Previous studies have reported a neuroprotective effect of 8-hydroxy-2-（di-n-propylamino）tetralin （8-OH-DPAT） against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal in...Previous studies have reported a neuroprotective effect of 8-hydroxy-2-（di-n-propylamino）tetralin （8-OH-DPAT） against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats. 8-OH-DPAT treated rats maintained at constant temperature served as normal temperature controls TUNEL results revealed that neural cell swelling, brain tissue necrosis and cell apoptosis occurred around the injured tissue. Moreover, the number of Bax-, Bcl-2- and caspase-3-positive cells increased at 6 hours after diffuse axonal injury, and peaked at 24 hours. However, brain injury was attenuated, the number of apoptotic cells reduced, Bax and caspase-3 expression decreased, and Bcl-2 expression increased at 6, 12, 24, 72 and 168 hours after diffuse axonal injury in normal temperature control and in 8-OH-DPAT-intervention rats. The difference was most significant at 24 hours. All indices in 8-OH-DPAT-intervention rats were better than those in the constant temperature group. These results suggest that 8-OH-DPAT inhibits Bax and caspase-3 expression, increases Bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury. This effect is associated with a decrease in brain temperature.展开更多
Motivated by the definition of the machining errors induced by tool path planning methods, a mapping curve of the tool axis of a cylindrical cutter is constructed on the tool surface. The mapping curve is a typical on...Motivated by the definition of the machining errors induced by tool path planning methods, a mapping curve of the tool axis of a cylindrical cutter is constructed on the tool surface. The mapping curve is a typical one that can be used to express the closeness between the tool surface and the surface to be machined. A novel tool path planning method is proposed for flank or plunge milling ruled surfaces based on the minimization of the one-sided Hausdorff distance （HD） from the mapping curve to the surface to be machined. It is a nonlinear optimization problem in best uniform approximation （BUA） or Chebyshev sense. A mathematical programming model for computing the minimum one-sided HD is proposed. The linearization method of the programming model is provided and the final optimal solutions are obtained by simplex method. The effectiveness of the proposed BUA method is verified by two numerical examples and compared with the least squares （LS） and double point offset （DPO） methods. The variation in tool orientation induced by the optimization of the tool positions is also evaluated.展开更多
The fast and accurate collision detection and distance calculation between geometric models is fundamen-tal in robotics, manufacturing and computer-simulated en-vironments. This paper surveys the state of the art in t...The fast and accurate collision detection and distance calculation between geometric models is fundamen-tal in robotics, manufacturing and computer-simulated en-vironments. This paper surveys the state of the art in the theory and algorithms of distance and pseudo distance func-tions between convex sets. An overview on the existing results, including fast algorithms for distance calculation, definitions and properties of various pseudo distance functions (the J-function, the growth distance, and the pseudo minimum translational distance), is presented. The distance and pseudo distance functions are versatile in a wide range of areas. Their applications in robot motion planning, grasp analy-sis/synthesis, form error evaluation, and engineering optimi-zation is demonstrated.展开更多
基金funded by the Natural Science Foundation of Technology Department of Liaoning Province, No.20032047
文摘Previous studies have reported a neuroprotective effect of 8-hydroxy-2-（di-n-propylamino）tetralin （8-OH-DPAT） against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats. 8-OH-DPAT treated rats maintained at constant temperature served as normal temperature controls TUNEL results revealed that neural cell swelling, brain tissue necrosis and cell apoptosis occurred around the injured tissue. Moreover, the number of Bax-, Bcl-2- and caspase-3-positive cells increased at 6 hours after diffuse axonal injury, and peaked at 24 hours. However, brain injury was attenuated, the number of apoptotic cells reduced, Bax and caspase-3 expression decreased, and Bcl-2 expression increased at 6, 12, 24, 72 and 168 hours after diffuse axonal injury in normal temperature control and in 8-OH-DPAT-intervention rats. The difference was most significant at 24 hours. All indices in 8-OH-DPAT-intervention rats were better than those in the constant temperature group. These results suggest that 8-OH-DPAT inhibits Bax and caspase-3 expression, increases Bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury. This effect is associated with a decrease in brain temperature.
基金supported by the National Natural Science Foundation of China (51175065)
文摘Motivated by the definition of the machining errors induced by tool path planning methods, a mapping curve of the tool axis of a cylindrical cutter is constructed on the tool surface. The mapping curve is a typical one that can be used to express the closeness between the tool surface and the surface to be machined. A novel tool path planning method is proposed for flank or plunge milling ruled surfaces based on the minimization of the one-sided Hausdorff distance （HD） from the mapping curve to the surface to be machined. It is a nonlinear optimization problem in best uniform approximation （BUA） or Chebyshev sense. A mathematical programming model for computing the minimum one-sided HD is proposed. The linearization method of the programming model is provided and the final optimal solutions are obtained by simplex method. The effectiveness of the proposed BUA method is verified by two numerical examples and compared with the least squares （LS） and double point offset （DPO） methods. The variation in tool orientation induced by the optimization of the tool positions is also evaluated.
基金supported by the National Natural Science Foundation of China(Grant Nos.50175014,50390063 and 59990470).
文摘The fast and accurate collision detection and distance calculation between geometric models is fundamen-tal in robotics, manufacturing and computer-simulated en-vironments. This paper surveys the state of the art in the theory and algorithms of distance and pseudo distance func-tions between convex sets. An overview on the existing results, including fast algorithms for distance calculation, definitions and properties of various pseudo distance functions (the J-function, the growth distance, and the pseudo minimum translational distance), is presented. The distance and pseudo distance functions are versatile in a wide range of areas. Their applications in robot motion planning, grasp analy-sis/synthesis, form error evaluation, and engineering optimi-zation is demonstrated.
