目的针对肿瘤患者经外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)相关血流感染(central line associated bloodstream infection,PICC-CLABSI)风险预测问题,利用Logistic回归和极限学习机(extreme learning ...目的针对肿瘤患者经外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)相关血流感染(central line associated bloodstream infection,PICC-CLABSI)风险预测问题,利用Logistic回归和极限学习机(extreme learning machine,ELM)分别建立预测模型并验证其预测效果。方法回顾性收集2019年1月至2023年3月在山西省某三级甲等综合医院肿瘤科接受PICC置管的1146例患者的临床病历资料,将2019年1月至2021年12月收集的786例PICC置管患者的临床病历资料作为建模组,将2022年1月2023年3月收集的360例患者的临床资料作为验证组。采用χ^(2)检验对建模组数据进行分析,将有统计学意义的变量进行Logistic回归分析,构建风险预测模型,并绘制列线图,采用Hosmer-Lemeshow检验和受试者工作特征(receiver operating characteristic,ROC)曲线下面积(area under the curve,AUC)评价该预测模型的拟合度及预测效果;将Logistic回归分析具有统计学意义的危险因素作为ELM预测模型的输入参数,肿瘤患者PICC-CLABSI发生风险作为输出参数,构建ELM预测模型;利用验证组数据对预测性能进行比较。结果(有)糖尿病史、化疗次数(≥3次)、维护周期(>7day)、维护地点(院外)、白细胞计数(<3.5×10^(9)/L)、白蛋白(<40g/L)是肿瘤患者发生经外周静脉置入中心静脉导管相关血流感染的风险因素(均P<0.05)。Logistic风险预测模型的Hosmer-Lemeshow检验结果显示:χ^(2)=5.201,P=0.736,AUC为0.860(95%CI:0.799~0.922),灵敏度是0.893,特异度是0.704,正确率为72.8%,表明模型具有良好的预测能力。ELM预测模型的决定系数为0.823,均方误差为0.051,模型的拟合度良好,正确率为74.5%,表明模型具有良好的预测能力。结论在Logistic回归分析筛选指标基础上建立的Logistic风险预测模型与ELM模型均具有较高的预测精度,可为临床医护人员筛查肿瘤PICC相关血流感染高危患者提供参考。展开更多
The authoros specialize in the field of optunization and automatic programme oftrain working graph. In this peper, at frist, a mixed 0-1 integer progranimingmodel about this problem for duuble-track lines is set up, t...The authoros specialize in the field of optunization and automatic programme oftrain working graph. In this peper, at frist, a mixed 0-1 integer progranimingmodel about this problem for duuble-track lines is set up, then the principle andProcess of selution are stated, with an application exaiiiple put forward.展开更多
A major concern in modern smart-phones and hand-held devices is a way of mitigating the time interval error (TIE) perceived at high-speed digital transits along the traces of the circuit-board (rigid and or flexible) ...A major concern in modern smart-phones and hand-held devices is a way of mitigating the time interval error (TIE) perceived at high-speed digital transits along the traces of the circuit-board (rigid and or flexible) used in baseband infrastructures. Indicated here is a way of adopting a planar fractal inductor configuration to improvise the necessary time-delay in the transits of digital signal phase jitter and reduce the TIE. This paper addresses systematic design considerations on fractal inductor geometry commensurate with practical aspects of its implementation as delaylines in the high-speed digital transports at the baseband operations of smart-phone infrastructures. Experimental results obtained from a test module are presented to illustrate the efficacy of the design and acceptable delay performance of the test structure commensurate with the digital transports of interest.展开更多
Plant respiration is characterized by two pathways for electron transfer to O2, namely the cytochrome pathway （CP） that is linked to ATP production, and the alternative pathway （AP）, where electrons from ubiquinol...Plant respiration is characterized by two pathways for electron transfer to O2, namely the cytochrome pathway （CP） that is linked to ATP production, and the alternative pathway （AP）, where electrons from ubiquinol are directly transferred to O2 via an alternative oxidase （AOX） without concomitant ATP production. This latter pathway is well suited to dispose of excess electrons in the light, leading to optimized photosynthetic performance. We have characterized T- DNA-insertion mutant lines of Arabidopsis thaliana that do not express the major isoform, AOXIA. In standard growth conditions, these plants did not show any phenotype, but restriction of electron flow through CP by antimycin A, which induces AOXIA expression in the wild-type, led to an increased expression of AOXID in leaves of the aoxla-knockout mutant. Despite the increased presence of the AOX1D isoform in the mutant, antimycin A caused inhibition of photosyn- thesis, increased ROS, and ultimately resulted in amplified membrane leakage and necrosis when compared to the wild- type, which was only marginally affected by the inhibitor. It thus appears that AOX1 D was unable to fully compensate for the loss of AOXIA when electron flow via the CP is restricted. A combination of inhibition studies, coupled to metabolite profiling and targeted expression analysis of the P-protein of glycine decarboxylase complex （GDC）, suggests that the aoxla mutants attempt to increase their capacity for photorespiration. However, given their deficiency, it is intriguing that increase in expression neither of AOX1D nor of GDC could fully compensate for the lack of AOXIA to optimize pho- tosynthesis when treated with antimycin A. We suggest that the aoxla mutants can further be used to substantiate the current models concerning the influence of mitochondrial redox on photosynthetic performance and gene expression.展开更多
文摘目的针对肿瘤患者经外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)相关血流感染(central line associated bloodstream infection,PICC-CLABSI)风险预测问题,利用Logistic回归和极限学习机(extreme learning machine,ELM)分别建立预测模型并验证其预测效果。方法回顾性收集2019年1月至2023年3月在山西省某三级甲等综合医院肿瘤科接受PICC置管的1146例患者的临床病历资料,将2019年1月至2021年12月收集的786例PICC置管患者的临床病历资料作为建模组,将2022年1月2023年3月收集的360例患者的临床资料作为验证组。采用χ^(2)检验对建模组数据进行分析,将有统计学意义的变量进行Logistic回归分析,构建风险预测模型,并绘制列线图,采用Hosmer-Lemeshow检验和受试者工作特征(receiver operating characteristic,ROC)曲线下面积(area under the curve,AUC)评价该预测模型的拟合度及预测效果;将Logistic回归分析具有统计学意义的危险因素作为ELM预测模型的输入参数,肿瘤患者PICC-CLABSI发生风险作为输出参数,构建ELM预测模型;利用验证组数据对预测性能进行比较。结果(有)糖尿病史、化疗次数(≥3次)、维护周期(>7day)、维护地点(院外)、白细胞计数(<3.5×10^(9)/L)、白蛋白(<40g/L)是肿瘤患者发生经外周静脉置入中心静脉导管相关血流感染的风险因素(均P<0.05)。Logistic风险预测模型的Hosmer-Lemeshow检验结果显示:χ^(2)=5.201,P=0.736,AUC为0.860(95%CI:0.799~0.922),灵敏度是0.893,特异度是0.704,正确率为72.8%,表明模型具有良好的预测能力。ELM预测模型的决定系数为0.823,均方误差为0.051,模型的拟合度良好,正确率为74.5%,表明模型具有良好的预测能力。结论在Logistic回归分析筛选指标基础上建立的Logistic风险预测模型与ELM模型均具有较高的预测精度,可为临床医护人员筛查肿瘤PICC相关血流感染高危患者提供参考。
文摘The authoros specialize in the field of optunization and automatic programme oftrain working graph. In this peper, at frist, a mixed 0-1 integer progranimingmodel about this problem for duuble-track lines is set up, then the principle andProcess of selution are stated, with an application exaiiiple put forward.
文摘A major concern in modern smart-phones and hand-held devices is a way of mitigating the time interval error (TIE) perceived at high-speed digital transits along the traces of the circuit-board (rigid and or flexible) used in baseband infrastructures. Indicated here is a way of adopting a planar fractal inductor configuration to improvise the necessary time-delay in the transits of digital signal phase jitter and reduce the TIE. This paper addresses systematic design considerations on fractal inductor geometry commensurate with practical aspects of its implementation as delaylines in the high-speed digital transports at the baseband operations of smart-phone infrastructures. Experimental results obtained from a test module are presented to illustrate the efficacy of the design and acceptable delay performance of the test structure commensurate with the digital transports of interest.
文摘Plant respiration is characterized by two pathways for electron transfer to O2, namely the cytochrome pathway （CP） that is linked to ATP production, and the alternative pathway （AP）, where electrons from ubiquinol are directly transferred to O2 via an alternative oxidase （AOX） without concomitant ATP production. This latter pathway is well suited to dispose of excess electrons in the light, leading to optimized photosynthetic performance. We have characterized T- DNA-insertion mutant lines of Arabidopsis thaliana that do not express the major isoform, AOXIA. In standard growth conditions, these plants did not show any phenotype, but restriction of electron flow through CP by antimycin A, which induces AOXIA expression in the wild-type, led to an increased expression of AOXID in leaves of the aoxla-knockout mutant. Despite the increased presence of the AOX1D isoform in the mutant, antimycin A caused inhibition of photosyn- thesis, increased ROS, and ultimately resulted in amplified membrane leakage and necrosis when compared to the wild- type, which was only marginally affected by the inhibitor. It thus appears that AOX1 D was unable to fully compensate for the loss of AOXIA when electron flow via the CP is restricted. A combination of inhibition studies, coupled to metabolite profiling and targeted expression analysis of the P-protein of glycine decarboxylase complex （GDC）, suggests that the aoxla mutants attempt to increase their capacity for photorespiration. However, given their deficiency, it is intriguing that increase in expression neither of AOX1D nor of GDC could fully compensate for the lack of AOXIA to optimize pho- tosynthesis when treated with antimycin A. We suggest that the aoxla mutants can further be used to substantiate the current models concerning the influence of mitochondrial redox on photosynthetic performance and gene expression.
