Dynamic Comprehensive Assessment of Power Development Based on Provincial Data

Dynamic comprehensive assessment of regional power industry development levels is of paramount importance for understanding the development characteristics and potential of the local power industry.A tri-level evaluation index system is established,describing five aspects of the local power industry development level,specifically,the coordination degree between the power industry and economy/energy,power generation,power consumption,power supply and development potential.A combination of information entropy and the analytic hierarchy process(AHP)is used to establish a static evaluation model,and a blend of subjective opinions and objective data information is then realized.By aggregating the static evaluation model for each time period based on a time-ordered weighting vector calculated using time-ordered information entropy,a dynamic comprehensive evaluation model of power industry development level is established.By considering provincial data from China recorded during 2007 to 2016 as the sample set,through synchronic and diachronic comparisons of the evaluation results,the differences,characteristics and potential of local power industry development in China are explored.

Similarity comprehensive evaluation of humanoid robot arm motion

A suitable comprehensive evaluation method for similarity comprehensive evaluation of humanoid motion(mainly to robotic arm) is proposed.For different robotic arms, a static comprehensive evaluation model is established by projection pursuit evaluation based on indexes of humanoid robot arm motion in robotics and ergonomics field. Based on projection pursuit evaluation with timing information entropy and time degrees, a dynamic comprehensive evaluation method is proposed by linear weighting to each time's static model's indexes weight according to timing weighted vectors. Through comparing similarity comprehensive evaluation result based on static and dynamic comprehensive evaluation model, the results show that similarity based on dynamic comprehensive evaluation model is high. By comparing reliability, similarity and dispersion of static and dynamic comprehensive evaluation models, the results show that dynamic comprehensive evaluation result has better accuracy, stability and lower dispersion, and the result is more reasonable and real. Therefore, the dynamic comprehensive evaluation method proposed in this paper is more suitable for similarity comprehensive evaluation of humanoid robot arm motion.

Exploring unbinding mechanism of drugs from SERT via molecular dynamics simulation and its implication in antidepressants

The human serotonin transporter(SERT)terminates neurotransmission by removing serotonin from the synaptic cleft,which is an essential process that plays an important role in depression.In addition to natural substrate serotonin,SERT is also the target of the abused drug cocaine and,clinically used antidepressants,escitalopram,and paroxetine.To date,few studies have attempted to investigate the unbinding mechanism underlying the orthosteric and allosteric modulation of SERT.In this article,the conserved property of the orthosteric and allosteric sites(S1 and S2)of SERT was revealed by combining the high resolutions of x-ray crystal structures and molecular dynamics(MD)simulations.The residues Tyr95 and Ser438 located within the S1 site,and Arg104 located within the S2 site in SERT illustrate conserved interactions(hydrogen bonds and hydrophobic interactions),as responses to selective serotonin reuptake inhibitors.Van der Waals interactions were keys to designing effective drugs inhibiting SERT and further,electrostatic interactions highlighted escitalopram as a potent antidepressant.We found that cocaine,escitalopram,and paroxetine,whether the S1 site or the S2 site,were more competitive.According to this potential of mean force(PMF)simulations,the new insights reveal the principles of competitive inhibitors that lengths of trails from central SERT to an opening were~18A for serotonin and~22 A for the above-mentioned three drugs.Furthermore,the distance between the natural substrate serotonin and cocaine(or escitalopram)at the allosteric site was~3A.Thus,it can be inferred that the potent antidepressants tended to bind at deeper positions of the S1 or the S2 site of SERT in comparison to the substrate.Continuing exploring the processes of unbinding four ligands against the two target pockets of SERT,this study observed a broad pathway in which serotonin,cocaine,escitalopram(at the S1 site),and paroxetine all were pulled out to an opening between MT1b and MT6a,which may be helpful to understand the dissociation mechanism of antidepressants.