Sijunzi Decoction,as one of the classic Chinese traditional prescriptions,has been used clinically by major physicians since the Song Dynasty.This article reviewed and sorted out the literature on the effective chemis...Sijunzi Decoction,as one of the classic Chinese traditional prescriptions,has been used clinically by major physicians since the Song Dynasty.This article reviewed and sorted out the literature on the effective chemistry of Sijunzi Decoction and the mechanism of its prevention and treatment of digestive system diseases.At present,its effective chemical components are derived from the saponins and flavonoids in ginseng and licorice,and are effective for gastrointestinal mucosal injury diseases and malignant digestive system.Digestive system diseases such as tumors,functional gastrointestinal diseases,non-alcoholic fatty liver,acute liver injury,and liver failure show a multi-path,multi-target effect mechanism.This article reviews the effective chemical components and research of Sijunzi Decoction and the related mechanisms of prevention and treatment of digestive system diseases,and provides valuable clues for the follow-up research of Sijunzi Decoction.展开更多
目的探索异甘草酸镁治疗自身免疫样药物性肝损伤的临床疗效和安全性。方法选取首都医科大学附属北京佑安医院2016年7月-2019年1月住院的自身免疫样药物性肝损伤患者53例为观察组,另选不伴有自身免疫现象的药物性肝损伤患者50例为对照组...目的探索异甘草酸镁治疗自身免疫样药物性肝损伤的临床疗效和安全性。方法选取首都医科大学附属北京佑安医院2016年7月-2019年1月住院的自身免疫样药物性肝损伤患者53例为观察组,另选不伴有自身免疫现象的药物性肝损伤患者50例为对照组。所有患者给予异甘草酸镁200 mg/d,治疗4周。观察治疗前后患者肝功能情况,观察治疗前后观察组患者的免疫学指标,记录两组患者的不良反应。治疗结束后每月随访肝功能,随访时间6个月。正态分布计量资料组间比较采用t检验,非正态分布的计量资料采用Mann-Whitney U检验,计数资料组间比较采用χ^2检验或Fisher精确概率检验。结果观察组治疗后与治疗前比较,ALT[35.4(29.2~42.0)U/L vs 289.0(226.6~460.3)U/L,Z=-8.661,P<0.001]、AST[46.3(15.6~183.5)U/L vs 306.3(32.2~589.8)U/L,Z=-5.271,P<0.001]、GGT[77.0(53.2~183.2)U/L vs 129.0(77.8~232.5)U/L,Z=-3.437,P=0.001)]、ALP[83.1(64.9~83.1U/L vs 119.4(104.9~146.9)U/L,Z=-3.485,P<0.001]和TBil[(27.5±10.3)μmol/L vs(59.7±18.6)μmol/L,t=6.673,P<0.001]水平均明显降低;对照组患者治疗后与治疗前比较,ALT[33.1(14.9~106.4)U/L vs 300.6(206.8~679.5)U/L,Z=-8.232,P<0.001]、AST[44.1(20.8~151.6)U/L vs 321.7(36.2~553.2)U/L,Z=-3.549,P<0.001]、GGT[82.7(50.6~168.5)U/L vs 133.5(72.2~254.2)U/L,Z=-2.364,P=0.018]、ALP[87.6(74.3~139.4)U/L vs 128.0(106.3~201.4)U/L,Z=-4.303,P<0.001]和TBil[(23.8±10.9)μmol/L vs(58.3±19.8)μmol/L,t=-8.450,P<0.001]水平也明显降低。但治疗后两组间比较差异均无统计学意义(P值均>0.05)。治疗后观察组患者IgG水平由(15.8±3.2)g/L降至(14.2±2.0)g/L,治疗前IgG水平升高(>16 g/L)患者22例中18例(81.8%)恢复正常。36例ANA阳性患者19例(52.7%)阴转。两组患者均无严重不良反应。行肝穿病理检查患者中,观察组患者中性粒细胞和(或)嗜酸性粒细胞浸润(17/32,53.1%)明显高于对照组(3/17,17.5%)(χ^2=5.785,P=0.016)。结论异甘草酸镁用于治疗自身免疫样药物性肝损伤安全有效,是临床治疗的可选择方案。展开更多
文摘Sijunzi Decoction,as one of the classic Chinese traditional prescriptions,has been used clinically by major physicians since the Song Dynasty.This article reviewed and sorted out the literature on the effective chemistry of Sijunzi Decoction and the mechanism of its prevention and treatment of digestive system diseases.At present,its effective chemical components are derived from the saponins and flavonoids in ginseng and licorice,and are effective for gastrointestinal mucosal injury diseases and malignant digestive system.Digestive system diseases such as tumors,functional gastrointestinal diseases,non-alcoholic fatty liver,acute liver injury,and liver failure show a multi-path,multi-target effect mechanism.This article reviews the effective chemical components and research of Sijunzi Decoction and the related mechanisms of prevention and treatment of digestive system diseases,and provides valuable clues for the follow-up research of Sijunzi Decoction.
文摘目的探索异甘草酸镁治疗自身免疫样药物性肝损伤的临床疗效和安全性。方法选取首都医科大学附属北京佑安医院2016年7月-2019年1月住院的自身免疫样药物性肝损伤患者53例为观察组,另选不伴有自身免疫现象的药物性肝损伤患者50例为对照组。所有患者给予异甘草酸镁200 mg/d,治疗4周。观察治疗前后患者肝功能情况,观察治疗前后观察组患者的免疫学指标,记录两组患者的不良反应。治疗结束后每月随访肝功能,随访时间6个月。正态分布计量资料组间比较采用t检验,非正态分布的计量资料采用Mann-Whitney U检验,计数资料组间比较采用χ^2检验或Fisher精确概率检验。结果观察组治疗后与治疗前比较,ALT[35.4(29.2~42.0)U/L vs 289.0(226.6~460.3)U/L,Z=-8.661,P<0.001]、AST[46.3(15.6~183.5)U/L vs 306.3(32.2~589.8)U/L,Z=-5.271,P<0.001]、GGT[77.0(53.2~183.2)U/L vs 129.0(77.8~232.5)U/L,Z=-3.437,P=0.001)]、ALP[83.1(64.9~83.1U/L vs 119.4(104.9~146.9)U/L,Z=-3.485,P<0.001]和TBil[(27.5±10.3)μmol/L vs(59.7±18.6)μmol/L,t=6.673,P<0.001]水平均明显降低;对照组患者治疗后与治疗前比较,ALT[33.1(14.9~106.4)U/L vs 300.6(206.8~679.5)U/L,Z=-8.232,P<0.001]、AST[44.1(20.8~151.6)U/L vs 321.7(36.2~553.2)U/L,Z=-3.549,P<0.001]、GGT[82.7(50.6~168.5)U/L vs 133.5(72.2~254.2)U/L,Z=-2.364,P=0.018]、ALP[87.6(74.3~139.4)U/L vs 128.0(106.3~201.4)U/L,Z=-4.303,P<0.001]和TBil[(23.8±10.9)μmol/L vs(58.3±19.8)μmol/L,t=-8.450,P<0.001]水平也明显降低。但治疗后两组间比较差异均无统计学意义(P值均>0.05)。治疗后观察组患者IgG水平由(15.8±3.2)g/L降至(14.2±2.0)g/L,治疗前IgG水平升高(>16 g/L)患者22例中18例(81.8%)恢复正常。36例ANA阳性患者19例(52.7%)阴转。两组患者均无严重不良反应。行肝穿病理检查患者中,观察组患者中性粒细胞和(或)嗜酸性粒细胞浸润(17/32,53.1%)明显高于对照组(3/17,17.5%)(χ^2=5.785,P=0.016)。结论异甘草酸镁用于治疗自身免疫样药物性肝损伤安全有效,是临床治疗的可选择方案。
