An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of a-thiocyanate ketones with malononitrile and am...An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of a-thiocyanate ketones with malononitrile and amines. The a-thiocyanate ketones were subjected with malononitrile to provide thiazol-2-ylidenemalononitrile derivatives, followed with various amines in the presence of dimedone to yield the final thiazol-2-yl substituted acrylonitrile derivatives.展开更多
基金Supporting information for this article is available On the WWW under http：Nd-xlcloi.orgi10. 1002/cjoc.201100719 or from the author.Acknowledgement We are grateful for financial support from the National Science Foundation of China （Nos. 21072163, 21102124）, PAPD of Jiangsu Higher Education Institutions, Jiangsu Science and Technology Support Program （No. BE2011045）, Science Foundation in Interdisciplinary Major Research Project of Xuzhou Normal University （No. 09XKXK01）, and the NSF of Jiangsu Education Committee （No. 11KJB 150016）.
文摘An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of a-thiocyanate ketones with malononitrile and amines. The a-thiocyanate ketones were subjected with malononitrile to provide thiazol-2-ylidenemalononitrile derivatives, followed with various amines in the presence of dimedone to yield the final thiazol-2-yl substituted acrylonitrile derivatives.
