A new type of ductile lowrise shearwall with many short horizontalkeyways is proposed in this paper in order to improve the earthquake resistant behav-ior of ordinary lowrise shearwall.The behavior of this wall is stu...A new type of ductile lowrise shearwall with many short horizontalkeyways is proposed in this paper in order to improve the earthquake resistant behav-ior of ordinary lowrise shearwall.The behavior of this wall is studied through low-frequency cyclic loading test.Based on the test results,the paper puts forward thedifferent restoring force models for different lowrise shearwalls,and a program fortheir nonlinear dynamic analysis is worked out.Thr(?)h directly inputting earth-quake waves,the paper analyses the dynamic response and energy dissipation of 3types of lowrise shearwalls.The calculation results dem(?)strate that the newly de-vised ductile shearwall has good earthquake resistant behavior.展开更多
In this study, a model for dynamic instability of embedded single-walled car- bon nanotubes (SWCNTs) is presented. SWCNTs are modeled by the sinusoidal shear deformation beam theory (SSDBT). The modified couple st...In this study, a model for dynamic instability of embedded single-walled car- bon nanotubes (SWCNTs) is presented. SWCNTs are modeled by the sinusoidal shear deformation beam theory (SSDBT). The modified couple stress theory (MCST) is con- sidered in order to capture the size effects. The surrounding elastic medium is described by a visco-Pasternak foundation model, which accounts for normal, transverse shear, and damping loads. The motion equations are derived based on Hamilton's principle. The differential quadrature method (DQM) in conjunction with the Bolotin method is used in order to calculate the dynamic instability region (DIR) of SWCNTs. The effects of differ- ent parameters, such as nonlocal parameter, visco-Pasternak foundation, mode numbers, and geometrical parameters, are shown on the dynamic instability of SWCNTs. The re- sults depict that increasing the nonlocal parameter shifts the DIR to right. The results presented in this paper would be helpful in design and manufacturing of nano-electromechanical system (NEMS) and micro-electro-mechanical system (MEMS).展开更多
Intracranial atherosclerotic disease(ICAD)is an important cause for ischemic stroke and transient ischemic stroke(TIA)throughout the world,especially in Asians,which is not fully appreciated,partly due to its inaccess...Intracranial atherosclerotic disease(ICAD)is an important cause for ischemic stroke and transient ischemic stroke(TIA)throughout the world,especially in Asians,which is not fully appreciated,partly due to its inaccessibility and limitations of current neuroimaging methods.The computational fluid dynamics(CFD)modeling technique provides a novel approach to reveal the hemodynamic characteristics in ICAD,e.g.,the distributions of pressure,wall shear stress and flow velocity.In this review article,we aim to provide an overview of the general methodology of CFD modeling in arterial stenotic diseases,the established application of this technique in coronary artery disease,and more importantly,perspectives and challenges of this technique in the investigation of ICAD.Promising findings of preliminary studies using a CFD model for hemodynamic analysis in ICAD warrant verifications.Further studies in this area will help rectify loopholes in the current secondary prevention strategy,and inform individualized treatment for ICAD patients in the near future.展开更多
The stent was a major breakthrough in the treatment of atherosclerotic vascular disease. The permanent vascular implant of a stent, however, changes the intra-stent blood flow hemodynamics. There is a growing consensu...The stent was a major breakthrough in the treatment of atherosclerotic vascular disease. The permanent vascular implant of a stent, however, changes the intra-stent blood flow hemodynamics. There is a growing consensus that the stent implant may change the artery wall shear stress distribution and hence lead to the restenosis process. Computational fluid dynamics (CFD) has been widely used to analyze hemodynamics in stented arteries. In this paper, two CFD models (the axisymmetric model and the 3-D stent model) were developed to investigate the effects of strut geometry and blood rheology on the intra-stent hemodynamics. The velocity profile, flow recirculation, and wall shear stress distribution of various stent strut geometries were studied. Results show strong correlations between the intra-stent hemodynamics and strut geometry. The intra-stent blood flow is very sensitive to the strut height and fillet size. A round strut with a large fillet size shows 36% and 34% reductions in key parameters evaluating the restenosis risk for the axisymmetric model and the 3-D stent model, respectively. This suggests that electrochemical polishing, a surface-improving process during stent manufacturing, strongly influences the hemodynamic behavior in stented arteries and should be controlled precisely in order to achieve the best clinical outcome. Rheological effects on the wall shear stress are minor in both axisymmetric and 3-D stent models for the vessel diameter of 4 mm, with Newtonian flow simulation tending to give more conservative estimates ofrestenosis risk. Therefore, it is reasonable to simulate the blood flow as a Newtonian flow in stented arteries using the simpler axisymmetric model. These findings will provide great insights for stent design optimization for potential restenosis improvement.展开更多
Stenting is a very effective treatment for stenotic vascular diseases, but vascular geometries altered by stent implantation may lead to flow disturbances which play an important role in the initiation and progression...Stenting is a very effective treatment for stenotic vascular diseases, but vascular geometries altered by stent implantation may lead to flow disturbances which play an important role in the initiation and progression of restenosis, especially in the near wall in stented arterial regions. So stent designs have become one of the indispensable factors needed to be considered for reducing the flow disturbances. In this paper, the structural designs of strut cross-section are considered as an aspect of stent designs to be studied in details. Six virtual stents with different strut cross-section are designed for deployments in the same ideal arterial model. Computational fluid dynamics(CFD) methods are performed to study how the shape and the aspect ratio(AR) of strut cross-section modified the local hemodynamics in the stented segments. The results indicate that stents with different strut cross-sections have different influence on the hemodynamics. Stents with streamlined cross-sectional struts for circular arc or elliptical arc can significantly enhance wall shear stress(WSS) in the stented segments, and reduce the flow disturbances around stent struts. The performances of stents with streamlined cross-sectional struts are better than that of stents with non-streamlined cross-sectional struts for rectangle. The results also show that stents with a larger AR cross-section are more conductive to improve the blood flow. The present study provides an understanding of the flow physics in the vicinity of stent struts and indicates that the shape and AR of strut cross-section ought to be considered as important factors to minimize flow disturbance in stent designs.展开更多
Background Wall shear stress is an important factor in the destabilization of atherosclerotic plaques. The purpose of this study was to assess the distribution of wall shear stress in advanced carotid plaques using hi...Background Wall shear stress is an important factor in the destabilization of atherosclerotic plaques. The purpose of this study was to assess the distribution of wall shear stress in advanced carotid plaques using high resolution magnetic resonance imaging and computational fluid dynamics.Methods Eight diseased internal carotid arteries in seven patients were evaluated. High resolution magnetic resonance imaging was used to visualize the plaque structures, and the mechanic stress in the plaque was obtained by combining vascular imaging post-processing with computational fluid dynamics.Results Wall shear stresses in the plaques in all cases were higher than those in control group. Maximal shear stresses in the plaques were observed at the top of plaque hills, as well as the shoulders of the plaques. Among them,the maximal shear stress in the ruptured plaque was observed in the rupture location in three cases and at the shoulder of fibrous cap in two cases. The maximal shear stress was also seen at the region of calcification, in thrombus region and in the thickest region of plaque in the other three cases, respectively.Conclusion Determination of maximal shear stress at the plaque may be useful for predicting the rupture location of the plaque and may play an important role in assessing plaque vulnerability.展开更多
In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)techniques.As o...In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)techniques.As one of the most common causes of death globally,coronary artery disease(CAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its progression.FSI can include the unique dynamical factors present in the coronary vasculature.To investigate the impact of these dynamical factors,we study an idealized artery model with sequential stenosis.The transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary artery.We compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI simulations.Results suggest that the motion of the artery can impact downstream patterns in both divergence and OSI.WSS magnitude is also decreased by up to 57%due to motion in some regions.WSS divergence patterns varied most significantly between simulations over the systolic period,the time of the largest displacements.This investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.展开更多
In vivo studies on association between wall shear stress(WSS)and intracranial plaque are deficient.Based on the three-dimensional T1-weighted high-resolution magnetic resonance imaging(3DT1 HR-MRI)data of patients wit...In vivo studies on association between wall shear stress(WSS)and intracranial plaque are deficient.Based on the three-dimensional T1-weighted high-resolution magnetic resonance imaging(3DT1 HR-MRI)data of patients with low-grade stenotic(<50%)atherosclerotic middle cerebral artery(MCA)and subjects with normal MCA,we built a three-dimensional reconstructed WSS model by computational fluid dynamics(CFD)technique.Three-dimensional registration of the CFD model to the HR-MRI was performed with projections based on the resolution and thickness of the images.The relationships between the Wss at each side of the vessel wall and plaque location were analyzed.A total of 94 MCA plaques from 43 patients and 50 normal MCAs were analyzed.In the normal MCAs,WSS was lower at the ventral-inferior wall than at the dorsal-superior wall(proximal segment,p<0.001;middle segment,p<0.001)and lower at the inner wall than at the outer wall of the MCA curve(p<0.001).In atherosclerotic MCAs,similar low Wss regions were observed where plaques developed.The WSS ratio of the ventral-inferior wall to the dorsal-superior wall in atherosclerotic MCAs was lower than that in normal MCAs(p=0.002).The WSS_(inmer-outer)ratio in atherosclerotic MCAs was lower than that in normal MCAs(p=0.002).Low WSS was associated with MCA atherosclerosis formation and occurred mainly at the ventral inferior wall,which was anatomically opposite the orifices of penetrating arteries,and at the inner wall of the MCA curve.Overall,the results were well consistent with the low WSS theory in atherosclerosis formation.The reconstructed WSS model is a promising novel method for assessing an individualized vascular profile once validated by further studies.展开更多
Replaceable flexural and shear fuse-type coupling beams are used in hybrid coupled shear wall(HCSW)systems,enabling concrete buildings to be promptly recovered after severe earthquakes.This study aimed to analytically...Replaceable flexural and shear fuse-type coupling beams are used in hybrid coupled shear wall(HCSW)systems,enabling concrete buildings to be promptly recovered after severe earthquakes.This study aimed to analytically evaluate the seismic behavior of flexural and shear fuse beams situated in short-,medium-and high-rise RC buildings that have HCSWs.Three building groups hypothetically located in a high seismic hazard zone were studied.A series of 2D nonlinear time history analyses was accomplished in OpenSees,using the ground motion records scaled at the design basis earthquake level.It was found that the effectiveness of fuses in HCSWs depends on various factors such as size and scale of the building,allowable rotation value,inter-story drift ratio,residual drift quantity,energy dissipation value of the fuses,etc.The results show that shear fuses better meet the requirements of rotations and drifts.In contrast,flexural fuses dissipate more energy,but their sectional stiffness should increase to meet other requirements.It was concluded that adoption of proper fuses depends on the overall scale of the building and on how associated factors are considered.展开更多
Hemodynamics plays a crucial role in the growth of an abdominal aortic aneurysm(AAA)and its possible rupture.Due to the serious consequences that arise from the aneurysm rupture,the ability to predict its evolution an...Hemodynamics plays a crucial role in the growth of an abdominal aortic aneurysm(AAA)and its possible rupture.Due to the serious consequences that arise from the aneurysm rupture,the ability to predict its evolution and the need for surgery are of primary importance in the medical field.Furthermore,the presence of intraluminal thrombus(ILT)strongly affects the evolution of the pathology.In this study,we analyzed the influence of hemodynamics on the growth and possible rupture of AAAs.Numerical investigations of pulsatile non-Newtonian blood flow were performed in six patient-specific AAAs reconstructed from diagnostic images,having different sizes and shapes,and with or without ILT.Wall shear stress and vorticity distribution in the bulge and their evolution during the cardiac cycle were analyzed.The results indicate that blood flow dynamics acts synergistically with atherosclerotic degeneration in the development of the disease.The high surface complexity and tortuosity of the aneurysms significantly affect the blood motion,and the presence of inflection in the aneurysm centerline has a noticeable effect on the vortex dynamics.Links between regions of slow recirculating flows,low values of time-averaged wall shear stress,high values of oscillatory shear index,and zones of ILT deposition were found.In the absence of ILT,possible thrombus accumulation areas and consequent aneurysm growth were identified.The findings of this study highlight the importance of hemodynamics in assessing the vulnerability of the aortic wall and underline the crucial role of patient-specific investigations in predicting the rupture of individual aneurysms.展开更多
The equations of the lateral deflection curve of the short pier shear wall under a lateral concentrated load at any level are derived by employing a continuous approach. Lateral flexibility matrixes for the dynamic an...The equations of the lateral deflection curve of the short pier shear wall under a lateral concentrated load at any level are derived by employing a continuous approach. Lateral flexibility matrixes for the dynamic analysis are also obtained by repeatedly calculating the lateral unit load on the wall at each level where a lumped mass located. Dynamic analyses are implemented for short pier shear walls with different parameters, called the integrative coefficient and the pier strength coefficient related to the dimensions of walls. The influences of two coefficients on the dynamic performances of the structure are studied. Results indicate that with the increase of the integrative coefficient, the periods of top two modes apparently decrease but the other periods of higher frequency modes show little variation when the pier strength coefficient remains constant. Similarly, if the integrative coefficient is constant, the top two periods of the free vibration decrease with the increase of the integrative coefficient but the other periods of higher frequency modes show less variation.展开更多
Objective:Because of the difficulty in obtaining patient specific flow data,branch arteries are often neglected in the flow simulations of a patient-specific type B aortic dissection(AD)following thoracic endovascular...Objective:Because of the difficulty in obtaining patient specific flow data,branch arteries are often neglected in the flow simulations of a patient-specific type B aortic dissection(AD)following thoracic endovascular repair(TEVAR).This study aims to investigate the influence of the aortic branch arteries on the hemodynamics and physical flow phenomena commonly associated with aortic modeling of an AD after TEVAR.Methods:The three-dimensional geometry of a type B AD following TEVAR was generated from a high-quality CT dataset.Simulations were performed with all branch arteries,without the four visceral arteries of the abdominal aorta(FVAoAA),and without the upper three branches of the aortic arch(UTBoAA).Results:The removal of the UTBoAA has marginal effect on the flow patterns and hemodynamic parameters in the false lumen(FL);however,regardless of whether there are aorta branches supplied to the FL or not,the omission of FVAoAA will result in a wrong prediction of the flow direction at tears and flow volume to the FL.Conclusions:The omission of aorta branch arteries has great impact on the hemodynamic prediction including flow field and wall shear stress related parameters in a type B AD after TEVAR,which may induce misleading estimates of the potential thrombus in the FL.It is strongly recommended to keep aorta branches in the computational model to predict the post-operative hemodynamic performance in a type B AD following TEVAR.展开更多
Shear-wall structures are quite common in seismic areas because of their successful seismic behavior during severe earthquakes. But shear walls are prone to brittle failure. This study proposes a new method of vertica...Shear-wall structures are quite common in seismic areas because of their successful seismic behavior during severe earthquakes. But shear walls are prone to brittle failure. This study proposes a new method of vertically installed dampers (VID) to reduce the vibration in shear-wall structures. The motion characteristic of a vertical damping system is that every mass has horizontal and rotational displacements simultaneously, The establishment of dynamic equations should take into account the equilibrium conditions of both horizontal and rotational vibrations. Dynamic equilibrium equations of VID systems are derived from a model of a structure with VID. An example shear-wall structure, with and with- out VID, is studied. There are some changes in the characteristics of the maximum horizontal displacement response. Without dampers, the relative displacements between different floors in the shear wall increase with height. With dampers, the relative displacements are more uniformly distributed, and lateral displacements at the top and at the bottom are closer. When the damping coefficient is 1 000 kN · s/ m, the numerical results reveal that the maximum horizontal displacement and the maximum rotational displacement of the top floor have reduced by 59.3 % and 54.8 % respectively.展开更多
文摘A new type of ductile lowrise shearwall with many short horizontalkeyways is proposed in this paper in order to improve the earthquake resistant behav-ior of ordinary lowrise shearwall.The behavior of this wall is studied through low-frequency cyclic loading test.Based on the test results,the paper puts forward thedifferent restoring force models for different lowrise shearwalls,and a program fortheir nonlinear dynamic analysis is worked out.Thr(?)h directly inputting earth-quake waves,the paper analyses the dynamic response and energy dissipation of 3types of lowrise shearwalls.The calculation results dem(?)strate that the newly de-vised ductile shearwall has good earthquake resistant behavior.
文摘In this study, a model for dynamic instability of embedded single-walled car- bon nanotubes (SWCNTs) is presented. SWCNTs are modeled by the sinusoidal shear deformation beam theory (SSDBT). The modified couple stress theory (MCST) is con- sidered in order to capture the size effects. The surrounding elastic medium is described by a visco-Pasternak foundation model, which accounts for normal, transverse shear, and damping loads. The motion equations are derived based on Hamilton's principle. The differential quadrature method (DQM) in conjunction with the Bolotin method is used in order to calculate the dynamic instability region (DIR) of SWCNTs. The effects of differ- ent parameters, such as nonlocal parameter, visco-Pasternak foundation, mode numbers, and geometrical parameters, are shown on the dynamic instability of SWCNTs. The re- sults depict that increasing the nonlocal parameter shifts the DIR to right. The results presented in this paper would be helpful in design and manufacturing of nano-electromechanical system (NEMS) and micro-electro-mechanical system (MEMS).
文摘Intracranial atherosclerotic disease(ICAD)is an important cause for ischemic stroke and transient ischemic stroke(TIA)throughout the world,especially in Asians,which is not fully appreciated,partly due to its inaccessibility and limitations of current neuroimaging methods.The computational fluid dynamics(CFD)modeling technique provides a novel approach to reveal the hemodynamic characteristics in ICAD,e.g.,the distributions of pressure,wall shear stress and flow velocity.In this review article,we aim to provide an overview of the general methodology of CFD modeling in arterial stenotic diseases,the established application of this technique in coronary artery disease,and more importantly,perspectives and challenges of this technique in the investigation of ICAD.Promising findings of preliminary studies using a CFD model for hemodynamic analysis in ICAD warrant verifications.Further studies in this area will help rectify loopholes in the current secondary prevention strategy,and inform individualized treatment for ICAD patients in the near future.
文摘The stent was a major breakthrough in the treatment of atherosclerotic vascular disease. The permanent vascular implant of a stent, however, changes the intra-stent blood flow hemodynamics. There is a growing consensus that the stent implant may change the artery wall shear stress distribution and hence lead to the restenosis process. Computational fluid dynamics (CFD) has been widely used to analyze hemodynamics in stented arteries. In this paper, two CFD models (the axisymmetric model and the 3-D stent model) were developed to investigate the effects of strut geometry and blood rheology on the intra-stent hemodynamics. The velocity profile, flow recirculation, and wall shear stress distribution of various stent strut geometries were studied. Results show strong correlations between the intra-stent hemodynamics and strut geometry. The intra-stent blood flow is very sensitive to the strut height and fillet size. A round strut with a large fillet size shows 36% and 34% reductions in key parameters evaluating the restenosis risk for the axisymmetric model and the 3-D stent model, respectively. This suggests that electrochemical polishing, a surface-improving process during stent manufacturing, strongly influences the hemodynamic behavior in stented arteries and should be controlled precisely in order to achieve the best clinical outcome. Rheological effects on the wall shear stress are minor in both axisymmetric and 3-D stent models for the vessel diameter of 4 mm, with Newtonian flow simulation tending to give more conservative estimates ofrestenosis risk. Therefore, it is reasonable to simulate the blood flow as a Newtonian flow in stented arteries using the simpler axisymmetric model. These findings will provide great insights for stent design optimization for potential restenosis improvement.
基金Supported by National Natural Science Foundation of China(Grant No.5775179)
文摘Stenting is a very effective treatment for stenotic vascular diseases, but vascular geometries altered by stent implantation may lead to flow disturbances which play an important role in the initiation and progression of restenosis, especially in the near wall in stented arterial regions. So stent designs have become one of the indispensable factors needed to be considered for reducing the flow disturbances. In this paper, the structural designs of strut cross-section are considered as an aspect of stent designs to be studied in details. Six virtual stents with different strut cross-section are designed for deployments in the same ideal arterial model. Computational fluid dynamics(CFD) methods are performed to study how the shape and the aspect ratio(AR) of strut cross-section modified the local hemodynamics in the stented segments. The results indicate that stents with different strut cross-sections have different influence on the hemodynamics. Stents with streamlined cross-sectional struts for circular arc or elliptical arc can significantly enhance wall shear stress(WSS) in the stented segments, and reduce the flow disturbances around stent struts. The performances of stents with streamlined cross-sectional struts are better than that of stents with non-streamlined cross-sectional struts for rectangle. The results also show that stents with a larger AR cross-section are more conductive to improve the blood flow. The present study provides an understanding of the flow physics in the vicinity of stent struts and indicates that the shape and AR of strut cross-section ought to be considered as important factors to minimize flow disturbance in stent designs.
基金This work was supported by National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science & Technology of China During the l lth Five-year Plan (No. 2007BAI05B07), Beijing Natural Science Foundation (No. 7002011) and Capital Medical Development and Research Foundation, China (No. 2005-2026).
文摘Background Wall shear stress is an important factor in the destabilization of atherosclerotic plaques. The purpose of this study was to assess the distribution of wall shear stress in advanced carotid plaques using high resolution magnetic resonance imaging and computational fluid dynamics.Methods Eight diseased internal carotid arteries in seven patients were evaluated. High resolution magnetic resonance imaging was used to visualize the plaque structures, and the mechanic stress in the plaque was obtained by combining vascular imaging post-processing with computational fluid dynamics.Results Wall shear stresses in the plaques in all cases were higher than those in control group. Maximal shear stresses in the plaques were observed at the top of plaque hills, as well as the shoulders of the plaques. Among them,the maximal shear stress in the ruptured plaque was observed in the rupture location in three cases and at the shoulder of fibrous cap in two cases. The maximal shear stress was also seen at the region of calcification, in thrombus region and in the thickest region of plaque in the other three cases, respectively.Conclusion Determination of maximal shear stress at the plaque may be useful for predicting the rupture location of the plaque and may play an important role in assessing plaque vulnerability.
基金Westpac Scholars Trust,Grant/Award Number:FL19518National Heart Foundation of Australia,Grant/Award Number:FLF102056National Health and Medical Research Council(NHMRC),Grant/Award Number:CDF1161506。
文摘In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)techniques.As one of the most common causes of death globally,coronary artery disease(CAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its progression.FSI can include the unique dynamical factors present in the coronary vasculature.To investigate the impact of these dynamical factors,we study an idealized artery model with sequential stenosis.The transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary artery.We compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI simulations.Results suggest that the motion of the artery can impact downstream patterns in both divergence and OSI.WSS magnitude is also decreased by up to 57%due to motion in some regions.WSS divergence patterns varied most significantly between simulations over the systolic period,the time of the largest displacements.This investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.
基金This work was supported by the National Science Fund for Distinguished Young Scholars(Grant No.8202500477)the National Natural Science Foundation of China(Grants No.81471207,81671370,81661168015)2016 PUMCH science fund for junior faculty,and Shenzhen Science and Technology Innovation Commission(Grant No.JCYJ20160608153506088).
文摘In vivo studies on association between wall shear stress(WSS)and intracranial plaque are deficient.Based on the three-dimensional T1-weighted high-resolution magnetic resonance imaging(3DT1 HR-MRI)data of patients with low-grade stenotic(<50%)atherosclerotic middle cerebral artery(MCA)and subjects with normal MCA,we built a three-dimensional reconstructed WSS model by computational fluid dynamics(CFD)technique.Three-dimensional registration of the CFD model to the HR-MRI was performed with projections based on the resolution and thickness of the images.The relationships between the Wss at each side of the vessel wall and plaque location were analyzed.A total of 94 MCA plaques from 43 patients and 50 normal MCAs were analyzed.In the normal MCAs,WSS was lower at the ventral-inferior wall than at the dorsal-superior wall(proximal segment,p<0.001;middle segment,p<0.001)and lower at the inner wall than at the outer wall of the MCA curve(p<0.001).In atherosclerotic MCAs,similar low Wss regions were observed where plaques developed.The WSS ratio of the ventral-inferior wall to the dorsal-superior wall in atherosclerotic MCAs was lower than that in normal MCAs(p=0.002).The WSS_(inmer-outer)ratio in atherosclerotic MCAs was lower than that in normal MCAs(p=0.002).Low WSS was associated with MCA atherosclerosis formation and occurred mainly at the ventral inferior wall,which was anatomically opposite the orifices of penetrating arteries,and at the inner wall of the MCA curve.Overall,the results were well consistent with the low WSS theory in atherosclerosis formation.The reconstructed WSS model is a promising novel method for assessing an individualized vascular profile once validated by further studies.
文摘Replaceable flexural and shear fuse-type coupling beams are used in hybrid coupled shear wall(HCSW)systems,enabling concrete buildings to be promptly recovered after severe earthquakes.This study aimed to analytically evaluate the seismic behavior of flexural and shear fuse beams situated in short-,medium-and high-rise RC buildings that have HCSWs.Three building groups hypothetically located in a high seismic hazard zone were studied.A series of 2D nonlinear time history analyses was accomplished in OpenSees,using the ground motion records scaled at the design basis earthquake level.It was found that the effectiveness of fuses in HCSWs depends on various factors such as size and scale of the building,allowable rotation value,inter-story drift ratio,residual drift quantity,energy dissipation value of the fuses,etc.The results show that shear fuses better meet the requirements of rotations and drifts.In contrast,flexural fuses dissipate more energy,but their sectional stiffness should increase to meet other requirements.It was concluded that adoption of proper fuses depends on the overall scale of the building and on how associated factors are considered.
文摘Hemodynamics plays a crucial role in the growth of an abdominal aortic aneurysm(AAA)and its possible rupture.Due to the serious consequences that arise from the aneurysm rupture,the ability to predict its evolution and the need for surgery are of primary importance in the medical field.Furthermore,the presence of intraluminal thrombus(ILT)strongly affects the evolution of the pathology.In this study,we analyzed the influence of hemodynamics on the growth and possible rupture of AAAs.Numerical investigations of pulsatile non-Newtonian blood flow were performed in six patient-specific AAAs reconstructed from diagnostic images,having different sizes and shapes,and with or without ILT.Wall shear stress and vorticity distribution in the bulge and their evolution during the cardiac cycle were analyzed.The results indicate that blood flow dynamics acts synergistically with atherosclerotic degeneration in the development of the disease.The high surface complexity and tortuosity of the aneurysms significantly affect the blood motion,and the presence of inflection in the aneurysm centerline has a noticeable effect on the vortex dynamics.Links between regions of slow recirculating flows,low values of time-averaged wall shear stress,high values of oscillatory shear index,and zones of ILT deposition were found.In the absence of ILT,possible thrombus accumulation areas and consequent aneurysm growth were identified.The findings of this study highlight the importance of hemodynamics in assessing the vulnerability of the aortic wall and underline the crucial role of patient-specific investigations in predicting the rupture of individual aneurysms.
文摘The equations of the lateral deflection curve of the short pier shear wall under a lateral concentrated load at any level are derived by employing a continuous approach. Lateral flexibility matrixes for the dynamic analysis are also obtained by repeatedly calculating the lateral unit load on the wall at each level where a lumped mass located. Dynamic analyses are implemented for short pier shear walls with different parameters, called the integrative coefficient and the pier strength coefficient related to the dimensions of walls. The influences of two coefficients on the dynamic performances of the structure are studied. Results indicate that with the increase of the integrative coefficient, the periods of top two modes apparently decrease but the other periods of higher frequency modes show little variation when the pier strength coefficient remains constant. Similarly, if the integrative coefficient is constant, the top two periods of the free vibration decrease with the increase of the integrative coefficient but the other periods of higher frequency modes show less variation.
基金Supported by the Applying Basic Research Project of Sichuan Province,China(2015JY0216)the National Natural Science Foundation of China(11421202,81500370)the National Key Research and Development Plan(2016YFC1102203).
文摘Objective:Because of the difficulty in obtaining patient specific flow data,branch arteries are often neglected in the flow simulations of a patient-specific type B aortic dissection(AD)following thoracic endovascular repair(TEVAR).This study aims to investigate the influence of the aortic branch arteries on the hemodynamics and physical flow phenomena commonly associated with aortic modeling of an AD after TEVAR.Methods:The three-dimensional geometry of a type B AD following TEVAR was generated from a high-quality CT dataset.Simulations were performed with all branch arteries,without the four visceral arteries of the abdominal aorta(FVAoAA),and without the upper three branches of the aortic arch(UTBoAA).Results:The removal of the UTBoAA has marginal effect on the flow patterns and hemodynamic parameters in the false lumen(FL);however,regardless of whether there are aorta branches supplied to the FL or not,the omission of FVAoAA will result in a wrong prediction of the flow direction at tears and flow volume to the FL.Conclusions:The omission of aorta branch arteries has great impact on the hemodynamic prediction including flow field and wall shear stress related parameters in a type B AD after TEVAR,which may induce misleading estimates of the potential thrombus in the FL.It is strongly recommended to keep aorta branches in the computational model to predict the post-operative hemodynamic performance in a type B AD following TEVAR.
文摘Shear-wall structures are quite common in seismic areas because of their successful seismic behavior during severe earthquakes. But shear walls are prone to brittle failure. This study proposes a new method of vertically installed dampers (VID) to reduce the vibration in shear-wall structures. The motion characteristic of a vertical damping system is that every mass has horizontal and rotational displacements simultaneously, The establishment of dynamic equations should take into account the equilibrium conditions of both horizontal and rotational vibrations. Dynamic equilibrium equations of VID systems are derived from a model of a structure with VID. An example shear-wall structure, with and with- out VID, is studied. There are some changes in the characteristics of the maximum horizontal displacement response. Without dampers, the relative displacements between different floors in the shear wall increase with height. With dampers, the relative displacements are more uniformly distributed, and lateral displacements at the top and at the bottom are closer. When the damping coefficient is 1 000 kN · s/ m, the numerical results reveal that the maximum horizontal displacement and the maximum rotational displacement of the top floor have reduced by 59.3 % and 54.8 % respectively.