Dual control of energy consumption is an effective method proposed in China to launch and deepen the transition in energy use.It has obtained favorable results;however,the resource consumption and pollution emissions ...Dual control of energy consumption is an effective method proposed in China to launch and deepen the transition in energy use.It has obtained favorable results;however,the resource consumption and pollution emissions per unit of Gross Domestic Product(GDP)remain high.This article quantitatively studies the current policies’effects to promote the advancement of dual control of energy consumption and develop future policies.Green production and consumption policies promote the development of dual control of energy consumption;therefore,this paper examines these policies through text mining and a quantitative evaluation system.The results suggest strong state demand for developing green production and consumption and the necessity for scientific evaluation;however,the state’s focus on the relevant policy tools is imbalanced.Constraint policy tools have the highest proportion of restricting pollutant emissions but lack comprehensiveness.Incentive and guidance policy tools have the problems of poor targets and low volume.Additionally,by constructing policy modeling consistency(PMC)index models for evaluating green production and consumption policies,six selected policies indicate solid performance,but some still have problems regarding policy timeframe,policy function,and green process.Based on the conclusions,this paper provides some targeted recommendations.展开更多
Objective To investigate the effect of fermented barley extracts with Lactobacillus plantarum dy-1（LFBE） for modulating glucose consumption in HepG2 cells via miR-212 regulation. Methods Hepatocellular carcinoma（He...Objective To investigate the effect of fermented barley extracts with Lactobacillus plantarum dy-1（LFBE） for modulating glucose consumption in HepG2 cells via miR-212 regulation. Methods Hepatocellular carcinoma（HepG2） cells were treated with palmitate. After 12 h, palmitate-induced HepG2 cells were treated with LFBE and its main components. Changes in glucose consumption, proinflammatory cytokine secretion, and miRNA-212 expression in HepG2 cells was observed. Results Treatment with LFBE rich in vanillic acid（VA） increased glucose consumption and reduced proinflammatory cytokine secretion in HepG2 cells. LFBE and VA normalized the upregulation of miR-212, which led to the upregulation of dual-specificity phosphatase-9（DUSP9）, a direct target of miR-212, at both protein and mR NA levels. Downregulation of miR-212 markedly increased glucose consumption and reduced proinflammatory cytokine secretion by enhancing DUSP9 expression. Conclusion The results showed the benefit of LFBE and miR-212 downregulation in modulating glucose consumption and reducing proinflammatory cytokine secretion by targeting DUSP9. VA in LFBE was a strong regulator of palmitate-induced abnormal glucose consumption in HepG2 cells and can be a primary mediator.展开更多
基金supported by the National Social Science Foundation of China[Grant No.20ZDA087].
文摘Dual control of energy consumption is an effective method proposed in China to launch and deepen the transition in energy use.It has obtained favorable results;however,the resource consumption and pollution emissions per unit of Gross Domestic Product(GDP)remain high.This article quantitatively studies the current policies’effects to promote the advancement of dual control of energy consumption and develop future policies.Green production and consumption policies promote the development of dual control of energy consumption;therefore,this paper examines these policies through text mining and a quantitative evaluation system.The results suggest strong state demand for developing green production and consumption and the necessity for scientific evaluation;however,the state’s focus on the relevant policy tools is imbalanced.Constraint policy tools have the highest proportion of restricting pollutant emissions but lack comprehensiveness.Incentive and guidance policy tools have the problems of poor targets and low volume.Additionally,by constructing policy modeling consistency(PMC)index models for evaluating green production and consumption policies,six selected policies indicate solid performance,but some still have problems regarding policy timeframe,policy function,and green process.Based on the conclusions,this paper provides some targeted recommendations.
基金supported by the priority academic program development of Jiangsu Higher education institutions and the National Natural Science Foundation of China [3150156931371760]
文摘Objective To investigate the effect of fermented barley extracts with Lactobacillus plantarum dy-1（LFBE） for modulating glucose consumption in HepG2 cells via miR-212 regulation. Methods Hepatocellular carcinoma（HepG2） cells were treated with palmitate. After 12 h, palmitate-induced HepG2 cells were treated with LFBE and its main components. Changes in glucose consumption, proinflammatory cytokine secretion, and miRNA-212 expression in HepG2 cells was observed. Results Treatment with LFBE rich in vanillic acid（VA） increased glucose consumption and reduced proinflammatory cytokine secretion in HepG2 cells. LFBE and VA normalized the upregulation of miR-212, which led to the upregulation of dual-specificity phosphatase-9（DUSP9）, a direct target of miR-212, at both protein and mR NA levels. Downregulation of miR-212 markedly increased glucose consumption and reduced proinflammatory cytokine secretion by enhancing DUSP9 expression. Conclusion The results showed the benefit of LFBE and miR-212 downregulation in modulating glucose consumption and reducing proinflammatory cytokine secretion by targeting DUSP9. VA in LFBE was a strong regulator of palmitate-induced abnormal glucose consumption in HepG2 cells and can be a primary mediator.
