A case report of abdominal distention caused by herpes zoster

Gastrointestinal complications caused by herpes zoster are extremely rare. Here, we described a case of abdominal distention caused by herpes zoster. The patient was a 59-year-old female who suffered from unexplained paroxysmal and a burning pain on the right part of her waist and abdomen, accompanied by abdominal distention. Intestinal pseudo-obstruction was diagnosed by abdominal radiography. Distention of the right abdominal wall was still apparent after one month. In this report, we found that recovery from abdominal distention caused by herpes zoster is difficult and may require surgical intervention.

Experimental Study on the Treatment of Gallbladder Distention by Dahuang Lingxian Prescription

Objective: To investigate the mechanism of inhibiting the secretion of “lithogenic bile” and treating gallbladder distention with the TCM prescription Dahuang Lingxian. Methods: Forty SPF-grade SD male mice were randomly divided into blank control group, model group, ursodeoxycholic acid group and TCM group, 10 mice in each group. The blank control group was kept normally, and the model group, ursodeoxycholic acid group and TCM group were established as gallbladder distention models. The blank control group and the model group were given 1.5 ml of saline by gavage daily;the ursodeoxycholic acid group was given 100 mg/kg/d of a mixture of saline and ursodeoxycholic acid capsules by gavage daily;the TCM group was given 39 g/kg/d of aqueous decoction of Dahuang Lingxian Prescription by gavage daily. After 6 weeks of continuous intervention, all mice were executed and the lithogenesis rate, ultrastructure and mRNA expression were observed. Results: The lithogenesis rate of mice in the TCM group was significantly reduced (P β1/Smads pathway was significantly improved (P < 0.05), which could achieve the same therapeutic effect as ursodeoxycholic acid capsules. Conclusion: Dahuang Lingxian Prescription can reduce the secretion of “lithogenic bile” by inhibiting the inflammatory reaction and fibrosis of biliary system. Dahuang Lingxian Prescription has certain advantages in the treatment of gallbladder distention.

A systematic study of Erzhu Erchen decoction against damp-heat internalized type 2 diabetes based on data mining and experimental verification

Background:Erzhu Erchen decoction(EZECD),which is based on Erchen decoction and enhanced with Atractylodes lancea and Atractylodes macrocephala,is widely used for the treatment of dampness and heat(The clinical manifestations of Western medicine include thirst,inability to drink more,diarrhea,yellow urine,red tongue,et al.)internalized disease.Nevertheless,the mechanism of EZECD on damp-heat internalized Type 2 diabetes(T2D)remains unknown.We employed data mining,pharmacology databases and experimental verification to study how EZECD treats damp-heat internalized T2D.Methods:The main compounds or genes of EZECD and damp-heat internalized T2D were obtained from the pharmacology databases.Succeeding,the overlapped targets of EZECD and damp-heat internalized T2D were performed by the Gene Ontology,kyoto encyclopedia of genes and genomes analysis.And the compound-disease targets-pathway network were constructed to obtain the hub compound.Moreover,the hub genes and core related pathways were mined with weighted gene co-expression network analysis based on Gene Expression Omnibus database,the capability of hub compound and genes was valid in AutoDock 1.5.7.Furthermore,and violin plot and gene set enrichment analysis were performed to explore the role of hub genes in damp-heat internalized T2D.Finally,the interactions of hub compound and genes were explored using Comparative Toxicogenomics Database and quantitative polymerase chain reaction.Results:First,herb-compounds-genes-disease network illustrated that the hub compound of EZECD for damp-heat internalized T2D could be quercetin.Consistently,the hub genes were CASP8,CCL2,and AHR according to weighted gene co-expression network analysis.Molecular docking showed that quercetin could bind with the hub genes.Further,gene set enrichment analysis and Gene Ontology represented that CASP8,or CCL2,is negatively involved in insulin secretion response to the TNF or lipopolysaccharide process,and AHR or CCL2 positively regulated lipid and atherosclerosis,and/or including NOD-like receptor signaling pathway,and TNF signaling pathway.Ultimately,the quantitative polymerase chain reaction and western blotting analysis showed that quercetin could down-regulated the mRNA and protein experssion of CASP8,CCL2,and AHR.It was consistent with the results in Comparative Toxicogenomics Database databases.Conclusion:These results demonstrated quercetin could inhibit the expression of CASP8,CCL2,AHR in damp-heat internalized T2D,which improves insulin secretion and inhibits lipid and atherosclerosis,as well as/or including NOD-like receptor signaling pathway,and TNF signaling pathway,suggesting that EZECD may be more effective to treat damp-heat internalized T2D.

Study on Sustainable Utilization of Resources of the Damp-heat Karst Mountainous Areas in China

Damp-heat karst mountainous areas are unique areas in terms of socialeconomic development, resource endowment and eco-environment in China, where natural resources are abundant,unique and diverse. However, fragile eco-environment, undeveloped economy and culture, and conflict of human and environment should not be ignored. In the research, a framework of integration of resource-development and environment-protection in damp-heat karst was designed on basis of resource and environment integration, which was applied to Daxin County in Guangxi Province. Furthermore, some integration models were proposed, including integration of development of characteristic agricultural resources and protection of eco-environment, integration of development of manganese ore resources and protection of eco-environment, integration of development of tourism resources and protection of ecoenvironment and integration of development of clean energy and protection of eco-environment.

Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia

Objective: To investigate the effect of Chinese medicine prescription-Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia and its influence on the immune function. Methods: A total of 48 Wistar rats were randomly divided into the normal control group, the damp-heat syndrome model group, the Haoqinqingdan decoction group (high, medium and low dose group) and the ribavirin group. The body temperature and weight of rats in each group were recorded after modeling. After treatment for 6 d, the concentration of T lymphocyte subgroup (CD3+ CD4+ , CD3+ CD8+ ) was determined by flow cytometry. The OD value of IFN毭/IL-4 was detected by double-antibody sandwich ELISA method, and its concentration was acquired through conversion. Results: After modeling, the temperature and weight of rats in each modeling group showed the increasing trend ( P<0.01). From the second day of treatment, there was significant difference in the body mass between groups, and the rat weight of the control group was higher than in the modeling group ( P<0.05 or 0.01). With the advances of treatment, only the temperature in the medium and high dose Haoqinqingdan decoction groups declined significantly ( P<0.05). After treatment, the CD4+ /CD8+ ratio of the damp-heat syndrome model group decreased more significantly compared with the control group. Elevated CD3+ CD8+ percentages and declined CD4+ /CD8+ ratios can be observed in the low dose group and ribavirin group ( P<0.05). Moreover, the CD3+ CD4+ percentage of ribavirin group was lower than in the control group ( P<0.05). After treatment, the IFN-毭 and IFN-毭/ IL-4 levels in the peripheral blood of rats in the dampheat syndrome group were obviously higher than in the control group ( P<0.05). Conclusions: Compared with ribavirin, the high dose Haoqinqingdan decoction can improve the ratio of T lymphocyte subgroup and Th1/Th2 cell balance more effectively.

Screening of Traditional Chinese Medicine Prescription for Treating Damp-heat Diarrhea of Piglets

[Objective] The paper was to explore the therapeutic effect of traditional Chinese medicine on damp-heat diarrhea of piglets in summer.[Method] Three prescriptions were developed with a dozen of traditional Chinese medicines,and in vitro antibacterial test against swine standard Escherichia coli [O149：K91,K88 ac（C83907）] was conducted.Moreover,106 natural cases of diarrhea piglets caused by coinfection of damp-heat and E.coli through clinical and laboratory diagnosis were then treated.[Result] The oral liquids prepared by three traditional Chinese medicine prescriptions had certain antibacterial effect on standard pathogenic E.coli.Prescription 2 presented the strongest inhibitory effects on swine E.coli in vitro,with the MIC of 31.25 mg/m L.It had better therapeutic effect,and the effective rate reached 94.74%.[Conclusion] The prescription 2 mainly consisted of Coptis chinensis and Prunus mume might be effective in treatment of piglet diarrhea caused by damp heat and E.coli in clinic.

"Heterozygous Treatment"Method to Improve the Biased Status of the Damp-Heat Constitution and Symptom Integral:Randomized Controlled Trial

Objective:To observe the clinical effect of"heterozygous treatment"intervening the damp-heat constitution.Method:One hundred and six cases with damp-heat constitution were randomly divided into the observation group and control group,fifty-three cases for each group.Lianpu drink was given to the two groups,and the observation group was treated with scraping,acupuncture,cupping,constitution care and popularization of constitution science for"heterozygous treatment"based on the control group.70 days later,"constitution classification and determination table of traditional Chinese medicine"was used to determine,and statistics was applied to analyze the change of the symptoms of the two groups before and after the intervention.Results:in the observation group,compared to before the intervention,symptoms like dirty and oily complexion,yellow greasy tongue,bitter taste,dullness and scanty dark urine were significantly improved(P<0.05),and improvement of the above symptoms was greater than the control group(P<0.05).Conclusion:There is no significant difference between the two groups(P>0.05).Conclusion:the"heterozygous treatment"method can significantly improve the clinical symptoms of people with damp-heat constitution,with a better role in regulating.

The role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease

Objective:To explore the role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease(DKD).Methods:A total of 183 patients with DKD were divided into 3 groups:the early DKD group,established DKD group,and advanced DKD group.All patients were classified according to traditional Chinese medicine(TCM)syndrome type,and clinical indexes were collected for statistical analysis.Results:A total of 183 DKD patients were included in this study.Fibroblast growth factor 23(FGF23),chitinase-3-like protein 1(CHI3L1),endocan,tumor necrosis factor receptor 1(TNFR1),secretory leukocyte protease inhibitor(SLPI),and vascular endothelial growth factor A(VEGF-A)were increased in advanced DKD.FGF23,CHI3L1,endocan,SLPI,and TNFR1 showed a negative correlation with estimated glomerular filtration rate(eGFR),while they had a positive correlation with 24 h urine protein.After adjusting for age,gender,diabetes duration,body mass index(BMI),hemoglobin,glucose,uric acid,24 h urine protein,cholesterol,triglyceride,low-density lipoprotein,and hemoglobin A1c(HbA1c),the multiple regression analysis showed that FGF23,endocan,TNFR1,and SLPI significantly correlated with eGFR.Conclusions:FGF23,endocan,TNFR1,and SLPI are elevated in advanced DKD compared with early stage,and they may take part in the pathogenesis and progression of DKD.Our study provides useful biomarkers for predicting the appearance of damp-heat syndrome,including FGF23,endocan,TNFR1,and SLPI.

Observation on the Therapeutic Effect of Heatclearing and Dampness-eliminating Dredging Collaterals Combined with Papaya Antirheumatic Pills on Treatment of Damp-heat Obstructive Ankylosing Spondylitis

Objective:Therapeutic effect of heatclearing and dampness-eliminating dredging collaterals combined with papaya antirheumatic pills on treatment of damp-heat obstructive ankylosing spondylitis.Methods:A total of 200 patients with ankylosing spondylitis who were treated in our hospital from January 2018 to October 2019 were selected as the research objects and randomly divided into 2 groups,each with 100 patients.The control group was treated with leflunomide+papaya antirheumatic pills,and the observation group was treated with self-drafted recipe of heat-clearing and dampness-eliminating,the curative effect,visual analogue score(VAS),barthel AS function index(BASFI)score,biochemical indicators and adverse reactions between the two groups were compared.Results:After 12 weeks of treatment,the efficacy of the observation group was higher than that of the control group.The pain score,BASFI score,and biochemical index were lower than those of the control group,and the differences were statistically significant(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Heat-clearing and dampnesseliminating dredging collaterals combined with papaya antirheumatic pills is effective in the treatment of damp-heat obstructive ankylosing spondylitis,which is beneficial to reduce the degree of pain and inflammation of the affected area,helps patients remain active,and improves activities of daily living.

Efficacy of Pidan Jianqing decoction in treatment of type 2 diabetes with spleen deficiency and damp-heat syndrome

Introduction:This study aimed to assess the clinical efficacy of Pidan Jianqing decoction in the treatment of type 2 diabetes.Methods:A total of 72 patients with type 2 diabetes differentiated as spleen deficiency with damp-heat syndrome were randomly assigned to a treatment group(n=35)or control group(n=32).Patients in the control group received diet and exercise guidance and medication in the form of 0.5 g metformin hydrochloride tablets,while patients in the treatment group received Pidan Jianqing decoction in addition to the treatment given to the control group.Efficacy was evaluated after 8 weeks of treatment.Results:Efficacy was 91.4%in the treatment group versus 68.8%in the control group,which was a statistically significant difference(P<0.05).Significant group differences were also noted in the number of patients with improvement in symptoms such as dry mouth and polydipsia,frequency of urination and polyuria,abdominal distention and loss of appetite,fatigue and weakness,and sticky stools(all P<0.05),with greater improvement in the treatment group compared to the control group.The fasting blood glucose(FBG)and 2 h postprandial blood glucose levels significantly improved in both groups after treatment(P<0.05);however,there was no significant difference in glycated hemoglobin levels before and after treatment in both groups.Conclusion:Pidan Jianqing decoction can lower blood glucose levels and improve symptoms in patients with type 2 diabetes.

Clinical Efficacy of Western Medicine Combined with Chinese Medicine for Pelvic Inflammatory Disease(Damp-Heat and Stasis Type)

Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who were diagnosed with pelvic inflammatory disease(damp-heat and stasis type)by our hospital during July 2021 to July 2022 were randomized into two groups:the participants in the control group received conventional Western medicine treatment,and the participants in the study group received Western medicine combined with Chinese medicine.Results:After treatment,the total effectiveness of the control group(72.98%)was significantly lower than that of the study group(94.59%),(P<0.05);the whole blood viscosity high cut,whole blood viscosity low cut,fibrinogen and plasma viscosity of the control group were all lower than those of the study group(P<0.05);the levels of CRP,IL-6,and TNF-αin the control group were higher and IL-2 levels in the control group were lower than those in the study group(P<0.05).Conclusion:Western medicine combined with Chinese medicine is more effective in curing damp-heat and stasis-type pelvic inflammatory disease by improving the blood rheological indexes and lowering the level of inflammatory factors.

中药敷脐治疗胃穿孔术后胃肠功能障碍临床观察

目的 探讨自制中药敷脐治疗胃穿孔术后胃肠功能障碍的临床效用。方法 选取2020年10月—2021年10月兴国县人民医院行胃穿孔手术治疗后胃肠功能障碍患者60例,按照随机数字表法分成2组,对照组30例采用常规基础治疗加温水袋敷脐治疗,试验组30例采用常规基础治疗加自制中药方敷脐治疗,连续治疗7 d,观察2组患者治疗有效率、胃肠功能改善情况、中医症状积分、胃肠激素水平变化。结果 试验组总有效率显著高于对照组(P<0.05);试验组术后胃肠功能改善情况、胃肠激素水平均优于对照组(P<0.05);试验组中医症状积分显著低于对照组(P<0.05)。结论 自制中药敷脐治疗胃穿孔术后胃肠功能障碍能促进胃肠激素的分泌,改善胃肠功能及中医症状积分,提升临床疗效,临床用药安全。

自拟利胆经验方治疗慢性胆囊炎临床观察

目的观察孙晓生教授自拟利胆1号方治疗慢性胆囊炎的临床疗效和安全性。方法选取108例慢性胆囊炎患者为研究对象,利用随机数字表法分为2组,各54例。对照组采取常规西医治疗,观察组加用自拟利胆1号方治疗,4周后对比2组临床疗效。结果治疗前2组患者的中医症状积分、肝胆功能指标、免疫指标、炎性细胞因子相比,组间差异无统计学意义(P>0.05),治疗4周后均较治疗前改善且观察组改善效果优于对照组(P<0.05);观察组不良反应发生率与对照组相比,差异无统计学意义(P>0.05)。结论自拟利胆1号方对慢性胆囊炎有效,不良反应发生率低,使用前景广阔。

耳穴压豆联合枯草杆菌二联活菌颗粒在心脏瓣膜置换术后腹胀患者中的应用效果

目的探析耳穴压豆联合枯草杆菌二联活菌颗粒在心脏瓣膜置换术后腹胀患者中的应用效果。方法选取2022年1月至6月于南昌大学第二附属医院心脏大血管外科100例行瓣膜置换术后腹胀患者作为研究对象,根据随机数字表法分为对照组和观察组,每组50例。对照组接受多潘立酮常规干预,观察组加用耳穴压豆联合枯草杆菌二联活菌颗粒干预,两组均干预1周。比较两组的护理效果、胃肠道症状消失时间(排气时间、排便时间以及肠胀气消失时间)以及安全性。结果观察组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者术后首次排气、排便时间以及肠胀气消失时间均短于对照组,差异有统计学意义(P<0.05)。两组患者术后并发症总发生率比较,差异无统计学意义(P>0.05)。结论耳穴压豆联合枯草杆菌二联活菌颗粒在心脏瓣膜置换术后腹胀患者中应用价值良好,可有效缩短患者术后排气时间、排便时间以及肠胀气消失时间,安全性尚可。

四合汤对脾胃虚弱证慢性萎缩性胃炎的影响

目的 探究加味四合汤对脾胃虚弱型慢性萎缩性胃炎的疗效。方法 选取2020年8月—2023年6月河南省永城市人民医院门诊收治的脾胃虚弱证慢性萎缩性胃炎患者120例,根据随机数字表法分为观察组和对照组,每组60例,观察组采用加味四合汤治疗,对照组采用西药治疗,比较2组中医证候积分、胃镜下黏膜表现、组织病理结果的改变。结果 观察组疗效明显优于对照组,差异具有统计学意义(P<0.05)。结论 加味四合汤对脾胃虚弱证慢性萎缩性胃炎患者疗效显著,能有效改善患者临床中医证候、症状、胃镜黏膜表现、组织病理的变化,部分患者黏膜腺体萎缩出现逆转。

基于“态靶辨证”理论探析举元煎加味对脾虚气陷型痔术后肛门坠胀的治疗作用

肛门坠胀是痔术后常见并发症之一,严重影响痔术后患者创面愈合情况。基于仝小林院士“态靶辨证”学术思想,临床观察到痔术后患者出现肛门坠胀时,多属于“虚”态,多辨为“脾虚气陷证”。现结合多年临床经验,观察发现应用举元煎补中益气、升阳举陷,可以调节“脾虚气陷”证之虚态。延胡索行气活血止痛,以“气络”为靶,贯通气血,理气通络;当归补血活血,以“血络”为靶,化瘀生新;黄柏清热燥湿、解毒疗疮,以“湿络”为靶,清下焦湿热,三药共打瘀滞湿热之靶。态靶结合,效如桴鼓,能有效改善患者肛门坠胀症状,提高痔术后创面愈合情况。

便秘型肠易激综合征的科普解读

肠易激综合征是一种常见的功能性胃肠病,其中便秘型肠易激综合征在我国最为常见且危害最大。从预防、早期识别、诊断、自我调护、中医特色治疗等方面科普便秘型肠易激综合征知识,并为患者提供更好的诊疗方案。

基于治未病探讨化湿解毒防治胃癌癌前病变理论研究

胃癌是全世界范围内高发的消化道恶性肿瘤之一,发病率及致死率均较高。胃癌癌前病变(PLGC)为胃癌早期阶段,积极诊治以逆转、截断其向胃癌发展的治疗理念,可类比为中医“治未病”观念。胃癌病机多为邪毒、湿邪内蕴,故论治以化湿解毒为中心,辅以扶正补虚,效果颇佳,获得临床工作者的广泛认同。基于此,作者将从未病先防、既病防变、愈后防复三方面,阐述运用化湿解毒法系统性诊治PLGC的理论研究。

韩捷基于脏腑气化论治溃疡性结肠炎腹胀经验

韩捷教授从脏腑气化学说探讨溃疡性结肠炎腹胀,认为土虚木贼导致的腹胀与肝脾气化失常有关,食积湿热导致的腹胀与脾胃气化失常有关,清浊相混、气机郁滞所致腹胀与肠胃气化紧密联系,虚寒所致腹胀与脾肾气化相关联。其中尤以脾胃气化为主。在治疗上斡旋中焦气机,辨证选用疏肝、通调腑气、温补肾阳等法,使脏腑气化功能复常,气机通调,水谷精微吸收布散复常,则无胀满之机。韩捷教授从脏腑气化学说探讨溃疡性结肠炎腹胀之机,探寻腹胀之治,在临床取得较好疗效。

穴位敷贴联合集束化护理对ICU机械通气胃肠功能障碍患者的影响

目的观察穴位敷贴联合集束化护理对重症加强护理病房(ICU)机械通气胃肠功能障碍(GID)患者的影响。方法选择泉州市第一医院ICU收治的64例GID患者,按照随机数字表法分为对照组和试验组,各32例。对照组在常规治疗和护理基础上接受集束化护理,试验组在对照组基础上接受穴位敷贴治疗;分别于治疗前后评价两组患者胃肠功能障碍与衰竭(GIDF)评分、胃肠功能恢复情况、腹围和急性生理与慢性健康状况Ⅱ(APACHEⅡ)评分变化。结果治疗后,两组GIDF评分,首次肛门排气、首次排便、肠鸣音恢复、进食恢复时间,腹围和APACHEⅡ评分均较治疗前明显降低,且试验组低于对照组(P<0.05)。结论穴位敷贴联合集束化护理可改善GID患者胃肠功能,促进排气、排便和身体健康恢复,值得临床推广。