A signal optimization model for roundabout was proposed based on dual-ring scheme and two stop lines for left turns control concept were used to eliminate the conflict points and weaving sections at a roundabout. A cy...A signal optimization model for roundabout was proposed based on dual-ring scheme and two stop lines for left turns control concept were used to eliminate the conflict points and weaving sections at a roundabout. A cycle length minimization problem was considered to generate optimal signal timings for roundabout, and a set of constraints to ensure feasibility and safety of the resulting optimal signal settings were proposed. Extensive experimental analyses in comparison with signalized intersection reveal that the proposed model is quite promising for application in design of roundabout signals, and the minimum cycle length can decrease from 186 s to 79 s while the capacity increases from 8 682 pcu/h to 9 011 pcu/h under high demand scenario. Sensitivity analysis with respect to the system performance show that the lane assignment plan, number of circulatory lanes and left turn ratio are three critical factors which have dominate impacts on performance of signalized展开更多
在理想环境下,双双曲调频(dual hyperbolic frequency modulation,Dual-HFM)速度谱估计方法可得到高分辨率的连续多普勒估计结果。然而由多径、双目标环境引起的旁瓣干扰,削弱了速度谱方法抑制噪声的能力,影响目标参数估计。针对该方法...在理想环境下,双双曲调频(dual hyperbolic frequency modulation,Dual-HFM)速度谱估计方法可得到高分辨率的连续多普勒估计结果。然而由多径、双目标环境引起的旁瓣干扰,削弱了速度谱方法抑制噪声的能力,影响目标参数估计。针对该方法在多径、双目标等各种复杂水声环境中的应用,进行了深入的讨论,推导了多径、双目标造成的速度谱旁瓣位置,并提出了基于多帧信号的速度谱旁瓣抑制方法,利用另一维度信号空间中目标回波信息与多径杂波旁瓣的差异性,抑制了复杂水下环境中的速度谱旁瓣,并保留了速度谱计算量低的优点。通过数值仿真验证了所提方法的适用性,为低信噪比、多径、双目标环境下的多普勒估计提供了理论依据。展开更多
针对视觉传感器采集到的图像进行三维人体姿态估计,提出一种双循环Transformer网络模型,有效地从二维关键关节点中提取时空维度高相关性特征,增大感受野,从而提高三维姿态估计的精度。通过在视觉传感器采集得到的公开数据集Human3.6M上...针对视觉传感器采集到的图像进行三维人体姿态估计,提出一种双循环Transformer网络模型,有效地从二维关键关节点中提取时空维度高相关性特征,增大感受野,从而提高三维姿态估计的精度。通过在视觉传感器采集得到的公开数据集Human3.6M上的仿真实验,验证了双循环Transformer算法的性能。分析结果表明,最终估计得到的三维人体关节点的平均关节点位置偏差MPJPE(Mean Per Joint Position Error)为41.6 mm,相比于现有方法有一定提升,可以应用到许多下游相关工作中,有着较强的应用价值。展开更多
Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogene...Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome.展开更多
In recent years, signal transducers and activators of transcription (STAT) proteins have been recognized as cytoplasmic transcription factors that mediate extracellular signaling to the nucleus controlling fundamental...In recent years, signal transducers and activators of transcription (STAT) proteins have been recognized as cytoplasmic transcription factors that mediate extracellular signaling to the nucleus controlling fundamental functions, such as cell proliferation, apoptosis, differentiation, immune responses and angiogenesis. Among them, STAT3 is a major player, aberrant activation of which is involved in several diseases, including cancer. Among other upstream regulators, IL-6/Jak signaling can activate STAT3 and its role appears to be critical in various types of cancer. Although STAT3 has been traditionally recognized as amoncogene, more recently the dual role of STAT3 in cancer, either tumor inductive or suppressive, has been appreciated. The importance and differential effect of STAT3 on tyrosine or serine residues are also a matter of continuing debate. Interestingly, recent findings suggesting that STAT3 plays an important role in cancer stem cell regulation have gained significant attention. This review summarizes current literature focusing on the significance of STAT3 in several diseases as well as in cancer. Understanding the complexity of STAT3 function has the potential to elucidate important molecular aspects of cancer with significant therapeutic implications.展开更多
基金Project(51178345) supported by the National Natural Science Foundation of ChinaProject(2011AA110305) supported by the National High Technology Research and Development Program of ChinaProject supported by the Program for Young Excellent Talents in Tongji University, China
文摘A signal optimization model for roundabout was proposed based on dual-ring scheme and two stop lines for left turns control concept were used to eliminate the conflict points and weaving sections at a roundabout. A cycle length minimization problem was considered to generate optimal signal timings for roundabout, and a set of constraints to ensure feasibility and safety of the resulting optimal signal settings were proposed. Extensive experimental analyses in comparison with signalized intersection reveal that the proposed model is quite promising for application in design of roundabout signals, and the minimum cycle length can decrease from 186 s to 79 s while the capacity increases from 8 682 pcu/h to 9 011 pcu/h under high demand scenario. Sensitivity analysis with respect to the system performance show that the lane assignment plan, number of circulatory lanes and left turn ratio are three critical factors which have dominate impacts on performance of signalized
文摘在理想环境下,双双曲调频(dual hyperbolic frequency modulation,Dual-HFM)速度谱估计方法可得到高分辨率的连续多普勒估计结果。然而由多径、双目标环境引起的旁瓣干扰,削弱了速度谱方法抑制噪声的能力,影响目标参数估计。针对该方法在多径、双目标等各种复杂水声环境中的应用,进行了深入的讨论,推导了多径、双目标造成的速度谱旁瓣位置,并提出了基于多帧信号的速度谱旁瓣抑制方法,利用另一维度信号空间中目标回波信息与多径杂波旁瓣的差异性,抑制了复杂水下环境中的速度谱旁瓣,并保留了速度谱计算量低的优点。通过数值仿真验证了所提方法的适用性,为低信噪比、多径、双目标环境下的多普勒估计提供了理论依据。
文摘针对视觉传感器采集到的图像进行三维人体姿态估计,提出一种双循环Transformer网络模型,有效地从二维关键关节点中提取时空维度高相关性特征,增大感受野,从而提高三维姿态估计的精度。通过在视觉传感器采集得到的公开数据集Human3.6M上的仿真实验,验证了双循环Transformer算法的性能。分析结果表明,最终估计得到的三维人体关节点的平均关节点位置偏差MPJPE(Mean Per Joint Position Error)为41.6 mm,相比于现有方法有一定提升,可以应用到许多下游相关工作中,有着较强的应用价值。
基金funded by a grant from Fundamental Research Grant Scheme, Ministry of Higher Education Malaysia (Grant No. 203.CIPPT.6711505)
文摘Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome.
文摘In recent years, signal transducers and activators of transcription (STAT) proteins have been recognized as cytoplasmic transcription factors that mediate extracellular signaling to the nucleus controlling fundamental functions, such as cell proliferation, apoptosis, differentiation, immune responses and angiogenesis. Among them, STAT3 is a major player, aberrant activation of which is involved in several diseases, including cancer. Among other upstream regulators, IL-6/Jak signaling can activate STAT3 and its role appears to be critical in various types of cancer. Although STAT3 has been traditionally recognized as amoncogene, more recently the dual role of STAT3 in cancer, either tumor inductive or suppressive, has been appreciated. The importance and differential effect of STAT3 on tyrosine or serine residues are also a matter of continuing debate. Interestingly, recent findings suggesting that STAT3 plays an important role in cancer stem cell regulation have gained significant attention. This review summarizes current literature focusing on the significance of STAT3 in several diseases as well as in cancer. Understanding the complexity of STAT3 function has the potential to elucidate important molecular aspects of cancer with significant therapeutic implications.
