This study examines the key factors that have impact on the successful adoption of Human Resource Information System (HRIS) within the Aqaba Special Economic Zone Authority (ASEZA)/Jordan. In order to accomplish the p...This study examines the key factors that have impact on the successful adoption of Human Resource Information System (HRIS) within the Aqaba Special Economic Zone Authority (ASEZA)/Jordan. In order to accomplish the purpose of the study four critical factors are inquired. So, four critical factors are inquired: First, TAM Model (Perceived Ease of Use (PEOU) and Perceived Usefulness (PU)). Second, Information Technology Infrastructure (ITI). Third, Top Management Support (TMS). Finally, Individual Experience with Computer (IEC). The research model was applied to collect data from the questionnaires answered by 45 users of HRIS as a source of primary data, based on a convenience sample the response rate was about 91%. In addition, the results were analyzed by utilizing the Statistical Package for Social Software (SPSS). Furthermore, the findings were analyzed;multiple Regression analysis indicated that all research variables have significant relationship on successful adoption of HRIS. The findings indicated IT infrastructures have a positive and significant effect on the successful adoption of HRIS. But there is no significant of PU, PEOU, TMS, and IEC on the successful adoption of HRIS. Finally, the results indicated that no significant statistical differences of demographic characteristics on HRIS adoption. Depending on the research’s findings;the researchers proposed a set of recommendations for better adoption of HRIS in SEZA.展开更多
The damage process of fractured rock mass showed that the fracture in rocks induced roof collapse in Yangchangwan Coal Mine, China. The rock mass was particularly weak and fractured. There occurred 6 large-scale dynam...The damage process of fractured rock mass showed that the fracture in rocks induced roof collapse in Yangchangwan Coal Mine, China. The rock mass was particularly weak and fractured. There occurred 6 large-scale dynamical roof falls in the excavation disturbed zone (EDZ) with the collapsing volume of 216 m^3. First, the field detailed geological environment, regional seismic dynamics, and dynamic instability of roadways were generally investigated. Second, the field multiple-index monitoring measurements for detecting the deep delamination of the roof, convergence deformation, bolt-cable load, acoustic emission (AE) characteristic parameters, total AE events, AE energy-releasing rate, rock mass fracture, and damage were arranged. Finally, according to the time-space-strength relations, a quantitative assessment of the influence of rock-mass damage on the dynamic roof instability was accomplished.展开更多
The hydrothermal wave was investigated numerically for large-Prandtl-number fluid (Pr = 105.6) in a shallow cavity with different heated sidewalls. The traveling wave appears and propagates in the direction opposite t...The hydrothermal wave was investigated numerically for large-Prandtl-number fluid (Pr = 105.6) in a shallow cavity with different heated sidewalls. The traveling wave appears and propagates in the direction opposite to the surface flow (upstream) in the case of zero gravity when the applied temperature difference grows and over the critical value. The phase relationships of the disturbed velocity,temperature and pressure demonstrate that the traveling wave is driven by the disturbed tem-perature,which is named hydrothermal wave. The hydrothermal wave is so weak that the oscillatory flow field and temperature distribution can hardly be observed in the liquid layer. The exciting mechanism of hydrothermal wave is analyzed and discussed in the present paper.展开更多
The quantitatively/semi-quantitatively formation conditions of vertical dominant hydrocarbon migration pathways were analyzed based on the big data analysis of petroleum geological parameters of complex fault Zone zon...The quantitatively/semi-quantitatively formation conditions of vertical dominant hydrocarbon migration pathways were analyzed based on the big data analysis of petroleum geological parameters of complex fault Zone zone in the central-south Bohai Bay. According to this condition, the vertical dominant migration pathway and its charge points/segments are searched through structural modeling assistant analysis in the East Sag of Huanghekou. Under the constraints of charge points/segments, numerical simulation of hydrocarbon charge and migration is carried out to successfully predict hydrocarbon migration pathways and hydrocarbon enrichment blocks in shallow layers of complex fault zone. The main results are as follows:(1) The hydrocarbon charge in shallow layers of the active fault zone is differential, the charge points/sections of vertical dominant migration pathways are the starting points of shallow hydrocarbon migration and are very important for the hydrocarbon migration and accumulation in the shallow layers.(2) Among the shallow faults, those cutting the deep transfer bins or deep major migration pathways, with fault throw of more than 80 m in the accumulation period and the juxtaposition thickness between fault and caprock of the deep layers of less than 400 m are likely to be vertical dominant migration pathways in the sag area.(3) By controlling the vertical dominant migration pathways and charging points/segments in carrier layer, Neo-tectonic movement caused the differential hydrocarbon accumulation in the complex fault zone. The research results are of great significance for the fine exploration of the complex fault zone.展开更多
Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness o...Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness of up to 9000 m.Previous studies identified many oil seedlings as well as asphalt and ancient hydrocarbon reservoirs in Northern Hebei depression and western Liaoning depression.This research indicates that the Mesoproterozoic and Neoproterozoic sedimentary units are ideally suited for the formation of significant oil and gas resources.The Niu D1 well was drilled by the China Geological Survey(CGS)in the Niuyingzi area and intercepted oil immersions and oil-and gas-bearing units within a limestone reservoir in the middle Proterozoic Gaoyuzhuang Formation(Fig.1).This study presents new biomarker compound and carbon isotope data that indicate that the oil within this formation was derived from hydrocarbon source rocks of the Hongshuizhuang Formation,part of the Mesoproterozoic Jixian Series,and the reservoir type is overthrust fault fractured anticline hydrocarbon reservoir.The oil reservoir within the Gaoyuzhuang Formation limestone might represent the oldest oil reservoir discovered to date within the Yanliao faulted depression zone.展开更多
Abstract Problem statement. Self-organization is not a universal property of matter, it exists under certain internal and external conditions and this is not associated with a special class of substances. The study of...Abstract Problem statement. Self-organization is not a universal property of matter, it exists under certain internal and external conditions and this is not associated with a special class of substances. The study of the morphology and dynamics of migration of anomalous zones associated with increased stresses is of particular importance in the development of deep deposits, complicated by dynamic phenomena in the form of rock impacts. Applied method and design: An important tool for this study is geophysical exploration. To describe the geological environment in the form of an array of rocks with its natural and technogenic heterogeneity, one should use its more adequate description, which is a discrete model of the medium in the form of a piecewise heterogeneous block medium with embedded heterogeneities of a lower rank than the block size. This nesting can be traced several times, i.e. changing the scale of the study;we see that heterogeneities of a lower rank now appear in the form of blocks for heterogeneities of the next rank. A simple averaging of the measured geophysical parameters can lead to distorted ideas about the structure of the medium and its evolution. Typical results: We have analyzed the morphology of the structural features of disintegration zones before a strong dynamic phenomenon. The introduction of the proposed integrated passive and active geophysical monitoring into the mining system, aimed at studying the transient processes of the redistribution of stress-strain and phase states, can help prevent catastrophic dynamic manifestations during the development of deep-located deposits. Concluding note (Practical value/implications): Active geophysical monitoring methods should be tuned to a model of a hierarchical heterogeneous environment. Iterative algorithms for 2-D modeling and interpretation for sound diffraction and a linearly polarized transverse elastic wave on the inclusion with a hierarchical elastic structure located in the J-th layer of the N-layer elastic medium are constructed.展开更多
BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generaliz...BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.展开更多
Potential fishing zones for skipjack tuna in the Bone Bay-Flores Sea were investigated from satellite-based oceanography and catch data, using a linear model (generalized linear model) constructed from generalized add...Potential fishing zones for skipjack tuna in the Bone Bay-Flores Sea were investigated from satellite-based oceanography and catch data, using a linear model (generalized linear model) constructed from generalized additive models and geographic information systems. Monthly mean remotely sensed sea surface temperature and surface chlorophyll-a concentration during the southeast monsoon (April-August) were used for the year 2012. The best generalized additive model was selected to assess the effect of marine environment variables (sea surface temperature and chlorophyll-a concentration) on skipjack tuna abundance (catch per unit effort). Then, the appropriate linear model was constructed from the functional relationship of the generalized additive model for generating a robust predictive model. Model selection process for the generalized additive model was based on significance of model terms, decrease in residual deviance, and increase in cumulative variance explained, whereas the model selection for the linear model was based on decrease in residual deviance, reduction in Akaike’s Information Criterion, increasing cumulative variance explained and significance of model terms. The best model was selected to predict skipjack tuna abundance and their spatial distribution patterns over entire study area. A simple linear model was used to verify the predicted values. Results indicated that the distribution pattern of potential fishing zones for skipjack during the southeast monsoon were well characterized by sea surface temperatures ranging from 28.5℃ to 30.5 ℃ and chlorophyll-a ranging from 0.10 to 0.20 mg·m-3. Predicted highest catch per unit efforts were significantly consistent with the fishing data (P 2 = 0.8), suggesting that the oceanographic indicators may correspond well with the potential feeding ground for skipjack tuna. This good feeding opportunity for skipjack was driven the dynamics of upwelling operating within study area which are capable of creating a highly potential fishing zone during the southeast monsoon.展开更多
The development, evolution and formation mechanism of faults and their control on the migration and accumulation of Mesozoic oil and gas in the middle-shallow layers of the slope zone of Mahu sag were studied by the i...The development, evolution and formation mechanism of faults and their control on the migration and accumulation of Mesozoic oil and gas in the middle-shallow layers of the slope zone of Mahu sag were studied by the interpretation of seismic and drilling data. Two types of faults, normal and strike-slip, are developed in the middle-shallow layers of the slope zone of the Mahu sag and they are mostly active in the Yanshanian period. They are divided into four grade faults: The grade I strike-slip faults with NWW to near EW direction are related to the left-lateral transpressive fault zones in the northwest of Junggar Basin since the end of the Triassic. The grade II faults with NE to NNE direction are the normal faults located at the junction of the fault zone and the slope zone, and their formation is related to the extension at the top of the nose-like structures in the fault zone. The grade III faults, which are also the normal faults, are the result of the extension at the top of the lower uplifts in the slope zone and differential compaction. The grade IV faults with NE direction are normal faults, which may be related to the extension environment at the tip of the lower uplifts. Faults not only are the channel for the vertical migration of oil and gas, but also control the oil-gas accumulation. There are two types of oil-gas reservoirs in the middle-shallow layers of slope zone of Mahu sag: fault block reservoirs and fault-lithologic reservoirs. They have large traps and promising exploration potential.展开更多
The two-dimensional cellular detonation propagating in a channel with area-changing cross section was numerically simulated with the dispersion-controlled dissipative scheme and a detailed chemical reaction model. Eff...The two-dimensional cellular detonation propagating in a channel with area-changing cross section was numerically simulated with the dispersion-controlled dissipative scheme and a detailed chemical reaction model. Effects of the flow ex-pansion and compression on the cellular detonation cell were investigated to illus-trate the mechanism of the transverse wave development and the cellular detona-tion cell evolution. By examining gas composition variations behind the leading shock,the chemical reaction rate,the reaction zone length,and thermodynamic parameters,two kinds of the abnormal detonation waves were identified. To explore their development mechanism,chemical reactions,reflected shocks and rarefac-tion waves were discussed,which interact with each other and affect the cellular detonation in different ways.展开更多
The 84 km Panama Canal connecting the Atlantic and Pacific oceans has historically been a strategic waterway for shipping and the location of United States (US) military bases. Since the construction of Lake Gatun res...The 84 km Panama Canal connecting the Atlantic and Pacific oceans has historically been a strategic waterway for shipping and the location of United States (US) military bases. Since the construction of Lake Gatun reservoir, canal locks and navigation channel through the Isthmus of Panama tropical forests in the 1910s, chemicals, pesticides, and herbicides have been essential for controlling upland and wetland vegetation as well as managing mosquito-borne diseases. Chemicals and pesticides flowed into Lake Gatun via land surface runoff and subsurface drainage either attached to the sediment or in solution during the rainy season. Lake Gatun and the Panama Canal was the drinking water source for most of the civilian and military population living in the Panama Canal Zone. Between 1948 and 1999, US military base commanders had the ability to order, from the Federal Supply Catalog, commercially available herbicide 2,4,5-T with unknown amounts of dioxin TCDD for use on the military base grounds in the Panama Canal Zone. The herbicide 2,4,5-T was transported to Panama Canal Zone ports, including the ports Cristobal on the Caribbean and Balboa on the Pacific, and distributed to the US military bases in Panama by rail or truck. The US National Toxicology Program and the International Agency for the Research on Cancer listed dioxin and TCDD as known human carcinogens. Dioxins are endocrine disrupters and can cause certain chloracne, cancers, developmental and reproductive effects. In 1985, the United States government banned the manufacture of the herbicide 2,4,5-T, with unknown amounts of dioxin TCDD, after it was shown to cause cancer in animals. The objectives of this study are to determine: 1) the fate of dioxin TCDD, a contaminant in the herbicide 2,4,5-T, sprayed on the US military base vegetation in the Panama Canal Zone from 1948 to 1999, 2) the transport of dioxin TCDD rich sediment via soil erosion and overland flow into Lake Gatun and Panama Canal waterways and 3) the human health impacts of dioxin TCDD, a known carcinogen, on US military and Panamanian civilians exposed to dioxin TCDD in the Panama Canal Zone.展开更多
A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults structure.Increasing numbers of fault accommodation zones are being identified in graben basins,in...A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults structure.Increasing numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation areas.This study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical modeling.Using three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation zones.Combined with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben basin.Integrating the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were summarized.Influenced by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:During the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale faults.During the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly developed.The junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation zones.During the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were furtherly inherited and developed.This stage was the molded and formative period of the FAZ,the low-order faults,and the depression in the DXFZ.展开更多
In this study,zircon U-Pb dating of volcanic rocks from the Zhongba ophiolite of the Yarlung Zangbo Suture Zone(YZSZ)in southern Xizang(Tibet)yielded an age of 247±3 Ma.According to whole rock geochemical and Sr-...In this study,zircon U-Pb dating of volcanic rocks from the Zhongba ophiolite of the Yarlung Zangbo Suture Zone(YZSZ)in southern Xizang(Tibet)yielded an age of 247±3 Ma.According to whole rock geochemical and Sr-NdPb isotopic data,the Early Triassic samples could be divided into two groups:Group 1 with P-MORB affinity,showing initial^(87)Sr/^(86)Sr ratios of 0.70253–0.70602,ε_(Nd)(t)values of 4.2–5.3,(^(206)Pb/^(204)Pb)_(t)ratios of 16.353–18.222,(^(207)Pb/^(204)Pb)_(t)ratios of 15.454–15.564,and(^(208)Pb/^(204)Pb)_(t)ratios of 35.665–38.136;Group 2 with OIB affinity,showing initial^(87)Sr/^(86)Sr ratios of 0.70249–0.70513,ε_(Nd)(t)values of 4.4–4.9,(^(206)Pb/^(204)Pb)_(t)ratios of 17.140–18.328,(^(207)Pb/^(204)Pb)_(t)ratios of 15.491–15.575,and(^(208)Pb/^(204)Pb)_(t)ratios of 36.051–38.247.Group 2 rocks formed by partial melting of the mantle source enriched by a former plume,and assimilated continental crustal material during melt ascension.The formation of Group 1 rocks corresponds to the mixing of OIB melts,with the same components as Group 2 and N-MORBs.The Zhongba Early Triassic rocks belong to the continental margin type ophiolite and formed in the continental–oceanic transition zone during the initial opening of the Neo-Tethys in southern Xizang(Tibet).展开更多
文摘This study examines the key factors that have impact on the successful adoption of Human Resource Information System (HRIS) within the Aqaba Special Economic Zone Authority (ASEZA)/Jordan. In order to accomplish the purpose of the study four critical factors are inquired. So, four critical factors are inquired: First, TAM Model (Perceived Ease of Use (PEOU) and Perceived Usefulness (PU)). Second, Information Technology Infrastructure (ITI). Third, Top Management Support (TMS). Finally, Individual Experience with Computer (IEC). The research model was applied to collect data from the questionnaires answered by 45 users of HRIS as a source of primary data, based on a convenience sample the response rate was about 91%. In addition, the results were analyzed by utilizing the Statistical Package for Social Software (SPSS). Furthermore, the findings were analyzed;multiple Regression analysis indicated that all research variables have significant relationship on successful adoption of HRIS. The findings indicated IT infrastructures have a positive and significant effect on the successful adoption of HRIS. But there is no significant of PU, PEOU, TMS, and IEC on the successful adoption of HRIS. Finally, the results indicated that no significant statistical differences of demographic characteristics on HRIS adoption. Depending on the research’s findings;the researchers proposed a set of recommendations for better adoption of HRIS in SEZA.
基金supported by the National Natural Science Foundation of China (No.10402033 and No.10772144)
文摘The damage process of fractured rock mass showed that the fracture in rocks induced roof collapse in Yangchangwan Coal Mine, China. The rock mass was particularly weak and fractured. There occurred 6 large-scale dynamical roof falls in the excavation disturbed zone (EDZ) with the collapsing volume of 216 m^3. First, the field detailed geological environment, regional seismic dynamics, and dynamic instability of roadways were generally investigated. Second, the field multiple-index monitoring measurements for detecting the deep delamination of the roof, convergence deformation, bolt-cable load, acoustic emission (AE) characteristic parameters, total AE events, AE energy-releasing rate, rock mass fracture, and damage were arranged. Finally, according to the time-space-strength relations, a quantitative assessment of the influence of rock-mass damage on the dynamic roof instability was accomplished.
基金Supported by the National Natural Science Foundation of China (Grant No. 10432060)
文摘The hydrothermal wave was investigated numerically for large-Prandtl-number fluid (Pr = 105.6) in a shallow cavity with different heated sidewalls. The traveling wave appears and propagates in the direction opposite to the surface flow (upstream) in the case of zero gravity when the applied temperature difference grows and over the critical value. The phase relationships of the disturbed velocity,temperature and pressure demonstrate that the traveling wave is driven by the disturbed tem-perature,which is named hydrothermal wave. The hydrothermal wave is so weak that the oscillatory flow field and temperature distribution can hardly be observed in the liquid layer. The exciting mechanism of hydrothermal wave is analyzed and discussed in the present paper.
基金Supported by the National Science and Technology Major Project(2016ZX05024-003)
文摘The quantitatively/semi-quantitatively formation conditions of vertical dominant hydrocarbon migration pathways were analyzed based on the big data analysis of petroleum geological parameters of complex fault Zone zone in the central-south Bohai Bay. According to this condition, the vertical dominant migration pathway and its charge points/segments are searched through structural modeling assistant analysis in the East Sag of Huanghekou. Under the constraints of charge points/segments, numerical simulation of hydrocarbon charge and migration is carried out to successfully predict hydrocarbon migration pathways and hydrocarbon enrichment blocks in shallow layers of complex fault zone. The main results are as follows:(1) The hydrocarbon charge in shallow layers of the active fault zone is differential, the charge points/sections of vertical dominant migration pathways are the starting points of shallow hydrocarbon migration and are very important for the hydrocarbon migration and accumulation in the shallow layers.(2) Among the shallow faults, those cutting the deep transfer bins or deep major migration pathways, with fault throw of more than 80 m in the accumulation period and the juxtaposition thickness between fault and caprock of the deep layers of less than 400 m are likely to be vertical dominant migration pathways in the sag area.(3) By controlling the vertical dominant migration pathways and charging points/segments in carrier layer, Neo-tectonic movement caused the differential hydrocarbon accumulation in the complex fault zone. The research results are of great significance for the fine exploration of the complex fault zone.
基金funded by the China Geological Survey Project(Grant No.DD20190098).
文摘Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness of up to 9000 m.Previous studies identified many oil seedlings as well as asphalt and ancient hydrocarbon reservoirs in Northern Hebei depression and western Liaoning depression.This research indicates that the Mesoproterozoic and Neoproterozoic sedimentary units are ideally suited for the formation of significant oil and gas resources.The Niu D1 well was drilled by the China Geological Survey(CGS)in the Niuyingzi area and intercepted oil immersions and oil-and gas-bearing units within a limestone reservoir in the middle Proterozoic Gaoyuzhuang Formation(Fig.1).This study presents new biomarker compound and carbon isotope data that indicate that the oil within this formation was derived from hydrocarbon source rocks of the Hongshuizhuang Formation,part of the Mesoproterozoic Jixian Series,and the reservoir type is overthrust fault fractured anticline hydrocarbon reservoir.The oil reservoir within the Gaoyuzhuang Formation limestone might represent the oldest oil reservoir discovered to date within the Yanliao faulted depression zone.
文摘Abstract Problem statement. Self-organization is not a universal property of matter, it exists under certain internal and external conditions and this is not associated with a special class of substances. The study of the morphology and dynamics of migration of anomalous zones associated with increased stresses is of particular importance in the development of deep deposits, complicated by dynamic phenomena in the form of rock impacts. Applied method and design: An important tool for this study is geophysical exploration. To describe the geological environment in the form of an array of rocks with its natural and technogenic heterogeneity, one should use its more adequate description, which is a discrete model of the medium in the form of a piecewise heterogeneous block medium with embedded heterogeneities of a lower rank than the block size. This nesting can be traced several times, i.e. changing the scale of the study;we see that heterogeneities of a lower rank now appear in the form of blocks for heterogeneities of the next rank. A simple averaging of the measured geophysical parameters can lead to distorted ideas about the structure of the medium and its evolution. Typical results: We have analyzed the morphology of the structural features of disintegration zones before a strong dynamic phenomenon. The introduction of the proposed integrated passive and active geophysical monitoring into the mining system, aimed at studying the transient processes of the redistribution of stress-strain and phase states, can help prevent catastrophic dynamic manifestations during the development of deep-located deposits. Concluding note (Practical value/implications): Active geophysical monitoring methods should be tuned to a model of a hierarchical heterogeneous environment. Iterative algorithms for 2-D modeling and interpretation for sound diffraction and a linearly polarized transverse elastic wave on the inclusion with a hierarchical elastic structure located in the J-th layer of the N-layer elastic medium are constructed.
文摘BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.
文摘Potential fishing zones for skipjack tuna in the Bone Bay-Flores Sea were investigated from satellite-based oceanography and catch data, using a linear model (generalized linear model) constructed from generalized additive models and geographic information systems. Monthly mean remotely sensed sea surface temperature and surface chlorophyll-a concentration during the southeast monsoon (April-August) were used for the year 2012. The best generalized additive model was selected to assess the effect of marine environment variables (sea surface temperature and chlorophyll-a concentration) on skipjack tuna abundance (catch per unit effort). Then, the appropriate linear model was constructed from the functional relationship of the generalized additive model for generating a robust predictive model. Model selection process for the generalized additive model was based on significance of model terms, decrease in residual deviance, and increase in cumulative variance explained, whereas the model selection for the linear model was based on decrease in residual deviance, reduction in Akaike’s Information Criterion, increasing cumulative variance explained and significance of model terms. The best model was selected to predict skipjack tuna abundance and their spatial distribution patterns over entire study area. A simple linear model was used to verify the predicted values. Results indicated that the distribution pattern of potential fishing zones for skipjack during the southeast monsoon were well characterized by sea surface temperatures ranging from 28.5℃ to 30.5 ℃ and chlorophyll-a ranging from 0.10 to 0.20 mg·m-3. Predicted highest catch per unit efforts were significantly consistent with the fishing data (P 2 = 0.8), suggesting that the oceanographic indicators may correspond well with the potential feeding ground for skipjack tuna. This good feeding opportunity for skipjack was driven the dynamics of upwelling operating within study area which are capable of creating a highly potential fishing zone during the southeast monsoon.
基金Supported by the China National Science and Technology Major Project(2017ZX05008-001,2011ZX05003-003)
文摘The development, evolution and formation mechanism of faults and their control on the migration and accumulation of Mesozoic oil and gas in the middle-shallow layers of the slope zone of Mahu sag were studied by the interpretation of seismic and drilling data. Two types of faults, normal and strike-slip, are developed in the middle-shallow layers of the slope zone of the Mahu sag and they are mostly active in the Yanshanian period. They are divided into four grade faults: The grade I strike-slip faults with NWW to near EW direction are related to the left-lateral transpressive fault zones in the northwest of Junggar Basin since the end of the Triassic. The grade II faults with NE to NNE direction are the normal faults located at the junction of the fault zone and the slope zone, and their formation is related to the extension at the top of the nose-like structures in the fault zone. The grade III faults, which are also the normal faults, are the result of the extension at the top of the lower uplifts in the slope zone and differential compaction. The grade IV faults with NE direction are normal faults, which may be related to the extension environment at the tip of the lower uplifts. Faults not only are the channel for the vertical migration of oil and gas, but also control the oil-gas accumulation. There are two types of oil-gas reservoirs in the middle-shallow layers of slope zone of Mahu sag: fault block reservoirs and fault-lithologic reservoirs. They have large traps and promising exploration potential.
文摘The two-dimensional cellular detonation propagating in a channel with area-changing cross section was numerically simulated with the dispersion-controlled dissipative scheme and a detailed chemical reaction model. Effects of the flow ex-pansion and compression on the cellular detonation cell were investigated to illus-trate the mechanism of the transverse wave development and the cellular detona-tion cell evolution. By examining gas composition variations behind the leading shock,the chemical reaction rate,the reaction zone length,and thermodynamic parameters,two kinds of the abnormal detonation waves were identified. To explore their development mechanism,chemical reactions,reflected shocks and rarefac-tion waves were discussed,which interact with each other and affect the cellular detonation in different ways.
文摘The 84 km Panama Canal connecting the Atlantic and Pacific oceans has historically been a strategic waterway for shipping and the location of United States (US) military bases. Since the construction of Lake Gatun reservoir, canal locks and navigation channel through the Isthmus of Panama tropical forests in the 1910s, chemicals, pesticides, and herbicides have been essential for controlling upland and wetland vegetation as well as managing mosquito-borne diseases. Chemicals and pesticides flowed into Lake Gatun via land surface runoff and subsurface drainage either attached to the sediment or in solution during the rainy season. Lake Gatun and the Panama Canal was the drinking water source for most of the civilian and military population living in the Panama Canal Zone. Between 1948 and 1999, US military base commanders had the ability to order, from the Federal Supply Catalog, commercially available herbicide 2,4,5-T with unknown amounts of dioxin TCDD for use on the military base grounds in the Panama Canal Zone. The herbicide 2,4,5-T was transported to Panama Canal Zone ports, including the ports Cristobal on the Caribbean and Balboa on the Pacific, and distributed to the US military bases in Panama by rail or truck. The US National Toxicology Program and the International Agency for the Research on Cancer listed dioxin and TCDD as known human carcinogens. Dioxins are endocrine disrupters and can cause certain chloracne, cancers, developmental and reproductive effects. In 1985, the United States government banned the manufacture of the herbicide 2,4,5-T, with unknown amounts of dioxin TCDD, after it was shown to cause cancer in animals. The objectives of this study are to determine: 1) the fate of dioxin TCDD, a contaminant in the herbicide 2,4,5-T, sprayed on the US military base vegetation in the Panama Canal Zone from 1948 to 1999, 2) the transport of dioxin TCDD rich sediment via soil erosion and overland flow into Lake Gatun and Panama Canal waterways and 3) the human health impacts of dioxin TCDD, a known carcinogen, on US military and Panamanian civilians exposed to dioxin TCDD in the Panama Canal Zone.
基金This research was supported by the Major Scientific and Technological Projects of CNPC under grant ZD2019-183-006the National Natural Science Foundation of China(42072234).The authors would like to appreciate all the people,who supported the data,testing,and analyses.Many thanks to the anonymous reviewers,whose comments improve the quality of our manuscript.
文摘A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults structure.Increasing numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation areas.This study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical modeling.Using three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation zones.Combined with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben basin.Integrating the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were summarized.Influenced by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:During the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale faults.During the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly developed.The junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation zones.During the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were furtherly inherited and developed.This stage was the molded and formative period of the FAZ,the low-order faults,and the depression in the DXFZ.
基金the National Natural Science Foundation of China(Grant Nos.91955206,41603038)Second Tibetan Plateau Scientific Expedition and Research program(Grant No.2019QZKK0803)+2 种基金Scientific Research Foundation for Advanced ScholarsWest Yunnan University of Applied Sciences(Grant No.2022RCKY0004)Yunnan Fundamental Research Projects(Grant No.202301AT070012).
文摘In this study,zircon U-Pb dating of volcanic rocks from the Zhongba ophiolite of the Yarlung Zangbo Suture Zone(YZSZ)in southern Xizang(Tibet)yielded an age of 247±3 Ma.According to whole rock geochemical and Sr-NdPb isotopic data,the Early Triassic samples could be divided into two groups:Group 1 with P-MORB affinity,showing initial^(87)Sr/^(86)Sr ratios of 0.70253–0.70602,ε_(Nd)(t)values of 4.2–5.3,(^(206)Pb/^(204)Pb)_(t)ratios of 16.353–18.222,(^(207)Pb/^(204)Pb)_(t)ratios of 15.454–15.564,and(^(208)Pb/^(204)Pb)_(t)ratios of 35.665–38.136;Group 2 with OIB affinity,showing initial^(87)Sr/^(86)Sr ratios of 0.70249–0.70513,ε_(Nd)(t)values of 4.4–4.9,(^(206)Pb/^(204)Pb)_(t)ratios of 17.140–18.328,(^(207)Pb/^(204)Pb)_(t)ratios of 15.491–15.575,and(^(208)Pb/^(204)Pb)_(t)ratios of 36.051–38.247.Group 2 rocks formed by partial melting of the mantle source enriched by a former plume,and assimilated continental crustal material during melt ascension.The formation of Group 1 rocks corresponds to the mixing of OIB melts,with the same components as Group 2 and N-MORBs.The Zhongba Early Triassic rocks belong to the continental margin type ophiolite and formed in the continental–oceanic transition zone during the initial opening of the Neo-Tethys in southern Xizang(Tibet).