Environmental temperature is a major factor affecting animal performance in South China. With global warming, heat stress will become more and more serious. This paper reviewed the effects of heat stress on metabolism...Environmental temperature is a major factor affecting animal performance in South China. With global warming, heat stress will become more and more serious. This paper reviewed the effects of heat stress on metabolism of proteins, glucose, fat and energy in skeletal muscle and related mechanisms so as to provide theoretical guidance for alleviating heat stress and improving production performance of animal suffering from heat stress.展开更多
Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in tra...Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in traditional Chinese medicine(TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi(FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu(ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism(glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na^+-K^+-ATPase), endocrine system(triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system(acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices(substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome(appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.展开更多
Vanadium is a vital strategic resource, and vanadium metabolism is an important part of the national socio-economic system of China. This study conducts accounting and scenario analysis on the life cycle of vanadium m...Vanadium is a vital strategic resource, and vanadium metabolism is an important part of the national socio-economic system of China. This study conducts accounting and scenario analysis on the life cycle of vanadium metabolism in China. Based on the character- istics of vanadium life cycle and substance flow analysis （SFA） framework, we present a quantitative evaluation of a static anthropogenic vanadium life cycle for the year 2010. Results show that anthropogenic vanadium consumption, stocks, and new domestic scrap are at 98.2, 21.2, and 4.1 kt, respectively; new scrap is usually discarded. The overall utilization ratio of vanadium is 32.2%. A large amount of vanadium is stockpiled into tailings, debris, slags, and other spent solids. A scenario analysis was conducted to analyze the future developmental trend of vanadium metabolism in China based on the SFA frame- work and the qualitative analysis of technology advance- ment and socio-economic development. The baseline year was set as 2010. Several indicators were proposed to simulate different scenarios from 2010 to 2030. The scenario analysis indicates that the next 20 years is a critical period for the vanadium industry in China. This paper discusses relevant policies that contribute to the improvement of sustainable vanadium utilization in China.展开更多
The energy substances(mainly carbohydrates and fats)are the basis and guarantee of life activity,especially the oxidative phosphorylation for energy supply.However,excessive absorption and accumulation of these substa...The energy substances(mainly carbohydrates and fats)are the basis and guarantee of life activity,especially the oxidative phosphorylation for energy supply.However,excessive absorption and accumulation of these substances can lead to metabolic diseases such as obesity,hyperlipidemia,diabetes,and cancers.A large amount of studies demonstrate that G protein-coupled receptors(GPCRs)play a key role in identification and absorption of energy substances,and the signaling network of nerves,immune,and endocrine regulates their storage and utilization.The gastrointestinal mucus layer not only identifies these substances through identification in diet components but also transfers immune,metabolic,and endocrine signals of hormones,cytokines,and chemokines by promoting interactions between receptors and ligands.These signaling molecules are transferred to corresponding organs,tissues,and cells by the circulatory system,and cell activity is regulated by amplifying of cell signals that constitute the wireless communication network among cells in the body.Absorption,accumulation,and utilization of energy substances in the body obey the law of energy conservation.Energy is stored in the form of fat,and meets the demand of body via two coupled mechanisms:catabolism and oxidative phosphorylation.Under normal physiological conditions,fat consumption involves ketone body metabolism through the circulatory system and glucose consumption requires blood lactic acid cycle.Accumulation of excessive energy leads to the abnormal activation of mammalian target of rapamycin(mTOR),thus promoting the excretion of glucose or glycogen in the form of blood glucose and urine glucose.Alternatively,the body cancels the intercellular contact inhibition and promotes cell proliferation to induce carcinogenesis,which can induce the consumption of large amounts of glucose.Intercellular communication is performed by signaling molecules via sensing,absorption,accumulation,and utilization of energy substances,and anabolism and catabolism are controlled by the central metabolic pathway.Therefore,slower catabolism will result in longer life expectancy,whereas faster catabolism results in shorter life expectancy.Energy substances in diet influence the balance between energy and metabolism in the body through the sensing function of the gastrointestinal system at two levels:cellular communication network and metabolic network.The present review of studies aims to strengthen our knowledge on cellular communication and metabolic networks to offer a dietary guidance on the metabolism and communication role of various foods.展开更多
为探究丁酸梭菌对小尾寒羊宰后成熟过程中挥发性风味物质的影响及其可能机制,以6月龄小尾寒羊为研究对象,取其背最长肌进行宰后成熟(4℃),然后分别在第0、1、2、3、4、5天对羊肉中的挥发性风味物质和腺苷酸活化蛋白激酶(adenosine monop...为探究丁酸梭菌对小尾寒羊宰后成熟过程中挥发性风味物质的影响及其可能机制,以6月龄小尾寒羊为研究对象,取其背最长肌进行宰后成熟(4℃),然后分别在第0、1、2、3、4、5天对羊肉中的挥发性风味物质和腺苷酸活化蛋白激酶(adenosine monophosphate activated protein kinase,AMPK)、乙酰辅酶A羧化酶(acetyl CoA carboxylase,ACC)和肉毒碱脂酰转移酶1(carnitine palmitoyltransferase,CPT1)等脂肪代谢相关酶活性进行测定。电子鼻测定结果显示,丁酸梭菌组小尾寒羊肉中的烷类、氢过氧化物和氮氧化合物的含量更加丰富;结合气相色谱-质谱联用技术测定结果可知,丁酸梭菌组小尾寒羊肉中醛、醇及酮类化合物的种类较为丰富,而脂肪氧化产物如辛醛、壬醛、癸醛、庚醛的含量均明显降低;利用相对气味活度值法筛选了宰后成熟过程中两组小尾寒羊肉中共有的关键风味物质,包括辛醛、壬醛、反-2-癸烯醛和1-辛烯-3-醇,其中癸醛对羊肉风味的贡献最大。与对照组相比,丁酸梭菌组小尾寒羊肉中AMPK和CPT1的含量在宰后成熟过程中均显著降低(P<0.05),而丁酸梭菌组小尾寒羊肉中ACC含量在宰后成熟第0、1、3、5天显著高于对照组(P<0.05);相关性分析结果表明,AMPK和CPT1与壬醛均呈极显著正相关(P<0.001),而ACC与壬醛和癸醛呈极显著负相关(P<0.001)。综上,日粮添加丁酸梭菌可能通过调控AMPK-ACC-CPT1通路进而影响小尾寒羊宰后成熟过程中的挥发性风味物质。展开更多
基金Supported by Key Project of Natural Science Foundation of Hubei Province(2013CFA100)National Natural Science Foundation of China(31472117)
文摘Environmental temperature is a major factor affecting animal performance in South China. With global warming, heat stress will become more and more serious. This paper reviewed the effects of heat stress on metabolism of proteins, glucose, fat and energy in skeletal muscle and related mechanisms so as to provide theoretical guidance for alleviating heat stress and improving production performance of animal suffering from heat stress.
基金supported by National Basic Research Program of China(No.2013CB531803)
文摘Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in traditional Chinese medicine(TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi(FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu(ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism(glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na^+-K^+-ATPase), endocrine system(triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system(acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices(substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome(appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.
文摘Vanadium is a vital strategic resource, and vanadium metabolism is an important part of the national socio-economic system of China. This study conducts accounting and scenario analysis on the life cycle of vanadium metabolism in China. Based on the character- istics of vanadium life cycle and substance flow analysis （SFA） framework, we present a quantitative evaluation of a static anthropogenic vanadium life cycle for the year 2010. Results show that anthropogenic vanadium consumption, stocks, and new domestic scrap are at 98.2, 21.2, and 4.1 kt, respectively; new scrap is usually discarded. The overall utilization ratio of vanadium is 32.2%. A large amount of vanadium is stockpiled into tailings, debris, slags, and other spent solids. A scenario analysis was conducted to analyze the future developmental trend of vanadium metabolism in China based on the SFA frame- work and the qualitative analysis of technology advance- ment and socio-economic development. The baseline year was set as 2010. Several indicators were proposed to simulate different scenarios from 2010 to 2030. The scenario analysis indicates that the next 20 years is a critical period for the vanadium industry in China. This paper discusses relevant policies that contribute to the improvement of sustainable vanadium utilization in China.
文摘The energy substances(mainly carbohydrates and fats)are the basis and guarantee of life activity,especially the oxidative phosphorylation for energy supply.However,excessive absorption and accumulation of these substances can lead to metabolic diseases such as obesity,hyperlipidemia,diabetes,and cancers.A large amount of studies demonstrate that G protein-coupled receptors(GPCRs)play a key role in identification and absorption of energy substances,and the signaling network of nerves,immune,and endocrine regulates their storage and utilization.The gastrointestinal mucus layer not only identifies these substances through identification in diet components but also transfers immune,metabolic,and endocrine signals of hormones,cytokines,and chemokines by promoting interactions between receptors and ligands.These signaling molecules are transferred to corresponding organs,tissues,and cells by the circulatory system,and cell activity is regulated by amplifying of cell signals that constitute the wireless communication network among cells in the body.Absorption,accumulation,and utilization of energy substances in the body obey the law of energy conservation.Energy is stored in the form of fat,and meets the demand of body via two coupled mechanisms:catabolism and oxidative phosphorylation.Under normal physiological conditions,fat consumption involves ketone body metabolism through the circulatory system and glucose consumption requires blood lactic acid cycle.Accumulation of excessive energy leads to the abnormal activation of mammalian target of rapamycin(mTOR),thus promoting the excretion of glucose or glycogen in the form of blood glucose and urine glucose.Alternatively,the body cancels the intercellular contact inhibition and promotes cell proliferation to induce carcinogenesis,which can induce the consumption of large amounts of glucose.Intercellular communication is performed by signaling molecules via sensing,absorption,accumulation,and utilization of energy substances,and anabolism and catabolism are controlled by the central metabolic pathway.Therefore,slower catabolism will result in longer life expectancy,whereas faster catabolism results in shorter life expectancy.Energy substances in diet influence the balance between energy and metabolism in the body through the sensing function of the gastrointestinal system at two levels:cellular communication network and metabolic network.The present review of studies aims to strengthen our knowledge on cellular communication and metabolic networks to offer a dietary guidance on the metabolism and communication role of various foods.
文摘为探究丁酸梭菌对小尾寒羊宰后成熟过程中挥发性风味物质的影响及其可能机制,以6月龄小尾寒羊为研究对象,取其背最长肌进行宰后成熟(4℃),然后分别在第0、1、2、3、4、5天对羊肉中的挥发性风味物质和腺苷酸活化蛋白激酶(adenosine monophosphate activated protein kinase,AMPK)、乙酰辅酶A羧化酶(acetyl CoA carboxylase,ACC)和肉毒碱脂酰转移酶1(carnitine palmitoyltransferase,CPT1)等脂肪代谢相关酶活性进行测定。电子鼻测定结果显示,丁酸梭菌组小尾寒羊肉中的烷类、氢过氧化物和氮氧化合物的含量更加丰富;结合气相色谱-质谱联用技术测定结果可知,丁酸梭菌组小尾寒羊肉中醛、醇及酮类化合物的种类较为丰富,而脂肪氧化产物如辛醛、壬醛、癸醛、庚醛的含量均明显降低;利用相对气味活度值法筛选了宰后成熟过程中两组小尾寒羊肉中共有的关键风味物质,包括辛醛、壬醛、反-2-癸烯醛和1-辛烯-3-醇,其中癸醛对羊肉风味的贡献最大。与对照组相比,丁酸梭菌组小尾寒羊肉中AMPK和CPT1的含量在宰后成熟过程中均显著降低(P<0.05),而丁酸梭菌组小尾寒羊肉中ACC含量在宰后成熟第0、1、3、5天显著高于对照组(P<0.05);相关性分析结果表明,AMPK和CPT1与壬醛均呈极显著正相关(P<0.001),而ACC与壬醛和癸醛呈极显著负相关(P<0.001)。综上,日粮添加丁酸梭菌可能通过调控AMPK-ACC-CPT1通路进而影响小尾寒羊宰后成熟过程中的挥发性风味物质。
