Somatic TP53 mutations and comparison of different TP53 functional domains in human cancers:data analysis from the IARC TP53 database and the National Cancer Institute GDC data portal

P53 gene mutations have been known to be highly related to the majority of human cancers.The colocation of biologists and bioinformaticians have constructed many databases for cancer research.Although the relationship between the presence of TP53 mutation and cancers has been reported in various studies,few reports TP53 mutation distribution in different functional domains.Hence,we use 2 databases(The TP53 Mutation Database of the International Agency for the Research on Cancer and The Genomic Data Commons data portal)to compare survival rate with and without TP53 mutations in a certain cancer,as well as to find most frequent mutation sites in different functional domains of the TP53 protein.Our study shows that most somatic mutations of TP53 and high mutation rate sites are concentrated in the DNA-binding domain,and the survival of certain cancers varies with and without P53.

Optimal Siting and Sizing of Distributed Renewable Energy in an Active Distribution Network

The distributed generation (DG) plays an important role in the context of the environmental problems and sustain- able development throughout the world. This paper proposes a DG siting and sizing model in an active distribution network (ADN). The objective is to minimize the total cost, including investment, operation and maintenance costs. The proposed model is transferred to a Mixed Integer Second-Order Cone Programming (MISOCP) model based on a distribution network forward backward-sweep power flow and constraint relaxation. The CVX platform and GUROBI solver are used for the solution. The scenario analysis is used for the uncertainties of load and DG. Different numbers of operational scenarios are considered in order to analyze the effect of a non-network solution to the final planning result and total investment. The planning results with and without consideration of active managements, and the planning results with and without taking environmental profits into consideration, are compared and analyzed. The proposed methodology is verified with a modified IEEE 33 example.

Relationship between archaeological sites distribution and environment from 1.15 Ma BP to 278 BC in Hubei Province

A total of 1362 archaeological sites from the Paleolithic Age to the Warring States time in Hubei Province increase gradually from west to east and from high land to low land.The number of Paleolithic sites with altitude of 50-500 m account for 78% of the whole,while 71%-95% of sites from the Neolithic Age to the Warring States time mainly distribute at the areas of 0-200 m.The temporal-spatial distribution of archeological sites in this area is affected by two factors.For one thing,the human beings of every period need to choose the first or the second terrace as living sites which are near water source and are easy to withstand flood.Additionally,affecting by the regional tectonic uplift since the Holocene,down cutting of rivers can form new river valley,and lateral erosion and accumulation of river in stable time of tectonic movement can result in increasing of many new terraces.So,the human beings migrated to adapt to the change of terrace location,leading to the sites increase gradually in the lower areas of the central and eastern parts of this province.For other things,the temporal-spatial distribution of archeological sites in this area is affected by the climate condition.The Paleolithic sites mostly distribute in the Hanshui River Valley in northeastern Shiyan,southeast of Jinzhou and east of Jinmen,which is because rivers distributed in higher areas in this period.During the Chengbeixi Culture period,the sites are rare in the quondam Paleolithic sites distribution area,but increase obviously along the Yangtze River near the southwest Yichang.The spore-pollen record of Dajiuhu Basin indicates that only 23 Chengbeixi cultural sites may be related to more precipitation and flood during the Holocene wet and hot period.The Daxi Culture,Qujialing Culture and Shijiahe Culture are corresponding to middle and top of the Dajiuhu spore-pollen Zone Ⅳ,during which the climate is in order as a whole and is propitious to agricultural development.In the Qujialing Culture period,32 of original 34 Daxi cultural sites disappeared,while 90 sites increase abruptly in the higher highlands in the north of Xiangfan-Jinmen-Xiaogan,which may respect with enlarging of water areas.The Chu Culture period is corresponding to Dajiuhu spore-pollen Zone V,which is in warm and dry Holocene phase,but it seems that the climate condition is still propitious to agricultural cultivation and the number of archeological sites increase heavily to 593.In addition,there are the least archaeological sites in the lake areas of southeast Hubei Province because of low-lying topography with altitude of 0-50 m and the severest flood.

Comments on "Reexamination of Correlations for Nucleate Site Distribution on Boiling Surface by Fractal Theory

In recently published paper by Yang Chunxin[1], I reexamined the paper. On page 128, the paper 'pointed out that the size and spatial distribution density of nucleation sites presented on real boiling surface can be described by the normalized fractal distribution function, and the physical meaning of parameters involved in some experimental correlations proposed by early investigations are identified according to fractal distribution'. However, the definition on fractal dimension given by Yang[1] is highly questionable, and the results obtained by Yang are contradictory to the basic fractal theory. Here are my comments:

Analytical Hybrid Particle Swarm Optimization Algorithm for Optimal Siting and Sizing of Distributed Generation in Smart Grid

In this paper,the hybridization of standard particle swarm optimisation(PSO)with the analytical method(2/3 rd rule)is proposed,which is called as analytical hybrid PSO(AHPSO)algorithm used for the optimal siting and sizing of distribution generation.The proposed AHPSO algorithm is implemented to cater for uniformly distributed,increasingly distributed,centrally distributed,and randomly distributed loads in conventional power systems.To demonstrate the effectiveness of the proposed algorithm,the convergence speed and optimization performances of standard PSO and the proposed AHPSO algorithms are compared for two cases.In the first case,the performances of both the algorithms are compared for four different load distributions via an IEEE 10-bus system.In the second case,the performances of both the algorithms are compared for IEEE 10-bus,IEEE 33-bus,IEEE 69-bus systems,and a real distribution system of Korea.Simulation results show that the proposed AHPSO algorithm converges significantly faster than the standard PSO.The results of the proposed algorithm are compared with those of an analytical algorithm,and the results of them are similar.

Predicting the effect of dissolved humic acid on sorption of benzotriazole to biochar

Dissolved organic matter plays a critical role in affecting sorption properties of biochar for organic contaminants.In this study,dissolved humic acid(DHA)as a representative of dissolved organic matter and oak sawdust-derived biochar as a sorbent were prepared and characterized.Roles of DHA in sorption of benzotriazole(BTA),an emerging organic contaminant,to biochar in different electrolyte solutions were investigated.The results revealed the dual roles of DHA in BTA sorption to biochar.On the one hand,DHA can compete for sites and/or block pores available for BTA to inhibit the adsorption of BTA to biochar.On the other hand,the sorbed DHA on biochar can serve as additional partitioning phase to promote the partition of BTA.The finding was in accordance with the site energy distribution analysis of BTA sorption that the site energy of the highest occurring frequency in the DHA-BTA system was lower than that in the DHA-free system(3.41-10.4 versus 13.1-20.1 kJ mol^(−1)).The variation in apparent BTA sorption to biochar affected by DHA was thus a combination of changes in both its partition and adsorption properties.A modified Dual-mode model including the aqueous concentration of DHA was proposed to predict the effect of DHA on BTA sorption to biochar in different electrolyte solutions,which showed good prediction performance with most BTA sorption coefficient(K_(d),L g^(−1))deviations within 0.1 log unit.