Injectable“cocktail”hydrogel with dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic effect

The combination of the first-line standard chemotherapeutic drug doxorubicin hydrochloride(DOX)and the molecular-targeted drug Herceptin(HCT)has emerged as a promising strategy for human epidermal growth receptor 2(HER-2)overexpressing breast cancer treatment.However,insufficient drug accumulation and severe cardiotoxicity are two major challenges that limit its clinical application.Herein,an in situ forming gold nanorods(AuNRs)-sodium alginate(ALG)hybrid hydrogel encapsulating DOX and HCT was engineered for tumor synergistic therapy involving injectable,dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic therapy.The photothermal agent AuNRs,anticancer drug DOX,and anticancer antibody HCT were mixed in ALG solution,and after injection,the soluble ALG was quickly transformed into a hydrogel in the presence of Ca^(2+)in the body.Significantly,the hybrid hydrogel exhibits an extremely high photothermal conversion efficiency of 70%under 808 nm laser irradiation.The thermal effect can also provide photothermal stimulation to trigger the drug release from the gel matrix.In addition,the drug release rate and the releasing degree are also sensitive to the pH.In vitro studies demonstrated that the PEI-AuNR/DOX/HCT/ALG hydrogel has facilitated the therapeutic efficiency of each payload and demonstrated a strong synergistic killing effect on SK-BR-3 cells.In vivo imaging results showed that the local drug delivery system can effectively reduce the nonspecific distribution in normal tissues and increase drug concentration at tumor sites.The proposed hydrogel system shows significant clinical implications by easily introducing a sustainable photothermal therapy and a potential universal carrier for the local delivery of multiple drugs to overcome the challenges faced in HER-2 overexpressing cancer therapy.

A dual-stimuli-responsive intelligent layered lanthanide hydroxide for application in information security and latent fingerprint identification

With the rapid changes in the field of information,the research and development of optical storage materials with high security and large storage capacity are particularly important in the development of contemporary society.However,conventional memo ry materials with static fluorescent outputs have the disadvantages of easy simulation and forgery,which limits their practical application in the protection of confidential information.In this research,a dual-stimuli-responsive intelligent fluorescent material based on Tb^(3+)and Eu^(3+)ions doped layered lanthanide hydroxide(LYH:Eu_(x)Tb_(1-x)DPA)was fabricated,which can realize reversible multi-color luminescence conversion(from green to red)by varying the pH and temperature.Combined with the Morse code and security pattern,the multiple encryption and decryption of confidential information and anti-counterfeiting can also be realized.Therefore,the obtained intelligent fluorescent material has a great application prospect for information security.In addition,due to the excellent color tunability,the material can provide the possibility to obtain potential fingerprints with high contrast and no background interference on different color substrates.The unique dual-stimuli-responsive behavior of this material provides more ingenious design inspiration for the design of multi-color intelligent fluorescent devices.