Unraveling the efficacy network: A network meta-analysis of adjuvant external beam radiation therapy methods after hepatectomy

BACKGROUND Primary liver cancer is a malignant tumor with a high recurrence rate that significantly affects patient prognosis.Postoperative adjuvant external radiation therapy(RT)has been shown to effectively prevent recurrence after liver cancer resection.However,there are multiple RT techniques available,and the differ-ential effects of these techniques in preventing postoperative liver cancer re-currence require further investigation.AIM To assess the advantages and disadvantages of various adjuvant external RT methods after liver resection based on overall survival(OS)and disease-free survival(DFS)and to determine the optimal strategy.METHODS This study involved network meta-analyses and followed the PRISMA guidelines.The data of qualified studies published before July 10,2023,were collected from PubMed,Embase,the Web of Science,and the Cochrane Library.We included relevant studies on postoperative external beam RT after liver resection that had OS and DFS as the primary endpoints.The magnitudes of the effects were determined using risk ratios with 95%confidential intervals.The results were analyzed using R software and STATA software.RESULTS A total of 12 studies,including 1265 patients with hepatocellular carcinoma(HCC)after liver resection,were included in this study.There was no significant heterogeneity in the direct paired comparisons,and there were no significant differences in the inclusion or exclusion criteria,intervention measures,or outcome indicators,meeting the assumptions of heterogeneity and transitivity.OS analysis revealed that patients who underwent stereotactic body radiotherapy(SBRT)after resection had longer OS than those who underwent intensity modulated radiotherapy(IMRT)or 3-dimensional conformal RT(3D-CRT).DFS analysis revealed that patients who underwent 3D-CRT after resection had the longest DFS.Patients who underwent IMRT after resection had longer OS than those who underwent 3D-CRT and longer DFS than those who underwent SBRT.CONCLUSION HCC patients who undergo liver cancer resection must consider distinct advantages and disadvantages when choosing between SBRT and 3D-CRT.IMRT,a RT technique that is associated with longer OS than 3D-CRT and longer DFS than SBRT,may be a preferred option.

An investigation of the influence of intestinal flora in external traditional Chinese medicine therapy

External therapy,which has been used for millennia to treat disease,has now become the newest member of complementary and alternative therapies.A growing number of clinical studies and animal experiments have shown that external therapy exerts a positive effect on the intestinal flora.In this paper,we review the research related to external therapy on various systemic diseases and focus on changes in the intestinal flora.We found that studies on external therapy are dominated by acupuncture and tuina,primarily aimed at the treatment of digestive and neurological diseases.However,the deeper mechanism of regulation of the intestinal flora by external therapy has not yet been experimentally confirmed.

The feasibility and safety of high-intensity focused ultrasound combined with low-dose external beam radiotherapy as supplemental therapy for advanced prostate cancer following hormonal therapy

The aim of this study was to investigate the feasibility and safety of high-intensity focused ultrasound （HIFU） combined with （＋） low-dose external beam radiotherapy （LRT） as supplemental therapy for advanced prostate cancer （PCa） following hormonal therapy （HT）. Our definition of HIFU＋LRT refers to treating primary tumour lesions with HIFU in place of reduced field boost irradiation to the prostate, while retaining four-field box irradiation to the pelvis in conventional-dose external beam radiotherapy （CRT）. We performed a prospective, controlled and non-randomized study on 120 patients with advanced PCa after HT who received HIFU, CRT, HIFU＋LRT and HT alone, respectively. CT/MR imaging showed the primary tumours and pelvic lymph node metastases visibly shrank or even disappeared after HIFU ＋LRT treatment. There were significant differences among four groups with regard to overall survival （OS） and disease-specific survival （DSS） curves （P=0.018 and 0.015）. Further comparison between each pair of groups suggested that the long-term DSS of the H IFU ＋ LRT group was higher than those of the other three groups, but there was no significant difference between the HIFU＋LRT group and the CRT group. Multivariable Cox＇s proportional hazard model showed that both HIFU＋LRT and CRT were independently associated with DSS （P=0.001 and 0.035） and had protective effects with regard to the risk of death. Compared with CRT, HIFU ＋LRT significantly decreased incidences of radiation-related late gastrointestinal （GI） and genitourinary （GU） toxicity grade ≥ II. In conclusion, long-term survival of patients with advanced PCa benefited from strengthening local control of primary tumour and reRional lymph node metastases after HT. As an alternative to CRT, HIFU＋LRT showed Rood efficacy and better safety.

Study of the External Dose Rate and Retained Body Activity of Patients with Hyperthyroidism Who Are Receiving Ⅰ-131 Therapy

Hyperthyroidism refers to a clinical state that results from inappropriately hight hyroid hormone levels in the tissues;.Ⅰ-131 therapy plays a critical role and provides a remarkable curative effect in targeting thyroid diseases. Thyroid cells can take up isotope I-131, which emits not only beta rays but also

Outcomes of External-Beam Radiation Therapy Boost with Conventional Fractionation in Cervical Cancer: A Retrospective Analysis about 133 Cases

Introduction: External-beam radiation therapy boost is a treatment option in cervical cancer when brachytherapy is not feasible. Though less effective than brachytherapy, some encouraging results have been reported from some institutions experiences. We conducted this study to assess outcomes of EBRT boost for our patients at National Institute of Oncology in Rabat. Patients and Methods: We collected data from patients treated for cervical cancer between January 2012 and December 2015. Patients, tumor and treatment characteristics were collected. Overall survival (OS), disease-free survival (DFS) and prognostic factors influencing DFS were assessed. Results: One hundred and thirty-three patients were enrolled. Median age was 52 years. Patient haemoglobin level ranged from 3.9 to 15.5 g/dl [mean: 11.2 g/dl]. Most tumors were classified stage III/IVA (63.2%) according to the FIGO classification. Regional lymph node metastases (pelvic and or para-aortic) were observed in 45.1%. Median total dose to tumor was 69.6 Gy (ranging from 66 to 70 Gy). Overall treatment time was protracted, with a median of 60 days. Most of patients received concurrent chemotherapy (94.7%) and the number of cycle ranged from 2 to 7 (median = 5). The follow-up median was 31.3 months, ranging from 6.2 to 96.8 months. At the first visit, most patients achieved complete response (80.5%). Five years OS and DFS were 47% and 44% respectively. In univariate and multivariate analysis, regional lymph nodes metastasis (presence or absence) and haemoglobin level (≤11 g/dl and >11 g/dl) were the two significant and independent prognostic factors influencing DFS (HR: 1.86;p = 0.01 for the former) (HR: 0.59;p = 0.03 for the latter). Conclusion: Our study showed that EBRT boost in conventional fractionation was an acceptable treatment option for cervical cancer unamenable to brachytherapy, especially in the two subgroups of patients that are those without pelvic and/or para-aortic lymph node metastasis and those with haemoglobin level above 11 g/dl.

Application of Statistical Process Control for Setting Action Thresholds as Quality Assurance of Dose Verifications in External Beam Radiotherapy

Purpose: To test the concept of Statistical Process Control (SPC) as a Quality Assurance (QA) procedure for dose verifications in external beam radiation therapy in conventional and 3D Conformal Radiotherapy (3D-CRT) treatment of cervical cancer. Materials and Methods: A study of QA verification of target doses of 198 cervical cancer patients undergoing External Beam Radiotherapy (EBRT) treatments at two different cancer treatment centers in Kenya was conducted. The target doses were determined from measured entrance doses by the diode in vivo dosimetry. Process Behavior Charts (PBC) developed by SPC were applied for setting Action Thresholds (AT) on the target doses. The AT set was then proposed as QA limits for acceptance or rejection of verified target doses overtime of the EBRT process. Result and Discussion: Target doses for the 198 patients were calculated and SPC applied to test whether the action limits set by the Process Behavior Charts could be applied as QA for verified doses in EBRT. Results for the two sub-groups of n = 3 and n = 4 that were tested produced action thresholds which are within clinical dose specifications for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. Conclusion: Action thresholds set by SPC were within the clinical dose specification of ±5% uncertainty for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. So the concept of SPC could be applied in setting QA action limits for dose verifications in EBRT.

Analysis of effect of external therapies of traditional Chinese medicine on eczema by data mining

Objective:To determine medication regularity external therapies of Traditional Chinese medicine of eczema by data mining.Methods:Papers were retrieved from databases Pubmed,CNKI,WF,VIP,CBM,Web of Science and Embase.From the establishment of the database to April 2020 were searched.The main points of Medication Regularity were established with Excel 2016 software;the characteristics and laws in external therapies of Traditional Chinese medicine Treatment of eczema were analyzed with the relevance rule and cluster analysis Methods in data mining technology.Results:The property and flavor of the herbs mainly used were cold,bitter,while the channel which are mostly involved included liver meridian,lung meridian and Bladder Meridian,The analysis of association rules showed that kushen and difuzi had the highest correlation.The clustering analysis figured out 7groups of the herbs.Conclusion:The study presents the common pair herbs in the treatment of external therapies of Traditional Chinese medicine of eczema,which provides the approach to syndrome differentiation and medication in clinical treatment of eczema.

Research progress of external therapies of traditional Chinese medicine in the treatment of non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease(NAFLD)is a common chronic liver disease characterized by diffuse hepatic steatosis.With the improvement of people's living standard,the incidence rate of NAFLD has been increasing,which has become one of the global health problems in 21st Century.However,there is no specific drug or standard treatment for NAFLD,which brings challenges to treatment.Acupuncture,moxibustion,massage and other external therapies based on the characteristics of traditional Chinese medicine have obvious curative effect in the clinical treatment of NAFLD,but the mechanism has not been systematically explained,which makes the clinical promotion evidence insufficient.This paper aims to summarize the researches on the treatment of NAFLD by external therapies of traditional Chinese medicine in recent years,and analyze its possible mechanism,so as to provide a scientific theoretical basis for future basic experiments and clinical research,and form a set of standardized clinical diagnosis and treatment scheme with the characteristics of traditional Chinese medicine.

Therapeutic Effect of Oral Administration and External Therapy of Traditional Chinese Medicine on Cervical Tuberculous Lymphadenopathy

Objective:To analyze the clinical effect and value of oral administration and external therapy of traditional Chinese medicine for treatment of cervical tuberculous lymphadenopathy.Methods:A total of 56 patients with cervical tuberculous lymphadenopathy admitted to our hospital from January 1 to January 2018 were recruited.By using double-blind method,the patients were divided into control group(n=28)and experimental group(n=28).Control group comprised of patients with conventional anti-tuberculosis treatment,while the experimental group comprised of patients treated with oral administration and external therapy of traditional Chinese medicine.Total effective rate,incidence of complication and level of T lymphocyte subsets were compared between the two groups of cervical tuberculous lymphadenopathy patients.Results:Post-treatment data of total effective rate,complication rate,CD3+,CD4+,CD8+,CD4+/CD8+of the experimental group were compared with the control group.P<0.05;statistical analysis showed statistical significance.Post-treatment data of CD3+,CD4+,CD8+,CD4+/CD8+of both control and experimental groups were compared with pre-treatment data.P<0.05;statistical analysis showed statistical significance.Conclusion:Oral administration and external therapy of traditional Chinese medicine possesses significant effect in treatment of cervical tuberculous lymphadenopathy.

Hypothesis on how Distance External Qi Therapy works

Distance External Qi Therapy(DEQT)is a form of Distance Intention Healing.Though it is getting popular,there is still no clear explanation on how it works.This article highlights the plausibility of supporting the mechanism of DEQT with the theory of quantum entanglement.

The use of traditional Chinese medicine internally and externally combined with auricular acupuncture point bloodletting in the treatment of vulvar leukoplakia

Vulvar leukoplakia refers to the chronic disease of degeneration and hypopigmentation of the skin and mucous membrane of the vulva with unbearable itching in women, seriously affecting the quality of life. The main treatment of western medicine for vulvar leukoplakia is the external use of glucocorticoids or estrogen, resulting to the high recurrence rate and side effects. Traditional Chinese medicine (TCM) has the characteristics of the overall concept and dialectical treatment with a variety of ways. Literature review in recent years found that the treatment of TCM decoction combined with external therapies, such as external fumigation, acupuncture and other treatments, or the combination of TCM decoction and external western medicine hormone ointment, can obtain good effects in vulvar leukoplakia. During the clinical practice, we found that the use of TCM internally and externally combined with auricular acupuncture point bloodletting was highly effective with unique advantages in the treatment of vulvar leukoplakia, providing the ideas guidance for clinicians.

Technical operation specification for pricking-cupping therapy

Pricking-cupping therapy is a Traditional Chinese Medicine(TCM)nursing technology that can adjust the viscera of the human body,make the meridians smooth,and Yin and Yang balanced mainly by means of relieving heat and detoxification,harmonizing Qi and blood,promoting blood circulation and removing blood stasis,dredging meridians and activating collaterals,reducing swelling and pain,purging heat and calming shock,clearing heat,and opening orifices.Pricking-cupping therapy has a long history and wide application.After thousands of years of development,it has made great progress.They are widely used to treat lumbar disc herniation,herpes zoster,acute arthritis,migraine,and other diseases in China.Through the clinical practice and theoretical exploration of physicians of past dynasties,the therapeutic mechanism and application scope of pricking-cupping therapy have been greatly enriched.Modern TCM practitioners have conducted in-depth researches on the operation norms of the therapy on the basis of the ancients,hoping to grasp the essence of the disease more accurately and make the rational use of the operation technology of the therapy.

中药外敷联合复合超声关节治疗仪治疗膝骨关节炎的临床效果

目的探究中药外敷联合复合超声关节治疗仪在膝骨关节炎(KOA)中的应用效果。方法选取2022年8月至2023年8月就诊于安阳市中医院的99例KOA患者为研究对象,随机分为3组,每组33例。超声组接受超声关节治疗仪治疗,中药组接受中药外敷治疗,联合组接受中药外敷联合超声关节治疗仪治疗。对比3组疗效及治疗前后西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、视觉模拟评分法(VAS)、奎森功能演算(Lequesne)指数评分、成纤维细胞生长因子2(FGF-2)、Ⅰ型胶原C-末端肽(CTX-I)、软骨寡聚基质蛋白(COMP)及不良反应。结果联合组总有效率[93.94%(31/33)]高于超声组[75.76%(25/33)]、中药组[72.73%(24/33)](P<0.05),超声组与中药组总有效率对比,差异无统计学意义(P>0.05);治疗3个疗程后联合组FGF-2高于超声组、中药组,CTX-1、COMP、Lequesne、WOMAC评分低于超声组、中药组(P<0.05),超声组、中药组组间对比,差异无统计学意义(P>0.05);治疗3个疗程后联合组静态、动态VAS评分<中药组<超声组(P<0.05);治疗期间3组均未出现不良反应。结论中药外敷与复合超声关节治疗仪联合治疗KOA患者效果确切,可有效调节骨代谢指标,有助于缓解患者疼痛感,恢复膝关节功能。

中医外治法治疗痛风性关节炎研究文献可视化分析

目的 分析中医外治法治疗痛风性关节炎相关文献,了解该领域研究现状、研究热点和发展趋势,为该领域后续研究提供研究思路。方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)2000年1月1日-2022年11月30日收录的中医外治法治疗痛风性关节炎研究文献,利用NoteExpress3.6.0软件对文献进行人工筛选,借助Excel2019绘制发文趋势图和期刊分布图;采用VOSviewer1.6.18软件绘制核心作者合作网络、机构合作密度视图和关键词共现图谱,使用CiteSpace6.1.R4软件绘制关键词聚类分析图、时间线图及关键词突现图谱,并对以上内容进行分析。结果 共纳入1 304篇文献,发文量总体呈增长态势;纳入文献涉及318本期刊、2 890位作者,发文量最多的是广州中医药大学;分析得出文献关键词1 181个,形成12个有意义的聚类,并展现出了湿热蕴结型、炎性因子、中医药疗法等20个突现词。结论 中医外治法治疗痛风性关节炎的研究热点主要集中于中药内服外敷、临床疗效观察及中药外敷、针刺、刺血疗法、电针、火针、针刀等中医外治法,备受关注的中医证型是湿热蕴结型。

中西医结合法治疗小儿阑尾周围脓肿的疗效

目的:探究中西医结合法治疗小儿阑尾周围脓肿的临床疗效。方法:选取161例阑尾周围脓肿患儿作为研究对象,根据不同治疗方案分为西医组(n=82)及中西医结合组(n=79)。西医组患儿予以西医常规治疗;中西医结合组在西医组治疗的基础上应用中药外敷治疗。比较两组患儿的临床疗效、不同时间点空腹静脉血中白细胞(WBC)、C-反应蛋白(CRP)及腹腔脓肿直径的变化情况。结果:中西医结合组的总体有效率为89.87%,高于西医组的71.95%(P<0.05)。治疗3、7、14 d后,两组WBC均降低,且中西医结合组低于西医组(P<0.05);治疗3、7、14 d后,两组CRP均降低,且治疗7、14 d后中西医结合组低于西医组(P<0.05)。中西医结合组腹腔脓肿直径小于西医组(P<0.05)。结论:中西医结合治疗小儿阑尾周围脓肿较常规的西医治疗更加有效,安全性高,值得在临床推广。

火针联合黄连膏包敷治疗慢性湿疹血虚风燥证的临床观察

目的观察火针联合黄连膏包敷治疗慢性湿疹血虚风燥证的临床疗效。方法将100例慢性湿疹血虚风燥证患者按照随机数字表法分为2组,对照组50例予局部火针方法治疗,治疗组50例在对照组基础上予黄连膏包敷方法治疗。2组均治疗4周。比较2组治疗前后湿疹面积及严重程度指数(EASI)评分、瘙痒程度评分、瘙痒频率评分,并统计2组疗效及复发率。结果治疗组总有效率96.00%(48/50),对照组总有效率82.00%(41/50),治疗组临床疗效优于对照组(P<0.05)。2组治疗后EASI各项评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后瘙痒程度评分、瘙痒频率评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。治疗组复发率低于对照组(P<0.05)。结论火针联合黄连膏包敷治疗慢性湿疹血虚风燥证患者效果显著,能够减轻患者的瘙痒症状,降低复发率,值得推广应用。

中药保留灌肠联合芒硝外敷的辨证施护治疗急性胰腺炎的效果

目的探讨中药保留灌肠联合芒硝外敷的中医辨证施护在急性胰腺炎患者中的应用效果。方法将80例急性胰腺炎患者随机分为观察组与对照组,对照组给予常规治疗护理,观察组在对照组基础上给予中药保留灌肠联合芒硝外敷的中医辨证施护治疗,观察两组的治疗效果及临床症状改善时间。结果观察组总有效率为97.5%(39/40),高于对照组的70.0%(28/40)(P<0.05)。经治疗,观察组临床症状改善时间均短于对照组(P<0.05)。结论中药保留灌肠联合芒硝外敷的中医辨证施护在急性胰腺炎患者中的应用效果显著,预后良好,患者乐意接受此项操作,可行推广。

排卵障碍性不孕中医外治法研究进展

排卵障碍性不孕是妇科临床常见病、多发病,排卵障碍包括持续性不排卵、稀发排卵、不恰当排卵(包括小卵泡排卵)、多囊卵巢综合征、高泌乳素血症、早发性卵巢功能不全、高雄激素血症、黄素化卵泡未破裂综合征、黄体功能不足和卵巢早衰,这些均可导致不孕。近年来,排卵障碍性不孕的发病率有明显上升的趋势,受到广泛关注,西医治疗主要是使用促排卵药物,促排卵药物除了具有排卵率高、妊娠率低的特点,大部分还能发挥替代外源性激素的作用,但不能从根本上调节体内的生殖内分泌紊乱,具有一定的局限性。而长期排卵障碍不仅增加了育龄期女性的受孕难度,而且严重影响怀孕。中医外治法在治疗排卵障碍性不孕方面,在个性化、辨证论治上占据独特优势,有多种治疗手法可供患者选择,患者易于接受,既可减少患者每日服药量,又不易产生依赖性、耐药性等不良反应,还能避免药物对肝肾等脏器的损害,减轻患者的心理负担,存在显著的优势,确有成效。文章主要探讨针刺疗法、艾灸疗法及综合疗法治疗排卵障碍性不孕患者的疗效,也包括中药保留灌肠、穴位注射、耳穴压豆等中医外治法的运用,以期为排卵障碍性不孕的临床研究及相关科研提供参考。

基于螺旋断层放射治疗摆位误差的靶区外放边界研究

目的分析鼻咽癌、乳腺癌、宫颈癌患者在兆伏级CT(MVCT)影像引导下螺旋断层放射治疗的摆位误差,计算鼻咽癌、乳腺癌、宫颈癌患者相应的靶区外扩边界,从而为临床靶区到计划靶区(CTV-PTV)的确定提供依据。方法选取2022年10月至2023年9月于广东省中医院放疗中心行螺旋断层放射治疗的90例患者,其中鼻咽癌、乳腺癌、宫颈癌患者各30例。治疗前,采用MVCT对所有患者进行摆位误差分析,鼻咽癌、乳腺癌、宫颈癌患者分别采集900次、870次、900次MVCT图像,通过与计划CT对比得到摆位误差,计算不同部位肿瘤在左右(x)、头脚(y)、腹背(z)方向的误差平均值(Σ)及标准差(δ),并确定靶区外扩的边界值。结果鼻咽癌患者的摆位误差为+x(1.45±1.12)、-x(1.50±1.56)、+y(2.01±1.51)、-y(1.65±1.25)、+z(2.10±1.26)、-z(1.25±1.13)mm,乳腺癌患者的摆位误差为+x(3.55±2.52)、-x(3.56±3.13)、+y(3.15±3.32)、-y(3.12±3.02)、+z(5.48±3.01)、-z(3.32±2.46)mm,宫颈癌患者的摆位误差为+x(3.02±2.35)、-x(3.12±2.32)、+y(3.11±2.56)、-y(3.04±2.86)、+z(5.02±2.89)、-z(3.12±2.13)mm,鼻咽癌患者6个方向的外放边界为(2,2,3,3,3,3)mm,乳腺癌患者6个方向的外放边界为(3,3,7,7,8,5)mm,宫颈癌患者6个方向的外放边界为(3,3,7,7,7,4)mm。结论螺旋断层放射治疗时,鼻咽癌患者摆位误差小于乳腺癌与宫颈癌患者,乳腺癌患者的摆位误差最大,通过摆位误差可确定靶区外扩边界,改善患者的放射治疗质量。

散结透脓方外敷联合消肿清热解毒汤内服治疗泛发性肛周脓肿术后的效果及对创面愈合时间、肛门功能的影响

目的观察散结透脓方外敷联合消肿清热解毒汤内服在泛发性肛周脓肿术后的应用效果及对创面愈合时间、肛门功能的影响。方法将102例热毒炽盛型泛发性肛周脓肿术后患者按照随机数字表法分为2组,对照组51例术后予以抗感染及对症支持等治疗方法,治疗组51例在对照组基础上予以散结透脓方外敷联合消肿清热解毒汤内服治疗,2组均治疗4周。比较2组治疗后创面愈合情况(创面腐肉脱落时间、创面愈合时间、治疗2周创面回缩率)、治疗前后中医证候评分、治疗前和治疗2周疼痛视觉模拟评分(VAS)、治疗前和术后2个月肛门失禁Wexner评分量表评分、治疗前和治疗2周炎症相关指标[白细胞计数(WBC)、C反应蛋白(CRP)、白细胞介素6(IL-6)],并统计2组临床疗效,记录治疗期间不良反应发生情况。结果治疗组总有效率90.20%(46/51),对照组总有效率74.51%(38/51),治疗组临床疗效优于对照组(P<0.05)。2组治疗后中医证候各项评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。治疗组创面腐肉脱落时间、愈合时间均低于对照组(P<0.05),治疗2周时创面回缩率高于对照组(P<0.05)。2组治疗2周时疼痛VAS均较本组治疗前降低(P<0.05),且治疗组治疗2周时疼痛VAS低于对照组同期(P<0.05)。2组术后2个月Wexner评分均较本组治疗前降低(P<0.05),且治疗组术后2个月Wexner评分低于对照组同期(P<0.05)。2组治疗2周后外周血WBC、CRP、IL-6水平均较本组治疗前降低(P<0.05),且治疗组治疗2周后均低于对照组同期(P<0.05)。结论散结透脓方外敷联合消肿清热解毒汤内服可提高泛发性肛周脓肿术后疗效,缩短愈合时间,减轻术后疼痛,缓解炎症反应,有利于改善患者肛门功能。