The Strict Swedish vs. the Loose Dutch System for Regulations on Prostitution and Drug Use

The author＇s research topics include economic and legal questions concerning prostitution and drug use. There are two extreme models in these two areas, one represented by Sweden and the other by the Netherlands. Sweden votes for the model of a ＂prostitution and drug free society＂, while the latter represents a looser, more liberal view. This presentation aims to answer the question whether the statistics support the presumptions of either model. To shed light on these issues, facts and figures published by the Swedish and Dutch statistics offices as well as other studies on the subject were analyzed. During the course of the past few decades. the income from the prostitution and drug markets in Sweden was virtually unchanged. This may be considered as a failure： prostitution and drug use could not be decreased further. It may also be considered as an achievement： while these two markets were growing in many countries, at least in the case of Sweden the situation did not become worse. It seems that the liberal regulation of drugs and prostitution in the Netherlands has not been a successful venture. It is no wonder that there are plans for changes and limitations to the prostitution sector with new regulations, although complete prohibition has not been raised as an issue. The consumption of drugs has been increasing. In this respect, alongside the liberal stance on the issue, increasing emphasis is placed on deterrence from light drugs.

Formulation,characterization and in vivo and in vitro evaluation of aloe-emodin-loaded solid dispersions for dissolution enhancement

OBJECTIVE:To prepare aloe-emodin solid dispersion(AE-SD)and determine the metabolic process of AE and AE-SD in vivo.METHODS:AE-SD was prepared via solvent evaporation or solvent melting using PEG-6000 and PVP-K30 as carriers.Thermogravimetric analysis,X-ray diffraction spectroscopy,differential scanning calorimetry,Fourier transform infrared spectroscopy and scanning electron microscopy were used to identify the physical state of AESD.Optimal prescriptions were screened via the dissolution degree determination method.Using Phoenix software,AE suspension and AE-SD were subjected to a pharmacokinetic comparison study analyzing the alteration of behavior in vivo after AE was prepared as a solid dispersion.Acute toxicity was assessed in mice,and the physiological toxicity was used as the determination criterion for toxicity.RESULTS:AE-SD showed that AE existed in the carrier in an amorphous state.Compared with polyethylene glycol,polyvinylpyrrolidone(PVP)inhibited AE crystallization,causing the drug to transform from a dense crystalline state to an amorphous form and increasing the degree of drug dispersion.Therefore,it was more suitable as a carrier material for AE-SD.The addition of poloxamer(POL)was more beneficial to the stability of solid dispersions and could reduce the amount of PVP.The dissolution test confirmed that the optimal ratio of AE to the composite vector AE-PVP-POL was 1:2:2,and its dissolution effect was also optimal.Based on the pharmacokinetic comparison,the drug absorption was faster and quickly reached the peak of blood drug concentration in AE-SD compared to AE,the Cmax of AE-SD was greater than that of AE,and t1/2 and mean residence time of AE-SD were less than AE.The results showed that the drug metabolism in AE-SD was better,and the residence time was shorter.The toxicology study showed that both AE and AE-SD had no toxicity.CONCLUSION:This paper established that the solubility of the drug could be increased after preparing a solid dispersion,as demonstrated by in vitro dissolution experiments.In vivo pharmacokinetics studies confirmed that AE-SD could improve the bioavailability of AE in vivo,providing a new concept for the research and development of AE preparations.