The rapid diffusion of nanoparticles （NPs） through mucus layer is critical for efficient transportation of NPs-loaded drug delivery system. To understand how the physical and surface properties of NPs affect their d...The rapid diffusion of nanoparticles （NPs） through mucus layer is critical for efficient transportation of NPs-loaded drug delivery system. To understand how the physical and surface properties of NPs affect their diffusion in mucus, we have developed a coarse-grained molecular dynamics model to study the diffusion of NPs in modeled mucus layer. Both steric obstruction and hydrodynamic interaction are included in the model capable of capturing the key characteristics of NPs＇ diffusion in mucus. The results show that both particle size and surface properties significantly affect the diffusivities of NPs in mucus. Furthermore, we find rodlike NPs can gain a higher diffusivity than spherical NPs with the same hydrodynamic diameter. In addition, the disturbed environment can enhance the diffusivity of NPs. Our findings can be utilized to design mucus penetrating NPs for targeted drug delivery system.展开更多
This paper aims at probing the flow characteristics of a jet in supersonic crossflow(JISC)by installing a vortex generator(VG)upstream of the jet orifice.Nanoparticle planar laser scattering(NPLS)and stereo-particle i...This paper aims at probing the flow characteristics of a jet in supersonic crossflow(JISC)by installing a vortex generator(VG)upstream of the jet orifice.Nanoparticle planar laser scattering(NPLS)and stereo-particle image velocimetry(SPIV)technologies were employed to observe the flowfield,and three cases were designed for comparison.CASE0 stands for JISC without passive VG.In CASE1 and CASE2,VG is installed at 20 mm and 80 mm upstream away from the jet orifice,respectively.Transient flow structures show that two flow modes exist when the VG wake interacts with the JISC.In CASE1,vortices are induced from both sides of the jet plume because of the VG wake.This leads to a complex streamwise vortex system.Penetration and lateral diffusion are enhanced.In CASE2,intermittent large-scale eddies in the VG wake cause large streamwise vortices at the windward side of the jet.The penetration depth is also enhanced while the lateral diffusion is restrained.In addition,experimental results show that the penetration depth is approximately 8.5%higher in CASE1 than that in CASE0,and the lateral diffusion is larger by about 17.0%.In CASE2,the penetration is increased by about 26.2%,while the lateral diffusion is enhanced by just 0.5%.展开更多
基金the financial support from the National Natural Science Foundation of China (No. 11422215, 11272327 and 11672079)supported by the Supercomputing Center of Chinese Academy of Sciences (SC CAS)
文摘The rapid diffusion of nanoparticles （NPs） through mucus layer is critical for efficient transportation of NPs-loaded drug delivery system. To understand how the physical and surface properties of NPs affect their diffusion in mucus, we have developed a coarse-grained molecular dynamics model to study the diffusion of NPs in modeled mucus layer. Both steric obstruction and hydrodynamic interaction are included in the model capable of capturing the key characteristics of NPs＇ diffusion in mucus. The results show that both particle size and surface properties significantly affect the diffusivities of NPs in mucus. Furthermore, we find rodlike NPs can gain a higher diffusivity than spherical NPs with the same hydrodynamic diameter. In addition, the disturbed environment can enhance the diffusivity of NPs. Our findings can be utilized to design mucus penetrating NPs for targeted drug delivery system.
基金supported by the National Natural Science Foundation of China(Nos.91541203 and 51676204)the Fenglei Youth Innovation Fund of China Aerodynamics Research and Development Center(No.PJD20170186)。
文摘This paper aims at probing the flow characteristics of a jet in supersonic crossflow(JISC)by installing a vortex generator(VG)upstream of the jet orifice.Nanoparticle planar laser scattering(NPLS)and stereo-particle image velocimetry(SPIV)technologies were employed to observe the flowfield,and three cases were designed for comparison.CASE0 stands for JISC without passive VG.In CASE1 and CASE2,VG is installed at 20 mm and 80 mm upstream away from the jet orifice,respectively.Transient flow structures show that two flow modes exist when the VG wake interacts with the JISC.In CASE1,vortices are induced from both sides of the jet plume because of the VG wake.This leads to a complex streamwise vortex system.Penetration and lateral diffusion are enhanced.In CASE2,intermittent large-scale eddies in the VG wake cause large streamwise vortices at the windward side of the jet.The penetration depth is also enhanced while the lateral diffusion is restrained.In addition,experimental results show that the penetration depth is approximately 8.5%higher in CASE1 than that in CASE0,and the lateral diffusion is larger by about 17.0%.In CASE2,the penetration is increased by about 26.2%,while the lateral diffusion is enhanced by just 0.5%.
