Discrimination of different types of sulfur-containing species not only helps us to deeply understand how sulfur affects cellular signaling,but also contribute to the early diagnosis of diseases.However,the current in...Discrimination of different types of sulfur-containing species not only helps us to deeply understand how sulfur affects cellular signaling,but also contribute to the early diagnosis of diseases.However,the current investigation about sulfur-containing species discrimination is mainly concentrated in biothiols,which is relatively limited for practical application.Toward circumventing this limitation,herein,a convenient sensor array consisting of three kinds of Au NCs-Cu2+ for simultaneous and rapid identification of different types of sulfur-containing species is reported.Based on the fingerprint-like fluorescence responses generated by competitive binding between Au NCs-Cu2+ and different sulfurcontaining species,not only ten different types of sulfur-containing species separately but also their binary or ternary randomly selected mixtures can be well discriminated even in human urine and serum samples.It is worth noting that it only takes 2 min to obtain the best response signals for sulfurcontaining species discrimination.Most importantly,serums from cancer patients(such as liver cancer and breast cancer) and healthy people as well as sulfur-oxidizing bacteria(SOB) and sulfur-free bacteria can be both effectively and rapidly identified within 2 min,respectively,making it a promising approach for point-of-care disease diagnostic.展开更多
基金support from the National Nature Science Foundation of China(Nos.21675093,21505081 and 21974075)the Natural Science Foundation of Shandong Province of China(No.ZR2019YQ13)+1 种基金the Science and Technology Support Plan for Youth Innovation of Colleges and Universities in Shandong Province(No.2019KJC007)the Taishan Scholar Program of Shandong Province,China(No.ts20110829)。
文摘Discrimination of different types of sulfur-containing species not only helps us to deeply understand how sulfur affects cellular signaling,but also contribute to the early diagnosis of diseases.However,the current investigation about sulfur-containing species discrimination is mainly concentrated in biothiols,which is relatively limited for practical application.Toward circumventing this limitation,herein,a convenient sensor array consisting of three kinds of Au NCs-Cu2+ for simultaneous and rapid identification of different types of sulfur-containing species is reported.Based on the fingerprint-like fluorescence responses generated by competitive binding between Au NCs-Cu2+ and different sulfurcontaining species,not only ten different types of sulfur-containing species separately but also their binary or ternary randomly selected mixtures can be well discriminated even in human urine and serum samples.It is worth noting that it only takes 2 min to obtain the best response signals for sulfurcontaining species discrimination.Most importantly,serums from cancer patients(such as liver cancer and breast cancer) and healthy people as well as sulfur-oxidizing bacteria(SOB) and sulfur-free bacteria can be both effectively and rapidly identified within 2 min,respectively,making it a promising approach for point-of-care disease diagnostic.
