Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our hospital.Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass.Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell carci-noma.The patient was diagnosed with MT of MCT.Due to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse effects.After CCRT,her performance status improved,and the tumor size was reduced;surgery was performed.Five months postoperatively,the patient developed dis-semination and lymph node metastases.Palliative chemotherapy was ineffective.She died 18 months after treatment initiation.CONCLUSION EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

Dual-Path Vision Transformer用于急性缺血性脑卒中辅助诊断

急性缺血性脑卒中是由于脑组织血液供应障碍导致的脑功能障碍,数字减影脑血管造影(DSA)是诊断脑血管疾病的金标准。基于患者的正面和侧面DSA图像,对急性缺血性脑卒中的治疗效果进行分级评估,构建基于Vision Transformer的双路径图像分类智能模型DPVF。为了提高辅助诊断速度,基于EdgeViT的轻量化设计思想进行了模型的构建;为了使模型保持轻量化的同时具有较高的精度,提出空间-通道自注意力模块,促进Transformer模型捕获更全面的特征信息,提高模型的表达能力;此外,对于DPVF的两分支的特征融合,构建交叉注意力模块对两分支输出进行交叉融合,促使模型提取更丰富的特征,从而提高模型表现。实验结果显示DPVF在测试集上的准确率达98.5%,满足实际需求。

Mechanical properties of fine-grained dual phase low-carbon steels based on dynamic transformation

The fine grained dual phase （FG-DP） steel with ferrite grains of 2-4.5 μm and martensite islands smaller than 3 μm was obtained through the mechanism of deformation-enhanced ferrite transformation （DEFT）. Mechanical properties of the steel were tested at room temperature. The results indicated that with a similar volume fraction of martensite （about 20vol%）,FG-DP steel exhibited a superior combination of higher strength and more rapid strain hardening at low strains compared with the coarse-grained dual phase （CG-DP） steel obtained by critical annealing. The combination of higher strength,large elongation,and more rapid strain hardening of FG-DP steel can be attributed to the fine ferrite grain and finely dispersed martensite islands. In addition,the uniformly distributed martensite islands in FG-DP steel have smaller interspacing compared with that of CG-DP steel. So,at the initial plastic deformation stage,the plastic deformation of ferrite was restrained and more pronounced load was transferred from ferrite to martensite. The plastic deformation of martensite in FG-DP steel started earlier.

LOCAL GOVERNMENT,ENTERPRISES AND INDIVIDUALS:ECONOMIC TRANSFORMATION IN THE PEARL RIVER DELTA—A Case Study in Beijiao Township,Shunde City

The Pearl River(Zhujiang)Delta(PRD)has been a focal point in reform era ac ademic circles not only for its dramatic industrial growth but a lso the simultaneous agricultural development.Unlike most of existing research on the PRDeconomic development and transformation fromthe whole region level,this paper explored this question f romthe perspec-tive of a township using Beijiao in Shunde City as a case study.Unlike the c onclusions of existing studies whic h attribute the regional economic transition to the macro factors,particularly the influence of external investment,t his research re-veals that at the level of township,t he local government,the town-villa ge owned enterprises and the individ uals have been playing remarkable roles in local economic transformation.In the early stage since the economic reform,Beijiao township government,replacing the central a nd provincial governments before,b egan to manipulate the development o f town-village owned enterprises and lead the local economic transformation from agricultural to industrial dominated.As the town-village owned enterprises grew during the later years,they gra dually acted as the main dominant pla yer leading the local agricultural and industrial growth.At the same time the individuals in Beijiao were playing more in dependent role to gain their most profits.While the local government changed to be t he real manager of local economies.S o the local economic transition was not entirely externally driven.In another word,the“driven from outsidemodel can not totally explain the economic fact in this specific region.

EFFECT OF RESIDUAL STRESS ON THE MARTENSITIC TRANSFORMATION OF SPUTTER-DEPOSITED SMA THIN FILMS

TiNi thin films were sputter-deposited on circular single-crystal silicon substrates un-der various sputtering parameters. The crystal structure and residual stress of the as-deposited films were determined by X-ray diffraction and substrate-curvature method. The phenomenon of stress-suppressed martensitic transformation was observed. R is considered that the residual stresses in SMA thin films based on circular substrates act as balanced biaxial tensile stresses. The status of equilibrant delays the align-ment of self-accommodated variants and the volume shrinkage during the martensitic transformation.

CALCULATION OF RESIDUAL STRESS FIELD IN LASER TRANSFORMATION HARDENED MoCu NODULAR IRON

In this paper,a thermal elastic-plastic 2-D finite element model of stress generation during laser transformation hardening process was developed. In this model, the mechanical properties of the material, Young's modules E, Poisson's ratio v, yield limit s, and thermal expansion coefficient α, are all change with temperature. The equivalent expansion method was used to deal with the problem with phase transformation. Based on this model, a program to calculate the residual stress field was developed using FORTRAN language. The residual stress fields in CO2 laser transformation hardened MoCu nodular iron were calculated. The calculated results showed that in the transformation hardened zone, the residual stress state is compress,whereas adjacent to this zone the residual stress state is tensile, and there is a tensile stress peak close to the transformation hardened zone. To verify this model, the residual stress fields were measured using X-ray diffraction method. The calculated results of residual stress fields are in good agreement with the experimental results.

Transformation toughening of Al_2O_3/ZrO_2 laminated ceramics with residual compressive stress

With the help of scanning electronic microscopy and X-ray diffraction, the relationships of microstructure characteristics, phase assemblage, and fracture micrograph of Al2O3/ZrO2 laminated ceramics were studied. Compared with monolithic Al2O3/ZrO2 ceramics, the existence of surface compressive stresses greatly restrained the growth of ZrO2 and Al2O3 grains at high sinter temperature, fined the grain size, and increased the content of metastable t-ZrO2, which made the fracture transformation energy quantity 70% higher than that of the monolithic ceramics. The trans-granular and inter-granular fracture features were observed in the surface and center layers, which further verified that transformation toughening is the main mechanism, whereas, micro-crack toughening is helpful for enhancing fracture toughness.

DUAL NUMBER TRANSFORMATION AND ITS APPLICATION TO ROBOT WITH REDUNDANCY

This paper presents the application of dual-number matrix to the formulation of Jacobian equations of robot with redundancy, the analytical technique that is based on the dual-number matrices, a 3 × 3 matrix with dualnumber elements, and the dual-number transformation method. Dual-number matrices make possible a concise representation of joint parameters. In particular, the method can effectively be used for direct determination of Jacobian matrices. It is shown that the proposed procedure contributes a simplified approach to the formulation of robotic kinematics, dynamics and control system modelling.

The Double Self—Dual Gravity with Cosmological Term and Constraints Under the Double Constant Conformal Transformation

The double constraint equations in the self-dual gravitational theory containing the cosmological term are derived in gravity. Furthermore, in order to deeply study the Lorentzian and Euclidean reality conditions for this theory, the relations between constraints are discussed by introducing the double constant conformal transformation and the double complex function method.

The Dual Functionals for the Generalized Ball Basis of Wang-Said Type and Basis Transformation Formulas

The generalized Ball curves of Wang-Said type with a position parameter L not only unify the Wang-Ball curves and the Said-Ball curves, but also include several useful intermediate curves. This paper presents the dual functionals for the generalized Ball basis of Wang-Said type. The relevant basis transformation formulae are also worked out.

FEM Simulation of Distortion and Residual Stress Generated by High Energy Beam Welding with Considering Phase Transformation

A series of experiments was carried out so as to elucidate the effect of the phase transformation in the cooling process on welding distortion and residual stress generated by laser beam welding (LBW) and laser-arc hybrid welding (HYBW) on the high strength steel (HT780). Then, the experiments were simulated by 3D thermal elasticplastic analysis with FEM (Finite Element Method) which was performed with using the idealized mechanical properties considering the transformation superplasticity. From the results, the effects of the phase transformation on welding distortion and residual stress generated by LBW and HYBW were elucidated. Furthermore, the generality of the idealization of the mechanical properties was verified.

CHARACTERISTICS OF MARTENSITIC TRANSFORMATION IN DUAL-PHASE STEELS

A theorectical expression for the driving force and M_(?) point of martensitic transformation has been proposed.The M_(?) values using this expression are in good agreement with that obtained experimentally.It was found that the values of M_(?) and M_(?) are not only related to the carbon content in martensite,but also to the volume fraction of ferrite.

EFFECT OF TRACE B AND Ga ON TRANSFORMATION CONTROL OF Mn-Si-Cr AS-ROLLED DUAL PHASE STEELS

Trace of B and Ga can substitute for Mo in Mn-Si-Cr dual phase steels.The technological process and CCT curves of steels treated with B and Ga are similar to those for Mn-Si-Cr-Mo steel.

Bcklund transformations for the Burgers equation via localization of residual symmetries

We obtain the non-local residual symmetry related to truncated Painlev~ expansion of Burgers equation. In order to localize the residual symmetry, we introduce new variables to prolong the original Burgers equation into a new system. By using Lie＇s first theorem, we obtain the finite transformation for the localized residual symmetry. More importantly, we also Iocalize the linear superposition of multiple residual symmetries to find the corresponding finite transformations. It is interesting to find that the n-th B^icklund transformation for Burgers equation can be expressed by determinants in a compact way.

Electron-distribution control via Pt/NC and MoC/NC dual junction:Boosted hydrogen electro-oxidation and theoretical study

The scarcity,high cost and susceptibility to CO of Platinum severely restrict its application in alkaline hydrogen oxidation reaction(HOR).Hybridizing Pt with other transition metals provides an effective strategy to modulate its catalytic HOR performance,but at the cost of mass activity due to the coverage of modifiers on Pt surface.Herein,we constructed dual junctions'Pt/nitrogen-doped carbon(Pt/NC)andδ-MoC/NC to modify electronic structure of Pt via interfacial electron transfer to acquire Pt-MoC@NC catalyst with electron-deficient Pt nanoparticles,simultaneously endowing it with high mass activity and durability of alkaline HOR.Moreover,the unique structure of Pt-MoC@NC endows Pt with a high COtolerance at 1,000 ppm CO/H_(2),a quality that commercial Pt-C catalyst lacks.The theoretical calculations not only confirm the diffusion of electrons from Pt/NC to Mo C/NC could occur,but also demonstrate the negative shift of Pt d-band center for the optimized binding energies of*H,*OH and CO.

Simultaneous Determination of Rare Earth Elements by Dual-System Iterative Target Transformation Factor Analysis

Dualcolor systems were used to reduce the collinearity of multicomponent spectra, which is described by the angles between spectra vectors. Combined with iterative target transformation factor analysis, single rare earth element was determined in its mixture. The calculated results show that the average angle between rare earth spectra in one color system(trichloroarsenazorare earths, pH 34) is 45, and that in two color systems(trichloroarsenazorare earths, pH 34, 14) is 215. This technique makes it easy to select the real number of the components in mixtures, and the determination results show dualcolor system method is an effective technique in rare earth mixture analysis.

Green Transformation of Chinese Oil and Gas Enterprises in Context of the “Dual Carbon” Goals

2021 was the first year of the“14th Five-year Plan”and the year in which the“30·60 Goals”were officially implemented.In the first year of the“Dual Carbon Goals”,domestic oil and gas enterprises vigorously expanded their new energy businesses while actively developing their main businesses,bravely shouldered their responsibility for supply guarantee and comprehensively accelerated their green transformation,creating typical experience and practices.

A strategy for strengthening chaotic mixing of dual shaft eccentric mixers by changing non-Newtonian fluids kinetic energy distribution

Efficiently modulating the velocity distribution and flow pattern of non-Newtonian fluids is a critical challenge in the context of dual shaft eccentric mixers for process intensification,posing a significant barrier for the existing technologies.Accordingly,this work reports a convenient strategy that changes the kinetic energy to controllably regulate the flow patterns from radial flow to axial flow.Results showed that the desired velocity distribution and flow patterns could be effectively obtained by varying the number and structure of baffles to change kinetic energy,and a more uniform velocity distribution,which could not be reached normally in standard baffle dual shaft mixers,was easily obtained.Furthermore,a comparative analysis of velocity and shear rate distributions is employed to elucidate the mechanism behind the generation of flow patterns in various dual-shaft eccentric mixers.Importantly,there is little difference in the power number of the laminar flow at the same Reynolds number,meaning that the baffle type has no effect on the power consumption,while the power number of both unbaffle and U-shaped baffle mixing systems decreases compared with the standard baffle mixing system in the transition flow.Finally,at the same rotational condition,the dimensionless mixing time of the U-shaped baffle mixing system is 15.3%and 7.9%shorter than that of the standard baffle and the unbaffle mixing system,respectively,which shows the advantage of the U-shaped baffle in stirring rate.

Hemorrhagic transformation in patients with large-artery atherosclerotic stroke is associated with the gut microbiota and lipopolysaccharide

Hemorrhagic transformation is a major complication of large-artery atheroscle rotic stroke(a major ischemic stro ke subtype)that wo rsens outcomes and increases mortality.Disruption of the gut microbiota is an important feature of stroke,and some specific bacteria and bacterial metabolites may contribute to hemorrhagic transformation pathogenesis.We aimed to investigate the relationship between the gut microbiota and hemorrhagic transformation in largearte ry atheroscle rotic stro ke.An observational retrospective study was conducted.From May 2020 to September 2021,blood and fecal samples were obtained upon admission from 32 patients with first-ever acute ischemic stroke and not undergoing intravenous thrombolysis or endovascular thrombectomy,as well as 16 healthy controls.Patients with stro ke who developed hemorrhagic transfo rmation(n=15)were compared to those who did not develop hemorrhagic transformation(n=17)and with healthy controls.The gut microbiota was assessed through 16S ribosomal ribonucleic acid sequencing.We also examined key components of the lipopolysaccharide pathway:lipopolysaccharide,lipopolysaccharide-binding protein,and soluble CD14.We observed that bacterial diversity was decreased in both the hemorrhagic transformation and non-hemorrhagic transfo rmation group compared with the healthy controls.The patients with ischemic stro ke who developed hemorrhagic transfo rmation exhibited altered gut micro biota composition,in particular an increase in the relative abundance and dive rsity of members belonging to the Enterobacteriaceae family.Plasma lipopolysaccharide and lipopolysaccharide-binding protein levels were higher in the hemorrhagic transformation group compared with the non-hemorrhagic transfo rmation group.lipopolysaccharide,lipopolysaccharide-binding protein,and soluble CD14 concentrations were associated with increased abundance of Enterobacte riaceae.Next,the role of the gut microbiota in hemorrhagic transformation was evaluated using an experimental stroke rat model.In this model,transplantation of the gut microbiota from hemorrhagic transformation rats into the recipient rats triggered higher plasma levels of lipopolysaccharide,lipopolysaccharide-binding protein,and soluble CD14.Ta ken togethe r,our findings demonstrate a noticeable change in the gut microbiota and lipopolysaccharide-related inflammatory response in stroke patients with hemorrhagic transformation.This suggests that maintaining a balanced gut microbiota may be an important factor in preventing hemorrhagic transfo rmation after stro ke.

Formation and transformation of metastable LPSO building blocks clusters in Mg-Gd-Y-Zn-Zr alloys by spinodal decomposition and heterogeneous nucleation

To study the formation and transformation mechanism of long-period stacked ordered(LPSO)structures,a systematic atomic scale analysis was conducted for the structural evolution of long-period stacked ordered(LPSO)structures in the Mg-Gd-Y-Zn-Zr alloy annealed at 300℃~500℃.Various types of metastable LPSO building block clusters were found to exist in alloy structures at different temperatures,which precipitate during the solidification and homogenization process.The stability of Zn/Y clusters is explained by the first principles of density functional theory.The LPSO structure is distinguished by the arrangement of its different Zn/Y enriched LPSO structural units,which comprises local fcc stacking sequences upon a tightly packed plane.The presence of solute atoms causes local lattice distortion,thereby enabling the rearrangement of Mg atoms in the different configurations in the local lattice,and local HCP-FCC transitions occur between Mg and Zn atoms occupying the nearest neighbor positions.This finding indicates that LPSO structures can generate necessary Schockley partial dislocations on specific slip surfaces,providing direct evidence of the transition from 18R to 14H.Growth of the LPSO,devoid of any defects and non-coherent interfaces,was observed separately from other precipitated phases.As a result,the precipitation sequence of LPSO in the solidification stage was as follows:Zn/Ycluster+Mg layers→various metastable LPSO building block clusters→18R/24R LPSO;whereas the precipitation sequence of LPSO during homogenization treatment was observed to be as follows:18R LPSO→various metastable LPSO building block clusters→14H LPSO.Of these,14H LPSO was found to be the most thermodynamically stable structure.