Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

The Least Distributive Lattice Congruence on Commutative Distributive Semiring

In this paper, we describe the least distributive lattice congruence on a commutative distributive semiring.

Sedimentary characteristics of distributive fluvial system in arid area: A case study of the Shule River distributive fluvial system, NW China

Based on detailed investigation of the modern sedimentation of the distributive fluvial system of Shule River and the data of unmanned aerial vehicle(UAV)aerial photography and satellite remote sensing,the sedimentary characteristics and differences of distributive fluvial system in arid areas are analyzed.By comparing the changes in slope,river morphology and sedimentary characteristics in different sections from the apex to the toe,the distributive fluvial system of Shule River can be divided into three facies belts:"proximal","middle"and"distal".The proximal belt has the largest slope and strongest hydrodynamic condition,mainly appears as large-scale braided river deposits;the fluvial bars in this belt are mainly composed of gravels,the gravels have good roundness and certain directionality,and are medium-large boulders,with low sand content;the main microfacies in this belt are braided channel and flood plain.The middle belt with slope smaller than the proximal belt,is mainly composed of braided bifurcating river deposits.Due to branching and infiltration,this belt has weaker hydrodynamic conditions,so some of the distributive rivers dry up,appearing as ephemeral rivers.This belt has small lenticular sandbodies,fine to medium gravels,higher sand content,and mainly braided channel,flood plain and aeolian dune microfacies.The distal belt has the smallest slope and flat terrain,where the river begins to transform from braided river to meandering river,the sediment is mainly sand.Due to the influence of slope,this belt has weaker erosion toward source and stronger lateral erosion,and point bars developing around the edge of the active lobes.In this belt,the river is completely meandering,and the main microfacies are braided channel,meandering channel,flood plain,aeolian dune,lake and swamp.

Global exponential stability of mixed discrete and distributively delayed cellular neural network

This paper concernes analysis for the global exponential stability of a class of recurrent neural networks with mixed discrete and distributed delays. It first proves the existence and uniqueness of the balance point, then by employing the Lyapunov-Krasovskii functional and Young inequality, it gives the sufficient condition of global exponential stability of cellular neural network with mixed discrete and distributed delays, in addition, the example is provided to illustrate the applicability of the result.

Divisible Semiring Congruences on Distributive Semiring

In this paper, we describe all the divisible semiring congruences on a distributive semiring S and also establish a one_to_one, inclusion_preserving mapping from the set of full, closed, self_conjagate, ideal subsemirings of S to the set of all divisible semiring congruences on S.

Linear Dynamical System over Finite Distributive Lattice

A finite dynamical system(FDS)over a lattice L is a pair(S(L),f),where S(L)is a left-L module and f is a mapping from S into itself.The phase space of(S(L),f)is a digraph whose vertex set is S(L)and there is an arc from x to y if y=f(x).Let L be a finite distributive lattice,A an n×n matrix over L,and f(x)=Ax.The structure of the phase space of the FDS(Ln,f)is discussed.The number of limit cycles in the phase space of(Ln,f)is described in Möbius function.The phase spaces of some invertible,nilpotent,and idempotent FDS(Ln,f)are characterized explicitly.

THE DISTRIBUTION REGION AND THE DISTRIBUTIVE TEMPERATURE AND HUMIDITY THRESHOLD OF OSIER WEEVIL IN CHINA

A distribution map of osier weevil (Crytorrynchus lapathi L.) was drown up based on widely collecting information and field survey. The results showed that Osier weevil has a widespread in China, stretching from 33°21' to 51°42' N latitude and 83°00' to 132°58' E longitude, and distributes in forms of big or small patches or sports uncontinously. According to the analysis of meteorological data, the temperature and humidity threshold for osier weevil's distribution were determined by methods of PCA (Principle Component Analysis) and RA(Relativity Analysis): January temperature is -30~ 0℃. Annual temperature -4~13℃, Annual precipitation from 411~ 1,136 min.The areas with January temperature under 0℃, annual temperature above 0℃ and annual precipitation of 400~ 800 mm are the optimum distributing places for osier weevil in China.

A Devaney Chaotic System Which Is Neither Distributively nor Topologically Chaotic

Weiss proved that Devaney chaos does not imply topological chaos and Oprocha pointed out that Devaney chaos does not imply distributional chaos. In this paper, by constructing a simple example which is Devaney chaotic but neither distributively nor topologically chaotic, we give a unified proof for the results of Weiss and Oprocha.

On the Distributive Justice of Land Added Value in the Process of Urban Expansion

It is an unarguable fact that the urban-rural dual structure led to two different results. On the one hand,it had been playing a great role in the city development and prosperity,and on the other hand,it had led the slow development of rural economy and the income gap between rural and urban areas. The government makes efforts to promote the process of urbanization to maintain the sustained development of China's economy and economic transformation which are the two needs of the Chinese reality. But in the top-level design of the policy,the government did not give a fair profits distribution to all social groups. On the contrary,the result of urban development is based on the expense of a part of the people's interests in exchange for the interests of another parts of the people,and especially on the government expropriation in the process of urban expansion. Under Land Administration Law of the People's Republic of China,the government monopolized the expropriation right of the rural land,and the rural collectives and farmers as the land owner and constructors respectively have no rights to decide the land use purposes. In fact,they are forced to accept the land compensation,and because of the little bargaining rights,they gain little from the land value increment. Comparatively,the governments became the biggest beneficiary who made use of the land as a source and capital to earn the achievement in their official career and more money required by the urban development. The paper mainly analyzes the current situation of the distribution of the land added value,elaborates the reasons why the government strives for the land interests,and discusses what farmers lose in the government expropriation. Last but not lest,the author reflects on the land reform and gives a proposal on distribution of land added value.

Distributed Nash Equilibrium Seeking Strategies Under Quantized Communication

This paper is concerned with distributed Nash equi librium seeking strategies under quantized communication. In the proposed seeking strategy, a projection operator is synthesized with a gradient search method to achieve the optimization o players' objective functions while restricting their actions within required non-empty, convex and compact domains. In addition, a leader-following consensus protocol, in which quantized informa tion flows are utilized, is employed for information sharing among players. More specifically, logarithmic quantizers and uniform quantizers are investigated under both undirected and connected communication graphs and strongly connected digraphs, respec tively. Through Lyapunov stability analysis, it is shown that play ers' actions can be steered to a neighborhood of the Nash equilib rium with logarithmic and uniform quantizers, and the quanti fied convergence error depends on the parameter of the quan tizer for both undirected and directed cases. A numerical exam ple is given to verify the theoretical results.

Spatial distribution of shallow landslides caused by Typhoon Lekima in 2019 in Zhejiang Province, China

In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous terrain of this area, combined with rapid rainfall accumulation, has led to a surge in flash floods and severe geological hazards. On August 10, 2019, Typhoon Lekima made landfall in Zhejiang Province, China, and its torrential rainfall triggered extensive landslides, resulting in substantial damage and economic losses. Utilizing high-resolution satellite images, we compiled a landslide inventory of the affected area, which comprises a total of 2,774 rainfallinduced landslides over an area of 2965 km2. The majority of these landslides were small to mediumsized and exhibited elongated, clustered patterns. Some landslides displayed characteristics of high-level initiation, obstructing or partially blocking rivers, leading to the formation of debris dams. We used the inventory to analyze the distribution pattern of the landslides and their relationship with topographical, geological, and hydrological factors. The results showed that landslide abundance was closely related to elevation, slope angle, faults, and road density. The landslides were predominantly located in hilly and low mountainous areas, with elevations ranging from 150 to 300 m, slopes of 20 to 30 degrees, and a NE-SE aspect. Notably, we observed the highest Landslide Number Density(LND) and Landslide Area Percentage(LAP) in the rhyolite region. Landslides were concentrated within approximately 4 km on either side of fault zones, with their size and frequency negatively correlated with distances to faults, roads, and river systems. Furthermore, under the influence of typhoons, regions with denser vegetation cover exhibited higher landslide density, reaching maximum values in shrubland areas. In areas experiencing significantly increased concentrated rainfall, landslide density also showed a corresponding rise. In terms of spatial distribution, the rainfall-triggered landslides primarily occurred in the northeastern part of the study area, particularly in regions characterized by complex topography such as Shanzao Village in Yantan Town, Xixia Township, and Shangzhang Township. The research findings offer crucial data on the rainfallinduced landslides triggered by Typhoon Lekima, shedding light on their spatial distribution patterns. These findings provide valuable references for mitigating risks and planning reconstruction in typhoon-affected area.

FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber principle.This method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined RAM.The performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data transmission.The experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 mm.The beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction method.The online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.

Mathematical Morphological Distributive Concepts over Unions and Intersections

Mathematical Morphological concepts outline techniques for analysing and processing geometric structures based on set theory. In this paper, we present proofs of our theorems on morphological distributive properties over Unions and Intersections with respect to Dilation and Erosion. These results provide new realizations of Dilation, Erosion and conclude that they are distributive over Unions but non-distributive over Intersections.

Sparse Adversarial Learning for FDIA Attack Sample Generation in Distributed Smart

False data injection attack(FDIA)is an attack that affects the stability of grid cyber-physical system(GCPS)by evading the detecting mechanism of bad data.Existing FDIA detection methods usually employ complex neural networkmodels to detect FDIA attacks.However,they overlook the fact that FDIA attack samples at public-private network edges are extremely sparse,making it difficult for neural network models to obtain sufficient samples to construct a robust detection model.To address this problem,this paper designs an efficient sample generative adversarial model of FDIA attack in public-private network edge,which can effectively bypass the detectionmodel to threaten the power grid system.A generative adversarial network(GAN)framework is first constructed by combining residual networks(ResNet)with fully connected networks(FCN).Then,a sparse adversarial learning model is built by integrating the time-aligned data and normal data,which is used to learn the distribution characteristics between normal data and attack data through iterative confrontation.Furthermore,we introduce a Gaussian hybrid distributionmatrix by aggregating the network structure of attack data characteristics and normal data characteristics,which can connect and calculate FDIA data with normal characteristics.Finally,efficient FDIA attack samples can be sequentially generated through interactive adversarial learning.Extensive simulation experiments are conducted with IEEE 14-bus and IEEE 118-bus system data,and the results demonstrate that the generated attack samples of the proposed model can present superior performance compared to state-of-the-art models in terms of attack strength,robustness,and covert capability.

Federated Learning Model for Auto Insurance Rate Setting Based on Tweedie Distribution

In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining the Tweedie regression model involves training on a centralized dataset,when the data is provided by multiple parties,training a privacy-preserving Tweedie regression model without exchanging raw data becomes a challenge.To address this issue,this study introduces a novel vertical federated learning-based Tweedie regression algorithm for multi-party auto insurance rate setting in data silos.The algorithm can keep sensitive data locally and uses privacy-preserving techniques to achieve intersection operations between the two parties holding the data.After determining which entities are shared,the participants train the model locally using the shared entity data to obtain the local generalized linear model intermediate parameters.The homomorphic encryption algorithms are introduced to interact with and update the model intermediate parameters to collaboratively complete the joint training of the car insurance rate-setting model.Performance tests on two publicly available datasets show that the proposed federated Tweedie regression algorithm can effectively generate Tweedie regression models that leverage the value of data fromboth partieswithout exchanging data.The assessment results of the scheme approach those of the Tweedie regressionmodel learned fromcentralized data,and outperformthe Tweedie regressionmodel learned independently by a single party.

Predicting the probability distribution of Martian rocks mechanical property based on microscale rock mechanical experiments and accurate grain-based modeling

The exploration of Mars would heavily rely on Martian rocks mechanics and engineering technology.As the mechanical property of Martian rocks is uncertain,it is of utmost importance to predict the probability distribution of Martian rocks mechanical property for the success of Mars exploration.In this paper,a fast and accurate probability distribution method for predicting the macroscale elastic modulus of Martian rocks was proposed by integrating the microscale rock mechanical experiments(micro-RME),accurate grain-based modeling(AGBM)and upscaling methods based on reliability principles.Firstly,the microstructure of NWA12564 Martian sample and elastic modulus of each mineral were obtained by micro-RME with TESCAN integrated mineral analyzer(TIMA)and nanoindentation.The best probability distribution function of the minerals was determined by Kolmogorov-Smirnov(K-S)test.Secondly,based on best distribution function of each mineral,the Monte Carlo simulations(MCS)and upscaling methods were implemented to obtain the probability distribution of upscaled elastic modulus.Thirdly,the correlation between the upscaled elastic modulus and macroscale elastic modulus obtained by AGBM was established.The accurate probability distribution of the macroscale elastic modulus was obtained by this correlation relationship.The proposed method can predict the probability distribution of Martian rocks mechanical property with any size and shape samples.

Synergetic optimization operation method for distribution network based on SOP and PV

The integration of distributed generation brings in new challenges for the operation of distribution networks,including out-of-limit voltage and power flow control.Soft open points(SOP)are new power electronic devices that can flexibly control active and reactive power flows.With the exception of active power output,photovoltaic(PV)devices can provide reactive power compensation through an inverter.Thus,a synergetic optimization operation method for SOP and PV in a distribution network is proposed.A synergetic optimization model was developed.The voltage deviation,network loss,and ratio of photovoltaic abandonment were selected as the objective functions.The PV model was improved by considering the three reactive power output modes of the PV inverter.Both the load fluctuation and loss of the SOP were considered.Three multi-objective optimization algorithms were used,and a compromise optimal solution was calculated.Case studies were conducted using an IEEE 33-node system.The simulation results indicated that the SOP and PVs complemented each other in terms of active power transmission and reactive power compensation.Synergetic optimization improves power control capability and flexibility,providing better power quality and PV consumption rate.

A study on distributive and modular lattice ordered fuzzy soft group and its duality

Soft set theory has a rich potential application in several fields. A soft group is a parameterized family of subgroups and a fuzzy soft group is a parameterized family of fuzzy subgroups. The concept of fuzzy soft group is the generalization of soft group. Abdulkadir Aygunoglu and Halis Aygun introduced the notion of fuzzy soft groups in 2009[1]. In this paper, the concept of lattice ordered fuzzy soft groups and its duality has been introduced. Then distributive and modular lattice ordered fuzzy soft groups are analysed. The objective of this paper is to study the lattice theory over the collection of fuzzy soft group in a parametric manner. Some pertinent properties have been analysed and hence established duality principle.

Coseismic deformation and fault slip distribution of the 2023 M_(W)7.8 and M_(W)7.6 earthquakes in Türkiye

On February 6,2023,a devastating earthquake with a moment magnitude of M_(W)7.8 struck the town of Pazarcik in south-central Türkiye,followed by another powerful earthquake with a moment magnitude of M_(W)7.6 that struck the nearby city of Elbistan 9 h later.To study the characteristics of surface deformation caused by this event and the influence of fault rupture,this study calculated the static coseismic deformation of 56 stations and dynamic displacement waveforms of 15 stations using data from the Turkish national fixed global navigation satellite system(GNSS)network.A maximum static coseismic displacement of 0.38 m for the M_(W)7.8 Kahramanmaras earthquake was observed at station ANTE,36 km from the epicenter,and a maximum dynamic coseismic displacement of 4.4 m for the M_(W)7.6 Elbistan earthquake was observed at station EKZ1,5 km from the epicenter.The rupture-slip distributions of the two earthquakes were inverted using GNSS coseismic deformation as a constraint.The results showed that the Kahramanmaras earthquake rupture segment was distinct and exposed on the ground,resulting in significant rupture slip along the Amanos and Pazarcik fault segments of the East Anatolian Fault.The maximum slip in the Pazarcik fault segment was 10.7 m,and rupture occurred at depths of 0–15 km.In the Cardak fault region,the Elbistan earthquake caused significant ruptures at depths of 0–12 km,with the largest amount of slip reaching 11.6 m.The Coulomb stress change caused by the Kahramanmaras earthquake rupture along the Cardak fault segment was approximately 2 bars,and the area of increased Coulomb stress corresponded to the subsequent rupture region of the M_(W)7.6 earthquake.Thus,it is likely that the M_(W)7.8 earthquake triggered or promoted the M_(W)7.6 earthquake.Based on the cumulative stress impact of the M_(W)7.8 and M_(W)7.6 events,the southwestern segment of the East Anatolian Fault,specifically the Amanos fault segment,experienced a Coulomb rupture stress change exceeding 2 bars,warranting further attention to assess its future seismic hazard risk.

Integrative biogeography: Validating hypotheses of species distribution

DEAR EDITOR,Biogeography is a scientific field dedicated to the investigation of the origins and distribution patterns of organisms,as well as predicting future alterations in their geographical distributions(Cox&Moore,2005).However,the majority of conclusions drawn within the field of biogeography are hypothetical.Rigorous testing of these biogeographic hypotheses remains a considerable challenge.This paper presents the concept of“integrative biogeography”,which emphasizes the experimental testing of biogeographic hypotheses through studies on geological history,as well as biotic and abiotic factors(Figure 1).