BACKGROUND Pulsatile tinnitus(PT)is an annoying sound that can be eliminated with targeted treatment of the cause.However,the causes of PT have not been fully elucidated.CASE SUMMARY A 38-year-old woman with right-sid...BACKGROUND Pulsatile tinnitus(PT)is an annoying sound that can be eliminated with targeted treatment of the cause.However,the causes of PT have not been fully elucidated.CASE SUMMARY A 38-year-old woman with right-sided objective PT underwent preoperative computed tomography arteriography and venography(CTA/V).A 3.8 mm vine diploic vein(DV),which passed through the mastoid air cells posteriorly in a dehiscent canal and was continuous with the transverse-sigmoid sinus,was thought to be the causative finding.Four-dimensional flow magnetic resonance(4D flow MR)imaging showed that the blood in the DV flowed toward the transverse-sigmoid sinus.The closer the blood was to the transverse-sigmoid sinus,the higher the velocity.No vortex or turbulence was found in the DV or adjacent transverse sinus.The sound was eliminated immediately after ligation of the DV with no recurrence during a three-month follow-up.No flow signal of the DV was noted on postoperative 4D flow MR.CONCLUSION A DV may be a treatable cause of PT.CTA/V and 4D flow MR could be utilized to determine the morphological and hemodynamic characteristics of the DV.展开更多
In skull bone tissue engineering,cells do not easily survive and proliferate in the scaffold because of the lack of nutrient transport channels.To address these problems,a vascular design and fabrication method based ...In skull bone tissue engineering,cells do not easily survive and proliferate in the scaffold because of the lack of nutrient transport channels.To address these problems,a vascular design and fabrication method based on human skull diploic vein characteristics was proposed.The skull sample was scanned by micro-CT,and the 3D model was constructed by Avizo.By analyzing the characteristics of the diploic vein,the vascular centerline model,path model,taper model and bifurcation model were proposed.Two vascular network examples were constructed by iteration of the bifurcation unit.The mold method of constructing vascular scaffolds embedded within the bionic channels was proposed.The scaffold material is PDMS,and the surface was coated with collagen.The Human Umbilical Vein Endothelial Cells(HUVECs)were planted into the lumen of the channels for 7 days in vitro and found to be able to proliferate.The cells cultured for three days were fluorescently stained,and it was found that the cells were well attached to the surfaces of the lumen.This vascular design and fabrication process can lay a foundation for vascularization in bone tissue engineering.展开更多
基金Supported by National Natural Science Foundation of China,No.61931013 and No.61801311.
文摘BACKGROUND Pulsatile tinnitus(PT)is an annoying sound that can be eliminated with targeted treatment of the cause.However,the causes of PT have not been fully elucidated.CASE SUMMARY A 38-year-old woman with right-sided objective PT underwent preoperative computed tomography arteriography and venography(CTA/V).A 3.8 mm vine diploic vein(DV),which passed through the mastoid air cells posteriorly in a dehiscent canal and was continuous with the transverse-sigmoid sinus,was thought to be the causative finding.Four-dimensional flow magnetic resonance(4D flow MR)imaging showed that the blood in the DV flowed toward the transverse-sigmoid sinus.The closer the blood was to the transverse-sigmoid sinus,the higher the velocity.No vortex or turbulence was found in the DV or adjacent transverse sinus.The sound was eliminated immediately after ligation of the DV with no recurrence during a three-month follow-up.No flow signal of the DV was noted on postoperative 4D flow MR.CONCLUSION A DV may be a treatable cause of PT.CTA/V and 4D flow MR could be utilized to determine the morphological and hemodynamic characteristics of the DV.
基金This work was supported by the National Natural Science Foundation of China(No.51575380).
文摘In skull bone tissue engineering,cells do not easily survive and proliferate in the scaffold because of the lack of nutrient transport channels.To address these problems,a vascular design and fabrication method based on human skull diploic vein characteristics was proposed.The skull sample was scanned by micro-CT,and the 3D model was constructed by Avizo.By analyzing the characteristics of the diploic vein,the vascular centerline model,path model,taper model and bifurcation model were proposed.Two vascular network examples were constructed by iteration of the bifurcation unit.The mold method of constructing vascular scaffolds embedded within the bionic channels was proposed.The scaffold material is PDMS,and the surface was coated with collagen.The Human Umbilical Vein Endothelial Cells(HUVECs)were planted into the lumen of the channels for 7 days in vitro and found to be able to proliferate.The cells cultured for three days were fluorescently stained,and it was found that the cells were well attached to the surfaces of the lumen.This vascular design and fabrication process can lay a foundation for vascularization in bone tissue engineering.
