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Discriminated Dimensional Analysis Versus Classical Dimensional Analysis and Applications to Heat Transfer and Fluid Dynamics
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作者 F. Alhama C.N. Madrid 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2007年第5期626-631,共6页
In contrast to classical dimensional analysis, discriminated dimensional analysis assumes that spatial coordinates are dimensionally independent of each other and allows other types of geometrical quantity to be used ... In contrast to classical dimensional analysis, discriminated dimensional analysis assumes that spatial coordinates are dimensionally independent of each other and allows other types of geometrical quantity to be used in the dimensional basis, such as surfaces and angles. As a consequence, discriminated dimensional analysis leads to a lower number of dimensional groups, which makes the solution more precise. Besides, these discriminated groups have a clear physical meaning in terms of force and energy balances. The paper introduces this technique and provides dimensional equations for the main quantities and physical parameters of the heat transfer and fluid flow fields. Two applications are presented to demonstrate the efficiency of this method. 展开更多
关键词 discriminated dimensional analysis heat transfer fluid dynamics dimensionless number
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Why Female College Graduates Are Discriminated in China?
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作者 王瑞祎 《神州》 2014年第15期266-266,共1页
The discrimination against female college graduates is a problem which cannot be ignored in Chinese labor market. This paper thus focuses on the analyses of why the discrimination exists in order to seek better soluti... The discrimination against female college graduates is a problem which cannot be ignored in Chinese labor market. This paper thus focuses on the analyses of why the discrimination exists in order to seek better solutions to the problem. 展开更多
关键词 DISCRIMINATION COLLEGE Female decided eventually GIVING UNTIL EMPLOYMENT themselves SPEAKING
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Underwater Pulse Waveform Recognition Based on Hash Aggregate Discriminant Network
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作者 WANG Fangchen ZHONG Guoqiang WANG Liang 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第3期654-660,共7页
Underwater pulse waveform recognition is an important method for underwater object detection.Most existing works focus on the application of traditional pattern recognition methods,which ignore the time-and space-vary... Underwater pulse waveform recognition is an important method for underwater object detection.Most existing works focus on the application of traditional pattern recognition methods,which ignore the time-and space-varying characteristics in sound propagation channels and cannot easily extract valuable waveform features.Sound propagation channels in seawater are time-and space-varying convolutional channels.In the extraction of the waveform features of underwater acoustic signals,the effect of high-accuracy underwater acoustic signal recognition is identified by eliminating the influence of time-and space-varying convolutional channels to the greatest extent possible.We propose a hash aggregate discriminative network(HADN),which combines hash learning and deep learning to minimize the time-and space-varying effects on convolutional channels and adaptively learns effective underwater waveform features to achieve high-accuracy underwater pulse waveform recognition.In the extraction of the hash features of acoustic signals,a discrete constraint between clusters within a hash feature class is introduced.This constraint can ensure that the influence of convolutional channels on hash features is minimized.In addition,we design a new loss function called aggregate discriminative loss(AD-loss).The use of AD-loss and softmax-loss can increase the discriminativeness of the learned hash features.Experimental results show that on pool and ocean datasets,which were collected in pools and oceans,respectively,by using acoustic collectors,the proposed HADN performs better than other comparative models in terms of accuracy and mAP. 展开更多
关键词 convolutional channel hash aggregate discriminative network aggregate discriminant loss waveform recognition
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Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library
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作者 Shi-Qi Wang Xun Zhao +10 位作者 Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee Lee Hai-Wei Shi 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第5期722-732,共11页
Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 compon... Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 components make accurate separation,identification,and quantification challenging.In this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple esters.The separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD analysis.The polysorbate compound database and library were expanded over 7-time compared to the commercial database.The method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process relationship.UHPLC-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different sources.The method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to change.HPLC-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products. 展开更多
关键词 Polysorbate 20 Component DATABASE DISCRIMINATION Degradation
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LociScan,a tool for screening genetic marker combinations for plant variety discrimination
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作者 Yang Yang Hongli Tian +5 位作者 Hongmei Yi Zi Shi Lu Wang Yaming Fan Fengge Wang Jiuran Zhao 《The Crop Journal》 SCIE CSCD 2024年第2期583-593,共11页
To reduce the cost and increase the efficiency of plant genetic marker fingerprinting for variety discrimination,it is desirable to identify the optimal marker combinations.We describe a marker combination screening m... To reduce the cost and increase the efficiency of plant genetic marker fingerprinting for variety discrimination,it is desirable to identify the optimal marker combinations.We describe a marker combination screening model based on the genetic algorithm(GA)and implemented in a software tool,Loci Scan.Ratio-based variety discrimination power provided the largest optimization space among multiple fitness functions.Among GA parameters,an increase in population size and generation number enlarged optimization depth but also calculation workload.Exhaustive algorithm afforded the same optimization depth as GA but vastly increased calculation time.In comparison with two other software tools,Loci Scan accommodated missing data,reduced calculation time,and offered more fitness functions.In large datasets,the sample size of training data exerted the strongest influence on calculation time,whereas the marker size of training data showed no effect,and target marker number had limited effect on analysis speed. 展开更多
关键词 Plant variety discrimination Genetic marker combination Variety discrimination power Genetic algorithm
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Impact pressure of waves generated by landslides on bank slopes
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作者 CAO Ting WANG Pingyi +1 位作者 QIU Zhenfeng LIU Jie 《Journal of Mountain Science》 SCIE CSCD 2024年第3期918-931,共14页
Impulse waves that are generated by landslides in narrow reservoir areas threaten the stability of buildings and bank slopes.To discuss the action process and evolution law of the wave pressure on bank slopes,a three-... Impulse waves that are generated by landslides in narrow reservoir areas threaten the stability of buildings and bank slopes.To discuss the action process and evolution law of the wave pressure on bank slopes,a three-dimensional physical model test that considers impulse waves generated by landslides was performed,and factors including landslide width,thickness,slope angles of the sliding surface,and bank slope angle were considered.Based on wave forms on the bank slopes,wave pressure curve characteristics,and peak value,the action process of wave pressure could be divided into the following stages:maximum pulsating pressure stage,wave impact stage(when waves break),and stationary pulsation stage.It was found that wave breaking is dependent on the value of the surf similarity parameterξ.The distribution pattern of impact pressure decays linearly on both sides of the maximum impact pressure point,and the attenuation degree decreases when it attains 40%of the maximum value.Thus,it is proposed that the prediction formula for the maximum effective impact pressure of the bank slope be related to the reciprocal of wave steepness,relative water depth,and slope rate.The prediction formula provides strong theoretical support for early safety warning and for predicting the bank slope under impulse waves generated by landslides. 展开更多
关键词 Model test Impact pressure Action stage Breaking discrimination Distribution model
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The Analysis of the Correlation between SPT and CPT Based on CNN-GA and Liquefaction Discrimination Research
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作者 Ruihan Bai Feng Shen +2 位作者 Zihao Zhao Zhiping Zhang Qisi Yu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第2期1159-1182,共24页
The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires f... The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires field testing and canbe time-consuming and labor-intensive. In contrast, the cone penetration test (CPT) provides a more convenientmethod and offers detailed and continuous information about soil layers. In this study, the feature matrix based onCPT data is proposed to predict the standard penetration test blow count N. The featurematrix comprises the CPTcharacteristic parameters at specific depths, such as tip resistance qc, sleeve resistance f s, and depth H. To fuse thefeatures on the matrix, the convolutional neural network (CNN) is employed for feature extraction. Additionally,Genetic Algorithm (GA) is utilized to obtain the best combination of convolutional kernels and the number ofneurons. The study evaluated the robustness of the proposed model using multiple engineering field data sets.Results demonstrated that the proposed model outperformed conventional methods in predicting N values forvarious soil categories, including sandy silt, silty sand, and clayey silt. Finally, the proposed model was employedfor liquefaction discrimination. The liquefaction discrimination based on the predicted N values was comparedwith the measured N values, and the results showed that the discrimination results were in 75% agreement. Thestudy has important practical application value for foundation liquefaction engineering. Also, the novel methodadopted in this research provides new ideas and methods for research in related fields, which is of great academicsignificance. 展开更多
关键词 CNN liquefaction discrimination SPT CPT
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I-DCGAN and TOPSIS-IFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images
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作者 Ming-jun Hou Hao Dong +7 位作者 Xiao-yuan Ji Wen-bing Zou Xiang-sheng Xia Meng Li Ya-jun Yin Bao-hui Li Qiang Chen Jian-xin Zhou 《China Foundry》 SCIE EI CAS CSCD 2024年第3期239-247,共9页
The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy castings.H... The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy castings.However,the efficacy of deep learning models hinges upon a substantial abundance of flaw samples.The existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality evaluation.To this end,a novel approach was put forward,which involves the creation of the Interpolation-Deep Convolutional Generative Adversarial Network(I-DCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSIS-IFP.I-DCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational complexity.TOPSIS-IFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion degree.The results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,respectively.The TOPSIS-IFP value reaches 78.7%and 73.8%similarity to the ideal solution,respectively.Compared to single index evaluation,the TOPSIS-IFP algorithm achieves higher-quality simulated images at the optimal training epoch.This approach successfully mitigates the issue of unreliable quality associated with single index evaluation.The image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks. 展开更多
关键词 light alloy casting flaw detection image generator DISCRIMINATOR comprehensive evaluation index
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Bearing Fault Diagnosis Based on Deep Discriminative Adversarial Domain Adaptation Neural Networks
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作者 Jinxi Guo Kai Chen +5 位作者 Jiehui Liu Yuhao Ma Jie Wu Yaochun Wu Xiaofeng Xue Jianshen Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2619-2640,共22页
Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received in... Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received increasingattention and achieved some results. It might lead to insufficient performance for using transfer learning alone andcause misclassification of target samples for domain bias when building deep models to learn domain-invariantfeatures. To address the above problems, a deep discriminative adversarial domain adaptation neural networkfor the bearing fault diagnosis model is proposed (DDADAN). In this method, the raw vibration data are firstlyconverted into frequency domain data by Fast Fourier Transform, and an improved deep convolutional neuralnetwork with wide first-layer kernels is used as a feature extractor to extract deep fault features. Then, domaininvariant features are learned from the fault data with correlation alignment-based domain adversarial training.Furthermore, to enhance the discriminative property of features, discriminative feature learning is embeddedinto this network to make the features compact, as well as separable between classes within the class. Finally, theperformance and anti-noise capability of the proposedmethod are evaluated using two sets of bearing fault datasets.The results demonstrate that the proposed method is capable of handling domain offset caused by differentworkingconditions and maintaining more than 97.53% accuracy on various transfer tasks. Furthermore, the proposedmethod can achieve high diagnostic accuracy under varying noise levels. 展开更多
关键词 Fault diagnosis transfer learning domain adaptation discriminative feature learning correlation alignment
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EDU-GAN:Edge Enhancement Generative Adversarial Networks with Dual-Domain Discriminators for Inscription Images Denoising
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作者 Yunjing Liu Erhu Zhang +2 位作者 Jingjing Wang Guangfeng Lin Jinghong Duan 《Computers, Materials & Continua》 SCIE EI 2024年第7期1633-1653,共21页
Recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research issue.Different fromnatural images,character images pay more attention to stroke information.Howev... Recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research issue.Different fromnatural images,character images pay more attention to stroke information.However,existingmodelsmainly consider pixel-level informationwhile ignoring structural information of the character,such as its edge and glyph,resulting in reconstructed images with mottled local structure and character damage.To solve these problems,we propose a novel generative adversarial network(GAN)framework based on an edge-guided generator and a discriminator constructed by a dual-domain U-Net framework,i.e.,EDU-GAN.Unlike existing frameworks,the generator introduces the edge extractionmodule,guiding it into the denoising process through the attention mechanism,which maintains the edge detail of the restored inscription image.Moreover,a dual-domain U-Net-based discriminator is proposed to learn the global and local discrepancy between the denoised and the label images in both image and morphological domains,which is helpful to blind denoising tasks.The proposed dual-domain discriminator and generator for adversarial training can reduce local artifacts and keep the denoised character structure intact.Due to the lack of a real-inscription image,we built the real-inscription dataset to provide an effective benchmark for studying inscription image denoising.The experimental results show the superiority of our method both in the synthetic and real-inscription datasets. 展开更多
关键词 Dual-domain discriminators inscription images DENOISING edge-guided generator
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A Dual Discriminator Method for Generalized Zero-Shot Learning
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作者 Tianshu Wei Jinjie Huang 《Computers, Materials & Continua》 SCIE EI 2024年第4期1599-1612,共14页
Zero-shot learning enables the recognition of new class samples by migrating models learned from semanticfeatures and existing sample features to things that have never been seen before. The problems of consistencyof ... Zero-shot learning enables the recognition of new class samples by migrating models learned from semanticfeatures and existing sample features to things that have never been seen before. The problems of consistencyof different types of features and domain shift problems are two of the critical issues in zero-shot learning. Toaddress both of these issues, this paper proposes a new modeling structure. The traditional approach mappedsemantic features and visual features into the same feature space;based on this, a dual discriminator approachis used in the proposed model. This dual discriminator approach can further enhance the consistency betweensemantic and visual features. At the same time, this approach can also align unseen class semantic features andtraining set samples, providing a portion of information about the unseen classes. In addition, a new feature fusionmethod is proposed in the model. This method is equivalent to adding perturbation to the seen class features,which can reduce the degree to which the classification results in the model are biased towards the seen classes.At the same time, this feature fusion method can provide part of the information of the unseen classes, improvingits classification accuracy in generalized zero-shot learning and reducing domain bias. The proposed method isvalidated and compared with othermethods on four datasets, and fromthe experimental results, it can be seen thatthe method proposed in this paper achieves promising results. 展开更多
关键词 Generalized zero-shot learning modality consistent DISCRIMINATOR domain shift problem feature fusion
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Artificial neural network-based method for discriminating Compton scattering events in high-purity germaniumγ-ray spectrometer
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作者 Chun-Di Fan Guo-Qiang Zeng +5 位作者 Hao-Wen Deng Lei Yan Jian Yang Chuan-Hao Hu Song Qing Yang Hou 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第2期64-84,共21页
To detect radioactive substances with low activity levels,an anticoincidence detector and a high-purity germanium(HPGe)detector are typically used simultaneously to suppress Compton scattering background,thereby resul... To detect radioactive substances with low activity levels,an anticoincidence detector and a high-purity germanium(HPGe)detector are typically used simultaneously to suppress Compton scattering background,thereby resulting in an extremely low detection limit and improving the measurement accuracy.However,the complex and expensive hardware required does not facilitate the application or promotion of this method.Thus,a method is proposed in this study to discriminate the digital waveform of pulse signals output using an HPGe detector,whereby Compton scattering background is suppressed and a low minimum detectable activity(MDA)is achieved without using an expensive and complex anticoincidence detector and device.The electric-field-strength and energy-deposition distributions of the detector are simulated to determine the relationship between pulse shape and energy-deposition location,as well as the characteristics of energy-deposition distributions for fulland partial-energy deposition events.This relationship is used to develop a pulse-shape-discrimination algorithm based on an artificial neural network for pulse-feature identification.To accurately determine the relationship between the deposited energy of gamma(γ)rays in the detector and the deposition location,we extract four shape parameters from the pulse signals output by the detector.Machine learning is used to input the four shape parameters into the detector.Subsequently,the pulse signals are identified and classified to discriminate between partial-and full-energy deposition events.Some partial-energy deposition events are removed to suppress Compton scattering.The proposed method effectively decreases the MDA of an HPGeγ-energy dispersive spectrometer.Test results show that the Compton suppression factors for energy spectra obtained from measurements on ^(152)Eu,^(137)Cs,and ^(60)Co radioactive sources are 1.13(344 keV),1.11(662 keV),and 1.08(1332 keV),respectively,and that the corresponding MDAs are 1.4%,5.3%,and 21.6%lower,respectively. 展开更多
关键词 High-purity germaniumγ-ray spectrometer Pulse-shape discrimination Compton scattering Artificial neural network Minimum detectable activity
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FPGA implementation of 500-MHz high-count-rate high-time-resolution real-time digital neutron-gamma discrimination for fast liquid detectors
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作者 Hui‑Yin Shen Jing‑Long Zhang +1 位作者 Jie Zhang Jian‑Hang Zhou 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第8期101-113,共13页
Fast neutron flux measurements with high count rates and high time resolution have important applications in equipment such as tokamaks.In this study,real-time neutron and gamma discrimination was implemented on a sel... Fast neutron flux measurements with high count rates and high time resolution have important applications in equipment such as tokamaks.In this study,real-time neutron and gamma discrimination was implemented on a self-developed 500-Msps,12-bit digitizer,and the neutron and gamma spectra were calculated directly on an FPGA.A fast neutron flux measurement system with BC-501A and EJ-309 liquid scintillator detectors was developed and a fast neutron measurement experiment was successfully performed on the HL-2 M tokamak at the Southwestern Institute of Physics,China.The experimental results demonstrated that the system obtained the neutron and gamma spectra with a time accuracy of 1 ms.At count rates of up to 1 Mcps,the figure of merit was greater than 1.05 for energies between 50 keV and 2.8 MeV. 展开更多
关键词 Neutron-gamma discrimination Liquid scintillation detector Real-time spectrum analyzer
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High-Precision Doppler Frequency Estimation Based Positioning Using OTFS Modulations by Red and Blue Frequency Shift Discriminator
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作者 Shaojing Wang Xiaomei Tang +3 位作者 Jing Lei Chunjiang Ma Chao Wen Guangfu Sun 《China Communications》 SCIE CSCD 2024年第2期17-31,共15页
Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Dopple... Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Doppler frequency for positioning is a promising research direction on communication and navigation integration. To tackle the high Doppler frequency and low signal-to-noise ratio(SNR) in satellite communication, this paper proposes a Red and Blue Frequency Shift Discriminator(RBFSD) based on the pseudo-noise(PN) sequence.The paper derives that the cross-correlation function on the Doppler domain exhibits the characteristic of a Sinc function. Therefore, it applies modulation onto the Delay-Doppler domain using PN sequence and adjusts Doppler frequency estimation by red-shifting or blue-shifting. Simulation results show that the performance of Doppler frequency estimation is close to the Cramér-Rao Lower Bound when the SNR is greater than -15dB. The proposed algorithm is about 1/D times less complex than the existing PN pilot sequence algorithm, where D is the resolution of the fractional Doppler. 展开更多
关键词 channel estimation communication and navigation integration Orthogonal Time Frequency and Space pseudo-noise sequence red-blue frequency shift discriminator
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Multi‑omics integration identifies regulatory factors underlying bovine subclinical mastitis
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作者 Mengqi Wang Naisu Yang +3 位作者 Mario Laterriere David Gagne Faith Omonijo Eveline M.Ibeagha‑Awemu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第3期987-1007,共21页
Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy industry.Multi-omics approaches enable the comprehensive investigation of the complex interactions between ... Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy industry.Multi-omics approaches enable the comprehensive investigation of the complex interactions between mul-tiple layers of information to provide a more holistic view of disease pathogenesis.Therefore,this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms underlying subclinical mastitis by integrating RNA sequencing data(mRNA and lncRNA),small RNA sequencing data(miRNA)and DNA methylation sequencing data of milk somatic cells from 10 healthy cows and 20 cows with naturally occurring subclinical mastitis caused by Staphylococcus aureus or Staphylococcus chromogenes.Results Functional investigation of the data sets through gene set analysis uncovered 3458 biological process GO terms and 170 KEGG pathways with altered activities during subclinical mastitis,provided further insights into subclin-ical mastitis and revealed the involvement of multi-omics signatures in the altered immune responses and impaired mammary gland productivity during subclinical mastitis.The abundant genomic and epigenomic signatures with sig-nificant alterations related to subclinical mastitis were observed,including 30,846,2552,1276 and 57 differential methylation haplotype blocks(dMHBs),differentially expressed genes(DEGs),lncRNAs(DELs)and miRNAs(DEMs),respectively.Next,5 factors presenting the principal variation of differential multi-omics signatures were identified.The important roles of Factor 1(DEG,DEM and DEL)and Factor 2(dMHB and DEM),in the regulation of immune defense and impaired mammary gland functions during subclinical mastitis were revealed.Each of the omics within Factors 1 and 2 explained about 20%of the source of variation in subclinical mastitis.Also,networks of impor-tant functional gene sets with the involvement of multi-omics signatures were demonstrated,which contributed to a comprehensive view of the possible regulatory mechanisms underlying subclinical mastitis.Furthermore,multi-omics integration enabled the association of the epigenomic regulatory factors(dMHBs,DELs and DEMs)of altered genes in important pathways,such as‘Staphylococcus aureus infection pathway’and‘natural killer cell mediated cyto-toxicity pathway’,etc.,which provides further insights into mastitis regulatory mechanisms.Moreover,few multi-omics signatures(14 dMHBs,25 DEGs,18 DELs and 5 DEMs)were identified as candidate discriminant signatures with capac-ity of distinguishing subclinical mastitis cows from healthy cows.Conclusion The integration of genomic and epigenomic data by multi-omics approaches in this study provided a better understanding of the molecular mechanisms underlying subclinical mastitis and identified multi-omics candidate discriminant signatures for subclinical mastitis,which may ultimately lead to the development of more effective mastitis control and management strategies. 展开更多
关键词 Candidate discriminant multi-omics signature Gene Long non-coding RNA Methylation haplotype block MicroRNA Multi-omics integration Natural killer cell mediated cytotoxicity pathway Staphylococcus aureus infection pathway
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Exploring the Pathways of Leprosy Patients from Their Communities to a Diagnosis in the Districts of Mayuge, Yumbe and Kasese-Uganda
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作者 Rose Kengonzi Stavia Turyahabwe +5 位作者 Samuel Orach Lisa Gerwing-Adima Ronald W. Nyote Vincent Kamara Kabugho Faith Consolata Mpambara 《Advances in Infectious Diseases》 CAS 2024年第2期346-373,共28页
Background: Leprosy is known to cause disability that leads to severe outcomes like stigma, discrimination, mental health problems and participation restriction. Furthermore, in cases of infectious leprosy, longer del... Background: Leprosy is known to cause disability that leads to severe outcomes like stigma, discrimination, mental health problems and participation restriction. Furthermore, in cases of infectious leprosy, longer delays increase the risk for the spread of the disease. Despite being preventable and curable, a significant proportion of new leprosy patients (39%) in 2019 had grade 2 (Described as Visible disability) at the time of diagnosis signifying late presentation. The aim of this study was to describe patient journeys from first symptoms suggestive of leprosy to a diagnosis and individual and community level factors associated with health seeking behavior of leprosy patients. Methods: This was a cross-sectional explorative study implemented in Kasese, Mayuge and Yumbe districts .A structured questionnaire was used to collect quantitative data. Qualitative assessment included patients, family members, health workers, voluntary health teams and the district health team. Descriptive statistics were presented in terms of percentages, frequency tables, pie Charts and graphs for easy interpretation and discussion. Results: The results indicate that 53% of the respondents identified as female. The median age of the respondents being 34 years, with a range of 1 to 76 years (Mean: 44.7, Mode: 65, Standard-Deviation: 19.6, Kurtosis: 0.6). The most common first symptom noticed by respondents was skin lesions (65%) followed by deformities (18%) (P value = 0.05%) occurring mostly in the feet (P-value = 0.48). Majority (52%) of the patients had taken more than 24 months (SD 18.72 OR 2.75) for a diagnosis to be made with a maximum delay of over 60 months. The most common cause of delay in seeking health care was lack of knowledge on leprosy (P value=Conclusions: There was a delay of 2 years in seeking health care for the majority of the patients. Key barriers to early diagnosis were lack of knowledge and infrastructure. Community sensitization and strengthening capacity building are needed to achieve early diagnosis of leprosy and proper management. 展开更多
关键词 LEPROSY Patient Pathway Skin Lesions DISABILITY Discrimination Delayed Diagnosis
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The Alzheimer’s Dementia Patients’ Observed Illness Course and Experience in Ghana and Care Lessons to Be Learnt: A Mental Health Professional’s Perspective
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作者 Albert M. E. Coleman 《Open Journal of Psychiatry》 2024年第2期91-106,共16页
Alzheimer’s disease (AD) and associated dementia patient numbers continue to increase globally with associated economic costs to healthcare systems. Of note is the increase in numbers in lower and middle-income count... Alzheimer’s disease (AD) and associated dementia patient numbers continue to increase globally with associated economic costs to healthcare systems. Of note is the increase in numbers in lower and middle-income countries (LMICs) including Sub-Saharan African (SSA) countries, which already face challenges with their health budgets from communicable and non-communicable diseases. Ghana, an SSA country, faces the problem of healthcare budgetary difficulties and the additional impact of AD as a consequence of increasing population strata of old aged persons (OAPs) due to the demographic transition effect. This article uses examples of known patients’ illness courses to give a perspective on the lived experience of patients with dementia (PWD) in Ghana, living amongst a populace with a culture of stigmatization of PWD, and a relatively fragile public mental health system (PMHS) for those with mental illness, including AD. The lived experience of AD patients is characterised by stigmatisation, discrimination, non-inclusiveness, diminished dignity and human rights abuses in the face of their mental disability, and eventually death. This article is an advocacy article giving voice to the voiceless and all persons suffering from AD and other dementias in Ghana, whilst pleading for a call to action from healthcare professionals and responsible state agencies. 展开更多
关键词 Alzheimer’s Dementia PATIENTS Ghana STIGMATIZATION Discrimination Human Rights DIGNITY
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The Influence of Price Discrimination from Airports on the Route Development Behavior of Airlines
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作者 Daniel Schnitzler 《Journal of Civil Engineering and Architecture》 2024年第1期17-29,共13页
Given the prominence and magnitude of airport incentive schemes,it is surprising that literature hitherto remains silent as to their effectiveness.In this paper,the relationship between airport incentive schemes and t... Given the prominence and magnitude of airport incentive schemes,it is surprising that literature hitherto remains silent as to their effectiveness.In this paper,the relationship between airport incentive schemes and the route development behavior of airlines is analyzed.Because of rare and often controversial findings in the extant literature regarding relevant influencing variables for attracting airlines at an airport,expert interviews are used as a complement to formulate testable hypotheses in this regard.A fixed effects regression model is used to test the hypotheses with a dataset that covers all seat capacity offered at the 22 largest German commercial airports in the week 46 from 2004 to 2011.It is found that incentives from primary choice,as well as secondary choice airports,have a significant influence on Low Cost Carriers.Furthermore,Low Cost Carriers,in general,do not leave any of both types of airports when the incentives cease.In the case of Network Carriers,no case is found where one joins a primary choice airport and receives an incentive.Insufficient data between Network Carriers and secondary choice airports in the time when incentives have ceased means that no statement can be given. 展开更多
关键词 AIRLINE rout development price discrimination
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Review of Women’s Employment in Greece in the 20th and Early 21st Centuries
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作者 Fotini Mastroianni 《Economics World》 2024年第3期109-116,共8页
In the early 20th century,the role of Greek women in the working environment was considered complementary,and the type of work they would do should fit their Review of Women’s Employment in Greece in the 20th and Ear... In the early 20th century,the role of Greek women in the working environment was considered complementary,and the type of work they would do should fit their Review of Women’s Employment in Greece in the 20th and Early 21st Centuries gender stereotypes.Therefore,they were low-paid workers and employees,and they were the first to be laid off.Despite the fact that the number of Greek women participating in the labor market has increased,many of them were obliged to work due to the high rate of men’s unemployment since there was no other way to sustain the living level of the household(Alpha Bank,2018).Greek women’s participation in the labor market was accompanied by an increase in flexible types of employment along with the pay gap between men and women,which remained persistent due to the existence of discrimination. 展开更多
关键词 UNEMPLOYMENT pay gap flexible employment DISCRIMINATION LABOR EMPLOYMENT Greek women
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A Review of the Research on the Influencing Factors of Enterprise Key Core Technology Breakthrough
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作者 Liangcan Liu Yuexian Zou 《Proceedings of Business and Economic Studies》 2024年第4期125-129,共5页
The breakthrough of key core technology is a theoretical and practical strategic issue to realize the rise of the country.This paper analyzes the concept of key core technology and its breakthrough and analyzes its ch... The breakthrough of key core technology is a theoretical and practical strategic issue to realize the rise of the country.This paper analyzes the concept of key core technology and its breakthrough and analyzes its characteristics.Based on the perspective of participants,this paper summarizes the influencing factors of key core technology breakthroughs in enterprises:internal and external enterprises,universities and scientific research institutions,and government.This paper expands the relevant research on key core technology breakthroughs and provides inspiration for enterprises to carry out key core technology research and breakthrough practices. 展开更多
关键词 Key core technology breakthrough Concept discrimination Technical features Influencing factors
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