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Bioactive superparamagnetic iron oxide-gold nanoparticles regulated by a dynamic magnetic field induce neuronal Ca^(2+)influx and differentiation 被引量:1
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作者 Elias Georgas Muzhaozi Yuan +2 位作者 Jingfan Chen Ya Wang Yi-Xian Qin 《Bioactive Materials》 SCIE CSCD 2023年第8期478-489,共12页
Treating neurodegenerative diseases,e.g.,Alzheimer’s Disease,remains a significant challenge due to the limited neuroregeneration rate in the brain.The objective of this study is to evaluate the hypothesis that exter... Treating neurodegenerative diseases,e.g.,Alzheimer’s Disease,remains a significant challenge due to the limited neuroregeneration rate in the brain.The objective of this study is to evaluate the hypothesis that external magnetic field(MF)stimulation of nerve growth factor functionalized superparamagnetic iron oxide-gold(NGF-SPIO-Au)nanoparticles(NPs)can induce Ca^(2+)influx,membrane depolarization,and enhance neuron differentiation with dynamic MF(DMF)outperforming static MF(SMF)regulation.We showed the that total intracellular Ca^(2+)influx of PC-12 cells was improved by 300%and 535%by the stimulation of DMF(1 Hz,0.5 T,30min)with NGF-SPIO-Au NPs compared to DMF alone and SMF with NGF-SPIO-Au NPs,respectively,which was attributed to successive membrane depolarization.Cellular uptake performed with the application of sodium azide proved that DMF enhanced cellular uptake of NGF-SPIO-Au NPs via endocytosis.In addition,DMF upregulated both the neural differentiation marker(β3-tubulin)and the cell adhesive molecule(integrin-β1)with the existence of NGF-SPIO-Au NPs,while SMF did not show these effects.The results imply that noninvasive DMF-stimulated NPs can regulate intracellular Ca^(2+)influx and enhance neuron differentiation and neuroregeneration rate. 展开更多
关键词 Calcium influx Membrane potential dynamic magnetic fields NEUROREGENERATION SPIO-Au Core-shell nanoparticles
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