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Jet formation and penetration performance of a double-layer charge liner with chemically-deposited tungsten as the inner liner 被引量:2
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作者 Bihui Hong Wenbin Li +2 位作者 Yiming Li Zhiwei Guo Binyou Yan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期374-385,共12页
This paper proposes a type of double-layer charge liner fabricated using chemical vapor deposition(CVD)that has tungsten as its inner liner.The feasibility of this design was evaluated through penetration tests.Double... This paper proposes a type of double-layer charge liner fabricated using chemical vapor deposition(CVD)that has tungsten as its inner liner.The feasibility of this design was evaluated through penetration tests.Double-layer charge liners were fabricated by using CVD to deposit tungsten layers on the inner surfaces of pure T2 copper liners.The microstructures of the tungsten layers were analyzed using a scanning electron microscope(SEM).The feasibility analysis was carried out by pulsed X-rays,slug-retrieval test and static penetration tests.The shaped charge jet forming and penetration law of inner tungsten-coated double-layer liner were studied by numerical simulation method.The results showed that the double-layer liners could form well-shaped jets.The errors between the X-ray test results and the numerical results were within 11.07%.A slug-retrieval test was found that the retrieved slug was similar to a numerically simulated slug.Compared with the traditional pure copper shaped charge jet,the penetration depth of the double-layer shaped charge liner increased by 11.4% and>10.8% respectively.In summary,the test results are good,and the numerical simulation is in good agreement with the test,which verified the feasibility of using the CVD method to fabricate double-layer charge liners with a high-density and high-strength refractory metal as the inner liner. 展开更多
关键词 Shaped charge Chemical vapor deposition TUNGSTEN double-layer charge liner X-ray PENETRATION
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Discovery and Significance of the Triassic–Late Paleozoic Double-layered Basement in the Songliao Basin:Based on the Complete Coring Data from ICDP Borehole SK2
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作者 YANG Zhuolong WANG Pujun +2 位作者 GAO Youfeng GAO Chuancheng TANG Xin 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第S01期75-76,共2页
The Songliao Basin(SLB)covers an area of approximately 260,000 km2in northeastern Asia and preserves a continuous and complete Cretaceous terrestrial record(Wang et al.,2021).The region is the most important petrolife... The Songliao Basin(SLB)covers an area of approximately 260,000 km2in northeastern Asia and preserves a continuous and complete Cretaceous terrestrial record(Wang et al.,2021).The region is the most important petroliferous sedimentary basin in China because of its continual annual oil and gas equivalent production of tens of millions of tons(ca.220–440 million barrels per year)since 1959.The SLB was previously thought to have developed on Hercynian basement and accumulated continuous sedimentary deposits during the Late Jurassic and Cretaceous(Wan et al.,2013;Wang et al.,2016). 展开更多
关键词 double-layered basement ICDP Triassic and Paleozoic Songliao Basin
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Performance and Application of Double-layered Microcapsule Corrosion Inhibitors
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作者 余海燕 WANG Yingxiang +2 位作者 WANG Ruizhi HU Lintong WANG Tianlei 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第4期845-853,共9页
Double-layered microcapsule corrosion inhibitors were developed by sodium monofluorophosphate as the core material,polymethyl methacrylate as the inner wall material,and polyvinyl alcohol as the outer wall material co... Double-layered microcapsule corrosion inhibitors were developed by sodium monofluorophosphate as the core material,polymethyl methacrylate as the inner wall material,and polyvinyl alcohol as the outer wall material combining the solvent evaporation method and spray drying method.The protection by the outer capsule wall was used to prolong the service life of the corrosion inhibitor.The dispersion,encapsulation,thermal stability of microcapsules,and the degradation rate of capsule wall in concrete pore solution were analyzed by ultra-deep field microscopy,scanning electron microscopy,thermal analyzer,and sodium ion release rate analysis.The microcapsules were incorporated into mortar samples containing steel reinforcement,and the effects of double-layered microcapsule corrosion inhibitors on the performance of the cement matrix and the actual corrosion-inhibiting effect were analyzed.The experimental results show that the double-layered microcapsules have a moderate particle size and uniform distribution,and the capsules were completely wrapped.The microcapsules as a whole have good thermal stability below 230 ℃.The monolayer membrane structure microcapsules completely broke within 1 day in the simulated concrete pore solution,and the double-layer membrane structure prolonged the service life of the microcapsules to 80 days in the simulated concrete pore solution before the core material was completely released.The mortar samples containing steel reinforcement incorporated with the double-layered microcapsule corrosion inhibitors still maintained a higher corrosion potential than the monolayer microcapsule corrosion inhibitors control group at 60 days.The incorporation of double-layered microcapsules into the cement matrix has no significant adverse effect on the setting time and early strength. 展开更多
关键词 corrosion inhibitors MICROCAPSULE double-layer structure potentiodynamic polarization curve
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CONVEXITY OF THE FREE BOUNDARY FOR AN AXISYMMETRIC INCOMPRESSIBLE IMPINGING JET
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作者 王晓慧 《Acta Mathematica Scientia》 SCIE CSCD 2024年第1期234-246,共13页
This paper is devoted to the study of the shape of the free boundary for a threedimensional axisymmetric incompressible impinging jet.To be more precise,we will show that the free boundary is convex to the fluid,provi... This paper is devoted to the study of the shape of the free boundary for a threedimensional axisymmetric incompressible impinging jet.To be more precise,we will show that the free boundary is convex to the fluid,provided that the uneven ground is concave to the fluid. 展开更多
关键词 Euler system axisymmetric impinging jet INCOMPRESSIBLE free boundary convexity
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Time-sequenced damage behavior of reactive projectile impacting double-layer plates
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作者 Ying Yuan Yi-qiang Cai +3 位作者 Huan-guo Guo Peng-wan Chen Rui Liu Hai-fu Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第9期263-272,共10页
The time-sequenced damage behavior of the reactive projectile impacting double-layer plates is discussed.The analytical model considering the combined effect of kinetic and chemical energy is developed to reveal the d... The time-sequenced damage behavior of the reactive projectile impacting double-layer plates is discussed.The analytical model considering the combined effect of kinetic and chemical energy is developed to reveal the damage mechanism.The influences of impact velocity and reactive projectile chemical characteristics on the damage effect are decoupled analyzed based on this model.These analyses indicate that the high energy releasing efficiency and fast reaction propagation velocity of the reactive projectile are conducive to enhancing the damage effect.The experiments with various reactive projectiles impact velocity increasing from 702 to 1385 m/s were conducted to verify this model.The experimental results presented that,the damage hole radius of the rear-plate increases with the increase of impact velocity.At the impact velocity of 1350 m/s,the radius of damage hole formed by PTFE/Al/Bi_(2)O_(3),PTFE/Al/MoO_(3),PTFE/Al/Fe_(2)O_(3)projectile on the rear-plate become smaller in sequence.These results are consistent with the analytical model prediction,demonstrating that this model can predict the damage effect quantitatively.This work is of constructive significance to the application of reactive projectiles. 展开更多
关键词 Reactive projectile Damage behaviors Impact double-layer plates
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Gas-and plasma-driven hydrogen permeation behavior of stagnant eutectic-solid GaInSn/Fe double-layer structure
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作者 荆文娜 刘建星 +8 位作者 郭恒鑫 王思蜀 毕海林 陈波 陈建军 王宏彬 韦建军 叶宗标 芶富均 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第4期482-492,共11页
Gas-driven permeation(GDP)and plasma-driven permeation(PDP)of hydrogen gas through Ga In Sn/Fe are systematically investigated in this work.The permeation parameters of hydrogen through Ga In Sn/Fe,including diffusivi... Gas-driven permeation(GDP)and plasma-driven permeation(PDP)of hydrogen gas through Ga In Sn/Fe are systematically investigated in this work.The permeation parameters of hydrogen through Ga In Sn/Fe,including diffusivity,Sieverts'constant,permeability,and surface recombination coefficient are obtained.The permeation flux of hydrogen through Ga In Sn/Fe shows great dependence on external conditions such as temperature,hydrogen pressure,and thickness of liquid Ga In Sn.Furthermore,the hydrogen permeation behavior through Ga In Sn/Fe is well consistent with the multilayer permeation theory.In PDP and GDP experiments,hydrogen through Ga In Sn/Fe satisfies the diffusion-limited regime.In addition,the permeation flux of PDP is greater than that of GDP.The increase of hydrogen plasma density hardly causes the hydrogen PDP flux to change within the test scope of this work,which is due to the dissolution saturation.These findings provide guidance for a comprehensive and systematic understanding of hydrogen isotope recycling,permeation,and retention in plasma-facing components under actual conditions. 展开更多
关键词 liquid metals double-layer gas-driven permeation plasma-driven permeation
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Preparation and Microwave Absorbing Properties of Double-layer Fine Iron Tailings Cementitious Materials
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作者 LI Huawei WANG Rong +3 位作者 WANG Yulin LIU Feiyu WANG Qian WEI Muwang 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2023年第5期1126-1135,共10页
To develop the microwave absorbing(MA)properties of cementitious material mixed with mine solid waste,the iron tailings cementitious microwave absorbing materials were prepared.The iron tailings was treated into diffe... To develop the microwave absorbing(MA)properties of cementitious material mixed with mine solid waste,the iron tailings cementitious microwave absorbing materials were prepared.The iron tailings was treated into different particle sizes by planetary ball mill,and the physicochemical properties of iron tailings were tested by laser particle size analyzer and scanning electron microscope(SEM).The electromagnetic parameters of iron tailings cementitious materials were characterized by a vector network analyzer and simulated MA properties,and the MA properties of iron tailings-cement composite system with steel fiber as absorber was studied.Based on the design of the single-layer structure,optimum mix ratio and thickness configuration method of double-layer structure were further studied,meanwhile,the mechanical properties and engineering application were analyzed and discussed.The results show that the particle size of iron tailings can afiect its electromagnetic behavior in cementitious materials,and the smaller particles lead the increase of demagnetisation efiect induced by domain wall motion and achieve better microwave absorbing properties in cementitious materials.When the thickness of matching layer and absorbing layer is 5 mm,the optimized microwave absorbing properties of C1/C3 double-layer cementitious material can obtain optimal RL value of-27.61 dB and efiective absorbing bandwidth of 0.97 GHz,which attributes to the synergistic efiect of impedance matching and attenuation characteristics.The double-layer microwave absorbing materials obtain excellent absorbing properties and show great design flexibility and diversity,which can be used as a suitable candidate for the preparation of favorable microwave absorbing cementitious materials. 展开更多
关键词 microwave absorbing properties iron tailings electromagnetic parameters single-layer structure double-layer structure impedance matching
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Double-Layer-Optimizing Method of Hybrid Energy Storage Microgrid Based on Improved Grey Wolf Optimization
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作者 Xianjing Zhong Xianbo Sun Yuhan Wu 《Computers, Materials & Continua》 SCIE EI 2023年第8期1599-1619,共21页
To reduce the comprehensive costs of the construction and operation of microgrids and to minimize the power fluctuations caused by randomness and intermittency in distributed generation,a double-layer optimizing confi... To reduce the comprehensive costs of the construction and operation of microgrids and to minimize the power fluctuations caused by randomness and intermittency in distributed generation,a double-layer optimizing configuration method of hybrid energy storage microgrid based on improved grey wolf optimization(IGWO)is proposed.Firstly,building a microgrid system containing a wind-solar power station and electric-hydrogen coupling hybrid energy storage system.Secondly,the minimum comprehensive cost of the construction and operation of the microgrid is taken as the outer objective function,and the minimum peak-to-valley of the microgrid’s daily output is taken as the inner objective function.By iterating through the outer and inner layers,the system improves operational stability while achieving economic configuration.Then,using the energy-self-smoothness of the microgrid as the evaluation index,a double-layer optimizing configuration method of the microgrid is constructed.Finally,to improve the disadvantages of grey wolf optimization(GWO),such as slow convergence in the later period and easy falling into local optima,by introducing the convergence factor nonlinear adjustment strategy and Cauchy mutation operator,an IGWO with excellent global performance is proposed.After testing with the typical test functions,the superiority of IGWO is verified.Next,using IGWO to solve the double-layer model.The case analysis shows that compared to GWO and particle swarm optimization(PSO),the IGWO reduced the comprehensive cost by 15.6%and 18.8%,respectively.Therefore,the proposed double-layer optimizationmethod of capacity configuration ofmicrogrid with wind-solar-hybrid energy storage based on IGWO could effectively improve the independence and stability of the microgrid and significantly reduce the comprehensive cost. 展开更多
关键词 Wind-solar microgrid hybrid energy storage optimization configuration double-layer optimization model IGWO
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On the Application of Mixed Models of Probability and Convex Set for Time-Variant Reliability Analysis
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作者 Fangyi Li Dachang Zhu Huimin Shi 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期1981-1999,共19页
In time-variant reliability problems,there are a lot of uncertain variables from different sources.Therefore,it is important to consider these uncertainties in engineering.In addition,time-variant reliability problems... In time-variant reliability problems,there are a lot of uncertain variables from different sources.Therefore,it is important to consider these uncertainties in engineering.In addition,time-variant reliability problems typically involve a complexmultilevel nested optimization problem,which can result in an enormous amount of computation.To this end,this paper studies the time-variant reliability evaluation of structures with stochastic and bounded uncertainties using a mixed probability and convex set model.In this method,the stochastic process of a limit-state function with mixed uncertain parameters is first discretized and then converted into a timeindependent reliability problem.Further,to solve the double nested optimization problem in hybrid reliability calculation,an efficient iterative scheme is designed in standard uncertainty space to determine the most probable point(MPP).The limit state function is linearized at these points,and an innovative random variable is defined to solve the equivalent static reliability analysis model.The effectiveness of the proposed method is verified by two benchmark numerical examples and a practical engineering problem. 展开更多
关键词 Mixed uncertainty probability model convex model time-variant reliability analysis
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Distributed Stochastic Optimization with Compression for Non-Strongly Convex Objectives
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作者 Xuanjie Li Yuedong Xu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第4期459-481,共23页
We are investigating the distributed optimization problem,where a network of nodes works together to minimize a global objective that is a finite sum of their stored local functions.Since nodes exchange optimization p... We are investigating the distributed optimization problem,where a network of nodes works together to minimize a global objective that is a finite sum of their stored local functions.Since nodes exchange optimization parameters through the wireless network,large-scale training models can create communication bottlenecks,resulting in slower training times.To address this issue,CHOCO-SGD was proposed,which allows compressing information with arbitrary precision without reducing the convergence rate for strongly convex objective functions.Nevertheless,most convex functions are not strongly convex(such as logistic regression or Lasso),which raises the question of whether this algorithm can be applied to non-strongly convex functions.In this paper,we provide the first theoretical analysis of the convergence rate of CHOCO-SGD on non-strongly convex objectives.We derive a sufficient condition,which limits the fidelity of compression,to guarantee convergence.Moreover,our analysis demonstrates that within the fidelity threshold,this algorithm can significantly reduce transmission burden while maintaining the same convergence rate order as its no-compression equivalent.Numerical experiments further validate the theoretical findings by demonstrating that CHOCO-SGD improves communication efficiency and keeps the same convergence rate order simultaneously.And experiments also show that the algorithm fails to converge with low compression fidelity and in time-varying topologies.Overall,our study offers valuable insights into the potential applicability of CHOCO-SGD for non-strongly convex objectives.Additionally,we provide practical guidelines for researchers seeking to utilize this algorithm in real-world scenarios. 展开更多
关键词 Distributed stochastic optimization arbitrary compression fidelity non-strongly convex objective function
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Relaxed Stability Criteria for Time-Delay Systems:A Novel Quadratic Function Convex Approximation Approach
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作者 Shenquan Wang Wenchengyu Ji +2 位作者 Yulian Jiang Yanzheng Zhu Jian Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第4期996-1006,共11页
This paper develops a quadratic function convex approximation approach to deal with the negative definite problem of the quadratic function induced by stability analysis of linear systems with time-varying delays.By i... This paper develops a quadratic function convex approximation approach to deal with the negative definite problem of the quadratic function induced by stability analysis of linear systems with time-varying delays.By introducing two adjustable parameters and two free variables,a novel convex function greater than or equal to the quadratic function is constructed,regardless of the sign of the coefficient in the quadratic term.The developed lemma can also be degenerated into the existing quadratic function negative-determination(QFND)lemma and relaxed QFND lemma respectively,by setting two adjustable parameters and two free variables as some particular values.Moreover,for a linear system with time-varying delays,a relaxed stability criterion is established via our developed lemma,together with the quivalent reciprocal combination technique and the Bessel-Legendre inequality.As a result,the conservatism can be reduced via the proposed approach in the context of constructing Lyapunov-Krasovskii functionals for the stability analysis of linear time-varying delay systems.Finally,the superiority of our results is illustrated through three numerical examples. 展开更多
关键词 Equivalent reciprocal combination technique quadratic function convex approximation approach STABILITY timevarying delay
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Accelerated Primal-Dual Projection Neurodynamic Approach With Time Scaling for Linear and Set Constrained Convex Optimization Problems
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作者 You Zhao Xing He +1 位作者 Mingliang Zhou Tingwen Huang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第6期1485-1498,共14页
The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence rates.Most previous studies in this field have primarily concentrated on... The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence rates.Most previous studies in this field have primarily concentrated on unconstrained smooth con-vex optimization problems.In this paper,on the basis of primal-dual dynamical approach,Nesterov accelerated dynamical approach,projection operator and directional gradient,we present two accelerated primal-dual projection neurodynamic approaches with time scaling to address convex optimization problems with smooth and nonsmooth objective functions subject to linear and set constraints,which consist of a second-order ODE(ordinary differential equation)or differential conclusion system for the primal variables and a first-order ODE for the dual vari-ables.By satisfying specific conditions for time scaling,we demonstrate that the proposed approaches have a faster conver-gence rate.This only requires assuming convexity of the objective function.We validate the effectiveness of our proposed two accel-erated primal-dual projection neurodynamic approaches through numerical experiments. 展开更多
关键词 Accelerated projection neurodynamic approach lin-ear and set constraints projection operators smooth and nonsmooth convex optimization time scaling.
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Double-layer model updating for steel-concrete composite beam cable-stayed bridge based on GPS 被引量:1
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作者 刘云 钱振东 《Journal of Southeast University(English Edition)》 EI CAS 2008年第1期80-84,共5页
In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is p... In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system (GPS) data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response. 展开更多
关键词 steel-concrete composite beam GPS dynamic respond double-layer model updating
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Necessary and Sufficient Conditions in Smooth Programming with Generalized Convexity 被引量:1
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作者 孙清滢 叶留青 《Chinese Quarterly Journal of Mathematics》 CSCD 2000年第4期33-37,共5页
Hanson and Mond have grven sets of necessary and sufficient conditions for optimality in constrained optimization by introducing classes of generalized functions, called type Ⅰ functions. Recently, Bector definded un... Hanson and Mond have grven sets of necessary and sufficient conditions for optimality in constrained optimization by introducing classes of generalized functions, called type Ⅰ functions. Recently, Bector definded univex functions, a new class of functions that unifies several concepts of generalized convexity. In this paper, additional conditions are attached to the Kuhn Tucker conditions giving a set of conditions which are both necessary and sufficient for optimality in constrained optimization, under appropriate constraint qualifications. 展开更多
关键词 necessary and sufficient conditions generalized convexity nonlinear programming multiobjective programming type functions
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Computation of the Fatigue Life of Road Wheel with Double-Layer Rubber Flange
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作者 郑慕侨 孙逢春 +1 位作者 蒋轩 张军 《Journal of Beijing Institute of Technology》 EI CAS 2001年第2期169-174,共6页
In order to increase the fatigue life (FL) of road wheels (RW), a kind of double layer rubber flange (DLRF) is put forward. It consists of two layers of rubber, where metal wires are laid in the inner layer and the ou... In order to increase the fatigue life (FL) of road wheels (RW), a kind of double layer rubber flange (DLRF) is put forward. It consists of two layers of rubber, where metal wires are laid in the inner layer and the outer layer has no inlaid metal wires. Stress, strain and temperature field of DLRF were calculated with ANSYS finite element analysis (FEA) software, FL of DLRF RW was also computed with fracture mechanics fatigue theory. The results of computation indicate that the heat generated in RW's rubber flange (RF) can be reduced by the use of DLRF, and the FL of RW can be increased without affecting the mechanical intensity of RW. 展开更多
关键词 double-layer rubber flange road wheel finite element analysis fatigue life
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THE SCHUR HARMONIC CONVEXITY FOR A CLASS OF SYMMETRIC FUNCTIONS 被引量:13
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作者 褚玉明 孙天川 《Acta Mathematica Scientia》 SCIE CSCD 2010年第5期1501-1506,共6页
In this article, we prove that the symmetric function Fn(x,r)=∑i1+i2+……in=r(x1(i1x2^i2……xn^in)1/r is Schur harmonic convex for x ∈ R+n and r ∈N -=(1, 2, 3,...} As its applications, some analytic inequa... In this article, we prove that the symmetric function Fn(x,r)=∑i1+i2+……in=r(x1(i1x2^i2……xn^in)1/r is Schur harmonic convex for x ∈ R+n and r ∈N -=(1, 2, 3,...} As its applications, some analytic inequalities are established. 展开更多
关键词 symmetric function Schur convex Schur harmonic convex
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MONOTONICITY,CONVEXITY AND INEQUALITIES INVOLVING THE GENERALIZED ELLIPTIC INTEGRALS 被引量:5
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作者 Miaokun WANG Wen ZHANG Yuming CHU 《Acta Mathematica Scientia》 SCIE CSCD 2019年第5期1440-1450,共11页
We establish the monotonicity and convexity properties for several special functions involving the generalized elliptic integrals, and present some new analytic inequalities.
关键词 Gaussian HYPERGEOMETRIC function generalized ELLIPTIC INTEGRALS convexity inequality
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THE SCHUR CONVEXITY OF GINI MEAN VALUES IN THE SENSE OF HARMONIC MEAN 被引量:4
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作者 夏卫锋 褚玉明 《Acta Mathematica Scientia》 SCIE CSCD 2011年第3期1103-1112,共10页
We prove that the Gini mean values S(a,b; x,y) are Schur harmonic convex with respect to (x,y)∈(0,∞)×(0,∞) if and only if (a, b) ∈{(a, b):a≥0,a ≥ b,a+b+1≥0}∪{(a,b):b≥0,b≥a,a+b+1≥0} ... We prove that the Gini mean values S(a,b; x,y) are Schur harmonic convex with respect to (x,y)∈(0,∞)×(0,∞) if and only if (a, b) ∈{(a, b):a≥0,a ≥ b,a+b+1≥0}∪{(a,b):b≥0,b≥a,a+b+1≥0} and Schur harmonic concave with respect to (x,y) ∈ (0,∞)×(0,∞) if and only if (a,b)∈{(a,b):a≤0,b≤0,a|b|1≤0}. 展开更多
关键词 Gini mean values Schur convex Schur harmonic convex
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Double-layered osmotic pump controlled release tablets of actarit: In vitro and in vivo evaluation 被引量:7
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作者 Yuenan Li Hao Pan +6 位作者 Hongliang Duan Jianting Chen Zhihong Zhu Jingxin Fan Pingfei Li Xinggang Yang Weisan Pan 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2019年第3期340-348,共9页
The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor... The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation;the pharmacokinetic study was performed in beagle dogs adopting actarit common tablets as reference tablets. The optimal formulation was as follows: drug layer: 150 mg actarit, 240 mg PEO-N80, 50 mg NaCl;push layer: 140 mg PEO-WSR303, 20 mg NaCl;coating solution: 30 g cellulose acetate and 6 g PEG 4000 in 1000 ml 94% acetone solution, 60 mg coating weight gain. The pharmacokinetic study showed that T max was prolonged by the contrast of commercial common tablets with constant drug release rate, but the bioavailability was equivalent. And a good in vivo –in vitro correlation of the actarit osmotic pump tablets was also established. The designed actarit osmotic pump tablets can be applied for rheumatoid arthritis, proposing a promising replacement for the marked common products. 展开更多
关键词 Actarit double-layered OSMOTIC pump TABLET PHARMACOKINETICS In vivo –in VITRO correlation
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Double-layered covered stent for the treatment of malignant oesophageal obstructions: Systematic review and meta-analysis 被引量:2
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作者 Zeiad Hussain Athanasios Diamantopoulos +1 位作者 Miltiadis Krokidis Konstantinos Katsanos 《World Journal of Gastroenterology》 SCIE CAS 2016年第34期7841-7850,共10页
AIM To investigate the efficacy of double-layered covered stent in the treatment of malignant oesophageal obstructions.METHODS A systematic review and meta-analysis was performed following the PRISMA process. Pub Med(... AIM To investigate the efficacy of double-layered covered stent in the treatment of malignant oesophageal obstructions.METHODS A systematic review and meta-analysis was performed following the PRISMA process. Pub Med(Medline),EMBASE(Excerpta Medical Database),AMED(Allied and Complementary medicine Database),Scopus and online content,were searched for studies reporting on the Ni Ti-S polyurethane-covered double oesophageal stent for the treatment of malignant dysphagia. Weighted pooled outcomes were synthesized with a random effects model to account for clinical heterogeneity. All studies reporting the outcome of palliative management of dysphagia due to histologically confirmed malignant oesophageal obstruction using double-layered covered nitinol stent were included. The level of statistical significance was set at α = 0.05.RESULTS Six clinical studies comprising 250 patients in total were identified. Pooled technical success of stent insertion was 97.2%(95%CI: 94.8%-98.9%; I2 = 5.8%). Pooled complication rate was 27.6%(95%CI: 20.7%-35.2%; I2 = 41.9%). Weighted improvement of dysphagia on a scale of 0-5 scoring system was-2.00 [95%CI:-2.29%-(-1.72%); I2 = 87%]. Distal stent migration was documented in 10 out of the 250 cases examined.Pooled stent migration rate was 4.7%(95%CI: 2.5%-7.7%; I2 = 0%). Finally,tumour overgrowth was reported in 34 out of the 250 cases with pooled rate of tumour overgrowth of 11.2%(95%CI: 3.7%-22.1%; I2 = 82.2%). No funnel plot asymmetry to suggest publication bias(bias = 0.39,P = 0.78). In the sensitivity analysis all results were largely similar between the fixed and random effects models.CONCLUSION The double-layered nitinol stent provides immediate relief of malignant dysphagia with low rates of stent migration and tumour 展开更多
关键词 double-layered covered STENT MALIGNANT OESOPHAGEAL OBSTRUCTIONS Dysphagia double-layered nitinol STENT
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