Nonlinearly induced steady-state photon–phonon entanglement of a dissipative coupled system is studied in the bistable regime. Quantum dynamical characteristics are analysed by solving the mean-field and fluctuation ...Nonlinearly induced steady-state photon–phonon entanglement of a dissipative coupled system is studied in the bistable regime. Quantum dynamical characteristics are analysed by solving the mean-field and fluctuation equations of the system. It is shown that dissipative coupling can induce bistable behaviour for the effective dissipation of the system.Under suitable parameters, one of the steady states significantly reduces the dissipative effect of the system. Consequently,a larger steady-state entanglement can be achieved compared to linear dynamics. Furthermore, the experimental feasibility of the parameters is analysed. Our results provide a new perspective for the implementation of steady-state optomechanical entanglement.展开更多
Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering emulsions.However,extensive research on the internal delivery mechanisms of these emulsions,especially the complex i...Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering emulsions.However,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly sparse.This gap in knowledge holds significant potential for enhancing vaccine efficacy.This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue.The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study.Various factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion itself.The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency.Additionally,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel.This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions.Such insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug delivery.Importantly,the desired transport efficiency varies depending on the specific application.For instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant No. 12074206)the Natural Science Foundation of Zhejiang Province of China (Grant No.LY22A040005)supported by the National Natural Science Foundation of China (Grant No. 22103043)。
文摘Nonlinearly induced steady-state photon–phonon entanglement of a dissipative coupled system is studied in the bistable regime. Quantum dynamical characteristics are analysed by solving the mean-field and fluctuation equations of the system. It is shown that dissipative coupling can induce bistable behaviour for the effective dissipation of the system.Under suitable parameters, one of the steady states significantly reduces the dissipative effect of the system. Consequently,a larger steady-state entanglement can be achieved compared to linear dynamics. Furthermore, the experimental feasibility of the parameters is analysed. Our results provide a new perspective for the implementation of steady-state optomechanical entanglement.
基金supported by the National Natural Science Foundation of China(22373104 and 22293024)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(21821005)+1 种基金supported by the National Key Research and Development Program of China(2021YFE020527)support by the Distinguished Young Scholars of the National Natural Science Foundation of China(T2222022).
文摘Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering emulsions.However,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly sparse.This gap in knowledge holds significant potential for enhancing vaccine efficacy.This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue.The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study.Various factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion itself.The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency.Additionally,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel.This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions.Such insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug delivery.Importantly,the desired transport efficiency varies depending on the specific application.For instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.
