Mechanism of Novel Natural Products Maintaining Skin

The inducement of skin carbonylation was briefly introduced,then the mechanism of protein carbonylation from skin was discussed and adverse reactions to human skin were analyzed.Finally,according to the mechanism of protein carbonylation and the degradation mode,the proposed solutions were as follows:diglucosyl gallic acid,Hibiscus sabdariffa flower extract;Prunus cerasus flower extract can reduce the protein carbonylation level of skin by reducing t ROS and Phaeodactylum tricornutum extract can improve the activity of 20s enzyme and accelerating the hydrolysis level of carbonyl protein,to achieve the perfect repair of skin.

二葡糖基没食子酸的合成及其性能研究

以没食子酸甲酯和五乙酰基葡萄糖为原料,经过乙酰化反应、成盐、酸化等过程合成了美白剂二葡糖基没食子酸,并通过IR,MS,^(1)H NMR和^(13)C NMR确认了最终产物的结构。同时考察了美白剂二葡糖基没食子酸对酪氨酸酶活性的影响、酪氨酸二酚酶的抑制作用机制以及抗氧化能力。研究表明:以L-酪氨酸为底物时,二葡糖基没食子酸对酪氨酸单酚酶的半抑制浓度IC_(50)为1.46 mg/mL,以L-多巴为底物时,二葡糖基没食子酸对酪氨酸二酚酶的半抑制浓度IC_(50)为2.68 mg/mL,而且从Lineweaver-Burk图获得的抑制机理表明二葡糖基没食子酸对酪氨酸二酚酶的抑制作用表现为竞争性抑制,抑制常数K_(m)为2.43 mg/mL。没食子酸相比于同质量浓度下的V_(max)对DPPH自由基的清除效果更好,而二葡糖基没食子酸相比于同质量浓度下的V_(c),其对DPPH自由基仍存在一定的清除作用。

新型天然活性物修护肌肤机理分析

简要介绍了皮肤羰基化反应的诱因,重点从皮肤中蛋白质羰基化产生机理分析了其对人体肌肤产生的不良反应。讨论了蛋白质的降解系统,最后根据蛋白质的羰基化产生机理以及降解方式,提出建议解决方案:二葡糖基棓酸、玫瑰茄花提取物、欧洲酸樱桃花提取物可以通过降低ROS含量和三角褐指藻提取物提高20S酶体活性加速羰基化蛋白质水解水平降低人体肌肤蛋白质羰基化水平,实现对肌肤的完美修护。