Electrochemical behaviours of Europium-ferrocene derivative complex chemically modified electrodes were studied in the paper. Various factors which affect the voltammetry of the thin film modified electrodes, and the...Electrochemical behaviours of Europium-ferrocene derivative complex chemically modified electrodes were studied in the paper. Various factors which affect the voltammetry of the thin film modified electrodes, and the charge transport process of the thin film electrode were discussed. Size of the hydrated anion (counter ion), concentration of the electrolyte, swelling property of the film in the solvent and thickness of the film have significant effects on the voltammetry of the thin film electrode. Electrochemical behaviours of europium-ferrocene derivative compelx chemically modified electrode were studied in an aqueous solution. When scan ning between 0-0.8 V (vs. SCE), experimental results indicate that the chemically modified electrode has good stability and reproducibility. The apparent rate constant of electrode reaction is deteminedd to be 6.7×10-1 s-1.展开更多
The rates of electron exchange between oxidized and reduced forms of sev- eral derivatives of ferrocene(1-3)have been measured in acetonitrile by the NMR line h(?)oadening method at 25℃。It was found that the r(?)tes...The rates of electron exchange between oxidized and reduced forms of sev- eral derivatives of ferrocene(1-3)have been measured in acetonitrile by the NMR line h(?)oadening method at 25℃。It was found that the r(?)tes vary with the lengtn of the substitutent chain and the potential of E_(Fe(Ⅲ)/Fe(Ⅱ))in the ferrocene derivatives.展开更多
Ethynylferrocene and iodoethynylferrocene were prepared in high yield as 88-90% through a one-pot procedure. 1, 1'-diiodoferrocenylene was in-situ prepared from reaction of CHI3 PPh3, t-BuOK and ferrocenecarboxald...Ethynylferrocene and iodoethynylferrocene were prepared in high yield as 88-90% through a one-pot procedure. 1, 1'-diiodoferrocenylene was in-situ prepared from reaction of CHI3 PPh3, t-BuOK and ferrocenecarboxaldehyde, further reaction with t-BuOK or n-BuLi gave the title compounds.展开更多
On the basis of investigation of molecular structure characteristics of model ferrocene derivatives, the correlation between stability and molecular structure of double-core ferrocene derivatives （DFDs） was studied....On the basis of investigation of molecular structure characteristics of model ferrocene derivatives, the correlation between stability and molecular structure of double-core ferrocene derivatives （DFDs） was studied. Then, the relation of stability of DFDs and impact sensitivity of fine-AP/DFD mixtures was investigated. The results showed that the DFDs with methylene bridge group were more stable than those with methylethylidene bridge group. The stability order of the five DFDs was DEFM〉EDFM≈BDFM〉GFP〉TBPF. The impact sensitivities of the fine-AP/DFD mixtures were in inverse proportion to the stabilities of the DFDs.展开更多
The sol-gel derived glucose biosensor was developed, and the sol-gel membrane was organically modified by N-（3-triethoxysilylpropyl）-ferrocenylmethylamine （FcSi） as sol-gel precursor to make electrochemical biosen...The sol-gel derived glucose biosensor was developed, and the sol-gel membrane was organically modified by N-（3-triethoxysilylpropyl）-ferrocenylmethylamine （FcSi） as sol-gel precursor to make electrochemical biosensor. The structure of biosensor was sol-gel/FcSi＋GOx/GC type （glucose oxidase, GOx）. The ferrocene mediator was chemically immobilized to the silane network, and GOx was entrapped to the sol-gel glass network. Therefore, these structures prevented mediator leakage and retained the enzyme activity. Additionally, pH of electrolyte, temperature effects, and interference of positive substances with biosensor were investigated. And the electrochemical performance of biosensor was studied by amperometry. The results indicated that the linear range, detection limit. and response slope of biosensor was 2.00×10^-4-1.57×10^-3 mol·L^-1, 2.0×10^-4 mol·L^-1 and 5.06×10^5 nA·mol^- 1·L, respectively.展开更多
1 Results In order to obtain liquid crystals including an ion atom as a transition metal, the ferrocene derivatives containing mesogenic group were designed with a view to prevent great bulk of ferrocenyl moiety in th...1 Results In order to obtain liquid crystals including an ion atom as a transition metal, the ferrocene derivatives containing mesogenic group were designed with a view to prevent great bulk of ferrocenyl moiety in the molecules, because rod-like molecular shape is preferable to show liquid crystallinity. Therefore, methylene chain was installed as a flexible spacer between ferocenyl moiety and mesogenic one. As a result, a lot of liquid crystalline ferrocene derivatives were synthesized successfully. Si...展开更多
Antimicrobial resistance has now become a very serious global public health problem. New drug discovery and development are urgently needed to combat the growing threat of multidrug-resistant (MDR) bacteria. The aim o...Antimicrobial resistance has now become a very serious global public health problem. New drug discovery and development are urgently needed to combat the growing threat of multidrug-resistant (MDR) bacteria. The aim of this study was to explore the potential application of three ferrocene-carborane derivatives as new promising agents to confront the problem of increasing antibiotic resistance. The results of agar diffusion bioassay, minimal inhibitory concentrations (MIC) testing and time-kill assay illustrate their broad-spectrum antimicrobial activities to both American Type Culture Collection (ATCC) control strains and MDR clinical isolates. It is evident that the relevant antimicrobial properties are all in a dose-dependent manner and gradually transform into a bactericidal effect from a bacteriostatic effect with the increasing of the drug concentration. Furthermore, these ferrocene-carborane derivatives have no/little toxic effect on normal cells like HELF cells and lead to little hemolysis at their MICs. This raises the possibility to develop novel antimicrobial drugs using these new ferrocene carborane derivants.展开更多
文摘Electrochemical behaviours of Europium-ferrocene derivative complex chemically modified electrodes were studied in the paper. Various factors which affect the voltammetry of the thin film modified electrodes, and the charge transport process of the thin film electrode were discussed. Size of the hydrated anion (counter ion), concentration of the electrolyte, swelling property of the film in the solvent and thickness of the film have significant effects on the voltammetry of the thin film electrode. Electrochemical behaviours of europium-ferrocene derivative compelx chemically modified electrode were studied in an aqueous solution. When scan ning between 0-0.8 V (vs. SCE), experimental results indicate that the chemically modified electrode has good stability and reproducibility. The apparent rate constant of electrode reaction is deteminedd to be 6.7×10-1 s-1.
文摘The rates of electron exchange between oxidized and reduced forms of sev- eral derivatives of ferrocene(1-3)have been measured in acetonitrile by the NMR line h(?)oadening method at 25℃。It was found that the r(?)tes vary with the lengtn of the substitutent chain and the potential of E_(Fe(Ⅲ)/Fe(Ⅱ))in the ferrocene derivatives.
基金key basic research grants in Ninth Five-year Plan of Chinese Academy of Sciences,the National Natural Science Foundation under 20074036.
文摘Ethynylferrocene and iodoethynylferrocene were prepared in high yield as 88-90% through a one-pot procedure. 1, 1'-diiodoferrocenylene was in-situ prepared from reaction of CHI3 PPh3, t-BuOK and ferrocenecarboxaldehyde, further reaction with t-BuOK or n-BuLi gave the title compounds.
基金We are grateful for the financial support from the joint fund of the National Natural Science Foundation Committee of China Academy of Engineering Physics （NSAF） （No. U1230102）.
文摘On the basis of investigation of molecular structure characteristics of model ferrocene derivatives, the correlation between stability and molecular structure of double-core ferrocene derivatives （DFDs） was studied. Then, the relation of stability of DFDs and impact sensitivity of fine-AP/DFD mixtures was investigated. The results showed that the DFDs with methylene bridge group were more stable than those with methylethylidene bridge group. The stability order of the five DFDs was DEFM〉EDFM≈BDFM〉GFP〉TBPF. The impact sensitivities of the fine-AP/DFD mixtures were in inverse proportion to the stabilities of the DFDs.
文摘The sol-gel derived glucose biosensor was developed, and the sol-gel membrane was organically modified by N-（3-triethoxysilylpropyl）-ferrocenylmethylamine （FcSi） as sol-gel precursor to make electrochemical biosensor. The structure of biosensor was sol-gel/FcSi＋GOx/GC type （glucose oxidase, GOx）. The ferrocene mediator was chemically immobilized to the silane network, and GOx was entrapped to the sol-gel glass network. Therefore, these structures prevented mediator leakage and retained the enzyme activity. Additionally, pH of electrolyte, temperature effects, and interference of positive substances with biosensor were investigated. And the electrochemical performance of biosensor was studied by amperometry. The results indicated that the linear range, detection limit. and response slope of biosensor was 2.00×10^-4-1.57×10^-3 mol·L^-1, 2.0×10^-4 mol·L^-1 and 5.06×10^5 nA·mol^- 1·L, respectively.
文摘1 Results In order to obtain liquid crystals including an ion atom as a transition metal, the ferrocene derivatives containing mesogenic group were designed with a view to prevent great bulk of ferrocenyl moiety in the molecules, because rod-like molecular shape is preferable to show liquid crystallinity. Therefore, methylene chain was installed as a flexible spacer between ferocenyl moiety and mesogenic one. As a result, a lot of liquid crystalline ferrocene derivatives were synthesized successfully. Si...
基金supported by the National Natural Science Foundation of China (21175020)National Key Basic Research Program (2010CB732404)+4 种基金Doctoral Fund of Ministry of Education of China (20090092110028)National High Technology Research and Development Program(2007AA022007)Guangdong Province (2011B090400357)Graduate Research and Innovation Program of Jiangsu Province (CXLX_0145)State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
文摘Antimicrobial resistance has now become a very serious global public health problem. New drug discovery and development are urgently needed to combat the growing threat of multidrug-resistant (MDR) bacteria. The aim of this study was to explore the potential application of three ferrocene-carborane derivatives as new promising agents to confront the problem of increasing antibiotic resistance. The results of agar diffusion bioassay, minimal inhibitory concentrations (MIC) testing and time-kill assay illustrate their broad-spectrum antimicrobial activities to both American Type Culture Collection (ATCC) control strains and MDR clinical isolates. It is evident that the relevant antimicrobial properties are all in a dose-dependent manner and gradually transform into a bactericidal effect from a bacteriostatic effect with the increasing of the drug concentration. Furthermore, these ferrocene-carborane derivatives have no/little toxic effect on normal cells like HELF cells and lead to little hemolysis at their MICs. This raises the possibility to develop novel antimicrobial drugs using these new ferrocene carborane derivants.
