Single atom catalysts have been recognized as potential catalysts to fabricate electrochemical biosensors,due to their unexpected catalytic selectivity and activity.Here,we designed and fabricated an ultrasensitive do...Single atom catalysts have been recognized as potential catalysts to fabricate electrochemical biosensors,due to their unexpected catalytic selectivity and activity.Here,we designed and fabricated an ultrasensitive dopamine(DA)sensor based on the flower-like MoS_(2) embellished with single Ni site catalyst(Ni-MoS_(2)).The limit of detection could achieve 1 pM in phosphate buffer solution(PBS,pH=7.4),1 pM in bovine serum(pH=7.4),and 100 pM in artificial urine(pH=6.8).The excellent sensing performance was attributed to the Ni single atom axial anchoring on the Mo atom in the MoS_(2) basal plane with the Ni-S_(3) structure.Both the experiment and density functional theory(DFT)results certify that this structural feature is more favorable for the adsorption and electron transfer of DA on Ni atoms.The high proportion of Ni active sites on MoS_(2) basal plane effectively enhanced the intrinsic electronic conductivity and electrochemical activity toward DA.The successful establishment of this sensor gives a new guide to expand the field of single atom catalyst in the application of biosensors.展开更多
基金This work was supported by China Ministry of Science and Technology(No.2021YFA1500404)the Anhui Provincial Natural Science Foundation(Nos.2108085QB70 and 2108085UD06)+4 种基金the DNL Cooperation Fund,CAS(No.DNL201918)the Collaborative Innovation Program of Hefei Science Center,CAS(No.2021HSC-CIP002)the Natural Science Foundation of Hefei,China(No.2021044)the Fundamental Research Funds for the Central Universities(Nos.WK2060000004,WK2060000021,WK2060000025,KY2060000180,and KY2060000195)the Fundamental Research Funds for the Central Universities(No.WK5290000003)。
文摘Single atom catalysts have been recognized as potential catalysts to fabricate electrochemical biosensors,due to their unexpected catalytic selectivity and activity.Here,we designed and fabricated an ultrasensitive dopamine(DA)sensor based on the flower-like MoS_(2) embellished with single Ni site catalyst(Ni-MoS_(2)).The limit of detection could achieve 1 pM in phosphate buffer solution(PBS,pH=7.4),1 pM in bovine serum(pH=7.4),and 100 pM in artificial urine(pH=6.8).The excellent sensing performance was attributed to the Ni single atom axial anchoring on the Mo atom in the MoS_(2) basal plane with the Ni-S_(3) structure.Both the experiment and density functional theory(DFT)results certify that this structural feature is more favorable for the adsorption and electron transfer of DA on Ni atoms.The high proportion of Ni active sites on MoS_(2) basal plane effectively enhanced the intrinsic electronic conductivity and electrochemical activity toward DA.The successful establishment of this sensor gives a new guide to expand the field of single atom catalyst in the application of biosensors.
