Recurrent Clostridium difficile infections:The importance of the intestinal microbiota

Clostridium difficile infections(CDI)are a leading cause of antibiotic-associated and nosocomial diarrhea.Despite effective antibiotic treatments,recurrent infections are common.With the recent emergence of hypervirulent isolates of C.difficile,CDI is a growing epidemic with higher rates of recurrence,increasing severity and mortality.Fecal microbiota transplantation(FMT)is an alternative treatment for recurrent CDI.A better understanding of intestinal microbiota and its role in CDI has opened the door to this promising therapeutic approach.FMT is thought to resolve dysbiosis by restoring gut microbiota diversity thereby breaking the cycle of recurrent CDI.Since the first reported use of FMT for recurrent CDI in 1958,systematic reviews of case series and case report have shown its effectiveness with high resolution rates compared to standard antibiotic treatment.This article focuses on current guidelines for CDI treatment,the role of intestinal microbiota in CDI recurrence and current evidence about FMT efficacy,adverse effects and acceptability.

难辨梭状芽孢杆菌性肠炎28例临床分析

目的 了解加强监护病房 (ICU)难辨梭状芽孢杆菌性肠炎 (CDAD)危险因素、症状及疗效。方法 选取1999～ 2 0 0 3年大便难辨梭状芽孢杆菌培养阳性患者 2 8例及治疗观察临床表现。结果 腹泻 2 8例 (10 0 % ) ,发热2 8例 (10 0 % ) ,腹痛 2 0例 (71 4 % )。结论 用抗生素过程中出现腹泻应首先怀疑难辨梭状芽孢杆菌性肠炎 ,行粪便难辨梭状芽孢杆菌培养 ,有条件应进行毒素A、B检测 ,尽早治疗。

体积全息图的弱衍射理论

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表面处理是铝轮毂制造工艺中最后一道流程,涂装工程可以对轮毂进行有效的表面防护,提高车轮的耐玷污性、运行可靠性,延长其使用寿命。铝轮毂亮面涂装技术标准非常严格,有多种工艺流程。文章主要介绍了一种锻造铝轮毂的镜面涂装工艺、技术难点及解决方案。

一种基于ECDLP有身份认证的ECDH密钥协商方案

为了解决ECDH(elliptic curve key agreement scheme-diffice-hellman version)密钥协商方案中,通信双方在公开信道上通过协议协商会话的临时密钥及双方都不能识别对方身份的问题。在研究ECDH密钥协商算法的基础上,提出了一种基于安全椭圆曲线离散对数问题的有身份认证的ECDH密钥协商方案。该方案可以实现密钥协商双方的双向身份认证,有效地防止了中间人的攻击。通过对密钥协商消息的双重保护,实现了公开信道上安全通信。