An efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF_(2)H has been developed.It is particularly remarkable that,when 1.5 equiv.of alkyl bromides ar...An efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF_(2)H has been developed.It is particularly remarkable that,when 1.5 equiv.of alkyl bromides are used,the substitution products are obtained in moderate to excellent yields.The prepared difluoro(phenylsulfonimidoyl)methylated alkanes can be readily transformed to gem-difluoroalkenes via base-mediatedβ-elimination reaction.展开更多
A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes in mild conditions was described.The combination of lithium organoborate and ZnBr_(2)...A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes in mild conditions was described.The combination of lithium organoborate and ZnBr_(2) generated in situ lithium aryl zincates,which facilitates the transmetalation step of the nickel-catalyzed cross coupling reaction.展开更多
基金Support of our work by the National Basic Research Program of China(Nos.2012CB215500 and 2012CB821600)the NNSFC(No.21372246)+1 种基金Shanghai QMX program(No.13QH1402400)the Chinese Academy of Sciences is gratefully acknowledged.
文摘An efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF_(2)H has been developed.It is particularly remarkable that,when 1.5 equiv.of alkyl bromides are used,the substitution products are obtained in moderate to excellent yields.The prepared difluoro(phenylsulfonimidoyl)methylated alkanes can be readily transformed to gem-difluoroalkenes via base-mediatedβ-elimination reaction.
基金the National Natural Science Foundation of China(Nos.21625206.21632009,21421002,22061160465)for financial support.
文摘A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes in mild conditions was described.The combination of lithium organoborate and ZnBr_(2) generated in situ lithium aryl zincates,which facilitates the transmetalation step of the nickel-catalyzed cross coupling reaction.
