The concept of dual roles design in clean organic preparation

Herein we summarized some clean preparation examples to emphasize the concept of dual roles design(or named as "two birds one stone strategy") in green and sustainable chemistry.In those examples,the reactants and/or solvent play dual roles rendering a cleaner organic preparation process.Consequently,both the chemical waste and manufacturing cost could be reduced.

Ultrasound-assisted tandem synthesis of tri-and tetra-substituted pyrrole-2-carbonitriles from alkenes,TMSCN and N,N-disubstituted formamides

An energy-saving and eco-friendly method for the efficient construction of various tri-and tetrasubstituted pyrrolecarbonitriles through ultrasound-assisted multicomponent tandem reaction of readily available alkenes,TMSCN and N,N-disubstituted formamides within 40 min under metal-,solvent-free and mild conditions was developed.The dual role of iodine(catalyst and oxidant)notably simplified the reaction conditions and reduced the chemical waste generated.

A radical addition and cyclization relay promoted by Mn(OAc)_(3)·2 H_(2)O:Synthesis of 1,2-oxaphospholoindoles and mechanistic study

Novel and efficient Mn(OAc)_(3)·2 H_(2)O promoted radical addition-[4+1]cyclization relay of 3-indolymethanols and phosphites was disclosed,which afforded 1,2-oxaphospholoindole derivatives in moderate to good yields.Based on the experimental and computational studies,a mechanism involving radical addition and intramolecular cyclization cascade was proposed.