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Lineal DNA logic gate for microRNA diagnostics with strand displacement and fluorescence resonance energy transfer
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作者 Tian-Tian Meng Ying-Xin Liu +4 位作者 Meng-Tan Liu Jiao-Bao Long Qing-Feng Cao Shu-Ya Yan Xiang-Xian Meng 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第9期1179-1182,共4页
Designing molecular logic gates to operate programmably for molecular diagnostics in molecular computing still remains challenging.Here,we designed a novel linear DNA logic gates for microRNA analysis based on strand ... Designing molecular logic gates to operate programmably for molecular diagnostics in molecular computing still remains challenging.Here,we designed a novel linear DNA logic gates for microRNA analysis based on strand displacement and fluorescence resonance energy transfer(FRET).Two labeled strands closed each other produce to FRET through hybridization with a complementary strand to form a basic work unit of logic gate.Two indicators of heart failure(microRNA-195 and microRNA-21) were selected as the logic inputs and the fluorescence mode was used as the logic output.We have demonstrated that the molecular logic gate mechanism worked well with the construction of YES and AND gates. 展开更多
关键词 Molecular logic gate Strand displacement Fluorescence resonance energy transfer
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