Assessment of Adaptive Rate Response Provided by Accelerometer, Minute Ventilation and Dual Sensor Compared with Normal Sinus Rhythm During Exercise： A Self-controlled Study in Chronotropically Competent Subjects

Background：Dual sensor （DS） for rate adaption was supposed to be more physiological.To evaluate its superiority,the DS （accelerometer [ACC] and minute ventilation [MV]） and normal sinus rate response were compared in a self-controlled way during exercise treadmill testing.Methods：This self-controlled study was performed in atrioventricular block patients with normal sinus function who met the indications of pacemaker implant.Twenty-one patients came to the 1-month follow-up visit.Patients performed a treadmill test 1-month post implant while programmed in DDDR and sensor passive mode.For these patients,sensor response factors were left at default settings （ACC =8,MV =3） and sensor indicated rates （SIRs） for DS,ACC and MV sensor were retrieved from the pacemaker memories,along with measured sinus node （SN） rates from the beginning to 1-minute after the end of the treadmill test,and compared among study groups.Repeated measures analysis of variance and profile analysis,as well as variance analysis of randomized block designs,were used for statistical analysis.Results：Fifteen patients （15/2 l） were determined to be chronotropically competent.The mean differences between DS SIRs and intrinsic sinus rates during treadmill testing were smaller than those for ACC and MV sensor （mean difference between SIR and SN rate：ACC vs.SN,MV vs.SN,DS vs.SN,respectively,34.84,17.60,16.15 beats/min）,though no sensors could mimic sinus rates under the default settings for sensor response factor （ACC vs.SN P-adjusted 〈 0.001; MV vs.SN P-adjusted =0.002; DS vs.SN P-adjusted =0.005）.However,both in the range of 1st minute and first 3 minutes of exercise,only the DS SIR profile did not differ from sinus rates （P-adjusted =0.09,0.90,respectively）.Conclusions：The DS under default settings provides more physiological rate response during physical activity than the corresponding single sensors （ACC or MV sensor）.Further study is needed to determine if individual optimization would further improve adaptive performance of the DS.

Specific sensing of antibiotics with metal-organic frameworks based dual sensor system

The illegal usage of antibiotics as veterinary drugs is an increasing threat for human health.The specific sensing of antibiotics with different toxicity levels is of high challenge,and mainly relies on expensive,time-consuming,and complex instruments.To realize specific sensing by rapid and handy optical sensors,a metal-organic framework(MOF)based dual sensor system is herein developed using two MOF materials BUT-128 and BUT-129 with high sensing selectivity and sensitivity.BUT-128 and BUT-129 exhibit the lowest limit of detection(LOD)towards chloramphenicol and furazolidone among reported MOF sensors.The corresponding dual sensor system with enriched signal readouts realized specific sensing of the strictly forbidden antibiotics(chloramphenicol and nitrofurans)from other regulated veterinary drugs including thiamphenicol,a structural analog of chloramphenicol.Besides,the strategy of this work is expected to flourish the development of optical sensors with high specificity for environment and food safety purposes.

A Research for Error Compensation Algorithm of Dual Range Pressure Sensor

Large range-high precision measurement has always been a challenge in the field of mechanical measurements. This paper built the input-output differential equation of Dual Range Pressure Sensor(DRPS) and gave an error compensation algorithm of DRPS after analyzing the mathematical model of DRPS. For a given situation, dynamic measurement errors of sensor parameters can be compensated by this method. Finally the accuracy and feasibility of the method were verified using Adams Software.