Application of Classical Prescriptions of Rhizome Chinese Herbal Medicines for Medicine and Food Homology and Development Status of Its Modern Food

The efficacy,application and compatibility of five kinds of Chinese Herbal Medicines medicine(including yam,licorice,Platyc-odonisi Radix,Polygonati Rhizoma,and Pueraria Lobata)for medicine and food homology in the past five years were systematically searched and summarized,and the current situation of their food development was reviewed to provide theoretical basis for the research and development of this kind of CHMs for health care.

Matching traditional Chinese medicine and western medicine-based research:Advanced nutraceutical development for proactive gastric cancer prevention

Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and heterogeneous.This review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer prevention.Using advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical development.Focusing on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated compounds.These agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive strategies.The convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health framework.This approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease prevention.The combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.

Mechanism of Herbal Medicine and Food Dandelion Effects May be Related to RNA or DNA Regulation: A Review

Background: A dandelion is a common plant with a global growth distribution that has been used as a medicinal and food with no adverse effects. Purpose: In this article, the products and effects of dandelions are reviewed to help further in-depth studies and develop more products derived from dandelions in the future. Method: The literature about dandelion in various databases such as Pubmed is searched. Results: Dandelions have many effects, such as virus inhibition, anti-tumor activity, nutritional value, anti-aging, potential as a vaccine and alleviation of heat stress. The mechanism underlying these effects is analyzed and it was found that dandelions were regulated by RNA or DNA. Conclusion: As a medicinal and food, dandelions are safe and have many effects. Many products derived from dandelions have been developed. The metabolic regulation is related with ribonucleic acid or possibly deoxynucleic acid. Further in-depth studies should be conducted on the regulation of dandelions through RNA or DNA. There will likely be more products derived from dandelions in the future.

Subcellular Distribution and Chemical Forms of Cadmium in the Medicine Food Homology Plant Platycodon grandiflorum(Jacq.)A.DC.

Although Platycodon grandiflorum(Jacq.)A.DC.is a renowned medicine food homology plant,reports of excessive cadmium(Cd)levels are common,which affects its safety for clinical use and food consumption.To enable its Cd levels to be regulated or reduced,it is necessary to first elucidate the mechanism of Cd uptake and accumulation in the plant,in addition to its detoxification mechanisms.This present study used inductively couple plasma-mass-spectrometry to analyze the subcellular distribution and chemical forms of Cd in different tissues of P.grandiflorum.The experimental results showed that Cd was mainly accumulated in the roots[predominantly in the cell wall(50.96%-61.42%)],and it was found primarily in hypomobile and hypotoxic forms.The proportion of Cd in the soluble fraction increased after Cd exposure,and the proportion of insoluble phosphate Cd and oxalate Cd increased in roots and leaves,with a higher increase in oxalate Cd.Therefore,it is likely that root retention mechanisms,cell wall deposition,vacuole sequestration,and the formation of low mobility and low toxicity forms are tolerance strategies for Cd detoxification used by P.grandiflorum.The results of this study provide a theoretical grounding for the study of Cd accumulation and detoxification mechanisms in P.grandiflorum,and they can be used as a reference for developing Cd limits and standards for other medicine food homology plants.

Determination of vanadium in food and traditional Chinese medicine by graphite furnace atomic absorption spectroscopy

Various experimental conditions were described for the vanadium determinationby graphite furnace atomic absorption spectroscopy (GFAAS). The experiments showed that whenatomization took place under the conditions where the combination of a pyrolytic coating graphitetube and fast raising temperature were used and the temperature was stable, the signal peak shapescould be improved, the sensitivity was enhanced, and the memory effect was removed. The vanadium infood and traditional Chinese medicinal herbs can be accurately determined using the standard curvemethod.

Application of the thought of "simultaneous treatment of medicine and food" in the treatment of intractable functional constipation

Intractable functional constipation is a type of constipation which is difficult to cure,which is usually characterized by persistent constipation,dependence on laxative and/or ineffective treatment of laxative.In recent years,with the change of diet structure,accelerated pace of life and the influence of socio-psychological factors,the incidence rate has increased year by year,seriously affecting the quality of life of patients.Professor Yao Shukun has remarkable clinical effect and experience in the treatment of intractable functional constipation.Professor Yao believes that,combined with the changes of people's diet structure,life style and physique,the main TCM syndrome type of clinical stubborn functional constipation is dampness-heat and blood stasis,and the main treatment should be clearing heat and resolving dampness,regulating qi and removing blood stasis;and we should pay attention to the application of the idea of"Simultaneous Treatment of Medicine and Food"in the process of diagnosis and treatment,and educate patients to change their diet structure in order to fundamentally dispel the etiology.

Samples of the Collection of Old Medicine Raw Materials of the Department of Pharmacognosy of St.Petersburg Chemical Pharmaceutical University,Which Can Be Used in Food

In the world there are many collections of the pharmaceutical trend.In America,the exhibits of this profile are in the Smithsonian Museum of Natural History in Washington,in Europe these are collections of pharmacy museums in Heidelberg(Germany),Krakow and Warsaw(Poland),Basel(Switzerland),Riga(Latvia),and others.Some of them have many thousands of exhibits.There are also separate collections of pharmaceutical items for educational institutions,for example,a collection of old medicinal raw materials in Vigan’s Cabinet,Queen College,Cambridge(Great Britain).All these meetings,however,have long been known and described in detail.Most of them do not have a strict orientation and are presented,along with old medicinal raw materials,as well as tools and appliances,dishes,books,herbaria and various auxiliary items.All the more interesting is the collection indicated in the title of the article,which arose literally from non-existence.She was transferred to the educational institution at its creation,and this year she,like him,turns a hundred years old.It has a strict focus and is represented almost exclusively by medicinal raw materials.Studying the samples of this old collection,as a whole of medical profile,makes it possible to understand that many plants,which initially had only food use,gradually became pharmaceutical objects.Probably,it was the long practice of food use,with the fixing of associated pharmacological effects in the memory,that became the reason for choosing certain types of raw materials as medicinal.Ordinary foods,protein and starchy,began to be perceived as strengthening,mucous—as enveloping and anti-ulcer,some fruits and herbs—as antiscorbutic,sharp—as appetizing and improving the work of the stomach,and so on.

Clinical Application of Radix Notoginseng and Its Homology of Medicine and Food

Clinical application of Radix Notoginseng in the last ten years is summarized,such as Radix Notoginseng powder,compatibility of Radix Notoginseng with other traditional Chinese medicines,and related preparations of Radix Notoginseng,as well as application of Radix Notoginseng in homology of medicine and food,such as preventing and controlling gynecological diseases,rheumatoid arthritis,hypertension,gastric cancer,arthritis,and anemia.

The Protective Effect of Jiujiuguiyi, a Medicine and Food Homologous Formula, on Acute Alcohol Poisoning Mice

Background: Nowadays, acute alcoholic intoxication has become the third public problem in China, and the anti-inebriation products mainly aimed at increasing the activity of enzyme involved in the alcohol metabolism, which is a single mechanism that can accelerate alcohol metabolism. Thus, a new formula, Jiujiuguiyi (JJGY) which could protect liver, relieve the abnormal excitability of the center and improve muscle retardation at the same time is designed by us. Methods: The model of acute alcoholic intoxication was established by intragastric administration with 0.12 ml/10g 50% alcohol in mice. JJGY was orally administrated (gavage) once a day for 20 consecutive days before the establishment of acute alcoholic model. Mice were randomly divided into 8 groups with 8 each: blank control group (CON), model group (M), Haiwangjinzun positive control group (HWJZ), experimental groups (AL, AH, BL, BH, AB). Giant, crawling time on the rota-rod, the activities of aspartate amino trans- ferase (AST), alanine amino transferase (ALT) and superoxide dismutase (SOD) in both liver and serum, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), glutathione peroxidase (GSH-PX) in liver as well as the HE staining of liver slices, the formation of malondialdehyde (MDA) in serum were determined after acute alcoholic intoxication. Results: Compared with model group, JJGY significantly decreased the AST and ALT activity in liver and serum and MDA activity in serum. Meanwhile, it enhanced the ADH and ALDH level in liver as well as the hepatic and serous SOD activity, indicating more efficient metabolism of alcohol and less hepatic injury. HE staining results also proved that JJGY could reduce alcoholic liver cell injury, and the effect was more obvious in the group medicated before alcohol administration. Moreover, JJGY significantly prolonged the crawling time on the rota-rod and improved the gait of mice and the effect was proved to be better than the widely used health product Haiwangjinzun. Conclusions: This study suggests that JJGY is able to protect liver, relieve the abnormal excitability of the center and improve muscle retardation after acute alcoholic intoxication. Its liver protection effect is likely related to its modulation on the alcohol metabolizing and antioxidant enzymes.

Analysis on patents of health care products with substances of medicine food homology in China

Objective:The concept of substances of medicine food homology(SMFH)has garnered significant attention in recent years.This study conducts a systematic analysis of patent literature related to SMFH,and elucidates the development trends,technical hotspots,and the overall patent protection landscape of SMFH in China over the past two decades.Methods:The patent search focused on the SMFH varieties as the objects of inquiry,with retrieval conducted in patent databases.Subsequently,the acquired data underwent processing,analysis,and visualization.Results:While the technical threshold for pharmaceutical applications surpasses that of the food service sector,the former may assume a prominent role in the future.Research and development(R&D)activities in the southeast of China demonstrate robust activity than other regions.Colleges and scientific research institutions exhibit substantial advantages in patent applications compared with individuals and hold greater potential for future development.Conclusion:The findings of this patent analysis indicate that China’s SMFH industry are presently undergoing a transition from an extensive model to a high-quality model.The quality and technical standards of SMFH products are consistently improving.Consequently,there is a need for more stringent patent application requirements to align with the evolving development needs.

Exploring a natural MDR reversal agent: potential of medicinal food supplement Nerium oleander leaf distillate

Objective:To investigate the molecular effects ofNerium oleanderleaf distillate on paclitaxel and vincristine resistant(MCF-7/Pac and MCF-7/Vinc)cells and sensitive(MCF-7/S)cell lines.Methods:Nerium oleander(N.oleander)leaf extract was obtained by hydrodistillation method.The toxicological effects ofN.oleanderdistillate,previously suggested as medicinal food supplement,on drug resistant cells were evaluated by XTT tests.MDR modulation potential of the plant material was evaluated by flow cytometry and fluorescent microscopy.Paclitaxel and vincristine were applied to the sublines in combination with N.oleanderdistillate.Results:Fractional inhibitory indices show thatN.oleanderdistillate did not increase the antiproliferative effects of anticancer drugs.N.oleandertreatment in to MCF-7/Pac and MCF-7/Vinc did not inhibit P-gp activity and MDR1 gene expression level.Conclusions:As a result it may be suggested that althoughN.oleanderdistillate has some medicinal effects as food supplement it may not be suitable as an MDR modulator for drug resistant breast cancer cells.

East to west:research progress in traditional Chinese medicine for antiaging strategies

Delaying the onset of aging is considered an important tool for dealing with the global crisis of the aging population.Accordingly,several antiaging studies have been conducted using strategies of modern medicine and traditional Chinese medicine(TCM).In this review,we summarize the current state of antiaging research related to both modern medicine and TCM and provide suggestions for further research.Various theories related to the aging process have been proposed,including the free radical theory,mitochondrial DNA damage theory,telomere theory,cross-linking theory,and intestinal flora theory,and a number of antiaging chemical treatments have been developed using modern medicine.These theories and achievements have resulted in major advancements in antiaging research.TCM is based on practical experience and has a long history with unique advantages in antiaging research.Some antiaging practices such as moderate diet consumption,acupuncture,Tai Chi(a traditional Chinese martial art that can relax the nerves to slow down the aging process),and Wuqin Xi(a traditional Chinese exercise to strengthen the body)have been adopted to maintain health.Several TCMs and prescriptions,particularly those related to medicine food homology,have been used in antiaging treatment,and their antiaging properties have been demonstrated to be effective based on pharmacological experiments and clinical applications.

Methods of preparation of egg and therapeutic uses:a review perspective of Persian Medicine

Background:The nutrients in eggs play an important role in the health of different body organs like the brain,cardiometabolic system,musculoskeletal system,skin and eyes and so the eggs can be considered as functional foods.In order to maintain the highest nutrient content of an egg,it is recommended to cook it properly,but no specific clinical research has been carried out yet on the role that the cooking of an egg plays in its food and health properties.For this reason,this study has collected and discussed the topics related to a variety of methods of cooking eggs,based on the texts of Persian Medicine,and conducted a comparison with modern sources of nutrition.Methods:The present study is a review in which sources of Persian Medicine(PM)were searched in software JamiTib(Version 1.5)and Persian electronic banks,sites of PubMed,Google Scholar,ScienceDirect,and Embase and websites of health reference of American food and water.Finally,the results obtained were classified and a content analysis was carried out.Results:In the PM books,in addition to referring to the different properties of eggs,different effects of different egg preparation have been investigated.The wise men of the school of medicine have proposed at least five methods of egg preparation,including very soft boiled,soft-boiled,hardboiled,fried,and omelet.In the texts,the healing properties of each case and the quality of digestion in the body were separately investigated.Among the five main methods of preparation eggs,the therapeutic and digestive effects of soft-boiled eggs are emphasized to a greater extent,because easy digestion leads to more beneficial effects of the yolk of the eggs.Conclusion:Though the wise men of Persian Medicine have proposed a variety of methods to cook eggs,ease of digestion is one of the most important factors in their decision-making while proposing the type of cooking method for therapeutic prescriptions.In contrast,in modern nutrition research,regardless of the method of cooking eggs,the effect of its use on diseases like heart disease or diabetes has been studied.Owing to the fact that many cases of eggs,as mentioned,have been confirmed in PM texts during modern scientific surveys,it appears that clinical studies on the relevant issues of eggs in this context are useful in better understanding therapeutic effects.

The research progress of Chinese medicinal food therapy on infertility

Infertility is one of the common gynecological diseases,and the incidence has been on the rise in recent years,and according to WHO,infertility will become the third most serious disease after tumor and cardiovascular disease in the 21st century.Food therapy and medicine in China has a long history,Sun Simiao Valuable Prescriptions for emergencies:"If you can use food to calm the disease,release the emotions and dispel the disease,can be said to be good workers",which is also an important embodiment of the Chinese medicine"cure the disease"idea.With the improvement of the living standard of Chinese residents in recent years,food therapy and medicinal food have become popular as a new treatment method because of its efficacy and ease of acceptance.The author summarizes and summarizes the research results of Chinese medicine and medicinal food in the treatment of infertility in recent years in order to provide reference for clinical treatment of infertility.

药食同源产品开发思路探讨

目的 为药食同源产品的开发提供思路。方法 采用计算机检索关于中药保健食品相关专利及药食同源相关文献,分析近年来中药保健食品和药食同源产品的相关政策、研发现状及市场前景。结果 药食同源产品可发挥中医药治未病的独特优势,药食同源产业是“健康中国”战略中不可或缺的一环。国家卫生部门发布了102种药食同源的中药材,提供了基于这102种药食同源目录中药材开发的药食同源产品具有保健功效的可能性依据。药食同源产品的开发,应基于性味归经及功效,遵循中医药调理配伍原则,现代生理功效相结合的组方原则,以及产品开发与市场需求紧密结合的开发原则,可从肿瘤类、不孕不育类、糖脂代谢类疾病及增强免疫力4个方面开发产品,还需注意产品体感与功效相结合。结论 基于102种药食同源目录中药材的药食同源产品是对中药保健食品的极大补充,也是中医药大健康产品的关键所在。

药食同源中药铁皮石斛的研究进展

铁皮石斛Dendrobii Officinalis Caulis是具有益胃生津,滋阴清热之效的药食同源中药。有丰富的化学成分以及药理活性,具有抗炎、抑菌、抗氧化、抗肿瘤、免疫调节、降血压、调节血糖等作用。常作为药膳以及保健品使用,在药品上也应用广泛,如石斛夜光丸、复方鲜石斛颗粒等,具有很高的药用价值和经济价值。通过对铁皮石斛的资源分布、化学成分、药理活性、药食两用产品开发等多个方面进行概述,对其应用现状进行分析,为铁皮石斛的可持续发展、药食同源开发和综合利用奠定理论基础。

基于专利数据的二氢槲皮素技术发展态势研究

目的以专利数据为对象,分析二氢槲皮素的专利申请态势、我国主要申请人、技术分布、重点专利申请等,对二氢槲皮素的相关研究提供参考和建议。方法利用黑马数据库和中国专利数据库对二氢槲皮素相关的专利数据进行检索筛查,并进行数据加工处理。结果二氢槲皮素作为近年获批的新食品原料,专利申请量稳步增加,应用于食品领域的专利申请增长较快,其作为药物制剂是近年来主要的研究方向。结论合成生物技术制备二氢槲皮素逐渐成为研发的热点,可进一步加强二氢槲皮素结构功能、合成路径等核心机制的研究,构建科学合理的专利布局。

药食同源植物杀虫剂制备及其防治效果

以常见药食同源植物辣椒和花椒的果实、大蒜鳞茎和洋葱鳞叶为试验材料,与有效微生物群(Effective microorganisms,EM)菌液混合发酵制作杀虫剂,使用液相色谱分析其杀虫成分含量;结合室内和田间试验,筛选高效生物杀虫剂并评估其杀虫效果。结果表明,花椒125g,辣椒25g,大蒜125g,洋葱250g混合发酵30d,稀释30倍液得到最佳杀虫活性物A;施药后第6天对桃蚜防治效果最佳,虫口减退率为92.38%。田间试验结果表明,杀虫剂A在施药后第5天对桃蚜防治效果最佳,校正防效为78.05%;与市售植物源杀虫剂比较,杀虫剂A持效时间较长,在施药后第6天虫口减退率为70.29%,校正防效为82.95%,杀虫效果显著高于0.3%印楝素乳油和1.3%苦参碱水剂。研究得到一种高效植物源杀虫剂A,为药食同源植物制备杀虫剂研发及其在生产中推广应用提供试验依据和有效方法。

外来植物资源土圞儿健康价值挖掘及产业化前景展望

土圞儿是一种外来资源植物,具有较高的经济和健康价值。然而,与国外相比,国内对土圞儿的开发和利用研究较少,在其种质资源培育、生产加工技术、产品开发及市场开拓等方面缺乏相关经验。通过对文献资料和专利数据的全面分析,深入剖析土圞儿的研究现状、国内外种植业的发展情况,以及其健康价值和应用前景。针对性地提出土圞儿产业绿色健康发展对策,构建其资源循环利用产业链,旨在为土圞儿资源的深入开发利用提供参考、拓宽其应用领域,为政策制定和产业规划提供依据,进一步推动其产业转型升级和可持续绿色健康发展。

山茱萸食品的研究进展及开发策略

山茱萸作为一种药食同源物质,具有极高的食用和药用价值,但一直以来作为药物进行研究,其相关食品研发相对较少。对山茱萸在食品领域开发的主要产品进行总结,分析当前研究中存在的问题,并对山茱萸产业的开发提出相应的建议,可为山茱萸的进一步研究与利用提供参考。