By adjusting the bond angle and stereocontrol substituent of the chiral bicyclic imidazole catalysts,direct enantioselective C-acetylation of indolones and their sequencial pattern have been successfully developed.Ind...By adjusting the bond angle and stereocontrol substituent of the chiral bicyclic imidazole catalysts,direct enantioselective C-acetylation of indolones and their sequencial pattern have been successfully developed.Indolones bearing a quaternary stereocenter were synthesized with satisfactory yields and excellent enantioselectivities(up to 97%ee).The reaction can be realized with 410 turnover numbers,and the products can be transformed into several functional compounds via simple derivations of the acetyl group.展开更多
基金supported by the National Key R&D Program of China(grant no.2018YFE0126800)the National Natural Science Foundation of China(grant nos.21831005,91856106,21991112,and 22071150)+1 种基金the Shanghai Municipal Education Commission(grant no.201701070002E00030)the China Postdoctoral Science Foundation(grant no.2021M692058).
文摘By adjusting the bond angle and stereocontrol substituent of the chiral bicyclic imidazole catalysts,direct enantioselective C-acetylation of indolones and their sequencial pattern have been successfully developed.Indolones bearing a quaternary stereocenter were synthesized with satisfactory yields and excellent enantioselectivities(up to 97%ee).The reaction can be realized with 410 turnover numbers,and the products can be transformed into several functional compounds via simple derivations of the acetyl group.
