同分组中乳腺癌组织中瘦素及其受体的表达,ELASE方法检测乳腺癌患者血清中瘦素的表达。结果良性乳腺疾病患者BMI为24.36±3.74,乳腺癌患者BMI为25.77±4.12,二者比较P=0.028。瘦素在乳腺癌组织中的表达为:A组163.87±16.33,B组147.24±8.03,C组133.54±18.82,D组105.73±10.39,E组81.52±8.72;乳腺癌组织中瘦素受体的表达为:A组147.93±12.31,B组125.03±16.15,C组113.85±17.59,D组107.25±12.85,E组80.47±7.38;乳腺癌血清中瘦素的表达为:A组16.378±0.471,B组21.393±1.551,C组28.978±2.570,D组35.706±2.942,E组39.186±7.377。结论肥胖是乳腺癌发病的高危因素。瘦素及其受体在乳腺癌组织中的表达随淋巴结转移数增多而依次升高,提示瘦素及其受体促进乳腺癌的转移、复发。
文摘甲状腺癌是最常见的内分泌系统恶性肿瘤,约占全身恶性肿瘤的1%[1],而甲状腺乳头状癌(papillary thyroid cancer,PTC)是甲状腺癌最常见的病理学类型[2]。Paes等[3]发现,患者较高的体质量指数(body mass index,BMI)与肿瘤侵袭性弱及复发风险降低有关,但相反地Trésallet等[4]认为BMI是PTC术后局部复发的独立危险因素。
