We investigate the steady optical response of a coherently driven five-level M-type atomic system in three different situations. When all three coupling fields have the same zero detuning, we just find one deep transp...We investigate the steady optical response of a coherently driven five-level M-type atomic system in three different situations. When all three coupling fields have the same zero detuning, we just find one deep transparency window accompanied by a steep normal dispersion in the probe absorption and dispersion spectra. When two coupling fields are detuned from the relevant transitions to the same extent, however, a second deep transparency window may be observed in the presence of a narrow absorption line of linewidth - 50 kHz. In this case, two single-photon far-detuned transitions can be replaced by a two-photon resonant transition, so the five-level M system in fact reduces into a four-level quasi-A system. Finally, we note that no deep transparency windows and no narrow absorption lines can be found when all three coupling fields have unequal detunings.展开更多
The liver is in charge of distributing and regulating the movement of qi throughout the whole body,coordinating the transportation and transformation of the internal organs in the middle part of the body,promoting the...The liver is in charge of distributing and regulating the movement of qi throughout the whole body,coordinating the transportation and transformation of the internal organs in the middle part of the body,promoting the biochemical circulation of qi,blood,and body fluids,and regulating emotions.Liver dysfunction can disrupt the transportation and transformation of qi,blood,and body fluids,causing phlegm turbidity,blood stasis,and other unwanted symptoms.Poor regulation of emotion further aggravates the accumulation of pathological substances,resulting in the obstruction of heart vessels,and ultimately coronary heart disease(CHD).Through regulating lipid metabolism,inflammatory reaction,vasoactive substances,platelet function,neuroendocrine,and other factors,liver controlling dispersing qi plays a comprehensive role in the prognosis of atherosclerosis,the primary cause of CHD.Therefore,it is recommended to treat CHD from the perspective of liver-controlling dispersion.展开更多
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate.However,most new chemical entities exhibit poor water solubility,and he...Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate.However,most new chemical entities exhibit poor water solubility,and hence are exempt from such benefits.Although combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage form.Here,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)membrane.Compared to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRASD bead surface,and greater extent of celecoxib release.All-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to PVP.This work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRASD.展开更多
The trend of economic globalisation and advances in i nformation technology has led to the emergence of dispersed manufacturing system s as a form of the virtual organisation. New manufacturing strategy pays more at t...The trend of economic globalisation and advances in i nformation technology has led to the emergence of dispersed manufacturing system s as a form of the virtual organisation. New manufacturing strategy pays more at tention to the management of the total value chain and therefore puts emphasis o n outsourcing. In fact, outsourcing is an efficient way of utilizing available r esources and has become one key aspect of the manufacturing strategy. Improved d ecision and organization on outsourcing will result in cost production and short er lead-times. However, most concepts and practice of traditional outsourcing do not adapt to t he changing environment and meet increasing performance requirements. On the oth er hand, virtual organisations might display instability between pure outsourcin g and establishing alliance. Balance and trade-off between independent agents a nd creating alliance are thus required. Therefore, the purpose of this paper is to develop a model to support decision-making, management and control on outsou rcing in a dispersed network manufacturing system and to discuss several key iss ues that are relevant to the relationship between the agents of the network. Dev elopment of the model will deploy Applied System Theory and will be built on fou ndations of earlier research on industrial management such the theories of Outso urcing, Order Entry Points, Design of Organisations and Logistic Control. The is sues that will be addressed in this paper are: · The selection of suppliers and co-makers; · Communication between suppliers and clients; · The mechanisms for profit-sharing between agents; · The product data management to integrate the knowledge of the different agent s into product design. Industrial companies will benefit from this research by the practical methods an d implementation extending their business models beyond concepts for outsourcing and alliances. Additionally, the exploration will lead to proactive contributio n of manufacturing during engineering, which would improve management and contro l of dispersed manufacturing systems.展开更多
In this paper, the dispersion managed soliton (DMS) transmission equation is built on considering the effects of polarization mode dispersion (PMD) and filter control. The DMS transmission of filtering control in cons...In this paper, the dispersion managed soliton (DMS) transmission equation is built on considering the effects of polarization mode dispersion (PMD) and filter control. The DMS transmission of filtering control in constant birefringence fibers is firstly analyzed by varitional method, from which the evolving rules of characteristical DMS parameters are obtained. Secondly, the stability of DMS transmission and its timing jitter are investigated in the random varying birefringence fibers with the conventional model of PMD. The results reveal that filter control DMS system has powerful robustness to PMD effects and DMS's timing jitter can be decreased considerably with the help of filters.展开更多
Glide symmetry,which is one kind of higher symmetry,is introduced in a special type of plasmonic metamaterial,the transmission lines(TLs)of spoof surface plasmon polaritons(SSPPs),in order to control the dispersion ch...Glide symmetry,which is one kind of higher symmetry,is introduced in a special type of plasmonic metamaterial,the transmission lines(TLs)of spoof surface plasmon polaritons(SSPPs),in order to control the dispersion characteristics and modal fields of the SSPPs.We show that the glide-symmetric TL presents merged pass bands and mode degeneracy,which lead to broad working bandwidth and extremely low coupling between neighboring TLs.Dual-conductor SSPP TLs with and without glide symmetry are arranged in parallel as two channels with very deep subwavelength separation(e.g.,λ0∕100 at 5 GHz)for the application of integrated circuits and systems.Mutual coupling between the hybrid channels is analyzed using coupled mode theory and characterized in terms of scattering parameters and near-field distributions.We demonstrate theoretically and experimentally that the hybrid TL array obtains significantly more suppressed crosstalk than the uniform array of two nonglide symmetric TLs.Hence,it is concluded that the glide symmetry can be adopted to flexibly design the propagation of SSPPs and benefit the development of highly compact plasmonic circuits.展开更多
A novel temperature controlled ionic liquid dispersive liquid phase microextracfion (TCIL-DLPME) coupled with rapid resolution liquid chromatography-electrospray tandem mass spectrometry (RRLC-ESI-MS-MS) has been ...A novel temperature controlled ionic liquid dispersive liquid phase microextracfion (TCIL-DLPME) coupled with rapid resolution liquid chromatography-electrospray tandem mass spectrometry (RRLC-ESI-MS-MS) has been developed for the enrichment and determination of three hexabromocyclododecane diastereomers (HBCDs) in water samples. Green solvent ionic liquid (IL) was used as extraction solvent instead of toxic organic solvents. This technique also avoided the usage of dispersive solvent. Some important parameters that might affect the extraction efficiency were optimized. Under the optimum conditions, good linear relationship, sensitivity and reproducibility were obtained. All the limits of detection for the three diastereomers were 0.1 ng/ mL. The linear range was obtained in the range of 1-100 ng/mL for the total amount of three HBCD diastereomers. It was satisfactory to analyze real environmental water samples with the recoveries ranging from 77.2% to 99.3%. The main advantage of the method is toxic organic solvent-free.展开更多
Dispersity(D)of polymers has a great effect on the properties of polymeric materials,and therefore how to control θ is very important but still a huge challenge in polymer synthesis,especially for reversible-deactiva...Dispersity(D)of polymers has a great effect on the properties of polymeric materials,and therefore how to control θ is very important but still a huge challenge in polymer synthesis,especially for reversible-deactivation radical polymerization(RDRP)strategy.Herein,we successfully developed a novel strategy to adjust D of polymers by visible light-controlled reversible complexation mediated living radical polymerizatio n(RCMP)and combi nation of single-electron transfer-degenerative chain tran sfer living radical polymerization(SET-DTLRP)at room temperature.In RCMP system,2-iodo-2-methylpropionitrile(CP-I)and ethyl 2-iodo-2-phenylacetate(EIPA)were used as alkyl iodide initiators,by using methyl methacrylate(MMA)as the model monomer and n-butylacrylate(BA)as the end-capping reagent to regulate D of polymers.Subsequently,we successfully prepared the block copolymer PMMA-b-PBA with adjustable D by reactivating the polymer end-chains via SET-DTLRP in the presence of copper wire,fully dem on strati ng that it is a promising strategy that can keep the"living"feature of polymers while regulating their molar mass dispersities easily.展开更多
Chromatic aberration-free meta-devices(e.g.,achromatic meta-devices and abnormal chromatic meta-devices)play an essential role in modern science and technology.However,current efforts suffer the issues of low efficien...Chromatic aberration-free meta-devices(e.g.,achromatic meta-devices and abnormal chromatic meta-devices)play an essential role in modern science and technology.However,current efforts suffer the issues of low efficiency,narrow operating band,and limited wavefront manipulation capability.We propose a general strategy to design chromatic aberration-free meta-devices with high-efficiency and ultrabroadband properties,which is realized by satisfying the key criteria of desirable phase dispersion and high reflection amplitudes at the target frequency interval.The phase dispersion is tuned successfully based on a multiresonant Lorentz model,and high reflection is guaranteed by the presence of the metallic ground.As proof of the concept,two microwave meta-devices are designed,fabricated,and experimentally characterized.An achromatic meta-mirror is proposed within 8 to 12 GHz,and another abnormal chromatic meta-mirror can tune the reflection angle as a linear function.Both meta-mirrors exhibit very high efficiencies(85%to 94%in the frequency band).Our findings open a door to realize chromatic aberration-free meta-devices with high efficiency and wideband properties and stimulate the realizations of chromatic aberration-free metadevices with other functionalities or working at higher frequency.展开更多
Well-dispersed BaSO4 nanoparticles were synthesized in the presence of sodium polyacrylate (PAAS) by a simple precipitation method, with BaCl2 and (NH4)2SO4 as reactants. The different roles performed by PAAS in t...Well-dispersed BaSO4 nanoparticles were synthesized in the presence of sodium polyacrylate (PAAS) by a simple precipitation method, with BaCl2 and (NH4)2SO4 as reactants. The different roles performed by PAAS in the synthesis of BaSO4 nanoparticles were investigated using X-ray diffractometry, Fourier transform infrared spectroscopy, and transmission electron microscopy. The results indicate that the assynthesized BaSO4 nanoparticles were spheres with an average diameter of 30 nm and that their surfaces were affected by the PAAS. Under a typical procedure employed, PAAS reacted with BaCl2 to yield an intermediate, serving as a control releasing agent and separating the nucleation and crystal growth processes of the BaSO4 nuclei. During formation of the BaSO4 nanospheres, the intermediate slowly dissolved and released barium and polyacrylate ions, inhibiting the growth and aggregation of newly formed BaSO4 seeds and resulting in particles of narrow diameter distribution and improved dispersibility. Moreover, these polyacrylate ions further modified the surfaces of the BaSO4 nanoparticles.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant No. 11174110)the National Basic Research Program of China (Grant No. 2011CB921603)the Basic Scientific Research Foundation of Jilin University,China
文摘We investigate the steady optical response of a coherently driven five-level M-type atomic system in three different situations. When all three coupling fields have the same zero detuning, we just find one deep transparency window accompanied by a steep normal dispersion in the probe absorption and dispersion spectra. When two coupling fields are detuned from the relevant transitions to the same extent, however, a second deep transparency window may be observed in the presence of a narrow absorption line of linewidth - 50 kHz. In this case, two single-photon far-detuned transitions can be replaced by a two-photon resonant transition, so the five-level M system in fact reduces into a four-level quasi-A system. Finally, we note that no deep transparency windows and no narrow absorption lines can be found when all three coupling fields have unequal detunings.
文摘The liver is in charge of distributing and regulating the movement of qi throughout the whole body,coordinating the transportation and transformation of the internal organs in the middle part of the body,promoting the biochemical circulation of qi,blood,and body fluids,and regulating emotions.Liver dysfunction can disrupt the transportation and transformation of qi,blood,and body fluids,causing phlegm turbidity,blood stasis,and other unwanted symptoms.Poor regulation of emotion further aggravates the accumulation of pathological substances,resulting in the obstruction of heart vessels,and ultimately coronary heart disease(CHD).Through regulating lipid metabolism,inflammatory reaction,vasoactive substances,platelet function,neuroendocrine,and other factors,liver controlling dispersing qi plays a comprehensive role in the prognosis of atherosclerosis,the primary cause of CHD.Therefore,it is recommended to treat CHD from the perspective of liver-controlling dispersion.
基金supported in part by an Ontario Research Fund-Research Excellence(ORF-RE)grant(Ontario,Canada)in partnership with Patheon by Thermo Fisher Scientific,Natural Sciences and Engineering Research Council(NSERC)of Canada Discovery Grant and Equipment Grants to Xiao Yu Wu,University of Toronto(Canada),Leslie Dan Faculty of Pharmacy Dean's Fund to Jamie Anne Lugtu-Pe,University of Toronto(Canada),Mitacs Accelerate Internship sponsored by Candoo Pharmatech Company Inc.to Xuning Zhang(Canada),NSERC CREATE ContRoL program support to Sako Mirzaie and Hao Han R.Chang(Canada),Ontario Graduate Scholarship(OGS)to Hao Han R.Chang(Canada),and Pharmaceutical Sciences graduate department scholarships to Hao Han R.Chang and Kuan Chen,University of Toronto(Canada).
文摘Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate.However,most new chemical entities exhibit poor water solubility,and hence are exempt from such benefits.Although combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage form.Here,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)membrane.Compared to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRASD bead surface,and greater extent of celecoxib release.All-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to PVP.This work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRASD.
文摘The trend of economic globalisation and advances in i nformation technology has led to the emergence of dispersed manufacturing system s as a form of the virtual organisation. New manufacturing strategy pays more at tention to the management of the total value chain and therefore puts emphasis o n outsourcing. In fact, outsourcing is an efficient way of utilizing available r esources and has become one key aspect of the manufacturing strategy. Improved d ecision and organization on outsourcing will result in cost production and short er lead-times. However, most concepts and practice of traditional outsourcing do not adapt to t he changing environment and meet increasing performance requirements. On the oth er hand, virtual organisations might display instability between pure outsourcin g and establishing alliance. Balance and trade-off between independent agents a nd creating alliance are thus required. Therefore, the purpose of this paper is to develop a model to support decision-making, management and control on outsou rcing in a dispersed network manufacturing system and to discuss several key iss ues that are relevant to the relationship between the agents of the network. Dev elopment of the model will deploy Applied System Theory and will be built on fou ndations of earlier research on industrial management such the theories of Outso urcing, Order Entry Points, Design of Organisations and Logistic Control. The is sues that will be addressed in this paper are: · The selection of suppliers and co-makers; · Communication between suppliers and clients; · The mechanisms for profit-sharing between agents; · The product data management to integrate the knowledge of the different agent s into product design. Industrial companies will benefit from this research by the practical methods an d implementation extending their business models beyond concepts for outsourcing and alliances. Additionally, the exploration will lead to proactive contributio n of manufacturing during engineering, which would improve management and contro l of dispersed manufacturing systems.
基金This work was supported by the National Natural Science Foundation under Grant No.69982006 and 60132040.
文摘In this paper, the dispersion managed soliton (DMS) transmission equation is built on considering the effects of polarization mode dispersion (PMD) and filter control. The DMS transmission of filtering control in constant birefringence fibers is firstly analyzed by varitional method, from which the evolving rules of characteristical DMS parameters are obtained. Secondly, the stability of DMS transmission and its timing jitter are investigated in the random varying birefringence fibers with the conventional model of PMD. The results reveal that filter control DMS system has powerful robustness to PMD effects and DMS's timing jitter can be decreased considerably with the help of filters.
基金This work was supported in part from the National Natural Science Foundation of China under Grant Nos.61631007 and 61971134,in part from the 111 Project under Grant No.111-2-05in part from the Fundamental Research Funds for the Central Universities under Grant No.2242020R40079.Xiao Tian Yan and Wenxuan Tang contributed equally to this work.
文摘Glide symmetry,which is one kind of higher symmetry,is introduced in a special type of plasmonic metamaterial,the transmission lines(TLs)of spoof surface plasmon polaritons(SSPPs),in order to control the dispersion characteristics and modal fields of the SSPPs.We show that the glide-symmetric TL presents merged pass bands and mode degeneracy,which lead to broad working bandwidth and extremely low coupling between neighboring TLs.Dual-conductor SSPP TLs with and without glide symmetry are arranged in parallel as two channels with very deep subwavelength separation(e.g.,λ0∕100 at 5 GHz)for the application of integrated circuits and systems.Mutual coupling between the hybrid channels is analyzed using coupled mode theory and characterized in terms of scattering parameters and near-field distributions.We demonstrate theoretically and experimentally that the hybrid TL array obtains significantly more suppressed crosstalk than the uniform array of two nonglide symmetric TLs.Hence,it is concluded that the glide symmetry can be adopted to flexibly design the propagation of SSPPs and benefit the development of highly compact plasmonic circuits.
基金financially supported by National Water Pollution Control and Management Technology Major Projects(No.2009ZX07210-009)Scientific and Technological Developing Project of Shandong Province(No. 2009GG20001021-9)+1 种基金Open Research Fund Program of Shandong Provincial Key Laboratory of Eco-Environmental Science for Yellow River Delta(No.2009KFJJ01)Basic Foundation of Shandong Academy of Sciences and Analysis and Test center of Shandong province
文摘A novel temperature controlled ionic liquid dispersive liquid phase microextracfion (TCIL-DLPME) coupled with rapid resolution liquid chromatography-electrospray tandem mass spectrometry (RRLC-ESI-MS-MS) has been developed for the enrichment and determination of three hexabromocyclododecane diastereomers (HBCDs) in water samples. Green solvent ionic liquid (IL) was used as extraction solvent instead of toxic organic solvents. This technique also avoided the usage of dispersive solvent. Some important parameters that might affect the extraction efficiency were optimized. Under the optimum conditions, good linear relationship, sensitivity and reproducibility were obtained. All the limits of detection for the three diastereomers were 0.1 ng/ mL. The linear range was obtained in the range of 1-100 ng/mL for the total amount of three HBCD diastereomers. It was satisfactory to analyze real environmental water samples with the recoveries ranging from 77.2% to 99.3%. The main advantage of the method is toxic organic solvent-free.
基金This work was financially supported by the National Natural Science Foundation of China(Nos.22071168 and 21774082)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Dispersity(D)of polymers has a great effect on the properties of polymeric materials,and therefore how to control θ is very important but still a huge challenge in polymer synthesis,especially for reversible-deactivation radical polymerization(RDRP)strategy.Herein,we successfully developed a novel strategy to adjust D of polymers by visible light-controlled reversible complexation mediated living radical polymerizatio n(RCMP)and combi nation of single-electron transfer-degenerative chain tran sfer living radical polymerization(SET-DTLRP)at room temperature.In RCMP system,2-iodo-2-methylpropionitrile(CP-I)and ethyl 2-iodo-2-phenylacetate(EIPA)were used as alkyl iodide initiators,by using methyl methacrylate(MMA)as the model monomer and n-butylacrylate(BA)as the end-capping reagent to regulate D of polymers.Subsequently,we successfully prepared the block copolymer PMMA-b-PBA with adjustable D by reactivating the polymer end-chains via SET-DTLRP in the presence of copper wire,fully dem on strati ng that it is a promising strategy that can keep the"living"feature of polymers while regulating their molar mass dispersities easily.
基金This work was supported by the National Natural Science Foundation of China under Grant Nos.61871394,61901512,11604167,61625502,11961141010,61975176, 62071423Postdoctoral Innovation Talents Support Program of China under Grant No.BX20190293, Natural Science Foundation of Shaanxi Province under Grant No.2019JQ-013.
文摘Chromatic aberration-free meta-devices(e.g.,achromatic meta-devices and abnormal chromatic meta-devices)play an essential role in modern science and technology.However,current efforts suffer the issues of low efficiency,narrow operating band,and limited wavefront manipulation capability.We propose a general strategy to design chromatic aberration-free meta-devices with high-efficiency and ultrabroadband properties,which is realized by satisfying the key criteria of desirable phase dispersion and high reflection amplitudes at the target frequency interval.The phase dispersion is tuned successfully based on a multiresonant Lorentz model,and high reflection is guaranteed by the presence of the metallic ground.As proof of the concept,two microwave meta-devices are designed,fabricated,and experimentally characterized.An achromatic meta-mirror is proposed within 8 to 12 GHz,and another abnormal chromatic meta-mirror can tune the reflection angle as a linear function.Both meta-mirrors exhibit very high efficiencies(85%to 94%in the frequency band).Our findings open a door to realize chromatic aberration-free meta-devices with high efficiency and wideband properties and stimulate the realizations of chromatic aberration-free metadevices with other functionalities or working at higher frequency.
基金supported by the National Natural Science Foundation of China(51172117)the Shandong Natural Science Foundation(ZR2010EM035)the Qingdao Science and Technology Project(10-3-4-4-12-jch)
文摘Well-dispersed BaSO4 nanoparticles were synthesized in the presence of sodium polyacrylate (PAAS) by a simple precipitation method, with BaCl2 and (NH4)2SO4 as reactants. The different roles performed by PAAS in the synthesis of BaSO4 nanoparticles were investigated using X-ray diffractometry, Fourier transform infrared spectroscopy, and transmission electron microscopy. The results indicate that the assynthesized BaSO4 nanoparticles were spheres with an average diameter of 30 nm and that their surfaces were affected by the PAAS. Under a typical procedure employed, PAAS reacted with BaCl2 to yield an intermediate, serving as a control releasing agent and separating the nucleation and crystal growth processes of the BaSO4 nuclei. During formation of the BaSO4 nanospheres, the intermediate slowly dissolved and released barium and polyacrylate ions, inhibiting the growth and aggregation of newly formed BaSO4 seeds and resulting in particles of narrow diameter distribution and improved dispersibility. Moreover, these polyacrylate ions further modified the surfaces of the BaSO4 nanoparticles.