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Association between Free Triiodothyronine Levels and Peripheral Arterial Disease in Euthyroid Participants 被引量:5
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作者 WANG Po DU Rui +8 位作者 LIN Lin DING Lin PENG Kui XU Yu XU Min BI Yu Fang WANG Wei Qing NING Guang LU Jie Li 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第2期128-133,共6页
This current cross-sectional study investigates the relationship between thyroid hormones and peripheral artery disease (PAD) among euthyroid Chinese population aged 40 years and above. Serum free triiodothyronine ... This current cross-sectional study investigates the relationship between thyroid hormones and peripheral artery disease (PAD) among euthyroid Chinese population aged 40 years and above. Serum free triiodothyronine (FT3), free thyroxin (FT4), thyroid-stimulating hormone (TSH), and thyroid antibodies were measured. 展开更多
关键词 PAD Association between free Triiodothyronine Levels and Peripheral Arterial disease in Euthyroid Participants TPOAb HDL SBP LDL TSH FPG
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Predicting prognosis of rectal cancer patients with total mesorectal excision using molecular markers 被引量:10
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作者 Jun-Jie Peng San-Jun Cai +5 位作者 Hong-Feng Lu Guo-Xiang Cai Peng Lian Zu-Qing Guan Ming-He Wang Ye Xu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第21期3009-3015,共7页
AIM:To explore the prognostic variables in rectal cancer patients undergoing curative total mesorectal excision and the effect of postoperative chemotherapy in advanced rectal cancer. METHODS:A total of 259 consecutiv... AIM:To explore the prognostic variables in rectal cancer patients undergoing curative total mesorectal excision and the effect of postoperative chemotherapy in advanced rectal cancer. METHODS:A total of 259 consecutive rectal cancer patients treated with curative total mesorectal excision between 1999 and 2004 were collected. p53,p21,PCNA,and CD44v6 were examined using immunohistochemistry (IHC). The correlation between clinicopathological or molecular variables and clinical outcomes,including local recurrence,metastasis,disease-free survival and overall survival,was analyzed. RESULTS:The median follow-up was 44 mo. Five-year survival rates and 5-year disease free survival rates were 75.43% and 70.32%,respectively. Multi-analysis revealed TNM staging,preoperative CEA,and CD44v6 level were independent risk factors predicting overall survival or disease free survival. The hazard ratio of peroperative CEA was 2.65 (95% CI 1.4-5) and 3.10 (95% CI 1.37-6.54) for disease free survival and overall survival,respectively. The hazard ratio of CD44v6 was 1.93 (95% CI 1.04-3.61) and 2.21 (95% CI 1.01-4.88) for disease free survival and overall survival,respectively. TNM staging was the only risk factor predicting local recurrence. Postoperative chemotherapy without radiotherapy did not improve patients' outcome. CONCLUSION:TNM staging,preoperative CEA and CD44v6 were independent prognostic factors for rectal cancer patients with total mesorectal excision. Postoperative chemotherapy may be only used together with radiotherapy for rectal cancer patients. 展开更多
关键词 Rectal cancer Total mesorectal excision IMMUNOHISTOCHEMISTRY disease free survival p53 P21 PCNA CD44V6 CEA PROGNOSIS
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ANALYSIS OF AN SI EPIDEMIC MODEL WITH NONLINEAR TRANSMISSION AND STAGE STRUCTURE 被引量:10
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作者 陆忠华 jupiter.cnc.ac.cn +3 位作者 高淑京 l63.net 陈兰荪 math08.math.ac.cn 《Acta Mathematica Scientia》 SCIE CSCD 2003年第4期440-446,共7页
A disease transmission model of SI type with stage structure is formulated. The stability of disease free equilibrium, the existence and uniqueness of an endemic equilibrium, the existence of a global attractor are in... A disease transmission model of SI type with stage structure is formulated. The stability of disease free equilibrium, the existence and uniqueness of an endemic equilibrium, the existence of a global attractor are investigated. 展开更多
关键词 SI epidemic model THRESHOLD disease free equilibrium endemic equilibrium global attractor
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Clinical Observation of Patients with Hematologic Malignancies Treated with Hematopoietic Stem Cell Transplantation 被引量:5
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作者 张东华 张路 +8 位作者 肖毅 黄伟 李登举 冉丹 黄亮 周剑锋 黄梅 孙汉英 刘文励 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2004年第4期345-349,共5页
To evaluate the therapeutic effect of hematopoietic stem cell transplantation (HSCT), we performed HSCT in 30 patients with hematologic maligancies. Of the 30 patients, 10 underwent autologous peripheral blood stem ce... To evaluate the therapeutic effect of hematopoietic stem cell transplantation (HSCT), we performed HSCT in 30 patients with hematologic maligancies. Of the 30 patients, 10 underwent autologous peripheral blood stem cell transplantation (auto-PBSCT), 13 underwent myeloablative allogeneic HSCT while 7 underwent nonmyeloablative allogeneic HSCT, which were designated as autologous group, myeloablative group and nonmyeloablative group, respectively. All patients except the one who underwent cord blood transplantation, were successfully engrafted. Median time for the granulocytes≥0.5×10\+9/L and platelets≥20×10\+9/L were 12 days and 13 days respectively in autologous group, 16 days and 19 days in myeloablative group, 15 days and 12 days in nonmyeloablative group. In myeloablative group, acute graft-versus-host diseases (aGVHD) was observed in 3 patients, all of which were I—Ⅱgrade. Oral mucous cGVHD was observed in 1 patient. In nonmyeloablative group, 1 patient developed intestinal aGVHD grade Ⅳ and cutaneous cGVHD was induced by donor lymphocyte infusions (DLI) in 3 patients. 1 patient had hematological relapse in autologous group. 1 patient had cytogenetic relapse in myeloablative group. In nonmyeloablative group 3 patients had cytogenetic relapse and were cured by DLI, 1 patient had hematological relapse. 4 of the 30 patients died of infection (2 patients), grade Ⅳ aGVHD (1) and relapse (1) respectively. 26 patients are still alive. 3 years overall survival (OS) and 3 years disease free survival (DFS) were 100 % and 64.81 % respectively in autologous group, 78.75 % and 63 % respectively in myeloablative group while both 66.67 % in nonmyeloablative group. In conclusion, autologous group had less transplant-related complications and mortality. Active prophylaxis of relapse could significantly promote DFS. The transplant-related mortality limited DFS in myeloablative group. More relapses occurred in nonmyeloablative group, but could be cured by DLI. 展开更多
关键词 hematopoietic stem cell transplantation LEUKEMIA LYMPHOMA disease free survival
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Prognostic significance of primary tumor localization in stage Ⅱ and Ⅲ colon cancer 被引量:1
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作者 Abdullah Sakin Serdar Arici +6 位作者 Saban Secmeler Orcun Can Caglayan Geredeli Nurgul Yasar Cumhur Demir Osman Gokhan Demir Sener Cihan 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2018年第11期410-420,共11页
AIM To investigate the effects of tumor localization on disease free survival(DFS) and overall survival(OS) in patients with stage Ⅱ-Ⅲ colon cancer.METHODS This retrospective study included 942 patients with stage ... AIM To investigate the effects of tumor localization on disease free survival(DFS) and overall survival(OS) in patients with stage Ⅱ-Ⅲ colon cancer.METHODS This retrospective study included 942 patients with stage Ⅱ and Ⅲ colon cancer, which were followed up in our clinics between 1995 and 2017. The tumors from the caecum to splenic flexure were defined as right colon cancer(RCC) and those from splenic flexure to the sigmoid colon as left colon cancer(LCC).RESULTS The median age of the patients was 58 years(range: 19-94 years). Male patients constituted 54.2%. The rates of RCC and LCC were 48.4%(n = 456) and 51.6%(n = 486), respectively. During the median follow-up of 90 mo(range: 6-252 mo), 14.6% of patients developed recurrence and 9.1% of patients died. In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, DFS was similar in terms of primary tumor localization(stage Ⅱ; P = 0.547 and P = 0.481, respectively; stage Ⅲ; P = 0.976 and P = 0.978, respectively). In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, OS was not statistically significant with respect to primary tumor localization(stage Ⅱ; P = 0.381 and P = 0.947, respectively; stage Ⅲ; P = 0.378 and P = 0.904, respectively). The difference between median OS of recurrent RCC(26 ± 6.2 mo) and LCC(34 ± 4.9 mo) cases was eight months(P = 0.092).CONCLUSION Our study showed no association of tumor localization with either DFS or OS in patients with stage Ⅱ or Ⅲ colon cancer managed with or without adjuvant therapy. However, post-recurrence OS appeared to be worse in RCC patients. 展开更多
关键词 Colon cancer Tumor localization Adjuvant treatment Overall survival disease free survival
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Global Asymptotic Stability of a Kind of Stochastic SIRS Model
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作者 徐敏 丁永生 胡良剑 《Journal of Donghua University(English Edition)》 EI CAS 2010年第6期792-795,共4页
A detailed analysis was carried out on global asymptotic behavior of a kind of stochastic SIRS(susceptible-infective-removed-susceptible)model.This model has been obtained by introducing stochasticity into the origina... A detailed analysis was carried out on global asymptotic behavior of a kind of stochastic SIRS(susceptible-infective-removed-susceptible)model.This model has been obtained by introducing stochasticity into the original deterministic SIRS model via the technique of parameter perturbation which is standard in stochastic population modeling.By making corresponding Lyapunov function and using It formula,the condition for the solution of the model tending to the disease free equilibrium asymptotically was obtained.Under this condition,the epidemics will die out as time goes by.Based on this,almost surely exponential stability was analyzed. 展开更多
关键词 stochastic SIRS model disease free equilibrium global asymptotic stability
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Stability Analysis of Bubonic Plague Model with the Causing Pathogen Yersinia pestis in the Environment
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作者 Rigobert Charles Ngeleja Livingstone Luboobi Yaw Nkansah-Gyekye 《Advances in Infectious Diseases》 2016年第3期120-137,共19页
Bubonic plague is a serious bacterial disease, mainly transmitted to human beings and rodents through flea bite. However, the disease may also be transmitted upon the interaction with the infected materials or surface... Bubonic plague is a serious bacterial disease, mainly transmitted to human beings and rodents through flea bite. However, the disease may also be transmitted upon the interaction with the infected materials or surfaces in the environment. In this study, a deterministic model for bubonic plague disease with Yersinia pestis in the environment is developed and analyzed. Conditions for existence and stability of the equilibrium points are established. Using Jacobian method disease free equilibrium (DFE) point, E<sup>0</sup> was proved to be locally asymptotically stable. The Metzler matrix method was used to prove that the DFE was globally asymptotically stable when R<sub>0</sub> < 1. By applying Lyapunov stability theory and La Salles invariant principle, we prove that the endemic equilibrium point of system is globally asymptotically stable when R<sub>0</sub> > 1. Numerical simulations are done to verify the analytical predictions. The results show that bubonic plague can effectively be controlled or even be eradicated if efforts are made to ensure that there are effective and timely control strategies. 展开更多
关键词 disease free Equilibrium Endemic Equilibrium Stability Analysis Bubonic Plague Pathogens in the Environment
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Effects of free radicals and amyloid β protein on the currents of expressed rat receptors in Xenopus oocytes
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作者 黄福南 李文彬 +6 位作者 张炳烈 崔旭 韩志涛 房征宇 蔡竖平 尹岭 王鲁宁 《Chinese Medical Journal》 SCIE CAS CSCD 2001年第3期20-23,103,共5页
Objective To investigate the effects of free radicals (FRs) and amyloid β protein 1 40 (Aβ 1 40 ) on the functions of expressed neurotransmitter receptors (NRs) in Xenopus oocytes Methods Total RNA and ... Objective To investigate the effects of free radicals (FRs) and amyloid β protein 1 40 (Aβ 1 40 ) on the functions of expressed neurotransmitter receptors (NRs) in Xenopus oocytes Methods Total RNA and messenger RNA (mRNA) was prepared from 3 month old Wistar rat brain tissues with Promega kits and microinjected into maturated Xenopus oocytes (stages Ⅴ Ⅵ) with 50?nl (50?ng) for each oocyte The microinjected oocytes were incubated with modified Bath's solution at 19 0℃±1 0℃ for receptor expression and their currents were recorded with double electrode voltage clamp technique Superoxide anion free radicals (SAFRs) were produced via a reaction system (HPX/XO) with hypoxanthine (HPX, 0 05?mol/L) and xanthine oxidase (XO, 0 1?U/L) In order to observe the effects of Aβ and SAFRs on the expressed glutamate receptor, HPX/XO and Aβ 1 40 were added to incubation solution at 12?h, 24?h and 96?h before recording Results The results showed that the oocytes expressed functional NRs originating from rat brain tissues These NRs included muscarinic acetylcholine (mACh), glutamate (Glu), dopamine (DA), serotonin (5 HT) and γ aminobutyric acid (GABA) The current characteristics of expressed receptors were inward currents carried by chloride ion with their equibrilium potentials close to -22?mV The extent of effect on the current of expressed glutamate receptor from rat brain was different among different Aβ concentrations and incubation times Aβ 1 40 at a concentration of 20?nmol/L had little effect on the currents of expressed rat brain glutamate receptors up to 24?h of incubation period; but the currents of glutamate receptor were significantly decreased (25% off, P <0 01) in the treatment of 60?nmol/L Aβ 1 40 over 24?h Moreover, when 20?nmol/L Aβ 1 40 was co incubated over 12?h with SAFRs produced by the reaction system of HPX/XO, it was found that the currents of expressed rat brain glutamate receptors had been changed markedly When the oocytes were co treated with 60?nmol/L Aβ 1 40 and SAFRs over a period of 12?h, the currents of glutamate receptor significantly decreased (21% off, P <0 05), and the decreased percentage reached 52% over 24?h co treatment with 60?nmol/L Aβ 1 40 and SAFRs In addition, vitamin E had a partial effect against this inhibitory effect Conclusion The results suggest that Aβ has a kind of inhibitory effect upon the current of the glutamate receptor, similar to the effects of free radicals The effects can be antagonized by vitamin E These imply that Aβ may play a role via inhibiting receptor function in the pathophysiology of Alzheimer's disease 展开更多
关键词 amyloid β protein · free radicals · neurotransmitter receptor · glutamate · Alzheimer's disease
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The asymptotic behavior of a stochastic multigroup SIS model 被引量:1
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作者 Chunyan Ji Daqing Jiang 《International Journal of Biomathematics》 SCIE 2018年第3期115-130,共16页
In this paper, we explore the long time behavior of a multigroup Susceptible-Infected Susceptible (SIS) model with stochastic perturbations. The conditions for the disease to die out are obtained. Besides, we also s... In this paper, we explore the long time behavior of a multigroup Susceptible-Infected Susceptible (SIS) model with stochastic perturbations. The conditions for the disease to die out are obtained. Besides, we also show that the disease is fluctuating around the endemic equilibrium under some conditions. Moreover, there is a stationary distribution under stronger conditions. At last, some numerical simulations are applied to support our theoretical results. 展开更多
关键词 A multigroup Susceptible-Infected-Susceptible (SIS) model disease free equilibrium endemic equilibrium exponential stability prevail stationary distribution.
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Autologous peripheral blood stem cell transplantation in the patients with hematologic malignancies and solid tumors
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作者 克晓燕 杨玉花 +1 位作者 赵昕 王良绪 《Chinese Medical Journal》 SCIE CAS CSCD 2001年第2期84-87,111,共5页
Objective To evaluate the long-term therapeutic effects of autologous peripheral blood stem cell transplantation (auto-PBSCT) on the treatment of hematological and solid tumors.Methods Fifty-one patients were recrui... Objective To evaluate the long-term therapeutic effects of autologous peripheral blood stem cell transplantation (auto-PBSCT) on the treatment of hematological and solid tumors.Methods Fifty-one patients were recruited in this auto-PBSCT study, in which several potentially important parameters were studied including the optimal time for stem cell collection, the dose of stem cell reinfusion, the time of hematopoietic reconstitution, the disease free survival (DFS) and overall survival (OS), complications related to transplantation, and maintenance chemotherapy after auto-PBSCT.Results After APBSCT, 3-year and 5-year survival rates of NHL were 83.3%; those of AML were 74.7%; those of MM were 37.9% and 19%; those of ALL were 40% and 0% respectively. Hematopoietic reconstitution was greatly promoted by granulocyte colony stimulating factor (G-CSF). The mean time for patients' neutrophil to recover up to >0.5×109/L after APBSCT was 11.14 days in the group of the patients receiving G-CSF in contrast to 17.6 days in the group receiving no G-CSF. The most common complications of transplantation were fever, liver dysfunction and hypokalaemia, which were curable. No death was due to transplantation related complications.Conclusion Comparing with conventional chemotherapy, our study suggests that auto-PBSCT is a very important therapeutic option that can significantly improve the prognosis in the patients with hematological and solid tumors, especially in the patients with AML and NHL. 展开更多
关键词 autologous peripheral blood stem cell transplantation · disease free survival · overall survival
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Association of an anaplastic lymphoma kinase pathway signature with cell de-differentiation, neoadjuvant chemotherapy response, and recurrence risk in breast cancer
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作者 Dingxie Liu Yong Wu 《Cancer Communications》 SCIE 2020年第9期422-434,共13页
Background:Aberrant activation of anaplastic lymphoma kinase(ALK)signaling has been found to be involved in the tumorigenesis of multiple types of cancer.The aim of this study was to determine the role of this pathway... Background:Aberrant activation of anaplastic lymphoma kinase(ALK)signaling has been found to be involved in the tumorigenesis of multiple types of cancer.The aim of this study was to determine the role of this pathway in the pathogenesis of breast cancer.Methods:An ALK pathway signature that we generated previously was used to compute the ALK pathway activity in 6381 breast cancer samples from 42 microarray datasets,and the associations between ALK pathway signature score and clinical variables were examined using logistic regression and survival analyses.Results:Our results indicated that high ALK pathway activity was a significant risk factor for hormone receptor-negative,high-grade breast cancer in the 42 datasets.ALK pathway activity was positively associated with pathological complete response(pCR)in 15 datasets annotated with patient’s neoadjuvant chemotherapy response information(overall odds ratio=1.67,P<0.01),and this association was more significant in HER2-negative and grade 1&2 tumors than in HER2-positive and grade 3 tumors.ALK pathway activity was also positively associated with recurrence risk in breast cancer patients from 30 datasets annotated with survival information(overall hazard ratio=1.21,P<0.01),particularly in patients with age>50 years old,with positive lymph nodes,or with residual disease after neoadjuvant chemotherapy.Conclusions:ALK may be involved in breast cancer tumorigenesis,and ALK pathway signature score may serve as a prognostic biomarker for breast cancer. 展开更多
关键词 Anaplastic Lymphoma Kinase Breast cancer DIFFERENTIATION disease free survival Gene signature Neoadjuvant chemotherapy response Prognosis prediction
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