Spotted Hyena Optimizer Driven Deep Learning-Based Drug-Drug Interaction Prediction in Big Data Environment

Nowadays,smart healthcare and biomedical research have marked a substantial growth rate in terms of their presence in the literature,computational approaches,and discoveries,owing to which a massive quantity of experimental datasets was published and generated(Big Data)for describing and validating such novelties.Drug-drug interaction(DDI)significantly contributed to drug administration and development.It continues as the main obstacle in offering inexpensive and safe healthcare.It normally happens for patients with extensive medication,leading them to take many drugs simultaneously.DDI may cause side effects,either mild or severe health problems.This reduced victims’quality of life and increased hospital healthcare expenses by increasing their recovery time.Several efforts were made to formulate new methods for DDI prediction to overcome this issue.In this aspect,this study designs a new Spotted Hyena Optimizer Driven Deep Learning based Drug-Drug Interaction Prediction(SHODL-DDIP)model in a big data environment.In the presented SHODL-DDIP technique,the relativity and characteristics of the drugs can be identified from different sources for prediction.The input data is preprocessed at the primary level to improve its quality.Next,the salp swarm optimization algorithm(SSO)is used to select features.In this study,the deep belief network(DBN)model is exploited to predict the DDI accurately.The SHO algorithm is involved in improvising the DBN model’s predictive outcomes,showing the novelty of the work.The experimental result analysis of the SHODL-DDIP technique is tested using drug databases,and the results signified the improvements of the SHODLDDIP technique over other recent models in terms of different performance measures.

Inter-Row Spacing of PV Power Plant

When designing a solar power plant, it is much more important to avoid the shadow on the PV Panels. As the shadow falls on the PV Panels;it significantly reduces the generation of required power as planned and designed. This research paper and case study will help a lot to avoid shadow, especially when selecting inter-row spacing between the strings of solar power plants.

Facial and bilateral lower extremity edema due to drug-drug interactions in a patient with hepatitis C virus infection and benign prostate hypertrophy: A case report

BACKGROUND New direct-acting antivirals(DAAs)-based anti-hepatitis C virus(HCV)therapies are highly effective in patients with HCV infection.However,safety data are lacking regarding HCV treatment with DAAs and drugs for comorbidities.CASE SUMMARY Herein,we reported a case of HCV-infection in a 46-year-old man with benign prostatic hypertrophy.The patient received sofosbuvir/velpatasvir as well as methadone maintenance therapy for drug abuse.The viral load became negative at week 1 post treatment.He developed facial and bilateral lower extremity edema 48 h after starting receiving tamsulosin.Edema disappeared 10 d after treatment with oral furosemide and spironolactone.CONCLUSION In conclusion,this is the first case of an acute edema in the course of treatment with new DAAs,methadone and tamsulosin.These agents are useful in clinical management of patients with HCV infection,particularly in men with benign prostatic hypertrophy.Clinicians should be aware of potential drug-drug interactions in this subset of patients.

Possibility of Drug-Drug Interaction in Prescription Dispensed by Community and Hospital Pharmacy

Objective: To analyze the use of all subsidized prescription drugs including their use of drug combination generally accepted as carrying a risk of severe interactions. Methodology: In a cross sectional study, we analyzed all prescriptions (n = 1014) involving two or more drugs dispensed to the population (age range 4-85 years) from all pharmacies, clinics and hospitals. Data were stratified by age and sex, and frequency of common interacting drugs. Potential drug interactions were classified according to clinical relevance as significance of severity (types A: major, B: moderate, and C: minor) and documented evidence (types 1, 2, 3, and 4). Result and Discussion: The growing use of pharmacological agents means that drug interactions are of increasing interest for public health. Monitoring of potential drug interactions may improve the quality of drug prescribing and dispensing, and it might form a basis for education focused on appropriate prescribing. To make the manifestation of adverse interaction subside, management strategies must be exercised if two interacting drugs have to be taken with each other, involving: adjusting the dose of the object drug;spacing dosing times to avoid the interaction. The pharmacist, along with the prescriber has a duty to ensure that patients are aware of the risk of side effects and a suitable course of action they should take. Conclusion: It is unrealistic to expect clinicians to memorize the thousands of drug-drug interactions and their clinical significance, especially considering the rate of introduction of novel drugs and the escalating appreciation of the importance of pharmacogenomics. Reliable regularly updated decision support systems and information technology are necessary to help avert dangerous drug combinations.

<i>In Vitro</i>and <i>in Vivo</i>(Mouse) Evaluation of Drug-Drug Interactions of Repaglinide with Anti-HIV Drugs

Repaglinide is type 2 short acting anti-diabetic drug which is primarily metabolized by CYP2C8 and CYP3A4 and is also a substrate of influx transporter OATP1B1. HIV drugs are potent inhibitors of CYP3A4 and OATP transporters. Several drug-drug interactions (DDIs) were noticed when protease inhibitors (PIs) coadministered with drugs metabolized by CYP3A4. The PIs are also potent mechanism based inhibitors, out which ritonavir is most potent. In the current study we evaluated in vitro (mouse and human liver microsomes) and in vivo DDIs of repaglinide with anti-HIV drugs. Out of the following tested drugs (Amprenavir, Indinavir, Nelfinavir, Ritonavir, Saquinavir, Delavirdine, Maraviroc, Efavirenz, Nevirapine and Ketoconazole) Amprenavir (APV), Ritonavir (RTV) and Ketoconazole (KTZ) showed inhibition of OH-repaglinide formation in human and mouse liver microsomes. The positive reversible inhibitions were further tested for irreversible inhibitions where we didn’t observe any irreversible inhibitions. In vitro inhibitions were further evaluated in the in vivo pharmacokinetics (mouse) where repaglinide pharmacokinetics was altered by RTV and KTZ. The DDIs in both studies were very strong;the dose of repaglinide is reduced to 20 fold. In conclusion, there could be possible DDIs when RTV dosed with repaglinide;we have also demonstrated that mouse could be useful preclinical tool when used in conjunction with in vitro screening models for DDIs.

Short-Term Drug-Drug Interaction between Sildenafil and Bosentan under Long-Term Use in Patients with Pulmonary Arterial Hypertension

Sildenafil and bosentan are often co-administered for pulmonary arterial hypertension (PAH) treatment. The plasma concentration of sildenafil can be decreased by half if co-administered with bosentan. Many patients take these agents simultaneously in the morning and the evening. The aim of this study was to examine the pharmacokinetics of sildenafil which was interfered with bosentan administration to ascertain whether these agents should be given concomitantly or separately. A two-way crossover study was conducted in 6 PAH patients with combination therapy of sildenafil and bosentan. Participants underwent the sequence of treatment phases: phase S (sildenafil administered 3 h before bosen-tan);phase B (bosentan administered 3 h before sildenafil);and phase C (administered concomitantly). Blood samples were collected on the last day of each phase. There was no significant difference in maximum plasma concentration or area under the plasma concentration-time curve (AUC0-8) between phase C and phase S (95.5 ± 24.8 vs. 72.9 ± 40.9 (p = 0.07), 209.7 ± 81.8 vs. 180.2 ± 126.4 (p = 0.24), respectively) or between phases C and B (87.8 ± 42.0 vs. 99.6 ± 33.9 (p = 0.59), 197.2 ± 88.2 vs. 240.7 ± 121.8 (p = 0.19), respectively) (ng/mL, mean ± standard deviation). Large intra-and inter-individual variability in sildenafil concentration was noted. The timing of administration of sildenafil and bosentan does not significantly influence the plasma concentration of sildenafil. Physicians do not need to be overly concerned about the timing of administration of these drugs to maximize the sildenafil concentration.

Multidisciplinary Approach to Drug-Drug Interactions between Tacrolimus and Sofosbuvir/Velpatasvir and Glecaprevir/Pibrentasvir in Kidney Transplant Patients during Hepatitis C Treatment:A Case Series Report

The direct acting antivirals(DAAs)are now the standard of care for hepatitis C virus(HCV)treatment with high and effective sustained virologic responserate(SVR)and great safety profile,including solid organ transplant patients.There are increasing reports showing DAAs are effective with high SVR rates and safety profile in kidney transplant recipients.There are reports on drug-drug interaction(DDI)between tacrolimus with DAAs.However,data remain lacking on potential DDIs between tacrolimus and DAA regimens and the management process.This case series reports three kidney transplant patients on tacrolimus who were successfully treated for HCV with multidisciplinary approach,although there was DDI between tacrolimus with sofosbuvir/velpatasvir and glecaprevir/pibrentasvir,which required tacrolimus dose adjustment to maintain therapeutic level during and after DAA treatment.Such DDIs should be aware of and closely monitored by pharmacist and physicians with tacrolimus dose adjustment as needed during and right after DAA treatment in post-kidney transplant patients.

Long-term and short-term stability characteristics of receiver inter system bias for BDS3/BDS2

The study of inter-system bias(ISB)is important for multi-system fusion and the performance of different signal compatibility.In this paper,the stability of ISB at the BDS3/BDS2 receiver end is calculated and analyzed for different time spans(DOY 060~090 in 2021)from a total of 31 MGEX and iGMAS stations.We adopted two estimation strategies,random walk and constant approach,using the precision products of orbit and clock bias provided by WUM,the influence of which on ISB was also analyzed.Our results showed that the ISB value varied little within a day,and the mean of daily ISB standard deviation was only 0.037 m when the observation condition was good.The signal reception was continuous,indicating a high ISB stability for one day.If extending the time series to one month,however,the ISB standard deviation calculated by constant approach,in which a constant ISB is estimated on a daily basis was about 0.1 m,and the results of adjacent days were not continuous,with no apparent pattern.Concerning the random walk approach,the obtained ISB time series also had a jump,and the conclusion was the same as that of the constant strategy.Besides,receiver types showed a strong regularity in ISB numerical situation,and the distribution of ISB values corresponding to the same receiver type was relatively close.Therefore,we conclude that the ISB parameters remain stable in the short term(one day)and less stable in the long-term period.It is recommended that the ISB term should be set as a constant estimate every day in BDS3/BDS2 solutions,regardless of receiver type consistency.

美国丽人 INTERATIONAL AUTO SHOW——2004纽约车展

2005 Jaguar xJ LWB 新的XJ比以前的XJ轻了约200公斤,而比最接近的对手,也轻了有100公斤。这个重量上的优势也同样的在LWB型号上得到了体现,它亦是同级中最轻的。如同最新一代的标准轴距XJ,新XJLWB也共享了先进的铝质结构的所有优势,包括轻重量以及突出的车身强度增强。

Tricube Weighted Linear Regression and Interquartile for Cloud Infrastructural Resource Optimization

Cloud infrastructural resource optimization is the process of precisely selecting the allocating the correct resources either to a workload or application.When workload execution,accuracy,and cost are accurately stabilized in opposition to the best possible framework in real-time,efficiency is attained.In addition,every workload or application required for the framework is characteristic and these essentials change over time.But,the existing method was failed to ensure the high Quality of Service(QoS).In order to address this issue,a Tricube Weighted Linear Regression-based Inter Quartile(TWLR-IQ)for Cloud Infrastructural Resource Optimization is introduced.A Tricube Weighted Linear Regression is presented in the proposed method to estimate the resources(i.e.,CPU,RAM,and network bandwidth utilization)based on the usage history in each cloud server.Then,Inter Quartile Range is applied to efficiently predict the overload hosts for ensuring a smooth migration.Experimental results show that our proposed method is better than the approach in Cloudsim under various performance metrics.The results clearly showed that the proposed method can reduce the energy consumption and provide a high level of commitment with ensuring the minimum number of Virtual Machine(VM)Migrations as compared to the state-of-the-art methods.

莱卡公司再度亮相Intertextile,用“新”诠释创新实力

8月30日,中国国际纺织面料及辅料(秋冬)博览会(Intertextile)正式落下帷幕。作为暌违两年的再度回归,The LYCRA Company(以下简称“莱卡公司”)携众多新品强势亮相,重磅推出LYCRA■ ADAPTIV fiber(莱卡■智合智纤)系列新产品。为了满足市场对耐用服装的需求,提供更具尺码包容性、更高舒适度和更强功能的服装。

基于Inter.iamb-Tabu算法的区域滑坡敏感性评价

确定滑坡敏感性概率的空间分布,可为滑坡防治政策制定和土地利用规划提供科学依据。由于成灾环境的空间差异和滑坡机理的复杂性,基于不同逻辑架构(物理模型、理论模型等)的滑坡敏感性评价针对特定孕灾环境,无法提前确定最优数学评价模型,而基于深度学习法的、融合多种模型的混合算法能较好地解决这个问题。本文以山东省淄博市博山区为研究区域,基于单因素Logistic回归法筛选了滑坡致灾因子,通过频率比法对致灾因子进行了分级;对4种基于贝叶斯网络的改进算法(MMHC、MMPC-Tabu、Fast.iamb-Tabu、Inter.iamb-Tabu)进行验证,引入错误指数确定了建模效果最佳的算法;计算了博山区774570个栅格的滑坡敏感性概率,绘制了博山区滑坡敏感性分布图;基于GIS的空间叠加和栅格计算器功能,对比了各模型的滑坡敏感性评价结果。研究结果表明:(1)基于Inter.iamb-Tabu开展博山区滑坡敏感性建模时效果最佳。该模型包含10个节点(9个致灾因子节点和1个结局节点)、14条有向边。研究区域可划分为极高敏感区、高敏感区、中敏感区、低敏感区和极低敏感区,分别占总面积的7.30%(49.80km^(2))、16.50%(112.56km^(2))、26.10%(178.05km^(2))、33.20%(226.49km^(2))和16.90%(115.29km^(2)),分别有67处、22处、7处、2处和1处滑坡位于上述敏感区。(2)MMHC、MMPC-Tabu和Fast.iamb-Tabu模型在训练时易舍弃样本中部分因子的特征信息,以达到模型整体精度最优的目的。研究成果可为山东省淄博市博山区滑坡防治提供理论依据,采用的研究方法同样适用于类似地区。

Research progress on inter-monthly winter temperature variation in East Asia and climate prediction

近年来,东亚冬季气温的月际间变化十分显著,冬季不同月份或不同阶段之间极端冷暖事件的转折或交替频发.由于月际间变化常常被季节平均掩盖,东亚冬季气候预测面临众多的挑战.因此,亟需研究东亚冬季气温月际间变化的特征和机理,明确其可预测性和预测来源,进而研制考虑月际变化的东亚冬季气温的有效预测方法和预测模型.本文回顾了过去5年对东亚冬季气温月际间变化的主要特征,物理过程,机制,可预测性和预测的研究进展,同时考虑了多个与气温相联系统的变化,包括冬季风,西伯利亚高压,平流层极涡.本文也进一步讨论了未来的研究前景.

对有关电能计量若干问题的思考

文中基于论证和较全面分析,就不同场景下电能计量所关注的截然不同的问题、更好利用大数据去构建电能表检验新方法、动态电能计量研究面临新挑战、关注超谐波电能计量、不宜将电能计量装置与电能表简单划等号,以及测量准确度不同于测量精度等六个问题,阐述了作者的观点和认识,旨在对开展相关研究,以及更清楚理解相关测量方法及概念等起到促进作用。

The Inter-Annual Variability of Rainfall Onset and Its Implication on Crop Planting in Selected East Africa Countries

The inter-annual variability of rainfall onset and crop replanting in East Africa (EA) was assessed using daily estimated rainfall data from climate hazard group infrared precipitation (CHIRPS Ver2.0) and monthly Sea Surface Temperature (SST) indices [Indian Ocean Dipole (IOD) and El-Ni?o Southern Oscillation (ENSO) at NINO3.4 region] from the National Center for Environmental Prediction (NCEP) and the National Center for Atmospheric Research (NCAR). The data covered a period of 40 years from1981 to 2020. The methods of cumulative of daily mean rainfall, percentage of onset date departure (PODD), Mann-Kendall (MK) trend test, student t-test, and correlation were applied in the analysis. The results showed that early onset with dry spell (WDS) consideration frequently occurs in Uganda between the first and second dekads of September, while late rainfall onset WDS occurs in the first and second dekads of December over central and Northern Kenya as well as in the Northeastern highlands, parts of the northern coast and unimodal regions in Tanzania. Rainfall onset with no dry spell (WnDS) portrayed an average of 10 days before the occurrence of true onset WDS, with maximum onset departure days (ODD) above 30 days across the Rift Valley area in Kenya and the Northeastern highlands in Tanzania. The high chance of minimum ODD is seen over entire Uganda and the area around Lake Victoria. However, few regions, such as Nakuru (Kenya) Gulu and Kibale (Uganda), and Gitega (Burundi), revealed a slight positive linear trend while others showed negative trend. Significant positive patterns for correlation between onset WDS and SST indices (IOD and NINO 3.4) were discovered in Northern and Northeastern Kenya, as well as areas along the Indian Ocean (over Tanzania’s Northern Coast). Inter-annual relationship between onset dates WDS and IOD (NINO3.4) indices exhibits a high correlation coefficient r = 0.23 (r = 0.48) in Uganda and r = 0.44 (r = 0.36) in Kenya. On the other hand, a negative correlation was revealed over Burundi and Tanzania (over a unimodal region). A high percentage of PODD was observed, ranging from 40% to 70% over the Rift Valley in Kenya and at the Northeastern highlands in Tanzania. However, a strong PODD above 70% was observed over Tanga and the Northern Pwani Region in Tanzania. These findings will help farmers to understand the appropriate time for crop planting, as well as help other socio-economic activities that strongly depend on rainfall.

干旱胁迫下油菜素内酯对植物-土壤化学计量特征及内稳性的影响

为探究施用油菜素内酯(Brassinosteroid,BR)对不同干旱条件下植物与土壤的生态化学计量特征及其相互关系,本研究以黄花决明(Cassia glauca Lam.)为研究对象,采用盆栽控水法,设置正常水分、中度胁迫、重度胁迫处理(田间持水量的75%±5%,55%±5%,35%±5%)及4种BR浓度处理(0,0.05,0.2和0.5 mg·L^(-1)),在干旱90天后测定株高、生物量和植物、土壤的养分含量及化学计量特征。研究发现:干旱胁迫导致株高、地上和地下生物量降低;随着施用BR浓度的增加,株高、生物量表现为先上升后下降;0.2 mg·L^(-1)BR有利于植物养分含量提升,地上部提升效果更好;干旱区生态修复中黄花决明的生长对N元素的供应需求较大;施用BR有助于提高黄花决明株高和生物量,调节养分分配策略,缓解干旱对植物的不利影响。本研究可为干旱地区的生态修复和植被重建提供新思路与新方法。

“互著”与“别裁”在中医古籍书目整理中的应用与思考

“互著”与“别裁”是我国古典目录学对图书文献进行分类著录的特殊辅助方法,具有重要理论和实践价值,中医古典目录学分类研究也离不开这2种方法的应用。首先,对“互著”与“别裁”的概念、内涵与源流进行梳理;其次,分别对古代中医专科书目和现代中医专科书目中使用“互著”与“别裁”的情况进行核查,重点对其在中医古籍书目整理中具体应用实例进行整理与评述;最后,总结目前存在的问题与对策建议,从而为现代中医古籍数字书目信息建设提供思路和方法。

Proposing Adjustments to the Dry Season Inter-Reservoir Operation Rules of the Red River System to Improve Water Use Efficiency of the Reservoirs

The Red-Thai Binh River system is an important water resource to the Northern Delta, serving the development of agriculture, people’s livelihood and other economic sectors through its upstream reservoirs and a system of water abstraction works along the rivers. However, due to the impact of climate change and pressure from socio-economic development, the operation of the reservoir system according to Decision No. 740/QD-TTg was issued on June 17, 2019 by the Prime Minister of Government promulgating the Red-Thai Binh River system inter-reservoir operation rules (Operation rules 740) has some shortcomings that need adjustments for higher water use efficiency, meeting downstream water demand and power generation benefits. Through the results of water balance calculation and analysis of economic benefits from water use scenarios, this research proposed adjustment to the inter-reservoir operation during dry season in the Red River system. The result showed that an average water level of 1.0 - 1.7 m should be maintained at Hanoi during the increased release period.

非均质气藏井间地层压力计算方法及应用

中国陆相沉积气藏储层普遍存在非均质性,常规地层压力计算方法具有很大局限性,难以准确评价井间地层压力。本文以均质地层中的点源解为基础,采用边界元思想,建立了一种可用于非均质气藏井间地层压力计算的半解析方法。基本思想是将非均质储层进行分块处理,分别建立单个均质区域的压力方程,通过各区交界面处的压力和流量连续条件,将各区压力方程耦合求解,并将求解结果回代至单个区域的压力方程,从而计算地层中任意一点的压力。建立了理论模型,对所提出的井间地层压力计算方法进行了数值验证,并将其应用于长庆靖边气田某区块。结果表明,本文所建立的非均质气藏井间地层压力半解析计算方法与数值模拟计算结果相吻合,仅在早期和井筒附近存在微小差异;半解析方法能很好地预测实际气藏中单井及井间的地层压力变化,与实测数据趋势一致。

热处理对选区激光熔化Al-Mn-Mg-Sc-Zr合金力学性能和腐蚀行为的影响

以Al-4.77Mn-1.37Mg-0.67Sc-0.25Zr(质量分数,%)合金粉末为原料,在激光功率330 W和扫描速率700 mm/s下进行选区激光熔化(Selective laser melting,SLM)形成SLM Al-Mn-Mg-Sc-Zr合金,结合慢应变速率拉伸实验、电化学测试、析氢浸泡实验及显微组织表征手段,分析了(350℃,8 h)热处理对SLM Al-Mn-Mg-Sc-Zr合金力学性能和腐蚀行为的影响。结果表明:SLM Al-Mn-Mg-Sc-Zr合金力学性能优异,抗拉强度、屈服强度和伸长率分别为423 MPa、376 MPa和25.1%。热处理后,SLM Al-Mn-Mg-Sc-Zr合金晶内析出大量针棒状纳米Al_(6)Mn相,抗拉强度和屈服强度分别提升至509 MPa和478 MPa。此外,SLM Al-Mn-Mg-Sc-Zr合金具有良好的耐蚀性能,热处理可以促进SLM Al-Mn-Mg-Sc-Zr合金的钝化,在-0.5 V极化电位时出现钝化台阶,降低SLM Al-Mn-Mg-Sc-Zr合金的电流密度,增加SLM Al-Mn-Mg-Sc-Zr合金的阳极极化率,使SLM Al-Mn-Mg-Sc-Zr合金的平均析氢速率从0.242 mL/(cm^(2)·h)降至0.216 mL/(cm^(2)·h),应力腐蚀敏感因子从3.379%降至0.405%。与此同时,热处理也促进了晶内微米富Si相以及晶界富Mn相和Mg相的析出,增加了SLM Al-Mn-Mg-Sc-Zr合金点蚀形核位置,增大了SLM Al-Mn-Mg-Sc-Zr合金的晶界电化学成分非均匀性,降低了SLM Al-Mn-Mg-Sc-Zr合金的点蚀和晶间腐蚀抗力。