Poincare dispersed dot plot was an important method in studying heart nonlinear state and rate variability(HRV). Based on the shape of Poincare dispersed dot plot, we proposed four quantitative parameters, introduced ...Poincare dispersed dot plot was an important method in studying heart nonlinear state and rate variability(HRV). Based on the shape of Poincare dispersed dot plot, we proposed four quantitative parameters, introduced the method and algorithm how to get them, and tested them with clinical and animal experiment data. The result showed that these four parameters have certain idiosyncrasy with different heart diseases, and the animal experiment result also showed that these parameters were changed remarkably after coronary artery ligation compared with before, which indicated these parameters might be useful for clinical diagnosis. Because the algorithm we used was based only on the shape of the graph, one can apply this algorithm on any other type of graphs like Poincare dispersed dot plot.展开更多
Neisseria meningitidis is the agent of invasive meningococcal disease, including cerebral meningitis and septicemia. Because the diseases caused by different clonal groups （sequence types） have their own epidemiolog...Neisseria meningitidis is the agent of invasive meningococcal disease, including cerebral meningitis and septicemia. Because the diseases caused by different clonal groups （sequence types） have their own epidemiological characteristics, it is important to understand the differences among the genomes of the N. meningitidis clonal groups. To this end, a novel interpretation of a structural dot plot of genomes was devised and applied; exact nu- cleotide matches between the genomes ofN. meningitidis serogroup A strain Z2491 and serogroup B strain MC58 were identified, leading to the specification of various structural regions. Known and putative virulence genes for each N. meningitidis strain were then classified into these regions. We found that virulence genes of MC58 tend more to the translocated regions （chromosomal segments in new sequence contexts） than do those of Z2491, notably tending towards the interface between one of the translocated regions and the collinear region. Within the col- linear region, virulence genes tend to occur within 16 kb of gaps in the exact matches. Verification of these tendencies using genes clustered in the cps locus was sufficiently supportive to suggest that these tendencies can be used to focus the search for and understanding of virulence genes and mechanisms of pathogenicity in these two organisms.展开更多
基金This project is supported by the National Natural Science Foundation of China(No.3 9970 2 0 5)
文摘Poincare dispersed dot plot was an important method in studying heart nonlinear state and rate variability(HRV). Based on the shape of Poincare dispersed dot plot, we proposed four quantitative parameters, introduced the method and algorithm how to get them, and tested them with clinical and animal experiment data. The result showed that these four parameters have certain idiosyncrasy with different heart diseases, and the animal experiment result also showed that these parameters were changed remarkably after coronary artery ligation compared with before, which indicated these parameters might be useful for clinical diagnosis. Because the algorithm we used was based only on the shape of the graph, one can apply this algorithm on any other type of graphs like Poincare dispersed dot plot.
文摘Neisseria meningitidis is the agent of invasive meningococcal disease, including cerebral meningitis and septicemia. Because the diseases caused by different clonal groups （sequence types） have their own epidemiological characteristics, it is important to understand the differences among the genomes of the N. meningitidis clonal groups. To this end, a novel interpretation of a structural dot plot of genomes was devised and applied; exact nu- cleotide matches between the genomes ofN. meningitidis serogroup A strain Z2491 and serogroup B strain MC58 were identified, leading to the specification of various structural regions. Known and putative virulence genes for each N. meningitidis strain were then classified into these regions. We found that virulence genes of MC58 tend more to the translocated regions （chromosomal segments in new sequence contexts） than do those of Z2491, notably tending towards the interface between one of the translocated regions and the collinear region. Within the col- linear region, virulence genes tend to occur within 16 kb of gaps in the exact matches. Verification of these tendencies using genes clustered in the cps locus was sufficiently supportive to suggest that these tendencies can be used to focus the search for and understanding of virulence genes and mechanisms of pathogenicity in these two organisms.
