Riparian habitat quality as an indicator of land use/land cover effects on riverine water quality

Riparian land use/land cover(LULC)plays a crucial role in maintaining riverine water quality by altering the transport of pollutants and nutrients.Nevertheless,establishing a direct relationship between water quality and LULC is challenging due to the multi-indicator nature of both factors.Water quality encompasses a multitude of physical,chemical,and biological parameters,while LULC represents a diverse array of land use types.Riparian habitat quality(RHQ)serves as an indicator of LULC.Yet,it remains to be seen whether RHQ can act as a proxy of LULC for assessing the impact of LULC on riverine water quality.This study examines the interplay between RHQ,LULC and water quality,and develops a comprehensive indicator to predict water quality.We measured several water quality parameters,including pH(potential of hydrogen),TN(total nitrogen),TP(total phosphorus),T_(water)(water temperature),DO(dissolved oxygen),and EC(electrical conductivity)of the Yue and Jinshui Rivers draining to the Han River during 2016,2017 and 2018.The water quality index(WQI)was further calculated.RHQ is assessed by the InVEST(Integrated Valuation of Ecosystem Services and Tradeoffs)model.Our study found noticeable seasonal differences in water quality,with a higher WQI observed in the dry season.The RHQ was strongly correlated with LULC compositions.RHQ positively correlated with WQI,and DO concentration and vegetation land were negatively correlated with T_(water),TN,TP,EC,cropland,and construction land.These correlations were stronger in the rainy season.Human-dominated land,such as construction land and cropland,significantly contributed to water quality degradation,whereas vegetation promoted water quality.Regression models showed that the RHQ explained variations in WQI better than LULC types.Our study concludes that RHQ is a new and comprehensive indicator for predicting the dynamics of riverine water quality.

A review of physicochemical and biological contaminants in drinking water and their impacts on human health

Clean drinking water is one of the United Nations Sustainable Development Goals.Despite significant progress in the water purification technology,many regions still lack access to clean water.This paper provides a review of selected water contaminants and their impacts on human health.The World Health Organization(WHO)guidelines and regional standards for key contaminants were used to characterise water quality in the European Union and UK.The concept of safe drinking water was explained based on the non-observed adverse effect level,threshold concentrations for toxic chemicals,and their total daily intake.Various techniques for monitoring water contaminants and the drinking water standards from five different countries,including the UK,USA,Canada,Pakistan and India,were compared to WHO recommended guidelines.The literature on actual water quality in these regions and its potential health impacts was also discussed.Finally,the role of public water suppliers in identifying and monitoring drinking water contaminants in selected developed countries was presented as a potential guideline for developing countries.This review emphasised the need for a comprehensive understanding of water quality and its impacts on human health to ensure access to clean drinking water worldwide.

Accessibility to Safe Drinking Water and Diarrheal Diseases: A Quasi-Experiment on a Case of Water Well Drilling in the Village of Kassouala, Municipality of Tchaourou, Benin, January 2018-July 2019

Background: In 2017, 900 million people in the world did not have sustainable access to safe drinking water (SDW). In addition, between 2016 and 2020, the global population with safely managed drinking water at home increased from 70 percent to 74 percent. Drinking water insecurity is the daily situation of people in developing countries. The lack of SDW supply is at the root of many diseases, including diarrheal diseases. Kassouala is a village in the municipality of Tchaourou without access to SDW, but having benefited from the drilling of a well in September 2018. The objective of this study was to study the effect of access to safe drinking water on the frequency of diarrheal diseases in Kassouala between January 2018 and July 2019. Methods: We conducted a quasi-experimental study in Kassouala using the natural experiments of the village of Bérétou as a control group for estimating the effect of a causal nature. There were double temporal (January 2018-July 2019) and geographical (Kassouala-Bérétou) comparisons based on data collected from health care registers. A population-based comparability survey of the two villages was conducted among 170 households in each village (experimental village, control village). A two-stage cluster sampling procedure was used to select the survey participants. Data were collected from heads of household by semi-structured questionnaire. We used Pearson or Mantel-Haenszel chi-square tests, as appropriate, and the “difference-in-difference” method to assess the effect. Results: In Kassouala, the proportion of households with access to safe drinking water had increased to 78.88%, whereas it was nil in 2018 before the well drilling, and the frequency of diarrheal diseases decreased significantly from January 2018 before drilling to July 2019 after drilling (57.11% to 44.64%;p Conclusion: Access to safe drinking water in Kassouala has a causal effect on the reduction of diarrheal diseases. However, for the supply of drinking water to be integrated into the community development plan of Tchaourou, it is necessary to support the scaling up of this intervention, which would be considered as a pilot, of a community participation program.

Assessment of Drinking Water Quality in Umoja Innercore Estate, Nairobi

Water quality is one of the main indicators of the quality of service provided to consumers. Quality has an impact on both the public health and aesthetic value of water as a consumable product. Kenya is classified as a water-scarce country with only 647 cubic meters of renewable freshwater per capita. Water distributed in Nairobi is faced with a myriad of challenges leading to a compromise to its quality. This study focused on evaluating quality of drinking water since human health depends on adequate, clean, reliable water. Analyses were carried out at National Environmental Management Authority (NEMA) accredited Jomo Kenyatta University of Agriculture and Technology (JKUAT) laboratories to determine the chemical, bacteriological and physical characteristics of consumed water in Umoja Innercore Estate in Nairobi. In the study area, 7 HH and 6 BH sites were randomly distributed. pH, turbidity and temperature measurements were analyzed in-situ while bacteria and chemicals were analyzed in laboratories. The study found that 100% of boreholes recorded unsatisfactory water with up to 1100 of Escherichia coli (E. coli) showing high contamination with faecal coliforms and 83% of boreholes recording pH of up to 9.53. Dissolved oxygen was 5.08 mg/L below recommended 12.0 mg/L, salinity of 0.47 mg/L and 0.03 mg/L for boreholes and households respectively. The study reveals the deprived quality of water available to the residents of Umoja Innercore, Nairobi. The study recommends the use of biosand filtration methods for septic tanks, digging of deeper boreholes and lining septic tanks with impermeable materials to prevent contamination of ground water with raw water from septic.

Spatial quality evaluation for drinking water based on GIS and ant colony clustering algorithm

To develop a better approach for spatial evaluation of drinking water quality, an intelligent evaluation method integrating a geographical information system(GIS) and an ant colony clustering algorithm(ACCA) was used. Drinking water samples from 29 wells in Zhenping County, China, were collected and analyzed. 35 parameters on water quality were selected, such as chloride concentration, sulphate concentration, total hardness, nitrate concentration, fluoride concentration, turbidity, pH, chromium concentration, COD, bacterium amount, total coliforms and color. The best spatial interpolation methods for the 35 parameters were found and selected from all types of interpolation methods in GIS environment according to the minimum cross-validation errors. The ACCA was improved through three strategies, namely mixed distance function, average similitude degree and probability conversion functions. Then, the ACCA was carried out to obtain different water quality grades in the GIS environment. In the end, the result from the ACCA was compared with those from the competitive Hopfield neural network(CHNN) to validate the feasibility and effectiveness of the ACCA according to three evaluation indexes, which are stochastic sampling method, pixel amount and convergence speed. It is shown that the spatial water quality grades obtained from the ACCA were more effective, accurate and intelligent than those obtained from the CHNN.

A Study on the Microbial Quality of Drinking Water in Rural Areas of Mazandaran Province in North of Iran (2011)

Backgrounds: One of the fundamental needs of a community is to have an access to healthy and safe drinking water. The lack of a concentrated accessibility to health facilities and services is among the serious problems facing villagers in the rural areas. The aims of this research was to investigate the drinking water quality of the villages in Babol township suburbs in north of Iran. Materials and Methods: In this cross-sectional descriptive study, a total of 140 water samples were taken from the water distribution network in16 villages for the low and high-rain seasons in sterile glass bottle. The microbial quality of gathered samples were determined based on standard methods in laboratory. Statistical analysis of the results was performed using a SPSS16 statistical software. Findings: Based on obtained results 13.6% of the samples were contaminated to coliform and 20% to fecal coliform bacteria. The residual chlorine in 12.5% of the samples were between 0.2 to 0.8 mg·L-1 and the PH in total samples were between 6.8 to 7.8. There were no signs of any contamination for 32.86% of the analysed samples which water resources is located to a distance of more than 30 m to the contamination sources. In addition, 43.1% of the samples taken from the water resources with no plumbing system, have had a fecal contamination. Conclusions: Considering the results achieved, the microbial quality of the drinking water of the studied villages classified as “moderate” status. For more water supply there is not sufficient residual chlorine in most cases. Poor sanitation of water supply is most causes of water contamination. It is therefore strongly recommended that sanitation measures are made to protect water resources from the contamination.

Monitoring and Assessment of Water Quality of Centralized Drinking Water Sources in Kaixian County during the " Twelfth Five-year Plan " Period

Based on the monitoring data of water quality of more than 40 centralized drinking water sources in 40 towns （townships or streets） of Kaixian County in the first and second half of each year during the ＂Twelfth Five-year Plan＂ period, the changing rules of the water quality were studied to provide scientific references for the improvement of drinking water safety of urban and rural residents and drinking water quality. The re- sults show that the water quality of centralized drinking water sources in Kaixian County improved year by year during the ＂Twelfth Five-year Plan＂ period, and most monitoring sites with water quality exceeding the standard are distributed in reservoirs. Total phosphorus, total nitrogen, chemical oxygen demand, and permanganate index exceeded the standard obviously. Main pollution sources are domestic pollution and non-point source pol- lution caused by excessive discharge of nitrogen, phosphorus and organic pollutants. To improve drinking water quality, it is suggested that some towns can get drinking water from other reservoirs, surface water or underground water with better quality instead of previous reservoirs with water quality exceeding the standard, and the control of non-point source pollution should be enhanced.

Research on organic matters in the drinking water of Kaschin-Beck disease area

Organic matters in drinking water of Kaschin-Beck disease areas were extracted. Then analyses and characterization were performed by means of multiply chemical and physical methods. The results did not show the obvious difference in the frame structure of humic substances and the structure of rmcromolecular compounds in the drinking water of disease and non-disease areas, but the difference in the contents of some micromolecular compounds and radicals. The investigation also includes the preliminary research on the photoreaction of drinking water from disease and non-disease areas and the accumulation of natural organic matter in the bone of tested animals.

The Potential Relationship between the Incidence of Neurodegenerative Disease and Trace Mineral Composition in the Drinking Water of Rural Residents of Ontario

Many chronic degenerative diseases have been linked to high intake of various trace and heavy metals. The presence of these compounds in drinking water may be a significant contributing factor to total dietary intake and deposition, resulting in the propagation of a disease cascade. Dairy farm families residing in rural Ontario completed a survey pertaining to the health status of the individuals living on-farm. Water samples were also collected at each location and analyzed for mineral content. Out of 200 surveys delivered to farms, 134 were returned, which formed a study group comprised of 218 adult and 230 children participants. Taking into consideration several factors, such as genetics, environment and diet, the data were analyzed for correlations between heavy metal and mineral status and the prevalence of neurodegenerative diseases. The findings from this study suggest phosphorus, potassium and magnesium concentrations may play a role in the development of neurodegenerative diseases. Total hardness and pH of water may also have an impact on the development of these diseases.

Drinking Water Quality Surveillance in a Vulnerable Urban Ward of Ahmedabad

The World Bank estimates that 21% of all communicable diseases in India are related to unsafe water with diarrhoea alone causing more than 0.1 million deaths annually. The WHO drinking water surveillance parameters of quality, quantity, accessibility, affordability and continuity were assessed in one vulnerable ward of Ahmedabad—a fast growing city in Western India. Interviews with key informants of the ward office, health centre and water supply department, secondary analysis and mapping of field test reports and a questionnaire-based survey of different household types were conducted. We found that Ahmedabad Municipal Corporation (AMC) supplies water to the ward intermittently for two hours during the day. Housing society clusters supplement their AMC water supply with untested bore-well water. The water quality surveillance system is designed for a twenty-four-hour piped distribution of treated surface water. However, in order to maintain surveillance over an intermittent supply that includes ground water, the sampling process should include periodic surveys of water actually consumed by the citizens. The laboratory capacity of the Central Water Testing Laboratory should expand to include more refined tests for microbial and chemical contamination.

An Air Operated Domestic Brackish Water Reverse Osmosis Plant: Economically Sustainable Solution for Safe Drinking Water Supply for Chronic Kidney Disease of Unknown Etiology Affected Areas in Sri Lanka

Chronic Kidney Disease with unknown etiology (CKDu) is one of the crucial health issues in North Central, Uva, North Western, North, Central, and Eastern Provinces of Sri Lanka and incapacitates the kidney function. The main source for the CKDu has not yet been identified, though many scientists believed that the number of certain drinking water quality parameters is changed due to the contamination of water sources by agricultural activities. Hence, the government of Sri Lanka introduces electrically driven Brackish Water Reverse Osmosis (BWRO) plants with a capacity of 10 tones/day to supply safe drinking water for the impacted community though it is an energy-intensive process. Concurrently, a smaller version of an electrically driven BWRO plant was introduced to the rural farming community for their domestic use. However, it was not practically worked out due to various reasons such as high cost, unavailability of electrical power supply for those villages. In this study, an economical air operated domestic use BWRO plant with zero-emission was designed. This anticipated system significantly reduces the government expenditures to subsidize the water purification cost by 50% of the existing expenses. Besides, simple payback time was found to be 2.5 years, and the benefit-cost ratio to be more than 1. Evaluating the performance with the conventional values, it comprehends with more sustainable and economically viable system compared to the existing method of water purification.

Drinking Water Quality Clinics and Outreach in Delaware Focusing on Educating Master Well Owners

The United States Environmental Protection Agency (EPA) has the authority to regulate the public water systems. The EPA does not have the jurisdiction to regulate private drinking water wells. This leaves approximately fifteen percent of the nation’s population without any regulation being held in place to protect their source of drinking water. With that fifteen percent of the US population having private wells for drinking water, it makes the number of people whose drinking water is unprotected by regulation at a little over 15 million US households. This concern is even more acute in areas with groundwater that is close to the surface. Delaware residents live in a region with low elevation which is very close to the coast with low elevation and the shallow groundwater makes us concern about contaminated well water even more intense. As one of the Water Resources Program partners, we have offered free Drinking Water Quality Clinics to local well owners over the past 4 years in Delaware State University. Since 2009, over 400 Delaware residents have benefited from these clinics. At each clinic, an information session was offered in the evening, with an opportunity to hear from and speak with a drinking water well expert. Participants were given sample bottles and water testing performed the following day included pH, nitrite, nitrate, sulfate, alkalinity, fluoride, hardness, iron, lead, cadmium, arsenic, Total Coliform, and E. coli. Over half of the samples returned out of range values for pH, while 72 returned results positive for Total Coliform and Escherichia coli bacterium. Data are examined for correlations, and improved understanding of local well owners. These tests shared with local well owners insights into what may be wrong with their water. In addition, any tests that came back outside of the normal range were reported to homeowners in writing. Mailed with the written reports were also information specific to what test results were outside of the limits, and actions to take to correct the exact problem the well owners encountered. The data reported here are examined to discuss the correlations of information, and ways that the Drinking Water Quality Clinics have improved our understanding of local wells and ownerships. In conclusion, regular testing on a yearly basis is the most effective way to ensure that public health is maintained.

Quality Monitoring of Various Local and Imported Brands of Bottled Drinking Water in Saudi Arabia

Minerals and constitutes in drinking water are vital for the nutrition of human bodies. Certain limits of water quality parameters must be met to ensure the safety of bottled drinking water for the human consumption. Thirty two local and twelve imported brands of bottled water in Saudi Arabia have been collected to verify their compliance with international and local standards which are EPA (2016), WHO (2013) and SASO (2009). A proposed scoring system is used to evaluate the water quality. Fayha and Hilwa brands have been selected as the best local brands whereas Volvic brand as the optimal imported brand in the western region of Saudi Arabia. The local water brands are more reliable to the standards than the imported brands. Licensed water brands in Saudi Arabia are found to have a good water quality which satisfied the quality requirements.

Water Quality Index of Pravara River for Drinking Purpose at Sangamner in Ahmednagar District, MS, India

River water is still a major source of drinking water for major part of population. Sangamner city is using the River water for drinking, domestic and industrial purpose. At the same time the waste generated is discharged into the River without or with partial treatment. So in present investigation the River water quality was analyzed for the parameters like pH, Electrical Conductivity, Total Dissolved Solids, Total Hardness, Calcium, Magnesium, Alkalinity, Chloride, Dissolved Oxygen, Chemical Oxygen Demand, Biological Oxygen Demand. Sodium, Potassium, Sulphate, Phosphate and Nitrate. The water quality index for drinking purpose was calculated using same data. The grading system was used to assess the water quality index. The result indicates that the poor water quality at four sites ranging from 250 to 745. Only site 1 shows good water quality which is 36.08 which lies in grade B.

Quality Problems in Waters Used for Drinking Purposes in Italy

With a grant from the Italian Ministry of the Environment, the National Institute of Health (Istituto Superiore di Sanita) promoted and coordinated some activities aimed at determining the extent and the intensity of contamination of waters used for human consumption by some chemical agents, and describing causes and modalities of contamination and human health implications. The chemical agents examined were herbicides, nitrates, trihalomethanes, asbestos, manganese and fluoride. In this paper a first nationwide picture of these problems is reported.

Hydro-Geochemistry and Application of Water Quality Index (WQI) for Ground Water Quality Assessment, Wadi Al-Samen—Hebron—West Bank

Located south of the West Bank, Wadi Al-Samen is considered one of the most important sources of groundwater recharge for the eastern aquifer in Hebron. It is polluted by sewage originating from domestic and industrial consumption in the Hebron area. Water quality assessment is an important criterion for achieving sustainable development. To evaluate water quality, twenty samples were collected from groundwater sources for two seasons and were analyzed for Physical properties (Total dissolved solids (TDS), Electrical conductivity (EC), potential hydrogen (pH), Temperature (T)), Four major cations (Mg2+, Ca2+, Na+ and K+), and the Major anions (HCO-3, Cl-, and SO2-4);geochemical methods such as Piper scheme were used for the sample result analysis. To characterize wastewater components, six samples were collected from the Wadi discharge for two seasons and were analyzed (potential hydrogen (pH), Electrical Conductivity (EC), Total Dissolved Solid (TDS), Total Suspended Solids (TDS), Total Suspended Solids (TSS), Biological Oxygen Demand (BOD5), and Chemical Oxygen Demand (COD). The results of nitrate levels showed that 20% of the ground water samples exceeded the standard limit of the World Health Organization (WHO). The quality of drinking water was assessed using the Water Quality Index (WQI), which suggests that 10% of samples are classified from poor to very poor. The abundance of cations from highest to lowest was found to be: Ca;Mg;Na, and for the anions it is HCO3;Cl;SO4. The dominant hydrochemical facies of 35% of collected aquifer samples reveal that Ca-Mg-Na-Cl-HCO3 are in the domain. Evaluation of irrigation suitability was performed using parameters of Sodium adsorption ratio (SAR), electric conductivity (EC), and Salinity. The results in both rounds for EC showed that all water sources are suitable for irrigation according to Todd’s classification. SAR was not suitable in three water resources samples. Wilcox analysis for the two seasons revealed that 85% of samples are not appropriate for irrigation uses.

Arsenic Distribution Pattern in Different Sources of Drinking Water and their Geological Background in Guanzhong Basin, Shaanxi, China

To study arsenic （As） content and distribution patterns as well as the genesis of different kinds of water,especially the different sources of drinking water in Guanzhong Basin,Shaanxi province,China,139 water samples were collected at 62 sampling points from wells of different depths,from hot springs,and rivers.The As content of these samples was measured by the intermittent flowhydride generation atomic fluorescence spectrometry method （HG-AFS）.The As concentrations in the drinking water in Guanzhong Basin vary greatly （0.00-68.08 tg/L）,and the As concentration of groundwater in southern Guanzhong Basin is different from that in the northern Guanzhong Basin.Even within the same location in southern Guanzhong Basin,the As concentrations at different depths vary greatly.As concentration of groundwater from the shallow wells （〈50 m deep,0.56-3.87 μg/L） is much lower than from deep wells （110-360 m deep,19.34-62.91 μg/L）,whereas As concentration in water of any depth in northern Guanzhong Basin is 〈10 μg/L.Southern Guanzhong Basin is a newly discovered high-As groundwater area in China.The high-As groundwater is mainly distributed in areas between the Qinling Mountains and Weihe River; it has only been found at depths ranging from 110 to 360 m in confined aquifers,which store water in the Lishi and Wucheng Loess （Lower and Middle Pleistocene） in the southern Guanzhong Basin.As concentration of hot spring water is 6.47-11.94 μg/L; that of geothermal water between 1000 and 1500 m deep is 43.68-68.08 μg/L.The high-As well water at depths from 110 to 360 m in southern Guanzhong Basin has a very low fluorine （F） value,which is generally 〈0.10 mg/L.Otherwise,the hot springs of Lintong and Tangyu and the geothermal water in southern Guanzhong Basin have very high F values （8.07-14.96 mg/L）.The results indicate that high As groundwater in depths from 110 to 360 m is unlikely to have a direct relationship with the geothermal water in the same area.As concentration of all reservoirs and rivers （both contaminated and uncontaminated） in the Guanzhong Basin is 〈10 μg/L.This shows that pollution in the surface water is not the source of the high-As in the southern Guanzhong Basin.The partition boundaries of the high-and low-As groundwater area corresponds to the partition boundaries of the tectonic units in the Guanzhong Basin.This probably indicates that the high-As groundwater areas can be correlated to their geological underpinning and structural framework.In southern Guanzhong Basin,the main sources of drinking water for villages and small towns today are wells between 110-360 m deep.All of their As contents exceed the limit of the Chinese National Standard and the International Standard （〉10 μg/L） and so local residents should use other sources of clean water that are 〈50 m deep,instead of deep groundwater （110 to 360 m） for their drinking water supply.

ComGIS-Based Early Warning System of Rural Drinking Water Safety in Ya’an City of Sichuan, China

According to characteristic index of spatial-temporal variability of rural drinking water safety in Ya’an City of Sichuan, China, such as water quantity, water quality, convenience degree and guaranteed rate, etc., this study elaborated the basic framework, model’s methodology structure in early warning system of rural drinking water safety on the basis of ComGIS and initially designed information collection, search and re-trieval, evaluation and analysis of factors, dynamic prediction and dynamic early-warning and functions of guidance and management in this system. The design of this system provided scientific basis to grasp the state of rural drinking water safety timely, release early warning information and properly take necessary control measures, etc. The evaluation results showed that the overall trend was getting better. It proved that the rising pressure value and response value were main reasons which caused the rising evaluation value of rural drinking water safety.

Trace Elements in the Drinking Water and Their Possible Health Effects in Aligarh City, India

Environmental degradation and unethical human intervention in the natural system has increased the concern for the betterment of healthy living. The deterioration of aquatic system is commonplace in the developing world. The present paper shows the trace elements (Ni, Zn, Fe, Pb, Cd, Co, Cu and Mn) concentrations in the drinking water of Aligarh city and their possible effect on the health of the inhabitants. The higher concen- tration of some elements in the drinking water and the poor health of inhabitants are found correlated. The statistical analysis of the data shows positive correlation between some elements. The principal component analysis of the data gives four factors with significance level of 42%, 29%, 15% and 12% respectively.

Evaluation of Drinking Water Pollution and Health Effects in Baghdad, Iraq

Contamination of water reserves by biological, chemical, and radiologic agents may affect the health of millions of residents in the Iraq as well as many others throughout the world. Fatal outbreaks of cholera struck several provinces of the country, including Baghdad. The United Nations Environment Programme (UNEP) also says air pollution, resulting from burning oil and aggravated by war, is cause for concern. The study area Baghdad has been divided into two parts: Central Baghdad and Outskirts of Baghdad (included in Baghdad but near the boundaries of Baghdad). The outskirts of Baghdad comprises of 4 cities: Al-Hussaniya located in northern part of Baghdad, Abu-Gurabe located in the western side of Baghdad, Jissr Diyala located in the eastern side of Baghdad and finally Al-Mahmodiya located in the southern side of Baghdad. These cities are in very poor situation in terms of water supply. The quality of water supplied is bad as no attention is given to WTP's in these places, which is also because of the fact that given the insecure war conditions, these areas are inaccessible. The sewage is thrown directly into the river because these areas do not have sewage treatment plants. In case of central Baghdad the water supply and sewerage network are broken in some places. Due to this there is mixing of water between the two networks. For this study we taking water supply samples and collect all the samples from WTPs and water supply network (houses, shops and different places). We made the analysis to parts first bacteriologies, second chlorine and after analysis these samples in lab we will give in our study numbers of fail samples, type of diseases and how many case during year 2007 in Baghdad City. Also in this study we will give Estimated Deaths from Water-Related Diseases 2010 to 2035.