Forkhead box P3(FOXP3)^+regulatory T(Treg)cells are crucial for the homeostasis of the immune system,and harbor suppressive capacities of which are maintained by or inherited with distinct epigenetic signatures.The fu...Forkhead box P3(FOXP3)^+regulatory T(Treg)cells are crucial for the homeostasis of the immune system,and harbor suppressive capacities of which are maintained by or inherited with distinct epigenetic signatures.The functional features of Treg cells are facilitated by multiple T cell differentiation-related transcription factors that therefore endow them with adaption capability to dynamic microenvironments.Recent studies also recalled the importance of immune cell metabolism,which is intimately linked with Treg cell differentiation,proliferation and function.Understanding the molecular mechanism underlying the functional stability of Treg cells could provide therapeutic opportunities to treat major human inflammatory diseases including infection,autoimmunity,allergy and cancer.展开更多
It is of great interest to allocate redundant component(s)in a coherent system in order to optimize the lifetime of the resulting system in reliability engineering,and system security.This topic has posed many interes...It is of great interest to allocate redundant component(s)in a coherent system in order to optimize the lifetime of the resulting system in reliability engineering,and system security.This topic has posed many interesting theoretical problems to which many researchers have devoted themselves in the past decades.In this article,we aim to review some recent results on the problem of optimal allocations of active[standby]redundancies in coherent systems.Some open problems in this research line are posed as well.Here we highlight the stochastic orderings as a powerful tool in our discussion.展开更多
基金supported by the National Basic Research Program of China(Grant Nos.2014CB541803 and 2014CB541903)the National Natural Science Foundation of China(Grant Nos.81330072,31370863,31200647,81271835 and 81161120417)the National Science and Technology Major Project(Grant Nos.2012ZX10002007-003 and STCSM 14JC1406100)
文摘Forkhead box P3(FOXP3)^+regulatory T(Treg)cells are crucial for the homeostasis of the immune system,and harbor suppressive capacities of which are maintained by or inherited with distinct epigenetic signatures.The functional features of Treg cells are facilitated by multiple T cell differentiation-related transcription factors that therefore endow them with adaption capability to dynamic microenvironments.Recent studies also recalled the importance of immune cell metabolism,which is intimately linked with Treg cell differentiation,proliferation and function.Understanding the molecular mechanism underlying the functional stability of Treg cells could provide therapeutic opportunities to treat major human inflammatory diseases including infection,autoimmunity,allergy and cancer.
基金supported by the National Natural Science Foundation of China(Grant Nos.11422109and 11271169)Natural Science Foundation of Jiangsu Province(Grant No.BK20141145)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘It is of great interest to allocate redundant component(s)in a coherent system in order to optimize the lifetime of the resulting system in reliability engineering,and system security.This topic has posed many interesting theoretical problems to which many researchers have devoted themselves in the past decades.In this article,we aim to review some recent results on the problem of optimal allocations of active[standby]redundancies in coherent systems.Some open problems in this research line are posed as well.Here we highlight the stochastic orderings as a powerful tool in our discussion.
