Occurrence and Decay of SARS-CoV-2 in Community Sewage Drainage Systems

The rapid spread of the coronavirus disease(COVID-19)pandemic in over 200 countries poses a substantial threat to human health.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes COVID-19,can be discharged with feces into the drainage system.However,a comprehensive understanding of the occurrence,presence,and potential transmission of SARS-CoV-2 in sewers,especially in community sewers,is still lacking.This study investigated the virus occurrence by viral nucleic acid testing in vent stacks,septic tanks,and the main sewer outlets of community where confirmed patients had lived during the early days of the epidemic in Wuhan,China.The results indicated that the risk of long-term emission of SARS-CoV-2 to the environment via vent stacks of buildings was low after confirmed patients were hospitalized.SARS-CoV-2 were mainly detected in the liquid phase,as opposed to being detected in aerosols,and its RNA in the sewage of septic tanks could be detected for only four days after confirmed patients were hospitalized.The surveillance of SARS-CoV-2 in sewage could be a sensitive indicator for the possible presence of asymptomatic patients in the community,though the viral concentration could be diluted more than ten times,depending on the sampling site,as indicated by the Escherichia coli test.The comprehensive investigation of the community sewage drainage system is helpful to understand the occurrence characteristics of SARS-CoV-2 in sewage after excretion with feces and the feasibility of sewage surveillance for COVID-19 pandemic monitoring.

The lymphatic drainage systems in the brain:a novel target for ischemic stroke?

Recent studies have proposed three lymphatic drainage systems in the brain,that is,the glymphatic system,the intramural periarterial drainage pathway,and meningeal lymphatic vessels,whose roles in various neurological diseases have been widely explored.The glymphatic system is a fluid drainage and waste clearance pathway that utilizes perivascular space and aquaporin-4 protein located in the astrocyte endfeet to provide a space for exchange of cerebrospinal fluid and interstitial fluid.The intramural periarterial drainage pathway drives the flow of interstitial fluid through the capillary basement membrane and the arterial tunica media.Meningeal lymphatic vessels within the dura mater are involved in the removal of cerebral macromolecules and immune responses.After ischemic stroke,impairment of these systems could lead to cerebral edema,accumulation of toxic factors,and activation of neuroinflammation,while restoration of their normal functions can improve neurological outcomes.In this review,we summarize the basic concepts of these drainage systems,including drainage routes,physiological functions,regulatory mechanisms,and detection technologies.We also focus on the roles of lymphatic drainage systems in brain injury after ischemic stroke,as well as recent advances in therapeutic strategies targeting these drainage systems.These findings provide information for potential novel strategies for treatment of stroke.

Experimental investigation on the invert stability of operating railway tunnels with different drainage systems using 3D printing technology

In recent years, the invert anomalies of operating railway tunnels in water-rich areas occur frequently,which greatly affect the transportation capacity of the railway lines. Tunnel drainage system is a crucial factor to ensure the invert stability by regulating the external water pressure(EWP). By means of a threedimensional(3D) printing model, this paper experimentally investigates the deformation behavior of the invert for the tunnels with the traditional drainage system(TDS) widely used in China and its optimized drainage system(ODS) with bottom drainage function. Six test groups with a total of 110 test conditions were designed to consider the design factors and environmental factors in engineering practice,including layout of the drainage system, blockage of the drainage system and groundwater level fluctuation. It was found that there are significant differences in the water discharge, EWP and invert stability for the tunnels with the two drainage systems. Even with a dense arrangement of the external blind tubes, TDS was still difficult to eliminate the excessive EWP below the invert, which is the main cause for the invert instability. Blockage of drainage system further increased the invert uplift and aggravated the track irregularity, especially when the blockage degree is more than 50%. However, ODS can prevent these invert anomalies by reasonably controlling the EWP at tunnel bottom. Even when the groundwater level reached 60 m and the blind tubes were fully blocked, the invert stability can still be maintained and the railway track experienced a settlement of only 1.8 mm. Meanwhile, the on-site monitoring under several rainstorms further showed that the average EWP of the invert was controlled within 84 k Pa, while the maximum settlement of the track slab was only 0.92 mm, which also was in good agreement with the results of model test.

Analyzing Anomalous Topographic Map Drainage System and Landform Evidence as a Glacial History Paradigm Problem: A Literature Review

While not usually stated, detailed topographic maps show well-mapped anomalous drainage system and other erosional landform evidence the accepted North American Cenozoic geologic and glacial history paradigm (accepted paradigm) does not permit geomorphologists to satisfactorily explain. A new and fundamentally different paradigm able to explain the drainage system and other erosional landform evidence has recently emerged, but requires what the accepted paradigm considers to be the preglacial (and probably mid-Cenozoic) Bell River drainage system to have formed on a melting continental ice sheet’s floor. The new paradigm’s melting ice sheet had previously eroded bedrock underneath it and caused crustal warping that raised continental regions and mountain ranges so as to create and occupy a deep “hole” while massive and prolonged meltwater floods flowed across rising continental regions and mountain ranges to the south. The new paradigm leads to a completely different middle Cenozoic geologic and glacial history than the accepted paradigm describes and the two paradigms are analyzed according to good science expectations such as using evidence anyone can see, applying common sense logic during each research step, producing consistent results, and simplicity of paradigm generated explanations. The new paradigm uses topographic map evidence anyone can see, appears to use common sense logic during each research step, and produces remarkably consistent results leading to a simpler Cenozoic northern Missouri River drainage basin region geologic and glacial history than what the accepted paradigm describes. Further work is needed to test the new paradigm’s ability to explain drainage system and erosional landform evidence in other geographic regions such as in the Ohio River drainage basin.

Seasonal evolution of the englacial and subglacial drainage systems of a temperate glacier revealed by hydrological analysis

Englacial and subglacial drainage systems of temperate glaciers have a strong influence on glacier dynamics, glacier-induced floods, glacier-weathering processes, and runoff from glacierized drainage basins. Proglacial discharge is partly controlled by the geometry of the glacial drainage network and by the process of producing meltwater. The glacial-drainage system of some alpine glaciers has been characterized using a model based on proglacial discharge analysis. In this paper, we apply cross-correlation analysis to hourly hydro-climatic data collected from China＇s Hailuogou Glacier, a typical temperate glacier in Mt. Gongga, to study the seasonal status changes of the englacial and subglacial drainage systems by discharge-temperature （Q-T） time lag analy-sis. During early ablation season （April-May） of 2003, 2004 and 2005, the change of englacial and subglacial drainage system usually leads several outburst flood events, which are also substantiated by observing the leakage of supraglacial pond and cre-vasses pond water during field works in April, 2008. At the end of ablation season （October-December）, the glacial-drainage net-works become less hydro-efficient. Those events are evidenced by hourly hydro-process near the terminus of Hailuogou Glacier, and the analysis of Q-T time lags also can be a good indicator of those changes. However, more detailed observations or experi-ments, e.g. dye-tracing experiment and recording borehole water level variations, are necessary to describe the evolutionary status and processes of englacial and subglacial drainage systems evolution during ablation season.

Influence of asymmetric blockage of the drainage system of a deep-buried tunnel on water gushing

Asymmetric blockage of drainage systems occasionally occurs,which seriously threatens the safety of tunnel operation.Based on theoretical analysis,a calculation expression of tunnel water inflow involving clogging parameters was derived.Degradation of the analytical solution was analysed with the Taylor equation and series expansion theorem,and a tunnel under construction was considered to conduct field tests to verify the rationality of the established model and correctness of the derived expression.Studies have demonstrated that with increasing drainage system blockage degree,the amount of water inflow in the nonblocked area slowly increases,and the total amount of water in the tunnel gradually decreases.The hydrodynamic pressure in the blocked area non-linearly decreased,and the water inrush velocity and hydraulic gradient in the non-blocked area gradually increased.When the drainage system was not blocked,the result of tunnel water inflow calculated by the formula derived in this paper was 8.3% higher than the measured value.When the drainage system was blocked,the theoretical water inflow was 10.5% higher than the measured value.The difference between the measured value and the theoretical value is small,which verifies the effectiveness of the calculation formula of water inflow deduced in this paper.

Study on the Whole Process Simulation and Regulation Mechanism of Urban Green Ecological Rainwater Drainage System

In view of the frequent waterlogging caused by rapid urbanization and the public’s dissatisfaction with the drainage system,the article based on the concept of the green ecological drainage system,constructed the urban green ecological drainage comprehensive simulation research system,and quickly evaluated pipe network operation and surface water of an industrial park under typical rainfall conditions.The results showed that the drainage capacity of the designed green ecological rainwater drainage system reached 100%,and there was no ponding phenomenon,which indicated that the green ecological rainwater drainage system could effectively solve the practical problems of urban drainage.The green ecological rainwater comprehensive simulation research system had good adaptability.The research results provided the scientific theoretical basis and reference significance for planning,designing,constructing,operating,and managing urban rainwater system scientifically and systematically.

On-Farm Effects of Drainage System on the Productivity of Chinese Cabbage(Brassica pekinensis L.Rupr.)of Farmers in Svay Rieng Province,Cambodia

The vegetable production in Cambodia has been plagued with poor productivity and broken chain,leaving the comparative advantage to the neighboring countries,namely Vietnam and Thailand.Poor soil condition during wet season has been significantly impacting the productivity of vegetable production in Cambodia which leads to an introduction of sub-surface drainage system at the root zone of Chinese cabbage under this paper.The aim of the experiment is to determine the possibility in increasing the effectiveness and productivity during wet season of Cambodian vegetable producers.The results of the experiment indicate positive improvement in terms of yield and growth of the Chinese cabbage at a rate of 24%and 34%for T2 and T3,respectively.There are,however,limited practicality and generalization for the research due to the controlling factors during the experiment and the detailed experimental setting which need further analysis,especially economic analysis and following up research work.

Novel abdominal negative pressure lavage-drainage system for anastomotic leakage after R0 resection for gastric cancer

BACKGROUND Anastomotic leakage(AL) is a severe complication associated with high morbidity and mortality after radical gastrectomy(RG) for gastric cancer(GC).We hypothesized that a novel abdominal negative pressure lavage-drainage system(ANPLDS) can effectively reduce the failure-to-rescue(FTR) and the risk of reoperation, and it is a feasible management for AL.AIM To report our institution's experience with a novel ANPLDS for AL after RG for GC.METHODS The study enrolled 4173 patients who underwent R0 resection for GC at our institution between June 2009 and December 2016. ANPLDS was routinely used for patients with AL after January 2014. Characterization of patients who underwent R0 resection was compared between different study periods. AL rates and postoperative outcome among patients with AL were compared before and after the ANPLDS therapy. We used multivariate analyses to evaluate clinicopathological and perioperative factors for associations with AL and FTR after AL.RESULTS AL occurred in 83(83/4173, 2%) patients, leading to 7 deaths. The mean time of occurrence of AL was 5.6 days. The AL rate was similar before(2009-2013, period1) and after(2014-2016, period 2) the implementation of the ANPLDS therapy(1.7% vs 2.3%, P = 0.121). Age and malnourishment were independently associated with AL. The FTR rate and abdominal bleeding rate after AL occurred were respectively 8.4% and 9.6% for the entire period; however, compared with period 1, this significantly decreased during period 2(16.2% vs 2.2%, P = 0.041;18.9% vs 2.2%, P = 0.020, respectively). Moreover, the reoperation rate was also reduced in period 2, although this result was not statistically significant(13.5% vs2.2%, P = 0.084). Additionally, only ANPLDS therapy was an independent protective factor for FTR after AL(P = 0.04).CONCLUSION Our experience demonstrates that ANPLDS is a feasible management for AL after RG for GC.

Comparative Analysis of Tunnel Seepage Field under Different Waterproof and Drainage System Using Analytical Methods

Tunnel seepage is an important factor affecting the progress and safety of tunnel construction. In this paper, the mining method tunnel construction in the water-rich weathered granite stratum is taken as the research object. Through the analytical calculation method, the distribution law of tunnel seepage field under different waterproof and drainage types is studied, and the comparative analysis is carried out. According to the analytical solution, the influencing factors of grouting parameters are proposed. The sensitivity of the tunnel seepage field to the variation of grouting parameters is analyzed. A novel waterproof and drainage system, and construction technology suitable for subway tunnels with large buried depth below groundwater level were proposed.

Control of Seepage through Earth Dams Based on Pervious Foundation Using Toe Drainage Systems

Many dangerous effects arise from seepage through earth dams based on pervious layer. Therefore, the dam embankment must be provided with seepage control measures to avoid such effects. In the present work, different control methods were used such as flat slopes, toe drainage systems, and a catch drain in the tail water. The hydraulic performance of each control measure was evaluated using the analytical solutions, previously developed, to estimate the seepage quantity (q), the height of seepage surface (h3), and the coordinates of the free surface (hx). Study was conducted on a physical model for a dam embankment having a top width (b) = 10.0 meter, height (Hd) = 30.0 meter, and slope factor (m) = 1.5. The obtained results were analyzed and presented in dimensionless charts. Results showed that, the used control measures possess a great effect on the characteristics of seepage through earth dams based on pervious foundations. A comparative study was conducted between the studied toe drainage systems to enable the designers the better choice for design purposes.

Abdominal drainage systems in modified piggyback orthotopic liver transplantation

To the Editor:Whether orthotopic liver transplantation requires the placement of an abdominal drainage system is a controversial topic.A number of studies have suggested that prophylactic placement of abdominal drainage systems do not improve the diagnostic rate of complications such as bile leakage and hemorrhage after liver transplantation,even increased the risk of infection[1–3].However,there is no uniform standard for the selection of drainage tube and how to place the drainage tube in orthotopic liver transplantation.The types and placement modes of the drainage tubes used in each center are different.If adequate drainage is not possible,it may affect the drainage efficiency,which may lead to the misunderstanding that“it is unnecessary to place the drainage tube”.Herein we aimed to explore the most efficient abdominal drainage in modified piggyback orthotopic liver transplantation,based on the types and placement modes of drainage tubes in our clinical practice.

Investigation of a Flow Modulation System for Siphonic Roof Drainage Systems

Siphonic roof drainage systems (SRDS’s) have been widespread used now for approximately 40 years and are an efficient method of removing rainwater rapidly from roofs. SRDS’s are designed to run full-bore, resulting in sub-atmospheric system pressures with high hydraulic driving heads and higher system flow velocities than conventionally guttered systems. Hence, SRDS’s normally require far fewer downpipes, and the depressurised conditions also mean that much of the collection pipework can be routed at a high level, thus reducing the extent of any underground pipework. But, they work properly at only one roof run-off rate and therefore suffer from sizing and operational problems including noise and vibration which limit their performance and adoption rate. Climate change is creating situations where normal ranges of rainfall intensity are being frequently exceeded, so the typical:storm ratios (rTS) are large increasing. Current SRDS’s typically operate within a small rTS range of 2. This may have an impact on the future uptake of SRDS’s. This paper describes the development of a novel SRDS which includes a small mobile cap at the roof of outlet appears to offer benefits and avoids sizing problems associated with current SRDS’s. The cap has the potential to avoid noise associated with making and breaking siphonic action through flow modulation. Laboratory scale tests demonstrate the basic feasibility of the cap system and indicate that the cap functions reliably. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Basic on sizing and design optimiza-tion factors are suggested. The rTS range is increased from approximately 2 to approximately 6.

Hydrogeochemical Assessment of Metals Contamination in an Urban Drainage System: A Case Study of Osogbo Township, SW-Nigeria

With increasing urban population, attention had been focused on environmental degradation of urban drain-age system with respect to trace/heavy metal contaminations. Such concerns underlie the ever-increasing impacts of urbanization and industrial activities on urban watershed in the developing regions of the world, especially in areas with inadequate land-use plan and poor waste disposal and management practices. Hence, this study highlights the hydrogeochemical assessment of surface water and bottom-sediment samples from an urban drainage system in Osogbo Township, SW-Nigeria with respect to trace metals contaminations. The results show that the surface water samples have generally low TDS with average value of 362mg/l, while the average dissolved concentrations of the trace metals (Cu, Pb, Zn, Ni, As and Cr) vary from 0.01 to 0.5mg/l. Cu, Cr and As exhibit concentrations similar to the local background concentrations (LBC) in the pristine stream water with low single metal contamination factor (CF ≈ 1). Pb, Zn and Ni are 5 folds enriched with contamination factor (CF) of >5 indicating moderate to high contamination. For the sediment phase, the adsorbed concentrations of the trace metals (Cu, Pb, Zn, Ni, As, Cr and Co) vary between 0.1 to 3.1mg/kg. These represent about 1 to 3% of the respective total metal concentrations with average values of 18.2– 533.4mg/kg. Also low anthropogenic factor, AF (0.002 to 0.08) and mostly negative values (–5 to –15) of Mueller’s geo-accumulation index (Igeo) for adsorbed metal contents in the sediments suggest dominant geo-genic controls. However, the total metals concentrations in the sediment phase have high estimated AF of 1.1 to 9.3 and positive values of the estimated Igeo (0.9–2.0) and metal contamination index (MCI) of 2.5–8.3. All these suggest a medium to high level enrichment (of 2 to 10 factor) for most of the metals with respect to the local background concentration (LBC) in the basement bedrock units (with the exception of Cr and Ni). This is consistent with the preferential metal enrichment in the sediment phase as indicated by the estimated parti-tioning/distribution coefficient, Kd of >1 exhibited by the total metal concentrations in the stream sediment. Nonetheless, the correlated high peaks of electrical conductivity of the stream water samples and adsorbed concentrations of some trace metals within the urban stretches are indications of point source inputs of un-treated sewage into the drainage system.

Using System Dynamics for Simulating Subsurface Drainage Systems in Clay Soils

The system dynamics technique is used as a decision tool for engineering problems. It is one of the object oriented approaches that study and manage complex feedback systems. In this paper, the system dynamics technique was used to simulate the performance of a drainage system under wheat crop in a clay soil. The model was calibrated and validated using observed experimental field data (drainage discharge and water table level) collected from Mashtul Pilot Area (MPA), Egypt. The results indicated that, the model is capable to predict hydrological parameters such as water table fluctuation, drainage discharge, upward flux, evapotranspiration, deep percolation, infiltration, runoff, soil moister content and unsaturated hydraulic conductivity on the basis of variation of soil moister content. The trends of the parameters found to be legible. Six statistical indexes were calculated to determine the agreement between the observed and simulated values of water table and drainage discharge. Results indicated that the system dynamics technique can be considered as a good decision tool to predict the subsurface drainage water precisely.

How to secure the connection between thoracostomy tube and drainage system?

BACKGROUND: Thoracostomy tube insertion is one of the common bedside procedures in emergency medicine and many acute specialties. Dislodgement of thoracostomy tube from the connection tube of chest drainage system is an important problem with potential complications such as contamination, infection and pneumothorax. Besides, mere loosening can also lead to malfunction. It is a common practice to tape the connection of the system. This study aimed to evaluate the materials and methods of connection of chest drain system to minimize drainage dislodgement. METHODS: We conducted an experimental study to assess the tightness of the connection with various taping materials and methods. We selected three commonly used adhesive materials(3M^(tm) Transpore^(tm) Medical tape, 3M^(tm) Micropore^(tm) Medical tape, 3M^(tm) Soft Cloth Tape on Liner) and three different methods(cross method, straight method, nylon band) to secure the junction between the thoracostomy tube and the bi-conical adaptor in the drainage system. The measured outcome was the weight causing visible loosening of the junction between thoracotomy tube and the adaptor.RESULTS: For each taping material and taping method, 10 trials were performed. The median weight required to disconnect the junction is 26.22 lb for Transpore^(tm), 31.29 lb for Micropore^(tm) and 32.44 lb for Soft Cloth Tape on Liner. A smaller force was required to disconnect if Transpore^(tm) is used(P<0.001). There was no statistical signifi cant difference between Micropore^(tm) and Soft Cloth Tape on Liner(P=0.98). The median disconnecting force is 32.44 lb for straight taping method, 40.55 lb for cross taping method and 21.15 lb for plastic band. The cross-taping method was the more secure method(P<0.0001 when compared with plastic band)(P=0.033 when compared with straight method).CONCLUSION: Cross-taping is the most secure method among the tested varieties in connecting the thoracostomy tube to the chest drainage system. Transpore^(tm) is not a recommended material for thoracostomy tube taping.

A Study on the Causes of Sediment Accumulation in the Drainage Systems

Accumulation of sediment and silt in the drainage canals is undesirable, yet inevitable occurrence in the course of the use and operation of any drainage canal network. In this study, D-25 drainage canal group, taking place in the Nazilli irrigation system with an area of 1165 ha is the only system where all planned activities have been completed. It has been determined that the drainage system was constructed according to original drainage project. The depth of accumulated sediment in the drainage canals in the research area was determined from the difference between the measured elevation and the elevation given in the design projects. The reasons for siltation in the D-25 drainage canal group have been studied by looking at the results of the elevation measurements made in 2010-2012. The measurements made in D-25 drainage canal group showed that there were significant differences between the actual structure (bridge, culvert, and conduit) bottom elevations and the elevations given in the design projects. In addition, the length of some canals would not coincide with the design project either. 83.3% (93.3% in length) of the canals had differences in structure bottom elevations. Of the total 55 structures 45 (81.8%) had a 0.10 m or more difference in bottom elevation from the project. Of the erroneous structures 73.3% had an average of 0.40 m, and 26.7% had an average of -0.25 m difference in bottom elevations from the design projects.

Identification of high oxygen-consuming substances in stormwater drainage systems illicitly connected with sewage system

The dissolved oxygen content in water is an important indicator for assessing the quality of the water environment,and maintaining a certain amount of dissolved oxygen is essential for the healthy development of the ecological environment.When a water body is anoxic,the activity of anaerobic microorganisms increases and organic matter is decomposed to produce a large number of blackening and odorizing substances,resulting in black and odorous water bodies,which is a very common and typical phenomenon in China.Presently,there is still a relatively universal occurrence of illicitly connected stormwater and sewage pipes in the urban drainage pipe network in China,which makes oxygen-consuming substances be directly discharged into rivers through stormwater pipes and consume the dissolved oxygen in the water bodies,resulting in an oxygen deficiency of the water.This induces seasonal or year-round black and stink phenomena in urban rivers.Hence,identifying high oxygen-consuming substances,which lays the foundation for the subsequent removal of oxygen-consuming substances,is essential.Through a series of comparisons of water quality indicators and analysis of organic characteristics,it was found that the oxygen consumption capacity of domestic sewage was higher than that of industrial wastewater in the selected area of this study,and the oxygen-consuming substances of domestic sewage were small molecular amino acids.By comparing 20 conventional free amino acids,it was found that seven of them consumed oxygen easily,and compared with chemical oxygen consumption,biological oxygen consumption was in a leading position.

Fast prototype and rapid construction of three-dimensional and multi-scaled pitcher for controlled drainage by systematic biomimicry

Biomimetic materials that use natural wisdom to solve practical problems are developing rapidly.The trend for systematic biomimicry is towards in-situ characterization of naturalcreatures with high spatial resolutions.Furthermore,rapid reconstruction of digital twin models with the same complex features as the prototype is indispensable.However,it faces bottlenecks and limits in fast characterization and fabrication,precise parameter optimization,geometricdeviations control,and quality prediction.To solve these challenges,here,we demonstrate astate-of-the-art method taking advantage of micro-computed tomography and three-dimensional printing for the fast characterization of the pitcher plant Nepenthes x ventrata and fabrication of its biomimetic model to obtain a superior drainage controller with multiscale structures withprecise surface morphology optimization and geometric deviation control.Thefilm-rupture-based drainage dynamic and mechanisms are characterized by x-ray and high-speed videography,which determines the crucial structures for unique directionaldrainage.Then the optimized artificial pitchers are further developed into sustained drainage devices with novel applications,such as detection,reaction,and smoke control.